High degrees of uncertainty and a lack of effective therapeutic treatments have characterized the COVID-19 pandemic and the provision of drug products outside research settings has been controversial. International guidelines for providing patients with experimental interventions to treat infectious diseases outside of clinical trials exist but it is unclear if or how they should apply in settings where clinical trials and research are strongly regulated. We propose the Professional Oversight of Emergency-Use Interventions and Monitoring System as an alternative pathway based (...) on guidance developed for the ethical provision of experimental interventions to treat COVID-19 in Singapore. We support our proposal with justifications that establish moral duties for physicians to record outcomes data and for institutions to establish monitoring systems for reporting information on safety and effectiveness to the relevant authorities. Institutions also have a duty to support generation of evidence for what constitutes good clinical practice and so should ensure the unproven intervention is made the subject of research studies that can contribute to generalizable knowledge as soon as practical and that physicians remain committed to supporting learning health systems. We outline key differences between POEIMS and other pathways for the provision of experimental interventions in public health emergencies. (shrink)

The sheer impact of the recent global financial turmoil and scandals (such as Enron and WorldCom) has demonstrated that unbridled commercial entrepreneurs who are allowed to pursue their short-term opportunities regardless of the consequences has led to a massive depreciation of the wealth of nations, social livelihood and environmental degradation. This article suggests that the time has come for entrepreneurs to adopt a more integrative view of business that blends economic, social and environmental values. Social entrepreneurs present such a proposition (...) through their deep commitment towards the social vision, appreciation of sustainable practices, innovativeness, ability to build social networks and also generate viable financial returns. It could be expected that social entrepreneurs often possess certain distinct personality characteristics which define their behaviours/actions. Personality traits are partly developed by innate nurturing, socialization and education. These tacit traits are also formed values/beliefs held and play an important role in driving social entrepreneurial decision making. Thus, personality traits may influence the intentions and the manner in which the individual acts. We hold that if social entrepreneurship is to be effective and impactful, business and management education can facilitate the development of these critical personality traits. Thus, this study primes at determining the personality traits that influence social entrepreneurs’ start-up intentions. It also reinforces the findings that personality traits do influence entrepreneurship in general. This study examines the influence of the Big Five personality traits on social entrepreneurship dimensions. The findings reveal that agreeableness positively influences all dimensions of social entrepreneurship, whereas openness exerts a positive influence on social vision, innovation and financial returns. Methodologically, this study develops valid and reliable scales for social entrepreneurship and verifies the adopted Big Five personality measure of Schmit et al. (Pers Psychol 53:153–193, 2000) using the five-point Likert scale. The implication of this study is that element of appreciation of social responsibility, sustainability and character development needs to be integrated within the business education curriculum to support social entrepreneurs in realizing genuine value and impact to the causes and communities they serve. Future business leaders also need to be equipped with entrepreneurship skills, while exuding independent and reflective thinking in the pursuit life-long learning. The originality of this study lies in its focus on personality traits on social rather than commercial entrepreneurship. It is hoped that the findings will trigger a paradigm shift towards greater social entrepreneurship through education by nurturing sustainable development values in future business graduates. (shrink)

Adopting an Ethics of Care theoretical framework, this paper aims to investigate the way in which the owner-mangers (OMs) of small and medium-sized enterprises in Malaysia engage in human resource management. Based on in-depth interviews with 48 OMs, the findings show that HRM practices occur within the remit of management but are described by the managers in terms of relational obligations and cannot be fully accounted for using a strategic, instrumental, or critical lens. The present study highlights the importance of (...) the caring attitudes of OMs who adopt a humanistic management approach, responding to the varied needs of their employees and the obligations which are inherent to relationships between humans. (shrink)

The Ethics of Care (EoC) theory has been widely applied in the field of management, and there is a growing consensus that it is important to recognise the value and practice of care in the workplace. In this paper, we consider the implications of the EoC at work, and in particular the risks unboundaried care demands may pose to employees who encounter unmanageable ‘calls to care’. We present findings from interviews with 27 nurses in Malaysia, which suggest that the demand (...) to care at work, in addition to demands made in the non-work sphere, may be unmanageable. We argue for a more boundaried approach to the EoC at work with a view to ensuring that in valuing care we do not over-burden the carer. (shrink)

Both Notch and NFκB signaling pathways are well‐known for regulating proliferation, differentiation and apoptosis. Recent studies have presented several lines of evidence supporting an integration of the Notch and NFκB signaling pathways in differentiation/maturation of a diverse range of cell types. It is notable that Notch and NFκB signaling pathways share many common features: (i) both are activated by common stimuli such as TNF‐α and hypoxia, (ii) activated Notch (NICD) and NFκB mediate transcription by regulating corepressors such as SMRT/N‐COR, and (...) (iii) both regulate similar target genes such as Hes‐1 and IκBα. This review expands on how the collaboration between these pathways may play an important role in the CNS. We will speculate on the mechanisms by which Notch and NFκB signaling may collaborate to regulate stem cell renewal and differentiation during brain development and function. BioEssays 29:1039–1047, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The desire-satisfaction theory of welfare says that what is basically good for a subject is the satisfaction of his desires. One challenge to this view is the existence of quirky desires, such as a desire to count blades of grass. It is hard to see why anyone would desire such things, and thus hard to believe that the satisfaction of such desires could be basically good for anyone. This suggests that only some desires are basically good when satisfied, and that (...) desire satisfactionists owe us an account of which desires these are, and why. In "Quirky Desires and Well-Being," Donald Bruckner proposes such an account: a desire is welfare-relevant (i.e., such that its satisfaction would be basically good for its subject) if and only if and because its subject could describe its object in a way that makes it comprehensible what about the object attracts him or appeals to him. We are inclined to view quirky desires as welfare-irrelevant because we assume that their objects cannot be described in such a way. But if there were a quirky desire whose object could be so described by the subject whose desire it is, then this desire would be relevant to that subject's welfare. I will argue that while Bruckner's view delivers plausible verdicts about the cases to which it is meant to apply, its account of what makes a desire welfare-relevant is unmotivated and implausible. Desire satisfactionists can retain what is plausible about his view while endorsing a better explanation of why welfare-relevant desires have that status if they accept the following account instead: a desire is welfare-relevant if and only if and because something about its object attracts, or appeals to, the subject who has the desire. (shrink)

The cost of basic income is typically estimated for a particular year. However, to assess the financial feasibility of basic income, it is also important to consider how much basic income will cost in the future. This is especially important in countries experiencing an ageing population, where the proportion of workers is expected to shrink. This article considers basic income as a universal life annuity and develops two models based on actuarial concepts to estimate the flat tax rate required to (...) finance basic income. The first model considers the cost of basic income over the lifetime of the current population and the second model additionally considers changing population dynamics. The proposed models are conceptually simple, providing a straightforward way to assess the financial feasibility of basic income. Using Singapore data, the models show that the monthly cut-off income separating net contributors and net recipients is around $2710 and benefits around 39 % of adult residents. A tax rate of around 22 % is required to support a basic income of $600. (shrink)

This essay draws on classical Confucian intellectual resources to argue that the person who emerges from a head transplant would be neither the person who provided the head, nor the person who provided the body, but a new, different person. We construct two types of argument to support this conclusion: one is based on the classical Confucian metaphysics of human life as qi activity; the other is grounded in the Confucian view of personal identity as being inseparable from one’s familial (...) relations. These Confucian ideas provide a reasonable alternative to the currently dominant view that one’s personal identity “follows” one’s head. Together, these arguments imply that head transplantation is ethically inappropriate. (shrink)

Das Problem des Seinsglaubens in der Phänomenologie Husserls läßt sich zweifelsohne zu deren zentralen Themen wie Wahmehmung, Phantasie und Zeitbewußtsein zählen und steht auch in engem Zusammenhang mit diesen. Das Buch Seinsglaube in der Phänomenologie Edmund Husserls versucht dieses Problem zu klaren und zu zeigen, wie weit Husserl bei der Lösung dieses Problems gekommen ist und welche Fragen dabei offen blieben, die weiterer Lösungen bedürfen. Zudem werden die Gründe für das Gelingen bzw. Mißlingen bei Husserls Bemühungen herausgearbeitet. Die Einleitung erörtert (...) die verschiedenen Bedeutungen des Begriffs 'Seinsglauben' und zeichnet den Ort des Seinsglaubens im phänomenologischen System Husserls vor. Der erste Teil des Buches stellt sich als Hauptaufgabe die Strukturanalyse des Seinsglaubens aus verschiedenen Aspekten. In den ersten vier Kapiteln wird Husserls Exposition der verschiedenen Richtungen des Seinsglaubens, der Modalitäten, Modifikationen sowie der Eigentlichkeit und der Uneigentlichkeit des Seinsglaubens stufenweise behandelt. Das V. Kapitel, das den zweiten Teil einleitet, bildet den Wendepunkt der Arbeit, da es sich einerseits weiter mit Husserls Darstellung des Seinsglaubens, und zwar hier der verschiedenen Glaubensweisen, beschäftigt, andererseits schon Bezug auf die verschiedenen Weisen der Ausschaltung des Seinsglaubens nimmt, welche im VI. VII. und VIII. Kapitel das Hauptthema bilden: die eidetische Reduktion, Neutralitätsmodifikation und die transzendentale Reduktion. Der Schwerpunkt der vorliegenden Arbeit liegt auf den in der Forschungsliteratur bisher wenig beachteten Husserlschen Analysen zur Neutralitätsmodifikation (Kapitel VII) im Zusammenhang mit dem Problem des Seinsglaubens in der Vergegenwärtigung. Da die transzendentale Reduktion, eine andere wichtige Methode der Ausschaltung des Seinsglaubens im Sinne der Neutralitätsmodifikation, in der phänomenologischen Literatur bereits gründlich behandelt ist, wird sie hier nur in dem Maß in Betracht gezogen, insofern sie sich von der Neutralitätsmodifikation deutlich abhebt. Eine rückblickende Zusammenfassung der ganzen Untersuchung beschließt die Arbeit. (shrink)

René Descartes is often thought to have exerted a pernicious influence on our views concerning the relationship of humans to the environment. The view that because animals are machines, “thoughtless brutes,” they have no moral standing, and we thus have a right to use them to further our own interests, is attributed to him. A celebrated passage from the Discourse on Method adds fuel to the view that he subscribes to the “dominion” theory. I argue that this picture is misleading (...) and unfair. Descartes does not hold the dominion theory, and there is evidence that he accords animals (and plants) moral standing. Most importantly, Descartes holds that it is a human good to subordinate one’s interests to those of the larger universe. He can, in fact, be seen as a forerunner of modern ecocentrism. (shrink)

Using Hofstede's culture theory (1980, 2001 Culture's Consequences: Comparing Values, Behaviours, Institutions, and Organizations Across Nation. Sage, NewYork), the current study incorporates the moral development (e.g. Thorne, 2000; Thorne and Magnan, 2000; Thorne et al., 2003) and multidimensional ethics scale (e.g. Cohen et al., 1993; Cohen et al., 1996b; Cohen et al., 2001; Flory et al., 1992) approaches to compare the ethical reasoning and decisions of Canadian and Mainland Chinese final year undergraduate accounting students. The results indicate that Canadian accounting (...) students' formulation of an intention to act on a particular ethical dilemma (deliberative reasoning) as measured by the moral development approach (Thorne, 2000) was higher than Mainland Chinese accounting students. The current study proposes that the five factors identified by the multidimensional ethics scale (MES), as being relevant to ethical decision making can be placed into the three levels of ethical reasoning identified by Kohlberg's (1958, The Development of Modes of Moral Thinking and Choice in the Years Ten to Sixteen. University of Chicago, Doctoral dissertation) theory of cognitive moral development. Canadian accounting students used post-conventional MES factors (moral equity, contractualism, and utilitarianism) more frequently and made more ethical audit decisions than Chinese accounting students. (shrink)

This study evidences turn actions done by ellipsis marks-only turns and blank turns as employed in quasisynchronous chats that are not discussed in prior literature. A brief introduction to the research background of ellipsis marks in online chats is followed by a description of the data collected before delving into the actions done by ellipsis marks-only turns and blank turns. Data were culled from multi-party chats among tertiary students during a critical reasoning class. A Conversation Analysis-informed approach is applied in (...) this article to analyze the preference organization of elliptical turns that illustrate several turn actions which include responses signaling disagreement, confusion and disapproval besides initial actions of eliciting responses and holding the floor. More than punctuation marks or paralinguistic restitution of silences, their interpersonal meaningfulness in sequential context and differentness/similarity vis-a-vis temporal silences are demonstratively shown in microscopic and interpretive description of chat excerpts. (shrink)

As social media becomes increasingly popular, human subjects researchers are able to use these platforms to locate, track, and communicate with study participants, thereby increasing participant retention and the generalizability and validity of research. The use of social media; however, raises novel ethical and regulatory issues that have received limited attention in the literature and federal regulations. We review research ethics and regulations and outline the implications for maintaining participant privacy, respecting participant autonomy, and promoting researcher transparency when using social (...) media to locate and track participants. We offer a rubric that can be used in future studies to determine ethical and regulation-consistent use of social media platforms and illustrate the rubric using our study team’s experience with Facebook. We also offer recommendations for both researchers and institutional review boards that emphasize the importance of well-described procedures for social media use as... (shrink)

In The Mysterious Relations to the East, Lin Ma takes a stance against a recent trend to see in Heidegger a thinker whose thought has been formed in an 'intercultural dialogue' with the Asian, Oriental tradition of thinking. In fact, Lin Ma demonstrates, words like 'Morning-Land', 'Orient', 'East' or 'Asia' can be shown to refer in each case to the beginning of philosophy in preSocratic, Greek thought. Thus to speak of the "mysterious relations [of philosophy] to the East" is not (...) to speak of a relation of European philosophy with other traditions of thinking, but rather concerns an investigation into the very roots of European philosophy itself. Despite Heidegger's concerns with the possibility of 'inter-cultural' dialogue, as evidenced, for example, in A Dialogue on Language Between a Japanese and an Inquirer, such a dialogue has to be questioned in its very possibility in order to avoid relapsing into the universalistic language of metaphysics. (shrink)

Elizabeth Anscombe is well-known for her insistence that there are absolutely prohibited actions, though she is somewhat obscure about why this is so. Nonetheless, I contend in this paper that Anscombe is more concerned with the epistemology of absolute prohibitions, and that her thought on connatural moral knowledge - which resembles moral intuition - is key to understanding her thought on moral prohibitions. I shall identify key features of Anscombe's moral epistemology before turning to investigate its sources, examining the roots (...) of connaturality in Aquinas and comparing it with rationalist ethical intuitionism, which Anscombe differs from in rejecting "good" as a simple, non-natural property. I then develop a two-stage argument about absolute prohibition: The first will be loosely Thomistic, while the second will suggest how Anscombe's absolute prohibitions can be seen as a continuation of Wittgenstein's anti-scepticism in On Certainty. I develop an account of absolute prohibitions as a form of Wittgensteinian hinge proposition - they are not the conclusions of deductive arguments, but the foundations for intelligibility in action. (shrink)

The Importance of Living is a wry, witty antidote to the dizzying pace of the modern world. Lin Yutang's prescription is the classic Chinese philosophy of life: Revere inaction as much as action, invoke humor to maintain a healthy attitude, and never forget that there will always be plenty of fools around who are willing-indeed, eager-to be busy, to make themselves useful, and to exercise power while you bask in the simple joy of existence.At a time when we're overwhelmed with (...) wake-up calls, here is a refreshing, playful reminder to savor life's simple pleasures. (shrink)

The development of genomic technologies has seemed almost magical. Excitement about it, both in medicine and among the public, stems from the belief that genomic techniques will illuminate the causes of health and disease, will lead to effective interventions for both rare and common genetic conditions, and will inform reproductive decision‐making. Novel diagnostic tools, however, are often deployed before targeted therapies are developed, tested, or available and before their psychosocial implications are explored. Newer technologies such as prenatal whole exome screening (...) are seen as offering “decisional autonomy” to expectant parents, although such technologies identify information about genetic sequencing that may not have clear meaning. The “therapeutic gap” between the ability to conduct genetic sequencing and the ability to fully understand what the test results mean, much less what treatments to offer, leaves families with complex and unclear information they cannot act upon with confidence during pregnancy. In this essay, we will consider the psychosocial and ethical implications of such assumptions—and of the uncertain information produced by these technologies—for individuals and families and for societal aspects such as medical service usage and demographic inequities. (shrink)

Modern Western medical individualism has had a significant impact on health care in China. This essay demonstrates the ways in which such Western-style individualism has been explicitly endorsed in China’s 2010 directive: The Basic Norms of the Documentation of the Medical Record. The Norms require that the patient himself, rather than a member of his family, sign each informed consent form. This change in clinical practice indicates a shift toward medical individualism in Chinese healthcare legislation. Such individualism, however, is incompatible (...) with the character of Chinese familism that is deeply rooted in the Chinese ethical tradition. It also contradicts family-based patterns of health care in China. Moreover, the requirement for individual informed consent is incompatible with numerous medical regulations promulgated in the past two decades. This essay argues that while Chinese medical legislation should learn from relevant Western ideas, it should not simply copy such practices by importing medical individualism into Chinese health care. Chinese healthcare policy is properly based on Chinese medical familist resources. (shrink)

We argue that all general concepts are family resemblance concepts. These include concepts introduced by ostension, such as colour. Concepts of colour and of each of the specific colours are family resemblance concepts because similarities concerning an open-ended range of colour or of appearance features crop up and disappear. After discussing the notion of “same colour” and Wittgenstein's use of the phrase “our colours”, we suggest family resemblance concepts in one tradition can often be extended to family resemblance concepts in (...) another tradition, illustrated by Wittgenstein's use of the words Spiel and “game”. (shrink)

AimTo investigate the status of positive mental characters and humanistic care ability among Chinese nursing students, and confirm the association between positive mental characters and humanistic care ability.MethodsA cross-sectional survey was conducted. Nine hundred eighty-one Chinese nursing students were recruited from hospitals and community healthcare services in Changsha, Hunan, China. Three different self-reported questionnaires were applied: The Demographic Characteristics Questionnaire, Humanistic care ability of Nursing Undergraduates Assessment Scale and Positive Mental Characters Scale for Chinese College Students. Pearson correlation analysis and (...) multiple liner regression analysis were performed to analyze the association between positive mental character and humanistic care ability for Chinese nursing students.ResultsThe mean scores of nursing students' humanistic care ability and positive mental character were 125.94 ± 21.19, 233.18 ± 38.59, respectively. The Pearson correlation results showed that positive mental character was significantly associated with humanistic care ability. Multiple liner regression analysis indicated that positive mental characters, four dimensions of courage, humanity, justice and transcendence in positive mental character, care from classmates were found to be independent predictors of humanistic care ability.ConclusionPositive mental characters are important considerations in the development, implementation and evaluation of humanistic care ability interventions. (shrink)

In this article we focus on the famous dialogue between Zhuangzi 莊子 and Huizi 惠子 concerning the question whether or not ren 人 (in particular the shengren 聖人) have qing 情. Most scholars have understood qing in this exchange as referring to “feelings” or “emotions.” We take issue with such readings. First, we demonstrate that, while Huizi probably understands qing as something like feelings or emotions, Zhuangzi’s view is that having qing is connected with making shifei 是非 judgments whereas having (...) no qing means that shifei has no grip on those ren, especially the shengren. What follows is that the expression wuqing 無情 should not be identified as a “doctrine of nonemotion.” Instead, wuqing implies that Zhuangzi advises us to lead a life of tranquility, calmness, and stillness. We show that these peaceful attitudes are associated with the idea of wuwei 無為 in the Zhuangzi. (shrink)

The Philosophical Forum, Volume 52, Issue 1, Page 65-78, Spring 2021.

A treatise on living a rich life from a Chinese point of view advocates a pursuit of self enjoyment through humor, joy, creativity, conversation, reading, nature appreciation, balanced inaction, and other non-material activities.

Modernism is often implicitly known and understood from the “Western modernist” perspective and history. The wide recognition of the Western modernist canon as centre and universal displaces the contribution and significance of the non-Western world in the modern movement. Within Asia, the modernisms that arose from various nations in the region had subtly different notions of culture, identity, nationhood, and modernity, although almost every Asian country was related in one way or another to the history of Western imperialism. Using a (...) comparative analysis, this article examines modernism in twentieth-century Asia from a multicultural viewpoint, and bringing into picture the place of Asia in the history of modernism. (shrink)

全书选收辞条近700条,主要包括马克思主义哲学史上的基本理论、主要著作、有关人物、流派、事件等内容.

In Singapore’s multicultural society, a sizable proportion of the population subscribes to complementary and alternative medicine. In this article, we discuss the impact this has on medical practice in the context of the four principles of medical ethics. To uphold the principle of autonomy, we propose a non-judgmental approach towards patients who use CAM. Nevertheless, in order to promote health and prevent harm, the safety profiles of CAM must be studied through systematic research. In addition, the principle of justice is (...) one concerned with the fair distribution of scarce healthcare resources, while granting equal access to healthcare regardless of beliefs. Understanding CAM from an ethical perspective allows for the provision of safe, holistic, and culturally relevant care. (shrink)

This book analyses and defends the deflationist claim that there is nothing deep about our notion of truth. According to this view, truth is a 'light' and innocent concept, devoid of any essence which could be revealed by scientific inquiry. Cezary Cieśliński considers this claim in light of recent formal results on axiomatic truth theories, which are crucial for understanding and evaluating the philosophical thesis of the innocence of truth. Providing an up-to-date discussion and original perspectives on this central and (...) controversial issue, his book will be important for those with a background in logic who are interested in formal truth theories and in current philosophical debates about the deflationary conception of truth. (shrink)

The utterance model is a popular basis for theories of interpretation in the contemporary analytic philosophy of literature. This model suggests that interpretation should be constrained by a work's identity‐relevant factors in its context of production because a work, like an utterance, acquires its identity and content in part from its relations with that context. From a descriptive point of view, I argue that the implied author account of interpretation best describes critical practice following the current positions based on the (...) utterance model. That is, people who interpret in accordance with these positions end up interpreting an implied author. (shrink)

This book traces a most obscure and yet most intriguing theme concealed in Heidegger’s thinking and work, which has hitherto not yet been made the focus of a thorough and sustained investigation: that is, the emergence and course of Heidegger’s interest in East Asian thought and of his reflection on East-West dialogue. Lin Ma covers such complex issues as Heidegger’s thoughts on language, Being, technology, the other beginning, and the journey abroad, with a view to their implications for East-West dialogue. (...) It reveals the significance of his remarks on the early Greek’s confrontation with the Asiatic, and presents contextualized interpretations of his fleeting references to the topic of East-West dialogue and of his encounter with the Daodejing. Finally, it delves into "A dialogue on language" and exposes the strains and tensions that accompany Heidegger’s extension of dialogue and the Same, the two notions central to his thought, to the question of East-West dialogue. In the end, Lin Ma concludes that Heidegger’s fundamental concerns and philosophical orientations as articulated in terms of the history of Being and the other beginning have restricted him from engaging more seriously with the irresolvable and yet enduring issue of East-West dialogue. (shrink)