Quantitative assessments of when infectious disease outbreaks end are crucial, as resources targeted towards outbreak responses typically remain in place until outbreaks are declared over. Recent improvements and innovations in mathematical approaches for determining when outbreaks end provide public health authorities with more confidence when making end-of-outbreak declarations. Although quantitative analyses of outbreaks have a long history, more complex mathematical and statistical methodologies for analysing outbreak data were developed early in the 20th century and continue to be refined. Historically, such (...) methodologies focused primarily on factors affecting the early and middle phases of an outbreak, with less attention given to determining how and when outbreaks end. This review discusses mathematical modelling methods from the last 20 years that have been developed for determining the ends of infectious disease outbreaks, and considers factors that affect the accuracy of such determinations. When disease surveillance systems provide timely and representative data to inform models, the timings of end-of-outbreak declarations can be fine-tuned to allow outbreaks to be declared over quickly and with a low risk of being incorrect. Premature declarations that outbreaks are over can undermine earlier achievements in disease control and may result in a resurgence of cases, but unnecessary delays in declaring outbreaks over can cause significant economic and social harm. Appropriate declarations that balance the benefits of relaxing control measures against the risk of a surge in cases allow public health resources to be conserved (and economic and social pressures to be reduced) while limiting the potential for additional transmission. (shrink)

環境問題が生じる存在論的根拠とは―。本書は、環境問題を存在論的問題として捉え、空間、時間、言語論の観点から、そして労働と環境の関連、環境倫理の存在論的根拠について論じる。.

A proof is given for the theorem that at least one bound state exists in a one-dimensional attractive potential however weak it may be. The proof is constructive in that it provides a method to explicitly solve the eigenvalue problem for the eigenvalues as well as the eigenfunctions. The method is well suited to precise numerical calculations.

In this paper we will study a formal system of intuitionistic modal predicate logic. The main result is its semantic completeness theorem with respect to algebraic structures. At the end of the paper we will also present a brief consideration of its syntactic relationships with some similar systems.

Minami–Sakai :883–898, 2016) investigated the cofinal types of the Katětov and the Katětov–Blass orders on the family of all \ ideals. In this paper we discuss these orders on analytic P-ideals and Borel ideals. We prove the following:The family of all analytic P-ideals has the largest element with respect to the Katětov and the Katětov–Blass orders.The family of all Borel ideals is countably upward directed with respect to the Katětov and the Katětov–Blass orders. In the course of the proof of (...) the latter result, we also prove that for any analytic ideal \ there is a Borel ideal \ with \. (shrink)

We investigate how weak square principles are denied by Chang’s Conjecture and its generalizations. Among other things we prove that Chang’s Conjecture does not imply the failure of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}, i.e. Chang’s Conjecture is consistent with \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}.

This book explores the contributions of East Asian traditions, particularly Buddhism and (Euro)Daoism, to environmental philosophy. It critically examines the conceptions of human responsibility toward nature and across time presented within these traditions as well as in European philosophy. The volume rethinks human relationships to the natural world by focusing on three main themes: Daoist and Eurodaoist perspectives on nature, human responsibility toward nature, and Buddhist perspectives on life and nature. By way of discussing East Asian traditions and European thinkers, (...) this collection reveals that the impact of humanity on the environment is shaped not only by distinctive modes of economic production, but also by cultural beliefs and practices. Representing a unique constellation of environmental and intercultural philosophy, the contributions present systematic approaches to the global need for cultivating environmental responsibility across cultures and generations to address the political, ethical, and aesthetic challenges arising from humanity’s transformative impact on the natural world. (shrink)

The primary objective of this anthology is to make intergenerational justice an issue for intercultural philosophy, and, conversely, to allow the latter to enrich the former. In times of large-scale environmental destabilization, fair- ness between generations is an urgent issue of justice across time, but it is also a global issue of justice across geographical and nation-state borders. This means that the future generations envisioned by the currently living also cross these borders. Thus, different philosophical cultures and traditions of thought (...) should converse to re ect on what is fair to future people. In the remainder of this introduction, we will detail these claims and give an overview of the volume’s chapters. (shrink)

We study the relationship between the semistationary reflection principle and stationary reflection principles. We show that for all regular cardinals Λ ≥ ω₂ the semistationary reflection principle in the space [Λ](1) implies that every stationary subset of $E_{\omega}^{\lambda}\coloneq \{\alpha \in \lambda \,|\,{\rm cf}(\alpha)=\omega \}$ reflects. We also show that for all cardinals Λ ≥ ω₃ the semistationary reflection principle in [Λ](1) does not imply the stationary reflection principle in [Λ](1).

This paper presents a new method that improves robustness of real-coded Genetic Algorithm (GA) for function optimization. It is reported that most of crossover operators for real-coded GA have sampling bias, which prevents to find the optimum when it is near the boundary of search space. They like to search the center of search space much more than the other. Therefore, they will not work on functions that have their optima near the boundary of the search space. Although several methods (...) have been proposed to relax this sampling bias, they could not cancel whole bias. In this paper, we propose a new method, Toroidal Search Space Conversion (TSC), to remove this sampling bias. TSC converts bounded search space into toroidal one without any parameter. Experimental results show that a GA with TSC has higher performance to find the optimum near the boundary of search space and the GA has more robustness concerning the relative position of the optimum. (shrink)

In this paper, we study the relationship among classical logic, intuitionistic logic, and quantum logic . These logics are related in an interesting way and are not far apart from each other, as is widely believed. The results in this paper show how they are related with each other through a dual intuitionistic logic . Our study is completely syntactical.

We give simple proofs of the Singular Cardinal Hypothesis from the Weak Reflection Principle and the Fodor-type Reflection Principle which do not use better scales.

The mitogenic action of cytokines such as epidermal growth factor (EGF)d̊ or platelet dericed growth factor (PDGF) involves the stimulation of a signal cascade controlled by a small G protein called Ras. Mutations of Ras can cause its constitutive activation and, as a consequence, bypass the regulation of cell growth by cytokines. Both growth factor‐induced and oncogenic activation of Ras involve the conversion of Ras from the GDP‐bound (D‐Ras) to the GTP‐bound (T‐Ras) forms. T‐Ras activates a network of protein kinases (...) including c‐Mos, c‐Raf‐1 and MAP kinase. Eventually the activation of MAP kinase leads to the activation of the elongation factor 4E and several transcription factors such as c‐Jun, c‐Myc and c‐Fos. There are several modulators of Ras activity, such as the GTPase activating proteins (GAP1 and NF1), which stimulate the coversion of T‐Ras to D‐Ras. A series of small NF1 fragments, which bind T‐Ras, as well as truncated forms or derivatives of c‐Raf‐1, c‐Jun and c‐Myc, are capable of blocking the T‐Ras‐activated mitogenesis in a competitive manner. These agents offer a unique opportunity to control the proliferation of T‐Ras‐associated tumors, which represent more than 30% of total human carcinomas. (shrink)