Apathy and depression are frequently observed as behavioral and psychological symptoms of dementia, respectively, and are important for ensuring adequate care. This study aims to explore effective non-pharmacological interventions for apathy and depression with mild cognitive impairment and dementia. Five search engines including PubMed, Scopus, CINAHL, PsycInfo, and Web of Science were used to extract relevant studies. Inclusion criteria were studies that involved participants who were diagnosed with MCI or dementia, included quantitative assessments of each symptom, and employed randomized controlled (...) trials. Twenty studies were extracted, with interventions have been conducted in care facilities, the community, and hospitals. Participants in many studies had MCI or mild-to-moderate dementia but were not diagnosed with the subtypes of dementia. Few studies had set apathy and depression as the primary outcomes of non-pharmacological interventions. The findings suggested that emotional and stimulation-oriented approaches to apathy and depression would be useful for people with MCI or mild-to-moderate dementia. It would be helpful for therapists to assess the clinical features of the target symptoms for selecting suitable interventions. Additionally, increasing the number of randomized controlled trials focusing on apathy or depression as primary outcomes would offer a more definite conclusion for future systematic reviews. (shrink)

Something should be done for a better global environment as soon as possible. This paper investigates the direction of management of the global environment and proposes new, concrete ideas for it.

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

During brain development, neural precursor cells (NPCs) in different brain regions produce different types of neurons, and each of these regions plays a different role in the adult brain. Therefore, precise regionalization is essential in the early stages of brain development, and irregular regionalization has been proposed as the cause of neurodevelopmental disorders. The mechanisms underlying brain regionalization have been well studied in terms of morphogen‐induced expression of critical transcription factors for regionalization. NPC potential in different brain regions is defined (...) by chromatin structures that regulate the plasticity of gene expression. Herein, we present recent findings on the importance of chromatin structure in brain regionalization, particularly with respect to its regulation by Polycomb‐group proteins and chromatin accessibility. (shrink)

In this article we assess the general claim that Durkheimian sociology has reactionary, fascist, or totalitarian affinities, and the specific claim that Marcel Déat’s Durkheimian background was a significant factor in his becoming a Nazi sympathizer. We do so by comparing the different trajectories of the interwar generation of young Durkheimians and find that only one, i.e. Déat, can be said to have become fascist. Indeed, what characterizes this generation of Durkheimians is the variety of the ways in which they (...) responded to the crises of the interwar years, both politically and scientifically. Nonetheless, most remained on the political left, and during the war many younger members of the Durkheimian group either fled the country or were involved in the French Resistance. As the only personal link between the Durkheimian group and fascism, Déat’s career is of particular interest. Instead of Déat’s being an orthodox Durkheimian, his successive engagements embody the intellectual fragmentation and heterodoxy characteristic of the interwar generation. We outline Déat’s career by foregrounding the conjunctural and dispositional factors that we believe point toward a more plausible explanation of Déat’s transformation than does an internalist history-of-ideas approach according to which his political evolution can be explained by reference to an underlying intellectual continuity. Déat’s fascism is better explained by the repeated frustration of his political and intellectual ambitions that ultimately led to a fateful accommodation with Nazi power than by any tendency inherent to Durkheimian sociology. (shrink)

The recent declaration of the largest municipal bankruptcy in US history has propelled Detroit’s plight into the international spotlight. Though a victim of the general decline of US manufacturing, drawing on Thomas Sugrue’s pioneering work I argue that Detroit’s crisis is better understood as a specifically urban crisis. The city’s concentrated poverty and desolation and its fiscal straits are not reducible to broader economic trends, nor are they exclusively the product of political mismanagement. Rather, they are the outcome of a (...) long history of economic decentralization and racial segregation, made worse by a politico-administrative arrangement that distributes wealth and services unequally across the metropolitan area. By imposing municipal austerity, Detroit’s bankruptcy is unlikely to do much to address these fundamental inequalities. Any plan to revitalize the city must move beyond boosterism and tackle head on the problems of racial and economic segregation that continue to affect Detroit’s 700,000 residents. (shrink)

本研究は、史料的裏付けにもとづく、東アジア三地域における気の思想・文化の歴史や内容、特徴を明らかにし、東アジアにおける気の総合的・体系的研究の基礎を構築している。.

In his book Bad Beliefs, Neil Levy defends the engineering of our epistemic environment by removing epistemic pollutions and by nudging people through second-order evidence. Although we agree with his core ideas, in this commentary, we aim at supplementing his approach in light of the participation of the general public in science. In the first part, we argue that the issue of participatory epistemic injustice in the scientific community remains unaddressed in Levy’s discussion and that addressing the issue is equal (...) to removing an epistemic pollution. In the second part, we address the issue of transparency in nudging. Here, we discuss the significance of public engagement in controlling the system of nudges to respect our rational and autonomous choices. (shrink)

Graphical AbstractYeast mitochondria frequently mutate, and some dysfunctional mitochondria out-compete wild-type versions. The retrograde response enables yeast to tolerate dysfunction, but also produces ribosomal DNA circles (ERCs). We propose that ERC accumulation increases expression of the rDNA antisense gene, TAR1, which counteracts spread of respiration-deficient mitochondria in matings with wild-type yeast.

科学技術と社会の間に、「新たな関係」を構築する。原発事故、気候工学、ゲノム編集、...現代に生じるさまざまな課題にどう取り組むか?科学技術社会論(STS)は、日ごろあたりまえと考えられている事柄の見え 方を変える力をもつ。イノベーション論や科学技術政策との関係もふくめて問い直す。.

Genetic Algorithms(GAs) are effective approximation algorithms which focus on “hopeful area” in the searching process. However, in harder problems, it is often very difficult to maintain a favorable trade-off between exploitation and exploration. All individuals leave the big-valley including the global optimum, and concentrate on another big-valley including a local optimum often. In this paper, we define such a situation on conventional GAs as the “UV-phenomenon”, and suggest UV-structures as hard landscape structures that will cause the UV-phenomenon. We introduce a (...) test function which has explicit UV-structures, and show UV-phenomenon caused by them. Next we analyze Fletcher and Powell function to confirm our hypothesis. Finally we propose a novel framework of GAs which can cope with UV-structures. (shrink)

Political developments in Japan from the latter part of 2000 to the year 2001 were highlighted by the executive transition from unpopular Yoshiro Mori to exceptionally popular Junichiro Koizumu as the nation's leader.

Kei Yoshida’s recent book Philosophy of the Social Sciences: An Introduction is the first introductory textbook on the philosophy of the social sciences written in Japanese. It concisely expounds on a wide range of topics in the discipline, while its explication of those topics is not impartial or neutral as the author himself says. This paper gives a critical review of the book. The first half of it briefly overviews and assesses the book as a whole. The latter half of (...) the paper reconstructs the gist of the author’s exposition of the naturalism/interpretivism debate and criticizes it. (shrink)

滝沢教授の古稀を祝して捧げられる論文集。生と死をめぐる法的問題と裁判と法をめぐる諸問題について、学恩を受けた気鋭の学者が執筆。.

We propose a new Real-coded GA(RCGA) using the combination of two crossovers, UNDX-m and EDX. The search region of UNDX-m is biased to the inside area that the population of the RCGA covers. Because of this search bias, the GA using UNDX-m causes stagnation of its search if the cost function has a kind of structure, so called, a ridge structure or a multiple-peak structure. In order to overcome this stagnation, we propose a new crossover EDX, whose search is biased (...) toward extrapolative one. Experimental results show that RCGA with EDX can deal with both ridge-structure function whose dimension reaches more than hundreds and multiple-peak function whose optimum resides at the corner of the search area. (shrink)

Job-shop Scheduling Problem (JSP) is one of the most difficult benchmark problems. GA approaches often fail searching the global optimum because of the deception UV-structure of JSPs. In this paper, we introduce a novel framework model of GA, Innately Split Model (ISM) which prevents UV-phenomenon, and discuss on its power particularly. Next we analyze the structure of JSPs with the help of the UV-structure hypothesys, and finally we show ISM's excellent performance on JSP.

This paper presents a kernel density estimation method by means of real-coded crossovers. Functions of real-coded crossover operators are composed of probabilistic density estimation from parental populations and sampling from estimated models. Real-coded Genetic Algorithm (RCGA) does not explicitly estimate probabilistic distributions, however, probabilistic model estimation is implicitly included in algorithms of real-coded crossovers. Based on this understanding, we exploit the implicit estimation of probabilistic distribution of crossovers as a kernel density estimator. We also propose an application of crossover kernels (...) to Expectation-Maximization estimation (EM) of Gaussian mixtures. (shrink)

In the last few decades, the emergence of mid-scale, intermediated marketing channels that fall between commodity and direct markets has attracted growing interest from scholars for their potential to preserve small and mid-sized farms while scaling up alternative agrifood sourcing. When such mid-scale supply chains are formed among multiple business partners with shared ethics or values related to the qualities of the food and the business relationships along the supply chain, they may be termed “values-based supply chains (VBSCs).” Most of (...) the research on VBSCs to date has relied primarily on a case study approach that investigates the performance of VBSCs from the perspective of VBSC founders or leaders. In contrast, this research seeks out the perspectives of farmers who participate in VBSCs. A nationwide farmer survey conducted in 2017 offers original insights on farmer motivations for participating in VBSCs and how they are being used by farmers relative to other marketing channels. We find that VBSCs serve farms of all sizes. Overall, smaller farms were more likely to market a higher percentage of overall sales through their VBSC and more likely to rank their VBSC as one of the top three marketing channels in their portfolio. But it was the larger farms that were more likely to perceive VBSC-specific benefits. Our findings confirm that while there is a limited volume of product that such regional supply chains can currently handle, farmers view VBSCs as a valuable marketing option that aligns with their own values and preserves their product’s identity. (shrink)