In bacteria, PriA protein, a conserved DEXH‐type DNA helicase, plays a central role in replication restart at stalled replication forks. Its unique DNA‐binding property allows it to recognize and stabilize stalled forks and the structures derived from them. Cells must cope with fork stalls caused by various replication stresses to complete replication of the entire genome. Failure of the stalled fork stabilization process and eventual restart could lead to various forms of genomic instability. The low viability of priA null cells (...) indicates a frequent occurrence of fork stall during normal growth that needs to be properly processed. PriA specifically recognizes the 3′‐terminus of the nascent leading strand or the invading strand in a displacement (D)‐loop by the three‐prime terminus binding pocket (TT‐pocket) present in its unique DNA binding domain. Elucidation of the structural basis for recognition of arrested forks by PriA should provide useful insight into how stalled forks are recognized in eukaryotes. (shrink)

After the unification process of 1918, in the former Hungarian State schools Romanian language was introduced as a teaching language. Consequently, the Hungarian as a teaching language was solely pre- served in the vocational schools. The governments showed little understanding toward the minorities’ vocational schools, aiming rather at the unification of the scholar system. The Roman Catholic Church sustained and administrated hundreds of elementary and secondary schools, many of them having a multi-secular history. Based on the documents from the churches’ (...) archives, this study presents the efforts of the Roman Catholic Church to preserve and maintain all these schools. (shrink)

I am honored to have been invited to participate in this Workshop on Comparative Studies of Building Molecular Biology, with a discussion of Japanese experiences in constructing a science — in this case, the discipline of molecular biology. As I understand it, the construction of a science must be equivalent to building a new culture. My having given this title to my paper suggests that I have enough knowledge about the subject to perhaps even extrapolate its course into the future (...) — which I do not. What I do have is a sincere admiration of my old friends and colleagues, in Japan and elsewhere, who together tried to build a new science of molecular biology in Japan. (shrink)

LANGUAGE NOTE | Document text in Chinese; abstract also in English. 世界衛生組織(WHO)在歷經自1976年伊波拉病毒病(EbolaHemorrhagicFever, 伊波拉出血熱)爆發以來，處理疫情爆發當中出現的種種倫理問題之後，於2016年出版“Guidance for Managing Ethical Issues in Infectious Disease Outbreaks”（中文暫譯：《傳染病爆發處理倫理議題之指引》）一書，其中整理出「正義、行善、效益、尊重自主、自由、團結、互惠」等七項倫理原則，於今面對新冠肺炎（COVID-19）的疫情上，各國防疫 政策，亦可作為應對。作為一名當代墨者，本文即以此為基礎，由醫療的角度，結合國內情況，企欲在墨學義理內作一生命倫理的反思，並試圖對後疫情時代給予具體作為之建議。 In response to various ethical problems that emerged after the 1976 Ebola hemorrhagic fever epidemic, WHO published the book Guidance for Managing Ethical Issues in Infectious Disease Outbreaks in 2016. The content of the book was organized around seven ethical principles, namely, justice, beneficence, benefit, respect for autonomy, freedom, reciprocity, and unity. These seven ethical principles can be used as (...) a framework for countries to develop policies for coping with the COVID-19 pandemic. Drawing from contemporary Mohism, this paper reflects on the situation in Taiwan through the lens of these seven ethical principles. It aims to arrive at a Mohist understanding of bioethics and proposes concrete actions for the post-epidemic era. (shrink)

狂信的な国粋主義者か、はたまた魂の尊厳を問うた求道者か。民俗学と国粋主義の親和性とは。多角的な視点からファシズムを再考する。.

Cellular pattern formations of some epithelia are believed to be governed by the direct lateral inhibition rule of cell differentiation. That is, initially equivalent cells are all competent to differentiate, but once a cell has differentiated, the cell inhibits its immediate neighbors from following this pathway. Such a differentiation repeats until all non-inhibited cells have differentiated. The cellular polygonal patterns can be characterized by the numbers of undifferentiated cells and differentiated ones. When the differentiated cells become large in size, the (...) polygonal pattern is deformed since more cells are needed to enclose the large cell. An actual example of such a cellular pattern was examined. The pupal wing epidermis of a butterfly Pieris rapae shows a transition of the equivalent-size cell pattern to the pattern involving large cells. The process of the transition was analyzed by using the method of weighted Voronoi tessellation that is useful for treatment of irregularly sized polygons. The analysis supported that the pattern transition of the early stage of the pupal wing epidermis is governed by the lateral inhibition rule. The differentiation takes place in order of largeness, but not smallness, of the apical polygonal area in the differentiating region of the pupal wing. (shrink)

The role of religion in the public space is a matter of debate. The public sphere understood as a space oriented to achieving interests of common concern, reaching social and political consensus by means of deliberation has relegated religion to the private sphere. The last decades have attested a revival of the public role of religion, a “de-privatization” of religion. This paper explores the contemporary influence of religious beliefs and liturgical practice on issues of public concern focusing on the statements (...) and liturgical gestures of Pope Francis, notably regarding the disenfranchised and the refugees, as well as his engagement for the environment. The statements and liturgical gestures of Pope Francis have challenged the dissociation between religious practice and social ethics, and have returned religion to the forefront of public debates. A symbolic example is his unconventional practice of a traditional rite, that of the washing of the feet during liturgical celebrations on Holy Thursday. This classical liturgical rite, brought to public attention through the media, has become the vehicle of Francis’ social ethical views, and due to his involvement in the refugee-debate, a powerful political statement. Such statements are not limited to Catholics or individuals of other denominations, but contribute to the agenda of public discussions. (shrink)

Dans quelle mesure peut-on reconnaître certaines influences du naturalisme français, mouvement éminemment représenté par Émile Zola, dans les œuvres romanesques de naturalistes américains tels que Dreiser et Norris? Stephen Crane, l’un de ces derniers, nie l’influence des œuvres romanesques zoliennes sur son chef d’œuvre, Maggie : A Girl of the Streets (1893). Pourtant, en lisant cette nouvelle de l’écrivain américain, on peut bel et bien retrouver des motifs zoliens, ce qui contredirait son affirmation. Il existe, en effet, des rapports d’intertextualité (...) avec certains romans de Zola. En prenant cette idée comme point de départ, nous nous proposons de réfléchir à la représentation de l’espace urbain, notamment à Paris dans L’Assommoir, ainsi qu’aux personnages féminins de ce roman, pour mettre en évidence l’importance de l’idéalisation de la vie rurale. En ce sens, nous voulons prendre ces aspects comme points de comparaison entre Zola et Crane. Comment, chez ce dernier, sont représentées la ville de New-York et les personnages féminins? In fine, cela permettra d’aboutir à une réflexion plus globale, tout en étant précise, sur les particularités de la littérature naturaliste des deux côtés de l’Atlantique. (shrink)

This essay consists of two parts. In the first part we show in general outline the development of modern Japanese philosophy since 1867. And as one of the typical products of that process we analyse in the second part the metaphysics of the late Prof. Nishida.

The paper explores the events that preceded the conclusion of the Concordat between the Holy See and Romania (1927) and its effects. Both the Vatican and the Romanian Monarchy aimed at concluding a Concordat: the first, because the document was expected to provide a legal frame for the life of the Catholic Church, and the second, because such document contributed to its international visibility. Early talks, during the reign of Prince Al. I. Cuza and King Carol I, were eventually unsuccessful. (...) Discussions were resumed after the end of World War I. The Concordat was drafted essentially by the representatives of the Greek Catholic Church, without the consultation of the Latin bishops of Transylvania. The finalization and the ratification of the document were delayed, partly because of the objections of the Orthodox Church, and partly due to the disagreement regarding the fate of the Latin dioceses of Transylvania and the Patrimonium Sacrum. The Concordat was highly contested by the Latin bishops of Transylvania as it produced serious changes and difficulties. It stipulated the merger of the dioceses of Oradea and Satu Mare and caused severe problems concerning the management of Latin Catholic funds, previously administered by the Roman Catholic Status. The Concordat also affected the functioning of the confessional schools. (shrink)

Some people in Japan are still comfortable with the paternalistic role of doctors, but others wish that their own decisions would receive a greater amount of respect. A total of 747 students of universities and colleges and 114 parents of these students participated in a questionnaire survey. Most of the participants thought that autonomy should be respected in situations involving death with dignity and euthanasia, whereas it should not be respected in attempted suicide and involuntary admission of individuals with mental (...) illness. A cluster analysis revealed that the participants could be divided into the following groups: aid in dying advocates, complete libertarians, protectors of the mentally ill, complete paternalists, and questionables. The assertion of independence score of the Scale for Independent and Interdependent Construal of the Self showed a significant difference among the 5 clusters. These findings suggest that the traditional paternalistic relationship between doctor and patient is undergoing a gradual transformation in Japan. (shrink)