Mediator is a coregulatory complex that plays essential roles in multiple processes of transcription regulation. One of the human Mediator subunits, MED26, has a role in recruitment of the super elongation complex (SEC) to polyadenylated genes and little elongation complex (LEC) to non‐polyadenylated genes, including small nuclear RNAs (snRNAs) and replication‐dependent histone (RDH) genes. MED26‐containing Mediator plays a role in 3′ Pol II pausing at the proximal region of transcript end sites in RDH genes through recruitment of Cajal bodies (CBs) (...) to histone locus bodies (HLBs). This finding suggests that Mediator is involved in the association of CBs with HLBs to facilitate 3′ Pol II pausing and subsequent 3′‐end processing by supplying 3′‐end processing factors from CBs. Thus, we argue the possibility that Mediator is involved in the organization of nuclear bodies to orchestrate multiple processes of gene transcription. (shrink)

The planet is experiencing a deep metamorphosis. The pressure that is being generated nowadays on the living can be felt in a human lifetime. The extreme speed of climate change and its impact on our ecosystem can no longer be ignored. When looking at the phenomenon of ecological resilience, we notice that after a disturbance, a shock on an ecosystem, like the burning of a forest, the resilient system rebuilds itself but not exactly as it was before, surprisingly new species (...) grow. In social systems, humans have the capacity to anticipate, adapt and invent new patterns of behaviours. In a world where everything is uncertain, moving, shifting, we are making an artistic proposal as an open dynamic system. We are developing two versions of the same HALO project to be presented on the sea and in public places. (shrink)

The form of higher plants is largely dependent upon cell division and expansion patterns. Taking a genetic approach, Takahashi et al.(1) have identified a regulatory molecule in Arabidopsis thaliana called DIMINUTO (DIM), which is involved in determining the degree and direction of plant cell expansion. Their extensive characterization of a dim mutant suggested a direct involvement of the DIM gene in regulating cell elongation, perhaps by modulating the expression of structural genes which determine the orientation and elasticity of the cell (...) wall. (shrink)

In nature, cells face a variety of stresses that cause physical damage to the plasma membrane and cell wall. It is well established that evolutionarily conserved cell cycle checkpoints monitor various cellular perturbations, including DNA damage and spindle misalignment. However, the ability of these cell cycle checkpoints to sense a damaged plasma membrane/cell wall is poorly understood. To the best of our knowledge, our recent paper described the first example of such a checkpoint, using budding yeast as a model. In (...) this review, we will discuss this important question as well as provide hypothetical explanations to be tested in the future. (shrink)

We proposed the Standards of Conducts to provide a general framework that will serve as the basis for guiding each biostatistician and stem cell researcher to formulate their personal standards, rather than as rules with which they are required to comply. Given the responsibility and characteristics of their work, they are expected to maintain independence and work autonomously as professionals. Each of the Standards of Conducts comprises a preamble, mission and values to uphold, Standards of Conducts, and background. When one (...) internalizes “self-formulated” standards, to make excuses for oneself would be akin to a self-betrayal; responsible actions can be anticipated. If one begins and continues to consider “who I am and what do I work for,” this will become their inner energy, and a source of motivation and pride to inspire oneself. In addition, this aspirational style might help citizens to recognize the autonomous stance of the professional body and that they share the same values. (shrink)

This article extends the concept of symmetry to ethics. Using the case of canola in Canada, the authors argue that grades and standards simultaneously subject humans and nonhumans to rites of passage that test their "goodness. " Then, they further develop a tentative typology of standards. The authors argue that these standards allow something resembling the neoclassical market to be established, create the conditions for economic analysis, and allocate power among human actors.

The sophisticated function of the central nervous system (CNS) is largely supported by proper interactions between neural cells and blood vessels. Accumulating evidence has demonstrated that neurons and glial cells support the formation of blood vessels, which in turn, act as migratory scaffolds for these cell types. Neural progenitors are also involved in the regulation of blood vessel formation. This mutual interaction between neural cells and blood vessels is elegantly controlled by several chemokines, growth factors, extracellular matrix, and adhesion molecules (...) such as integrins. Recent research has revealed that newly migrating cell types along blood vessels repel other preexisting migrating cell types, causing them to detach from the blood vessels. In this review, we discuss vascular formation and cell migration, particularly during development. Moreover, we discuss how the crosstalk between blood vessels and neurons and glial cells could be related to neurodevelopmental disorders. (shrink)

In this paper, we conceptually explore the role of empathy as a connectedness organising mechanism. We expand ideas underlying positive organisational scholarship and examine leading-edge studies from neuroscience and quantum physics that give support to our claims. The perspective we propose has profound implications regarding how we organise and how we manage. First, we argue that empathy enhances connectedness through the unconscious sharing of neuro-pathways that dissolves the barriers between self and other. This sharing encourages the integration of affective and (...) cognitive consciousness which facilitates the ability to find common ground for solution building. Second, empathy enhances connectedness through altruistic action. In giving to others, feelings of joy and harmony are activated. This in turn allows personal freedom to be enriched and transcendence from the rational ego-self is reduced to develop a more expansive, integrated and enlightened state underlying connectedness. Finally, empathy enhances connectedness which results in sharing the quantum field of coherence where there is little separation between self and other. This means living beyond self-interest in a coherent world based upon interdependent wholeness rather than atomization and separation. Empathy allows us to find that state of coherent connectedness. (shrink)

KM (Knowledge Management) systems have recently been adopted within the realm of enterprise management. On the other hand, data mining technology is widely acknowledged within Information systems' R&D Divisions. Specially, acquisition of meaningful information from Web usage data has become one of the most exciting eras. In this paper, we employ a Web based KM system and propose a framework for applying Web Usage Mining technology to KM data. As it turns out, task duration varies according to different user operations (...) such as referencing a table-of-contents page, down-loading a target file, and writing to a bulletin board. This in turn makes it possible to easily predict the purpose of the user's task. By taking these observations into account, we segmented access log data manually. These results were compared with results abstained by applying the constant interval method. Next, we obtained a segmentation rule of Web access logs by applying a machine-learning algorithm to manually segmented access logs as training data. Then, the newly obtained segmentation rule was compared with other known methods including the time interval method by evaluating their segmentation results in terms of recall and precision rates and it was shown that our rule attained the best results in both measures. Furthermore, the segmented data were fed to an association rule miner and the obtained association rules were utilized to modify the Web structure. (shrink)

In this article I examine Lavoisier's collaboration with his wife in the translation of Kirwan's An essay on phlogiston into French (Essai sur le phlogistique, 1788). This translation is a kind of counter attack by the school of French scholars around Lavoisier. Mrs Lavoisier is generally considered only to have translated Kirwan's book, not to have refuted it. Through a detailed analysis of the translation, of her manuscripts, and of other documents of the period, I conclude that Mrs Lavoisier not (...) only actively attacked the doctrine of phlogiston in her translation, but in the notes and preface to it as well. In addition to her high-level knowledge of chemistry, her close scientific relationship with her husband should be noted. In the first three parts of the translation, the two shared the work between them, in order to convine the readers. A show that Mrs Lavoisier advocated the study of gases from the point of view of their motions, and that she always believed that her husband's theory would prevail. Moreover, Lavoisier assessed his wife's talent at its true value. (shrink)

While much has been written about the uniquely Hawaiian take on the category “local” – usually in terms of resistance to colonization, the alternative or counterhegemonic – little has been written about “haole”, the trope that served to silhouette the “local” and has evolved in dialectical opposition to it. A term that emerged during the plantation era to represent working-class immigrant workers mostly from Asia, “local” is constructed by exclusion. It has evolved to represent solidarity against all “external forces” controlling (...) Hawai'i from without, such as land development, tourism and the military – all readily equated with haole, the visible sign of whiteness. The prevalence of the prescription “local vs. haole” in contemporary Hawai'i begs an inquiry into other interpretations that are being suppressed. This paper explores some suppressed histories, imaginings and subconscious aspects of identity in Hawai'i through the figure of the white person whose parents – and possibly great-great-great-grandparents – were born and raised in Hawai'i. (shrink)

What Does Only Assert and Entail? This paper investigates the semantics of English only and two equivalent expressions in Japanese -dake and -shika, giving attention to two aspects: the debate over the status of two propositions that are involved in the use of ONLY expressions and the semantic and pragmatic differences among ONLY items, if any. We claim that a sentence with ONLY expressions entails both the affirmative and negative propositions. This view raises issues with Horn's original claim as well (...) as van Rooij and Schulz's while supporting Atlas and Horn. We claim then that the difference in strength between the affirmative and negative propositions emerges from what is asserted by that sentence. One of the bases for our claim is that there is a significant difference in behavior between entailment and assertion of a given sentence, following Horn. This difference explains the difference between -dake on the one hand and -shika and -only on the other: -dake differs from only and -shika in that it asserts the affirmative proposition while -shika and only asserts the negative proposition. (shrink)

Social dilemmas, in which individually selfish behavior leads to collectively deficient outcomes, continue to be an important topic of research because of their ubiquity. The present research with Japanese participants replicates, with slight modifications, public goods games previously run in the United States. In contrast to recent work showing profound cross-cultural differences, the results of two studies reported here show remarkable cross-cultural similarities. Specifically, results suggest that (1) as in the U.S., allowing incremental commitment to a public good is effective (...) at eliciting contributions, (2) individual differences in trust affect contributions, (3) the distribution of player types in the U.S. and Japan are very similar, and (4) the dynamics of play in the public goods games used here are strikingly parallel. These results are discussed in the context of the relationship between cross-cultural differences and economic institutional environments. (shrink)

One’s generosity to others declines as a function of social distance, which is known as social discounting. We examined cultural similarities and differences in social discounting and the mediating roles of the two aspects of interdependence (self-expression and distinctiveness of the self) as well as the two aspects of independence (harmony-seeking and rejection avoidance). Using the same procedure that previous researchers used to test North Americans, Study 1 showed that compared to North Americans, Japanese discount more steeply a partner’s outcomes (...) compared to their own future outcomes, whereas the decrease in the subjective value of the partner’s outcomes accelerates less as a function of social distance. To examine the cultural similarities and differences in social discounting in more detail, Study 2 tested Japanese and Germans and found that the hyperbolic with exponent model fitted the participants’ discounting behaviors better than the other models, except for the loss condition in Germans where the utility of the q-exponential model was indicated. Moreover, although the social discounting rate was higher in Japanese than in Germans, the cultural difference was limited to the gain frame. However, the decline in a person’s generosity accelerated less as a function of social distance in Japanese than in Germans. Furthermore, the cultural difference in the social discounting in gains was mediated by the level of harmony-seeking, which was higher in Germans than in Japanese. Implications for individuals’ generosity against the backdrop of cultural characteristics are discussed. (shrink)

Stomata are microscopic pores on the surface of land plants used for gas and water vapor exchange. A pair of highly specialized guard cells surround the pore and adjust pore size. Studies in Arabidopsis have revealed that cell–cell communication is essential to coordinate the asymmetric cell divisions required for proper stomatal patterning. Initial research in this area identified signaling molecules that negatively regulate stomatal differentiation. However, genes promoting cell‐fate transition leading to mature guard cells remained elusive. Now, three closely related (...) basic helix–loop–helix (bHLH) proteins, SPEECHLESS, MUTE and FAMA have been identified as positive regulators that direct three consecutive cell‐fate decisions during stomatal development. The identification of these genes opens a new direction to investigate the evolution of stomatal development and the conserved functions of bHLH proteins in cell type differentiation adopted by plants and animals. BioEssays 29:861–870, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The author proposes the development of systems learning guidebooks to accompany famous children's classic books. Children's classic books can make excellent bases for children's learning guidebooks on systems thinking and global ecology, because they are fun to read and well known worldwide. If such learning guidebooks are properly designed with humor and entertaining aspects, they could stimulate children to learn more about systems thinking. Lewis Carroll's Alice's Adventures in Wonderland is chosen as a pilot case for developing such a children's (...) guidebook. The systems learning guidebook that accompanies Alice's Wonderland shall be entitled Alice in Systems Wonderland and will help its readers look at the Alice's Wonderland story with a systems perspective. (shrink)

As its name implies, Vasubandhu’s _Vyākhyāyukti_ (VyY) explains the logic or methodology (_yukti_) of exegesis or sūtra interpretation (_vyākhyā_) and only survives in a Tibetan translation. In recent years, research on this treatise has been gradually accumulating. However, due to the difficulty of the Tibetan translation, some of the arguments therein have been misunderstood. In this article, after reviewing the general framework of Vasubandhu’s method of interpreting the sūtras, I will present a newly discovered parallel regarding his discussion of the (...) “purpose, _prayojana_” of the sūtras and reread it through a close philological examination of various sources in Sanskrit and Tibetan. Thus, this article will first elucidate the details of Vasubandhu’s explanation of the purpose of the Buddha’s preaching using synonyms and will clarify an aspect of his views on the Buddha’s word. In addition, concerning this “purpose,” I will elucidate the characteristics of the final chapter of this text, which provides stories about hearing the Buddha’s words with respect. By doing so, I would like to reveal the characteristics of the VyY as a manual for vivid preaching. (shrink)

It is one of the peculiar features of the movement of translation of Western scientific treatises from Dutch into Japanese, known as Dutch learning , that if first originated in Nagasaki with a group of Japanese interpreters. This group differed from the scholarly community of the capital, Edo, by both training and social status. This article shows how this difference contributes to explaining some of the particularities of rangaku in its initial phase. A case in point is Shizuki Tadao's introduction (...) of Newtonian physics and astronomy. Yet, Sugita Genpaku, a major representative of the Edo scholarly community, gave an account of the beginning of Dutch learning that attempted to minimise, or even to erase, the contribution of the Nagasaki interpreters, who were dismissed as unscholarly. This attempt, too, is best understood in the light of the difference between the two communities. (shrink)

This investigation examines ‘teasing’ of non-combatant children by US military service personnel in occupied Iraq and Afghanistan. The majority of existent investigations of teasing and related practices place significant conceptual importance on the intentions of the teaser – such that a target can understand that the tease is not true. However, in data examined here it appears that targets do not understand the language in which the teasing is undertaken. Drawing from publicly available video footage posted on the video sharing (...) website Liveleak, we provide an ethnomethodological and conversation analytic informed examination of how persons initiating teasing strategically exploit asymmetries in the sequential and preferential organization of interactions when tease recipients do not have sufficient English skills to redress the negative assessments being made of them. Three types of candidate teasing practices are identified: soldier initiated negative other-assessments; target parroting negative other-assessments; and offer-withdrawal games. Analysis examines how such interactions effectively fail as teases and explores how children can resist soldiers’ pursuit of degrading responses. (shrink)

This article explores the concept of knowledge as an internal process of inner knowing. In the educational context, we describe our experiences in using art in the classroom to assist our students in accessing this inner knowing. We describe the design and use of such creative expressions. Our findings indicate that students have to integrate both right- and left-brain thinking to access their inner tuition. This slows down linear thinking in order to access the more affective-based learning process. Further, it (...) encourages students to experiment with non-linear methods of learning. We argue that these findings assist students in accessing more choices in their decision making, which in turn will build managers who energize, revitalize and facilitate the growth of humanity through organizational compassion and understanding. (shrink)

Using the case of food safety governance reform in Japan between 2001 and 2003, this paper examines the relationship between science and trust. The paper explains how the discovery of the first BSE positive cow and consequent food safety scandals in 2001 politicized the role of science in protecting the safety of the food supply. The analysis of the Parliamentary debate focuses on the contestation among legislators and other participants over three dimensions of risk science, including “knowledge,” “objects,” and “beneficiaries.” (...) The metaphor of “seven samurai” and the relationally situated roles of “samurai,” “bandits,” and “beneficiaries” are used to show that in the process of policy making certain moral and ethical expectations on a new expert institution for food safety were contested and negotiated to frame responsibilities and commitments of social actors for creating the food system based on trust. (shrink)

Adopting a modified Stroop task, the authors tested the hypothesis that processing systems brought to bear on comprehension of emotional speech are attuned primarily to word evaluation in a low-context culture and language (i.e., in English), but they are attuned primarily to vocal emotion in a high-context culture and language (i.e., in Japanese). Native Japanese (Studies 1 and 2) and English speakers (Study 3) made a judgement of either vocal emotion or word evaluation of an emotionally spoken evaluative word. Word (...) evaluations and vocal emotions were comparable in extremity in the two languages. In support of the hypothesis, an interference effect by competing word evaluation in the vocal emotion judgement was significantly stronger in English than in Japanese. In contrast, an interference effect by competing vocal emotion in the word evaluation judgement was stronger in Japanese than in English. Implications for the cultural grounding of communication, emotion, and cognition are discussed. (shrink)