Immunity against SARS‐CoV‐2 that is acquired by convalescent COVID‐19 patients is examined in reference to (A) the Th17 cell generation system in psoriatic epidermis and (B) a recently discovered phenomenon in which Th17 cells are converted into tissue‐resident memory T (TRM) cells with Th1 phenotype. Neutrophils that are attracted to the site of infection secrete IL‐17A, which stimulates lung epithelial cells to express CCL20. Natural Th17 (nTh17) cells are recruited to the infection site by CCL20 and expand in the presence (...) of IL‐23. These nTh17 cells are converted to TRM cells upon encounter with SARS‐CoV‐2 and continue to exist as ex‐Th17 cells, which exert Th1‐like immunity during a memory response. G‐CSF can induce nTh17 cell accumulation at the infection site because it promotes neutrophil egress from the bone marrow. Hence, G‐CSF may be effective against COVID‐19. Administration of G‐CSF to patients infected with SARS‐CoV‐2 is worth a clinical trial. (shrink)

Rheumatoid arthritis (RA) may not be a multifactorial disease; it can be hypothesized that RA is developed through a series of events following a triggering event, which is the emergence of a chemokine for neutrophils in the synovium. IL‐17A, secreted by infiltrated neutrophils, stimulates synoviocytes to produce CCL20, which attracts various CCR6‐expressing cells, including Th17 cells. Monocytes (macrophages) appear after neutrophil infiltration according to the natural course of inflammation and secrete IL‐1β and TNFα. Then, IL‐17A, IL‐1β, and TNFα stimulate synoviocytes (...) to produce CCL20, amplifying the inflammation. Varieties of chemokines secreted by infiltrating cells accumulate in the synovium and induce synoviocyte proliferation by binding to the corresponding G protein‐coupled receptors, thus expanding the synovial tissue. CCL20 in this tissue attracts circulating monocytes that express both CCR6 and receptor activator of NF‐κB (RANK), which differentiate into osteoclasts in the presence of RANKL. In this way, pannus is formed, and bone destruction begins. (shrink)

We investigate how weak square principles are denied by Chang’s Conjecture and its generalizations. Among other things we prove that Chang’s Conjecture does not imply the failure of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}, i.e. Chang’s Conjecture is consistent with \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}.

A proof is given for the theorem that at least one bound state exists in a one-dimensional attractive potential however weak it may be. The proof is constructive in that it provides a method to explicitly solve the eigenvalue problem for the eigenvalues as well as the eigenfunctions. The method is well suited to precise numerical calculations.

Against the background of enormous interest in virtue ethics, a new trend in moral education has appeared. This new trend, called 'the virtue approach to moral education', faces a strong challenge. If virtues are rooted in and developed within practices of a particular tradition, how is moral relativism to be avoided? Ironically, Alasdair MacIntyre, the foremost proponent of virtue ethics, has drawn the pessimistic conclusion that a shared public system of moral education is impossible in a plural society like ours. (...) This paper aims to challenge MacIntyre's pessimistic conclusion, and to explore the viability of moral education in virtues as a shared public practice. (shrink)

Minami–Sakai :883–898, 2016) investigated the cofinal types of the Katětov and the Katětov–Blass orders on the family of all \ ideals. In this paper we discuss these orders on analytic P-ideals and Borel ideals. We prove the following:The family of all analytic P-ideals has the largest element with respect to the Katětov and the Katětov–Blass orders.The family of all Borel ideals is countably upward directed with respect to the Katětov and the Katětov–Blass orders. In the course of the proof of (...) the latter result, we also prove that for any analytic ideal \ there is a Borel ideal \ with \. (shrink)

Investigates Aristotle's views on the ontological status of artifacts in the Metaphysics, with implications for a variety of metaphysical problems.

This book explores the contributions of East Asian traditions, particularly Buddhism and (Euro)Daoism, to environmental philosophy. It critically examines the conceptions of human responsibility toward nature and across time presented within these traditions as well as in European philosophy. The volume rethinks human relationships to the natural world by focusing on three main themes: Daoist and Eurodaoist perspectives on nature, human responsibility toward nature, and Buddhist perspectives on life and nature. By way of discussing East Asian traditions and European thinkers, (...) this collection reveals that the impact of humanity on the environment is shaped not only by distinctive modes of economic production, but also by cultural beliefs and practices. Representing a unique constellation of environmental and intercultural philosophy, the contributions present systematic approaches to the global need for cultivating environmental responsibility across cultures and generations to address the political, ethical, and aesthetic challenges arising from humanity’s transformative impact on the natural world. (shrink)

The primary objective of this anthology is to make intergenerational justice an issue for intercultural philosophy, and, conversely, to allow the latter to enrich the former. In times of large-scale environmental destabilization, fair- ness between generations is an urgent issue of justice across time, but it is also a global issue of justice across geographical and nation-state borders. This means that the future generations envisioned by the currently living also cross these borders. Thus, different philosophical cultures and traditions of thought (...) should converse to re ect on what is fair to future people. In the remainder of this introduction, we will detail these claims and give an overview of the volume’s chapters. (shrink)

In this paper we will study a formal system of intuitionistic modal predicate logic. The main result is its semantic completeness theorem with respect to algebraic structures. At the end of the paper we will also present a brief consideration of its syntactic relationships with some similar systems.

We study the relationship between the semistationary reflection principle and stationary reflection principles. We show that for all regular cardinals Λ ≥ ω₂ the semistationary reflection principle in the space [Λ](1) implies that every stationary subset of $E_{\omega}^{\lambda}\coloneq \{\alpha \in \lambda \,|\,{\rm cf}(\alpha)=\omega \}$ reflects. We also show that for all cardinals Λ ≥ ω₃ the semistationary reflection principle in [Λ](1) does not imply the stationary reflection principle in [Λ](1).

The mitogenic action of cytokines such as epidermal growth factor (EGF)d̊ or platelet dericed growth factor (PDGF) involves the stimulation of a signal cascade controlled by a small G protein called Ras. Mutations of Ras can cause its constitutive activation and, as a consequence, bypass the regulation of cell growth by cytokines. Both growth factor‐induced and oncogenic activation of Ras involve the conversion of Ras from the GDP‐bound (D‐Ras) to the GTP‐bound (T‐Ras) forms. T‐Ras activates a network of protein kinases (...) including c‐Mos, c‐Raf‐1 and MAP kinase. Eventually the activation of MAP kinase leads to the activation of the elongation factor 4E and several transcription factors such as c‐Jun, c‐Myc and c‐Fos. There are several modulators of Ras activity, such as the GTPase activating proteins (GAP1 and NF1), which stimulate the coversion of T‐Ras to D‐Ras. A series of small NF1 fragments, which bind T‐Ras, as well as truncated forms or derivatives of c‐Raf‐1, c‐Jun and c‐Myc, are capable of blocking the T‐Ras‐activated mitogenesis in a competitive manner. These agents offer a unique opportunity to control the proliferation of T‐Ras‐associated tumors, which represent more than 30% of total human carcinomas. (shrink)

Monothematic delusions are delusions whose contents pertain to a single subject matter. Examples include Capgras delusion, the delusion that a loved one has been replaced by an impostor, and Cotard delusion, the delusion that one is dead or does not exist. Two-factor accounts of such delusions hold that they are the result of both an experiential deficit, for instance flattened affect, coupled with an aberrant cognitive response to that deficit. In this paper we develop a new expressivist two-factor account of (...) delusion. In contrast to existing endorsement and explanationist accounts, which treat delusions as either explanations or endorsements of the contents of these disordered experiences, we hold that delusional beliefs have an expressive function: they characterize, in impressionistic terms, what the subject’s experience is like for them. We show how our account improves upon existing two-factor views in explaining the central features of monothematic delusions, in particular the way in which delusional subjects fall short of the ideal of rationality. (shrink)

This paper presents a new method that improves robustness of real-coded Genetic Algorithm (GA) for function optimization. It is reported that most of crossover operators for real-coded GA have sampling bias, which prevents to find the optimum when it is near the boundary of search space. They like to search the center of search space much more than the other. Therefore, they will not work on functions that have their optima near the boundary of the search space. Although several methods (...) have been proposed to relax this sampling bias, they could not cancel whole bias. In this paper, we propose a new method, Toroidal Search Space Conversion (TSC), to remove this sampling bias. TSC converts bounded search space into toroidal one without any parameter. Experimental results show that a GA with TSC has higher performance to find the optimum near the boundary of search space and the GA has more robustness concerning the relative position of the optimum. (shrink)

現代を生き抜くための武器としての哲学を、西野カナ、ミスチル、いきものがかり等Jポップの歌詞を題材に、気鋭の哲学者が説く。.

I examine the tension between biopolitics and necropolitics through three themes that I have perceived and that are related to my life in Japan. First, I examine the transformation of hospitals and medical care, particularly for the elderly, through my experience of sharing the end of my mother’s life. Modern medicine has made great achievements in treating diseases that used to be fatal, but it has become institutionalized in the context of Big Pharma interests, with no insight into the natural (...) ageing and death of human beings. Second, I discuss how the ecological worldview on parasitism and symbiosis has been distorted by industrial logic, drawing on the work of my esteemed friend and parasitologist Professor Koichiro Fujita, who passed away in 2021. Finally, with regard to the Covid-19 pandemic, I would argue that it is not a sudden phenomenon triggered by a new virus, but in a sense a disaster that has been prepared for decades and must be seen as a war using bioengineering and epidemiology as weapons, rather than tanks and bombs. (shrink)

We give simple proofs of the Singular Cardinal Hypothesis from the Weak Reflection Principle and the Fodor-type Reflection Principle which do not use better scales.

It has been reported as a robust effect that people are likely to select a matching case in the Wason selection task. For example, they usually select the 5 case, in the Wason selection task with the conditional "if an E, then a not-5". This was explained by the matching bias account that people are likely to regard a matching case as relevant to the truth of the conditional (Evans, 1998). However, because a positive concept usually constructs a smaller set (...) than its negative one does (a rarity assumption), it is more effective to get information on the truth of the conditional in a positive set than in a negative set. Thus the optimal data selection account can also explain the effect. The set size of Q and matching by introducing negation were manipulated independently in four experiments. From the results it was inferred that the so-called matching bias was an amalgam of two different cognitive components-relevance judgement by matching and optimal data selection. (shrink)

dai 1-kan. Ningen, kyōiku ga umarekawaru tame -- dai 2-kan. Ningen to no deai, kyōiku to no deai -- dai 3 kan. Ningenrashiku naru tedate -- dai 4-kan. Jinrui no kibō, osanago -- dai 5-kan. Shishū, ushinawareta kisetsu o motomete -- dai 6-kan. Aru mazushiki shōgai no kiroku -- [7] Kyōiku to kyōikugaku.

Since the first half of the nineteenth century in which English was introduced as the language of higher education in India, the word and concept of “philosophy” has played an important role in Indian intellectual life. First the study of philosophy must have meant the study of Western philosophy in Indian universities, butlater various attempts were made to discover the Indian versions of philosophical traditions in Sanskrit literature. Today no one doubts that there has been a rich and very long (...) tradition of such intellectual activities as are fully compatible with what European philosophers have actually been doing. Nevertheless, it is sometimes very difficult to draw a strict line between philosophy and religion in Indian thought. The present study will focus on that passage of the Nyāyamañjarī by a Kashmirian Nyāya scholar Jayanta which deals with the justification of the authority of the Vedas and other religious scriptures. From the analysis of the passage we may detect that there are two different dimensions in his application of logic for this issue. On the one hand he appeals to logical thinking for the defence of the Vedic authority and tries to establish the proper proof. But on the other hand he seems to be conscious of the limitation of reasoning, for he refers to those thinkers without refuting them in the latter half of the passage, according to whom every religious scripture must be accepted as valid insofar as the path of reasoning and argumentation is taken. (shrink)

What is the meaning of “Japanese” culture? In earlier ages, it was about temples, Noh plays, Kabuki, Utamaro and Wabi-sabi. These traditional icons have, since the Meiji era (1868-1912), been identified as typically Japanese. Are they, however, still relevant today? Has there been any crucial mutation in the cultural identity of Japan? In the contemporary era, more and more people associate Japanese culture with Manga, animation and video games, in other words with cultural developments of the post-World War II era. (...) The Japanese Government has actively promoted the popularity of these new aspects of Japanese culture as evidenced in their eagerness to adopt the expression “Cool Japan,” inspired by its British predecessor’s “Cool Britannia.” Everyone does not share that perception though. Following the 11th March 2011 series of disasters, Japanese artist Tadasu Takamine (1968-) worked on a critical questioning of Japanese society and culture, culminating in a work titled Tadasu Takamine's Cool Japan that was shown at the Art Tower Mito, in Ibaraki Prefecture (2012). The present essay reflects on and develops further the message conveyed by Takamine about contemporary Japanese cultural identity. (shrink)