The sophisticated function of the central nervous system (CNS) is largely supported by proper interactions between neural cells and blood vessels. Accumulating evidence has demonstrated that neurons and glial cells support the formation of blood vessels, which in turn, act as migratory scaffolds for these cell types. Neural progenitors are also involved in the regulation of blood vessel formation. This mutual interaction between neural cells and blood vessels is elegantly controlled by several chemokines, growth factors, extracellular matrix, and adhesion molecules (...) such as integrins. Recent research has revealed that newly migrating cell types along blood vessels repel other preexisting migrating cell types, causing them to detach from the blood vessels. In this review, we discuss vascular formation and cell migration, particularly during development. Moreover, we discuss how the crosstalk between blood vessels and neurons and glial cells could be related to neurodevelopmental disorders. (shrink)

KM (Knowledge Management) systems have recently been adopted within the realm of enterprise management. On the other hand, data mining technology is widely acknowledged within Information systems' R&D Divisions. Specially, acquisition of meaningful information from Web usage data has become one of the most exciting eras. In this paper, we employ a Web based KM system and propose a framework for applying Web Usage Mining technology to KM data. As it turns out, task duration varies according to different user operations (...) such as referencing a table-of-contents page, down-loading a target file, and writing to a bulletin board. This in turn makes it possible to easily predict the purpose of the user's task. By taking these observations into account, we segmented access log data manually. These results were compared with results abstained by applying the constant interval method. Next, we obtained a segmentation rule of Web access logs by applying a machine-learning algorithm to manually segmented access logs as training data. Then, the newly obtained segmentation rule was compared with other known methods including the time interval method by evaluating their segmentation results in terms of recall and precision rates and it was shown that our rule attained the best results in both measures. Furthermore, the segmented data were fed to an association rule miner and the obtained association rules were utilized to modify the Web structure. (shrink)

The form of higher plants is largely dependent upon cell division and expansion patterns. Taking a genetic approach, Takahashi et al.(1) have identified a regulatory molecule in Arabidopsis thaliana called DIMINUTO (DIM), which is involved in determining the degree and direction of plant cell expansion. Their extensive characterization of a dim mutant suggested a direct involvement of the DIM gene in regulating cell elongation, perhaps by modulating the expression of structural genes which determine the orientation and elasticity of the cell (...) wall. (shrink)

In April of 2006, the prominent cultural anthropologist Noriyuki Ueda sat down with the Dalai Lama for a two day conversation. This book is based on that long and lively conversation in Dharamsala.

The planet is experiencing a deep metamorphosis. The pressure that is being generated nowadays on the living can be felt in a human lifetime. The extreme speed of climate change and its impact on our ecosystem can no longer be ignored. When looking at the phenomenon of ecological resilience, we notice that after a disturbance, a shock on an ecosystem, like the burning of a forest, the resilient system rebuilds itself but not exactly as it was before, surprisingly new species (...) grow. In social systems, humans have the capacity to anticipate, adapt and invent new patterns of behaviours. In a world where everything is uncertain, moving, shifting, we are making an artistic proposal as an open dynamic system. We are developing two versions of the same HALO project to be presented on the sea and in public places. (shrink)

We proposed the Standards of Conducts to provide a general framework that will serve as the basis for guiding each biostatistician and stem cell researcher to formulate their personal standards, rather than as rules with which they are required to comply. Given the responsibility and characteristics of their work, they are expected to maintain independence and work autonomously as professionals. Each of the Standards of Conducts comprises a preamble, mission and values to uphold, Standards of Conducts, and background. When one (...) internalizes “self-formulated” standards, to make excuses for oneself would be akin to a self-betrayal; responsible actions can be anticipated. If one begins and continues to consider “who I am and what do I work for,” this will become their inner energy, and a source of motivation and pride to inspire oneself. In addition, this aspirational style might help citizens to recognize the autonomous stance of the professional body and that they share the same values. (shrink)

In nature, cells face a variety of stresses that cause physical damage to the plasma membrane and cell wall. It is well established that evolutionarily conserved cell cycle checkpoints monitor various cellular perturbations, including DNA damage and spindle misalignment. However, the ability of these cell cycle checkpoints to sense a damaged plasma membrane/cell wall is poorly understood. To the best of our knowledge, our recent paper described the first example of such a checkpoint, using budding yeast as a model. In (...) this review, we will discuss this important question as well as provide hypothetical explanations to be tested in the future. (shrink)

A critical examination of Japanese literary and art theories.

ABSTRACT “Meister Eckhart’s Mysticism in Comparison with Zen Buddhism” originally appeared as the concluding section of Ueda Shizuteru’s first book, Die Gottesgeburt in der Seele und der Durchbruch zur Gottheit: Die mystische Anthropologie Meister Eckharts und ihre Konfrontation mit der Mystik des Zen-Buddhismus. It was first published in 1965 as an expanded version of Ueda’s doctoral dissertation, which was written under the supervision of Ernst Benz at the University of Marburg. Ueda’s careful analysis not only illuminates important (...) points of affinity between Eckhart and Zen, but also explains why Eckhart’s mysticism cannot be simply interchanged with Zen Buddhism. To allow the reader to read for themselves, I kept all interpretative notes to a minimum. The text is translated from the most recent edition of the German text, published in 2018 by Verlag Karl Alber, and edited by Wolf Burbat. The German pagination is interpolated in bold throughout the text. (shrink)

Autonomous sensory meridian response is a complex sensory-emotional experience characterized by pleasant tingling sensations initiating at the scalp. ASMR is triggered in some people by stimuli including whispering, personal attention, and crisp sounds. Since its inception, ASMR has been likened to synesthesia, but convincing empirical data directly linking ASMR with synesthesia is lacking. In this study, we examined whether the prevalence of synesthesia is indeed significantly higher in ASMR-responders than non-responders. A sample of working adults and students were surveyed about (...) their experience with ASMR and common types of synesthesia. The proportion of synesthetes who were classified as ASMR-responders was 52%, whereas 22% of ASMR-responders were also synesthetes. These results suggest that: over half of those identifying as synesthetes also experience ASMR, and that synesthesia is up to four times as common among ASMR-responders as among non-responders. Findings also suggest a prevalence rate for ASMR of approximately 20%. Overall, the co-occurrence of ASMR and synesthesia lends empirical support to the idea that ASMR may be driven by synesthetic mechanisms, but future research would benefit from examining how ASMR and synesthesia are different, as well as similar. (shrink)

In this article I examine Lavoisier's collaboration with his wife in the translation of Kirwan's An essay on phlogiston into French (Essai sur le phlogistique, 1788). This translation is a kind of counter attack by the school of French scholars around Lavoisier. Mrs Lavoisier is generally considered only to have translated Kirwan's book, not to have refuted it. Through a detailed analysis of the translation, of her manuscripts, and of other documents of the period, I conclude that Mrs Lavoisier not (...) only actively attacked the doctrine of phlogiston in her translation, but in the notes and preface to it as well. In addition to her high-level knowledge of chemistry, her close scientific relationship with her husband should be noted. In the first three parts of the translation, the two shared the work between them, in order to convine the readers. A show that Mrs Lavoisier advocated the study of gases from the point of view of their motions, and that she always believed that her husband's theory would prevail. Moreover, Lavoisier assessed his wife's talent at its true value. (shrink)

This article extends the concept of symmetry to ethics. Using the case of canola in Canada, the authors argue that grades and standards simultaneously subject humans and nonhumans to rites of passage that test their "goodness. " Then, they further develop a tentative typology of standards. The authors argue that these standards allow something resembling the neoclassical market to be established, create the conditions for economic analysis, and allocate power among human actors.

人間の存在は元来「場所」的である。が、その「場所」の根本性格はどのようなものなのであろうか。私たちの存在が「世界の内にあること」と見られる場合、その世界そのものは「限りない開け」に於いてある。したがっ て我々の存在は「限りない開けに於いてある世界に於いてある」ことになる。この二重の「於いてある」は、二重性としては見えない構造のものであるが、我々の実際の生活の様々な領域の様々な営為にまで拡がる。本書は ハイデッガーの基礎存在論、ボルノウの空間論、エリアーデのヒエロファニー論、西田幾多郎の場所論、禅の十牛図などを手掛かりにして人間存在の基本的な構造を解明、考察する。.

In this paper, we conceptually explore the role of empathy as a connectedness organising mechanism. We expand ideas underlying positive organisational scholarship and examine leading-edge studies from neuroscience and quantum physics that give support to our claims. The perspective we propose has profound implications regarding how we organise and how we manage. First, we argue that empathy enhances connectedness through the unconscious sharing of neuro-pathways that dissolves the barriers between self and other. This sharing encourages the integration of affective and (...) cognitive consciousness which facilitates the ability to find common ground for solution building. Second, empathy enhances connectedness through altruistic action. In giving to others, feelings of joy and harmony are activated. This in turn allows personal freedom to be enriched and transcendence from the rational ego-self is reduced to develop a more expansive, integrated and enlightened state underlying connectedness. Finally, empathy enhances connectedness which results in sharing the quantum field of coherence where there is little separation between self and other. This means living beyond self-interest in a coherent world based upon interdependent wholeness rather than atomization and separation. Empathy allows us to find that state of coherent connectedness. (shrink)

Social dilemmas, in which individually selfish behavior leads to collectively deficient outcomes, continue to be an important topic of research because of their ubiquity. The present research with Japanese participants replicates, with slight modifications, public goods games previously run in the United States. In contrast to recent work showing profound cross-cultural differences, the results of two studies reported here show remarkable cross-cultural similarities. Specifically, results suggest that (1) as in the U.S., allowing incremental commitment to a public good is effective (...) at eliciting contributions, (2) individual differences in trust affect contributions, (3) the distribution of player types in the U.S. and Japan are very similar, and (4) the dynamics of play in the public goods games used here are strikingly parallel. These results are discussed in the context of the relationship between cross-cultural differences and economic institutional environments. (shrink)

What Does Only Assert and Entail? This paper investigates the semantics of English only and two equivalent expressions in Japanese -dake and -shika, giving attention to two aspects: the debate over the status of two propositions that are involved in the use of ONLY expressions and the semantic and pragmatic differences among ONLY items, if any. We claim that a sentence with ONLY expressions entails both the affirmative and negative propositions. This view raises issues with Horn's original claim as well (...) as van Rooij and Schulz's while supporting Atlas and Horn. We claim then that the difference in strength between the affirmative and negative propositions emerges from what is asserted by that sentence. One of the bases for our claim is that there is a significant difference in behavior between entailment and assertion of a given sentence, following Horn. This difference explains the difference between -dake on the one hand and -shika and -only on the other: -dake differs from only and -shika in that it asserts the affirmative proposition while -shika and only asserts the negative proposition. (shrink)

The topic of this article is the self-less self (selbst-lose Selbst) and more particularly this self in its connection with the problem of language. There exists a movement of the self-less self from itself toward itself. This movement also occurs as the liberation from language toward language; language reaches into the core of being self because our understanding of self and of the world is linguistically constituted. Similarly the fundamental conversion - as the occurence of the breakthrough (by means of (...) the I-am-myself) to the truth of the self - is nothing else than an original word event. The self-less, the true self says at this moment: “I am myself by not being myself (Ich bin, indem ich nicht ich bin, ich).” In order to gain a better understanding we now start from the problem of language. (shrink)

One’s generosity to others declines as a function of social distance, which is known as social discounting. We examined cultural similarities and differences in social discounting and the mediating roles of the two aspects of interdependence (self-expression and distinctiveness of the self) as well as the two aspects of independence (harmony-seeking and rejection avoidance). Using the same procedure that previous researchers used to test North Americans, Study 1 showed that compared to North Americans, Japanese discount more steeply a partner’s outcomes (...) compared to their own future outcomes, whereas the decrease in the subjective value of the partner’s outcomes accelerates less as a function of social distance. To examine the cultural similarities and differences in social discounting in more detail, Study 2 tested Japanese and Germans and found that the hyperbolic with exponent model fitted the participants’ discounting behaviors better than the other models, except for the loss condition in Germans where the utility of the q-exponential model was indicated. Moreover, although the social discounting rate was higher in Japanese than in Germans, the cultural difference was limited to the gain frame. However, the decline in a person’s generosity accelerated less as a function of social distance in Japanese than in Germans. Furthermore, the cultural difference in the social discounting in gains was mediated by the level of harmony-seeking, which was higher in Germans than in Japanese. Implications for individuals’ generosity against the backdrop of cultural characteristics are discussed. (shrink)

This investigation examines ‘teasing’ of non-combatant children by US military service personnel in occupied Iraq and Afghanistan. The majority of existent investigations of teasing and related practices place significant conceptual importance on the intentions of the teaser – such that a target can understand that the tease is not true. However, in data examined here it appears that targets do not understand the language in which the teasing is undertaken. Drawing from publicly available video footage posted on the video sharing (...) website Liveleak, we provide an ethnomethodological and conversation analytic informed examination of how persons initiating teasing strategically exploit asymmetries in the sequential and preferential organization of interactions when tease recipients do not have sufficient English skills to redress the negative assessments being made of them. Three types of candidate teasing practices are identified: soldier initiated negative other-assessments; target parroting negative other-assessments; and offer-withdrawal games. Analysis examines how such interactions effectively fail as teases and explores how children can resist soldiers’ pursuit of degrading responses. (shrink)

Stomata are microscopic pores on the surface of land plants used for gas and water vapor exchange. A pair of highly specialized guard cells surround the pore and adjust pore size. Studies in Arabidopsis have revealed that cell–cell communication is essential to coordinate the asymmetric cell divisions required for proper stomatal patterning. Initial research in this area identified signaling molecules that negatively regulate stomatal differentiation. However, genes promoting cell‐fate transition leading to mature guard cells remained elusive. Now, three closely related (...) basic helix–loop–helix (bHLH) proteins, SPEECHLESS, MUTE and FAMA have been identified as positive regulators that direct three consecutive cell‐fate decisions during stomatal development. The identification of these genes opens a new direction to investigate the evolution of stomatal development and the conserved functions of bHLH proteins in cell type differentiation adopted by plants and animals. BioEssays 29:861–870, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

While much has been written about the uniquely Hawaiian take on the category “local” – usually in terms of resistance to colonization, the alternative or counterhegemonic – little has been written about “haole”, the trope that served to silhouette the “local” and has evolved in dialectical opposition to it. A term that emerged during the plantation era to represent working-class immigrant workers mostly from Asia, “local” is constructed by exclusion. It has evolved to represent solidarity against all “external forces” controlling (...) Hawai'i from without, such as land development, tourism and the military – all readily equated with haole, the visible sign of whiteness. The prevalence of the prescription “local vs. haole” in contemporary Hawai'i begs an inquiry into other interpretations that are being suppressed. This paper explores some suppressed histories, imaginings and subconscious aspects of identity in Hawai'i through the figure of the white person whose parents – and possibly great-great-great-grandparents – were born and raised in Hawai'i. (shrink)

This article explores the concept of knowledge as an internal process of inner knowing. In the educational context, we describe our experiences in using art in the classroom to assist our students in accessing this inner knowing. We describe the design and use of such creative expressions. Our findings indicate that students have to integrate both right- and left-brain thinking to access their inner tuition. This slows down linear thinking in order to access the more affective-based learning process. Further, it (...) encourages students to experiment with non-linear methods of learning. We argue that these findings assist students in accessing more choices in their decision making, which in turn will build managers who energize, revitalize and facilitate the growth of humanity through organizational compassion and understanding. (shrink)