The universities of Oxford and Cambridge had developed different attitudes towards the award of honorary degrees through the early and middle decades of the twentieth century. Recently, both have adopted a similar cautious and apolitical stance. This essay describes the role of honorary degrees in the production and reproduction of their cultural and intellectual authority of these two ancient universities.

The biopolitics of empire : slavery and "the Muslim" -- The biopolitics of settlement : temporality, desire, and civilization -- Foucault and queer theory -- Society must be destroyed -- Queer terror -- Bibliography.

This paper sets out to conduct an embodied and situated aural analysis of what silence in Northern Norway is about, with the aim of bringing forward the background noise. The paper brings together theories on construction of the rural, time-space relations, soundscape ecology, and on affect and power, and it merges academic traditions about how to communicate findings from non-visual biased studies. This interdisciplinary framework provides a novel structure for both analysing material and communicating findings from embodied studies of listening (...) out. The study found that silence in Northern Norway is about not listening to the economy of scale, to the commodification of the natural conditions and the suppression of lifestyles and territory. The paper illustrates how power is an inherent part of listening and how listening is a practice that is enacted to create emotions that are associated with a specific time-space relation. (shrink)

Wearable robots and exoskeletons are relatively new technologies designed for assisting and augmenting human motor functions. Due to their different possible design applications and their intimate connection to the human body, they come with specific ethical, legal, and social issues, which have not been much explored in the recent ELS literature. This paper draws on expert consultations and a literature review to provide a taxonomy of the most important ethical, legal, and social issues of wearable robots. These issues are categorized (...) in wearable robots and the self, wearable robots and the other, and wearable robots in society. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.1 (2003) 123-124 [Access article in PDF] Andrew Barker. Scientific Method in Ptolemy's Harmonics. New York: Cambridge University Press, 2001. Pp. viii + 281. Cloth, $69.95. Ptolemy's Harmonics is an important source not only for the history of music, but also for the history and philosophy of science. Two recent monographs, by J. Solomon, and A. Barker, now provide a basis for a (...) more widespread discussion of this much neglected work. Barker focuses on the part that is concerned with musical science proper (I, 1-III, 3), and more specifically on the scientific method it displays.Barker uses an analysis of Ptolemy's programmatic statements in I, 1/2, as a key to a reading of Ptolemy's treatise. His exposition has the format of a commentary, with special emphasis on the methodologically relevant passages. For the most part, he follows the order of Ptolemy's text closely, providing historical background information in excursus form. One needs to read a complete text of Ptolemy's treatise along with Barker's exposition in order to understand some of his arguments. It is preferable to also use Düring's [End Page 123] edition of the Greek text. One is rewarded with a detailed and in-depth analysis of the passages that helps one understand Ptolemy's method in harmonics as it unfolds in his treatise. This is so even if one disagrees with Barker's claims concerning Ptolemy's methodology.These claims are outlined in chapter 2, on the basis of I, 1/2 of the Harmonics. The methodological program Barker filters out of the text remains vague in a number of important respects. One misses, for example, a clear exposition on what will count as a sufficient integration of "empirical and theoretical phases," and on what will count as "empirical." This is a serious drawback, since Barker claims that Ptolemy instantiates a complex scientific methodology with a decisive, fully integrated empiricist trait. The drawback is aggravated by the fact that the already vague terms of the postulated methodology have to be watered down considerably in the subsequent chapters to make them fit with Ptolemy's actual procedures. Ptolemy does not seem to deliver even on the vague terms. One may very well remain unconvinced both by Barker's initial arguments concerning Ptolemy's methodology, and by his attempts to show that Ptolemy's procedure in the Harmonics can count as a satisfactory instantiation. Perhaps Ptolemy's intentions are less ambitious. When he states (5.13 ff. Düring, ed.) that "the aim of the student of harmonics must be to preserve the hupotheseis..., as never in any way conflicting with the perceptions that correspond to most people's estimation," he may just mean that he intends to vindicate an essentially Pythagorean (locally modified) account by showing it does not conflict with the phenomena. In my view, he certainly delivers on this less ambitious program. In fact, it seems to me that the understanding of Ptolemy's argumentative path is impeded by Barker's interpretation of Ptolemy's goal of "saving the hupotheseis" as a commitment to the integration of a genuine empiricist trait.Chapters 7 and 8 give an exposition of Ptolemy's tetrachord divisions. For the reader interested in an evaluation of the theoretical aspect of Ptolemy's scientific method, these are the central chapters of Barker's book. Barker provides a detailed analysis, together with an exposition of the historical and technical information needed for a non-specialist to follow both his and Ptolemy's argument. Barker's analysis reveals inter alia that a considerable part of Ptolemy's theory has no counterpart in the realm of phenomena perceived as musical, and that another part, concerning the single most important division of musical practice, is not justified, and not justifiable, by derivation from the principles. It is difficult to see how Ptolemy's account can nevertheless be viewed as a genuine integration of empirical and theoretical aspects. It appears to be an attempt at showing that an essentially Pythagorean theory... (shrink)

Patient ambivalence is a little studied phenomenon. Therefore, the contribution of Moore et al. (2022) about patient ambivalence in medical decision-making is welcome. Also, the idea that ambivalen...

Transparency is now a fundamental principle for data processing under the General Data Protection Regulation. We explore what this requirement entails for artificial intelligence and automated decision-making systems. We address the topic of transparency in artificial intelligence by integrating legal, social, and ethical aspects. We first investigate the ratio legis of the transparency requirement in the General Data Protection Regulation and its ethical underpinnings, showing its focus on the provision of information and explanation. We then discuss the pitfalls with respect (...) to this requirement by focusing on the significance of contextual and performative factors in the implementation of transparency. We show that human–computer interaction and human-robot interaction literature do not provide clear results with respect to the benefits of transparency for users of artificial intelligence technologies due to the impact of a wide range of contextual factors, including performative aspects. We conclude by integrating the information- and explanation-based approach to transparency with the critical contextual approach, proposing that transparency as required by the General Data Protection Regulation in itself may be insufficient to achieve the positive goals associated with transparency. Instead, we propose to understand transparency relationally, where information provision is conceptualized as communication between technology providers and users, and where assessments of trustworthiness based on contextual factors mediate the value of transparency communications. This relational concept of transparency points to future research directions for the study of transparency in artificial intelligence systems and should be taken into account in policymaking. (shrink)

Despite appearances, Agamben’s engagement with Foucault in Homo Sacer: Sovereign Power and Bare Life is not an extension of Foucault’s analysis of biopolitics but rather a disciplining of Foucault for failing to take Nazism seriously. This moralizing rebuke is the result of methodological divergences between the two thinkers that, I argue, have fundamental political consequences. Re-reading Foucault’s most explicitly political work of the mid-1970s, I show that Foucault’s commitment to genealogy is aligned with his commitment to “insurrection”—not simply archival or (...) historical, but practical and political insurrection—even as his non-moralizing understanding of critique makes space for the resistances he hopes to proliferate. By contrast, Agamben’s resurrection of sovereignty turns on a moralizing Holocaust exceptionalism that anoints both sovereignty and the state with inevitably totalitarian powers. Thus, while both Agamben and Foucault take positions “against” totalitarianism, their very different understandings of this term and method of investigating it unwittingly render Agamben complicit with the totalitarianism he otherwise seeks to reject. (shrink)

Nietzsche’s Revolution argues that Nietzsche is a revolutionary who aims to liberate modernity by overthrowing Christianity. Although Nietzsche’s terrified inability to follow through on this revolutionary project causes him to retreat into a retrograde essentialism of race and gender that betrays his own revolutionary promise, Nietzsche’s complicity in this failure bequeaths this revolution to us, his future readers, who can take it up in the form of poststructuralist queer theory and politics. This is a revolutionary future Nietzsche could neither have (...) foreseen nor endorsed, but is the necessary consequence of his quest to overthrow Christianity’s cult of meaning. (shrink)

In this dissertation, I investigate the role of Aristotle's theory of science, and specifically the homogeneity criterion, for the set-up of Aristotle's metaphysics project as sketched in Met. IV, 1--3 and VI, 1. I argue that Aristotelian metaphysics takes shape through a dialectical argument stretching from Met. I to VI, 1. Along this path, both Aristotle's theory of science , and the Platonist competitor in metaphysics are constantly kept in view. They propel the argument at crucial stages. The resulting metaphysics (...) is compatible with Aristotle's theory of science, though it is not a direct application of it. Rather, metaphysics is a content-neutral complement to the content-specific sciences. The Platonist competitor remains refuted. Some of its central ideas and tools are nevertheless assimilated into Aristotelian metaphysics. ;Aristotle's postulate of a universal science of being seems to contradict a central requirement for a science: the homogeneity principle. According to the Posterior Analytics, every science has its specific subject matter , which it explores in terms of predicative content, and to which it is restricted. Being, does not constitute such a genos. Aristotle has to find a feature which can play a role for 'being' that is analogous to 'genos' in a special science. Aristotle finds it in the pros hen notion . Pros hen makes the content-neutral, focal structure of being transparent. It is not an extension of synonymy . With the help of pros hen, Aristotle can construct a content-neutral universal metaphysics project, solving the puzzles which arose in III, 1/2 precisely as a conflict between the questions which metaphysics should address and the homogeneity criterion for content-specific sciences. His theory of science remains fully intact for the sciences for which it was designed. The objections against Platonist metaphysics remain in place as well. The content-neutral analysis of being meets the expectations formulated for metaphysics in I, 1/2, on the basis of endoxa. Aristotle's project is constituted by what is commonly called 'general metaphysics'. It includes a consideration of the divine. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.3 (2003) 409-410 [Access article in PDF] Christoph Riedweg. Pythagoras: Leben, Lehre, Nachwirkung. Munich: Beck, 2002. Pp. 206. Cloth, € 19.90.Another book about Pythagoras? Hasn't it been shown that we do not have any precise information about him, especially about his contributions as a scholar and a philosopher? Maybe we have been overly skeptical about the information transmitted about Pythagoras. In Pythagoras: Leben, (...) Lehre, Nachwirkung, Christoph Riedweg suggests we should take a different perspective, and he shows what we might gain if we loosen our standards on what counts as information about Pythagoras's contribution to the history of philosophy and science. We can reconstruct a cluster of ideas, motifs, and motivations relevant for early Pythagoreanism. This will give us an idea of the factors influencing Pythagoras and those influenced in turn by him. Even if we will not know what exactly he claimed or achieved (whether he did or did not use the Pythagorean psephoi, for example), we can still get a reasonably informative (if somewhat fuzzy) picture of Pythagoras's contribution and his significance. Riedweg's book outlines the terrain for such an approach. It is what it announces to be: an introduction (Einführung). It does not promise, nor does it offer, any radically new theories on Pythagoras.I will focus on chapters 2 and 3 (61-149) of the book. After a survey of ancient reports and legends about Pythagoras (chapter 1), Riedweg approaches the historical Pythagoras through a sketch of the cultural setting in which he lived and worked, and through the reactions of his contemporaries and near contemporaries (chapter 2, sections 1-2). Unfortunately, a reference to the socio-political sphere is missing. This is a serious gap, given the poignancy of the socio-political changes in the sixth-century Ionian poleis, and given Pythagoras's cooperation with the local aristocratic elites, for political purposes. One is, however, provided with a sketch of the contemporary cultural setting in which Pythagoras put forth his religious and his philosophical teachings—philosophy, art, technology, contacts (chapter 2, section 1). Apparently (Riedweg documents this conclusively), Pythagoras provoked extreme reactions from the very beginning, even from people that lived far away. Riedweg's label "Charismatiker"—a borrowing from Weberian sociology of religion—seems fitting. The sixth- and fifth-century "outside" testimonies (chapter 2, section 2) are predominantly polemical. In the religious sphere, Pythagoras comes across as a mystic, with a guru-attitude. But he also constructed a sophia, using the writings and ideas of others. The contents of this sophia remain unclear. The witnesses accuse Pythagoras of foul trickery and plagiarism. Nevertheless, he must have produced some sort of systematic explanatory account of the world, its origin and its meaning. From the very beginning, both the "guru" and the "scholar" aspect are thus attested for Pythagoras. The content of the religious teachings is much more concrete than the content of Pythagoras's own philosophical and scientific doctrines. This trend continues as Riedweg examines later sources for the reconstruction of Pythagoras's ideas (chapter 2, section 3). As is already known, we get a relatively accurate picture of Pythagoras's position regarding rituals, lifestyle, and beliefs about the nature of the human soul (chapter 2, section 3, a-f), i.e., his ethical and religious [End Page 409] teachings. With regard to his contributions to science and philosophy, however, we are faced with the problem that we are no longer in the position to differentiate between early Pythagoreanism and Pythagoras himself—even if we leave the Platonic and the Platonist tradition out of the picture, and even where we can reconstruct details. Riedweg bases his outline predominantly on Aristotle's reports on pre-Platonic Pythagoreanism.Though Aristotle's evaluation rests mostly on Philolaus, the picture he develops for early Pythagoreanism throws some light also on Pythagoras himself. Riedweg thus uses Aristotle for an elucidation of a context for Pythagoras's contributions as a philosopher and scientist (chapter II, section 3, i). Another source of indirect information consists in comparisons with Orphic texts. Riedweg succeeds... (shrink)

Intensified and extensive data production and data storage are characteristics of contemporary western societies. Health data sharing is increasing with the growth of Information and Communication Technology platforms devoted to the collection of personal health and genomic data. However, the sensitive and personal nature of health data poses ethical challenges when data is disclosed and shared even if for scientific research purposes. With this in mind, the Science and Values Working Group of the COST Action CHIP ME ‘Citizen's Health through (...) public-private Initiatives: Public health, Market and Ethical perspectives’ identified six core values they considered to be essential for the ethical sharing of health data using ICT platforms. We believe that using this ethical framework will promote respectful scientific practices in order to maintain individuals’ trust in research. We use these values to analyse five ICT platforms and explore how emerging data sharing platforms are reconfiguring the data sharing experience from a range of perspectives. We discuss which types of values, rights and responsibilities they entail and enshrine within their philosophy or outlook on what it means to share personal health information. Through this discussion we address issues of the design and the development process of personal health data and patient-oriented infrastructures, as well as new forms of technologically-mediated empowerment. (shrink)

This book treats practical and political reasoning as an active engagement with the world and other people; it cannot be understood as exclusively cognitive and this is seen as a virtue rather than a deficiency. Informal, emotional, characterological, aesthetic and interactional aspects of thought can be constituents of reasonable arguing. The work examines key capacities connected with argumentation, in a variety of fields from professional and medical ethics to work organization and the practice of art.

BackgroundInnovations in technology have contributed to rapid changes in the way that modern biomedical research is carried out. Researchers are increasingly required to endorse adaptive and flexible approaches to accommodate these innovations and comply with ethical, legal and regulatory requirements. This paper explores how Dynamic Consent may provide solutions to address challenges encountered when researchers invite individuals to participate in research and follow them up over time in a continuously changing environment.MethodsAn interdisciplinary workshop jointly organised by the University of Oxford (...) and the COST Action CHIP ME gathered clinicians, researchers, ethicists, lawyers, research participants and patient representatives to discuss experiences of using Dynamic Consent, and how such use may facilitate the conduct of specific research tasks. The data collected during the workshop were analysed using a content analysis approach.ResultsDynamic Consent can provide practical, sustainable and future-proof solutions to challenges related to participant recruitment, the attainment of informed consent, participant retention and consent management, and may bring economic efficiencies.ConclusionsDynamic Consent offers opportunities for ongoing communication between researchers and research participants that can positively impact research. Dynamic Consent supports inter-sector, cross-border approaches and large scale data-sharing. Whilst it is relatively easy to set up and maintain, its implementation will require that researchers re-consider their relationship with research participants and adopt new procedures. (shrink)

Der Zeuge spielt eine zentrale Rolle in den Szenarien der Wahrheitsfindung und in Kontexten der Verhandlung und Verwaltung von Erkenntnis und Wissen. Gleichzeitig gilt, dass ein mittels Zeugenschaft generiertes Wissen immer einen umstrittenen Status hatte - und hat. Das Zeugnis bedarf stets einer Akkreditierung durch den oder die Empfänger, um Geltung erlangen zu können. In diesem Band werden verschiedene Typen und Formen des testimonialen Wissens diskutiert, kulturhistorische und systematische Perspektiven zusammengeführt und in ihren Verflechtungen zwischen epistemischem Wert und ethischer, politischer, (...) sozialer, künstlerischer und religiöser Bedeutung beleuchtet. Im Fokus stehen dabei vor allem die Praktiken und Handlungsszenarien der Bezeugung, da sich in ihren Konstellationen und Dynamiken die Frage der Glaubwürdigkeit des Zeugnisses und die Optionen zur Etablierung eines Zeugenwissens entscheiden.--Backcover. (shrink)

Taking its cue from contemporary western debates on presence in the social sciences and the humanities, this volume focuses on "presence" both as everyday experience and as an experience of intense moments. It raises questions about diverse social configurations of presence as well as about the specific cultural repertoires which encode, articulate, and shape discourses of presence. The contributions take as a premise that phenomena of presence are connected to particular forms of knowledge. Especially tacit knowledge (pre)determines experiences of individual (...) and collective presence and becomes tangible in moments of presence or presentification. (shrink)

We are living in an algorithmic age where mathematics and computer science are coming together in powerful new ways to influence, shape and guide our behaviour and the governance of our societies. As these algorithmic governance structures proliferate, it is vital that we ensure their effectiveness and legitimacy. That is, we need to ensure that they are an effective means for achieving a legitimate policy goal that are also procedurally fair, open and unbiased. But how can we ensure that algorithmic (...) governance structures are both? This article shares the results of a collective intelligence workshop that addressed exactly this question. The workshop brought together a multidisciplinary group of scholars to consider barriers to legitimate and effective algorithmic governance and the research methods needed to address the nature and impact of specific barriers. An interactive management workshop technique was used to harness the collective intelligence of this multidisciplinary group. This method enabled participants to produce a framework and research agenda for those who are concerned about algorithmic governance. We outline this research agenda below, providing a detailed map of key research themes, questions and methods that our workshop felt ought to be pursued. This builds upon existing work on research agendas for critical algorithm studies in a unique way through the method of collective intelligence. (shrink)

Biotechnology might contribute to solving food safety and security challenges. However, gene technology has been under public scrutiny, linked to the framing of the media and public discourse. The study aims to investigate people’s perceptions and acceptance of food biotechnology with focus on transgenic genetic modification versus genome editing. An online experiment was conducted with participants from the United Kingdom and Switzerland. The participants were presented with the topic of food biotechnology and more specifically with experimentally varied vignettes on transgenic (...) and genetic modification and genome editing. The results suggest that participants from both countries express higher levels of acceptance for genome editing compared to transgenic genetic modification. The general and personal acceptance of these technologies depend largely on whether the participants believe the application is beneficial, how they perceive scientific uncertainty, and the country they reside in. Our findings suggest that future communication about gene technology should focus more on discussing trade-offs between using an agricultural technologies and tangible and relevant benefits, instead of a unidimensional focus on risk and safety. (shrink)

Driven by interests in workforce planning and patient safety, a growing body of literature has begun to identify the reality and the prevalence of missed nursing care, also specified as care left undone, rationed care or unfinished care. Empirical studies and conceptual considerations have focused on structural issues such as staffing, as well as on outcome issues – missed care/unfinished care. Philosophical and ethical aspects of unfinished care are largely unexplored. Thus, while internationally studies highlight instances of covert rationing/missed care/care (...) left undone – suggesting that nurses, in certain contexts, are actively engaged in rationing care – in terms of the nursing and nursing ethics literature, there appears to be a dearth of explicit decision-making frameworks within which to consider rationing of nursing care. In reality, the assumption of policy makers and health service managers is that nurses will continue to provide full care – despite reducing staffing levels and increased patient turnover, dependency and complexity of care. Often, it would appear that rationing/missed care/nursing care left undone is a direct response to overwhelming demands on the nursing resource in specific contexts. A discussion of resource allocation and rationing in nursing therefore seems timely. The aim of this discussion paper is to consider the ethical dimension of issues of resource allocation and rationing as they relate to nursing care and the distribution of the nursing resource. (shrink)

The placozoan Trichoplax adhaerens is a tiny hairy plate and more simply organized than any other living metazoan. After its original description by F.E. Schulze in 1883, it attracted attention as a potential model for the ancestral state of metazoan organization, the “Urmetazoon”. Trichoplax lacks any kind of symmetry, organs, nerve cells, muscle cells, basal lamina, and extracellular matrix. Furthermore, the placozoan genome is the smallest (not secondarily reduced) genome of all metazoan genomes. It harbors a remarkably rich diversity of (...) genes and has been considered the best living surrogate for a metazoan ancestor genome. The phylum Placozoa presently harbors three formally described species, while several dozen “cryptic” species are yet awaiting their description. The phylogenetic position of placozoans has recently become a contested arena for modern phylogenetic analyses and view‐driven claims. Trichoplax offers unique prospects for understanding the minimal requirements of metazoan animal organization and their corresponding malfunctions. (shrink)

With the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), global researchers were confronted with major challenges. The German National Pandemic Cohort Network (NAPKON) was launched in fall 2020 to effectively leverage resources and bundle research activities in the fight against the coronavirus disease 2019 (COVID-19) pandemic. We analyzed the setup phase of NAPKON as an example for multicenter studies in Germany, highlighting challenges and optimization potential in connecting 59 university and nonuniversity study sites. We examined the ethics application (...) process of 121 ethics submissions considering durations, annotations, and outcomes. Study site activation and recruitment processes were investigated and related to the incidence of SARS-CoV-2 infections. For all initial ethics applications, the median time to a positive ethics vote was less than two weeks and 30 of these study sites (65%) joined NAPKON within less than three weeks each. Electronic instead of postal ethics submission (9.5 days (Q1: 5.75, Q3: 17) vs. 14 days (Q1: 11, Q3: 26), p value = 0.01) and adoption of the primary ethics vote significantly accelerated the ethics application process. Each study center enrolled a median of 37 patients during the 14-month observation period, with large differences depending on the health sector. We found a positive correlation between recruitment performance and COVID-19 incidence as well as hospitalization incidence. Our analysis highlighted the challenges and opportunities of the federated system in Germany. Digital ethics application tools, adoption of a primary ethics vote and standardized formal requirements lead to harmonized and thus faster study initiation processes during a pandemic. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.3 (2003) 409-410 [Access article in PDF] Christoph Riedweg. Pythagoras: Leben, Lehre, Nachwirkung. Munich: Beck, 2002. Pp. 206. Cloth, € 19.90.Another book about Pythagoras? Hasn't it been shown that we do not have any precise information about him, especially about his contributions as a scholar and a philosopher? Maybe we have been overly skeptical about the information transmitted about Pythagoras. In Pythagoras: Leben, (...) Lehre, Nachwirkung, Christoph Riedweg suggests we should take a different perspective, and he shows what we might gain if we loosen our standards on what counts as information about Pythagoras's contribution to the history of philosophy and science. We can reconstruct a cluster of ideas, motifs, and motivations relevant for early Pythagoreanism. This will give us an idea of the factors influencing Pythagoras and those influenced in turn by him. Even if we will not know what exactly he claimed or achieved (whether he did or did not use the Pythagorean psephoi, for example), we can still get a reasonably informative (if somewhat fuzzy) picture of Pythagoras's contribution and his significance. Riedweg's book outlines the terrain for such an approach. It is what it announces to be: an introduction (Einführung). It does not promise, nor does it offer, any radically new theories on Pythagoras.I will focus on chapters 2 and 3 (61-149) of the book. After a survey of ancient reports and legends about Pythagoras (chapter 1), Riedweg approaches the historical Pythagoras through a sketch of the cultural setting in which he lived and worked, and through the reactions of his contemporaries and near contemporaries (chapter 2, sections 1-2). Unfortunately, a reference to the socio-political sphere is missing. This is a serious gap, given the poignancy of the socio-political changes in the sixth-century Ionian poleis, and given Pythagoras's cooperation with the local aristocratic elites, for political purposes. One is, however, provided with a sketch of the contemporary cultural setting in which Pythagoras put forth his religious and his philosophical teachings—philosophy, art, technology, contacts (chapter 2, section 1). Apparently (Riedweg documents this conclusively), Pythagoras provoked extreme reactions from the very beginning, even from people that lived far away. Riedweg's label "Charismatiker"—a borrowing from Weberian sociology of religion—seems fitting. The sixth- and fifth-century "outside" testimonies (chapter 2, section 2) are predominantly polemical. In the religious sphere, Pythagoras comes across as a mystic, with a guru-attitude. But he also constructed a sophia, using the writings and ideas of others. The contents of this sophia remain unclear. The witnesses accuse Pythagoras of foul trickery and plagiarism. Nevertheless, he must have produced some sort of systematic explanatory account of the world, its origin and its meaning. From the very beginning, both the "guru" and the "scholar" aspect are thus attested for Pythagoras. The content of the religious teachings is much more concrete than the content of Pythagoras's own philosophical and scientific doctrines. This trend continues as Riedweg examines later sources for the reconstruction of Pythagoras's ideas (chapter 2, section 3). As is already known, we get a relatively accurate picture of Pythagoras's position regarding rituals, lifestyle, and beliefs about the nature of the human soul (chapter 2, section 3, a-f), i.e., his ethical and religious [End Page 409] teachings. With regard to his contributions to science and philosophy, however, we are faced with the problem that we are no longer in the position to differentiate between early Pythagoreanism and Pythagoras himself—even if we leave the Platonic and the Platonist tradition out of the picture, and even where we can reconstruct details. Riedweg bases his outline predominantly on Aristotle's reports on pre-Platonic Pythagoreanism.Though Aristotle's evaluation rests mostly on Philolaus, the picture he develops for early Pythagoreanism throws some light also on Pythagoras himself. Riedweg thus uses Aristotle for an elucidation of a context for Pythagoras's contributions as a philosopher and scientist (chapter II, section 3, i). Another source of indirect information consists in comparisons with Orphic texts. Riedweg succeeds... (shrink)

Introduction: Congenital myasthenic syndromes refer to a heterogenic group of neuromuscular transmission disorders. CMS-subtypes are diverse regarding exercise intolerance and muscular weakness, varying from mild symptoms to life-limiting forms with neonatal onset. Long-term follow-up studies on disease progression and treatment-response in pediatric patients are rare.Patients and Methods: We analyzed retrospective clinical and medication data in a cohort of 32 CMS-patients including the application of a standardized, not yet validated test to examine muscular strength and endurance in 21 patients at the (...) last follow-up. Findings obtained in our cohort were compared with long-term follow-up studies of CMS-cohorts from the literature by considering the underlying molecular mechanisms. Outcomes of CMS-ST were compared to results of normal clinical assessment.Results: Thirty-two pediatric patients with defects in eight different CMS-genes were followed by a median time of 12.8 years. Fifty-nine percentage of patients manifested with first symptoms as neonates, 35% as infants. While 53% of patients presented a reduced walking distance, 34% were wheelchair-bound. Even under adequate therapy with pyridostigmine and 3,4-diaminopyridine, CHAT-mutations led to the progression of muscular weakness partly in combination with persistent respiratory and bulbar symptoms. RAPSN, CHRND, and CHRNB1 patients with neonatal manifestation, early respiratory problems, and bulbar symptoms showed a good and maintained treatment response. CHAT and CHRNE patients required higher PS dosages, whereas RAPSN patients needed a lower mean dosage at the last follow-up. The benefits of short-term medication and long-term progression of symptoms were highly dependent on the specific genetic defect. CMS-ST was carried out in 17/21 patients, determined affected muscle groups including bulbar and ocular symptoms, some of which were not reported by the patients.Conclusions: Our findings and comparison with the literature- suggest a better treatment-response and less severe progression of symptoms present in patients suffering from mutations in CMS-genes directly associated with receptor deficiency, while patients with defects leading to synaptopathy and presynaptic defects tend to have worse outcomes. Assessment of affected muscular groups and clinical symptoms by CMS-ST may be a useful tool for optimal therapeutic management of the patients, especially for future clinical studies. (shrink)

Multivariate pattern analysis can reveal new information from neuroimaging data to illuminate human cognition and its disturbances. Here, we develop a methodological approach, based on multivariate statistical/machine learning and time series analysis, to discern cognitive processing stages from functional magnetic resonance imaging (fMRI) blood oxygenation level dependent (BOLD) time series. We apply this method to data recorded from a group of healthy adults whilst performing a virtual reality version of the delayed win-shift radial arm maze (RAM) task. This task has (...) been frequently used to study working memory and decision making in rodents. Using linear classifiers and multivariate test statistics in conjunction with time series bootstraps, we show that different cognitive stages of the task, as defined by the experimenter, namely, the encoding/retrieval, choice, reward and delay stages, can be statistically discriminated from the BOLD time series in brain areas relevant for decision making and working memory. Discrimination of these task stages was significantly reduced during poor behavioral performance in dorsolateral prefrontal cortex (DLPFC), but not in the primary visual cortex (V1). Experimenter-defined dissection of time series into class labels based on task structure was confirmed by an unsupervised, bottom-up approach based on Hidden Markov Models. Furthermore, we show that different groupings of recorded time points into cognitive event classes can be used to test hypotheses about the specific cognitive role of a given brain region during task execution. We found that whilst the DLPFC strongly differentiated between task stages associated with different memory loads, but not between different visual-spatial aspects, the reverse was true for V1. Our methodology illustrates how different aspects of cognitive information processing during one and the same task can be separated and attributed to specific brain regions based on information contained in multivariate patterns of voxel activity. (shrink)

Though âeoepejorationâe is an important notion for linguistic analysis and theory, there is still a lack of theoretical understanding and sound descriptive analysis. In this timely collection, the phenomenon of pejoration is studied from a number of angles. It contains studies from phonology, morphology, syntax, semantics and pragmatics, and deals with diverse languages and their variants. Thus, the collection will appeal to all those linguists with a genuine interest in locating pejoration at the grammar-pragmatics interface.

" La science avance plus vite que l'homme ". La formule de François Mitterrand se révèle, chaque jour davantage en matière de bioéthique, d'une étonnante actualité! Alors qu'il est encore bien malaisé de porter un jugement éthique et juridique sur le développement des biotechnologies, chacun s'interroge sur la justification et les risques des techniques les plus récentes, les perspectives qu'elles ouvrent à l'homme, mais également leur compatibilité avec la dignité de la personne. Lors d'un colloque pluridisciplinaire et international organisé par (...) la Faculté de droit de Nancy, le Centre Juridique Franco-Allemand et le Groupe de recherche de droit médical de l'Université de la Sarre, juristes, philosophes et médecins se sont penchés ensemble sur ces questions essentielles. Leurs réflexions et les discussions qu'elles ont engendrées, à la lumière des sensibilités française et allemande, font l'objet du présent ouvrage. En langue française, les diverses contributions sont suivies d'un résumé en allemand. Les fulgurants progrès des biotechnologies offrent incontestablement à l'humanité des chances nouvelles. Mais face à des biologistes dont certains se prennent déjà pour Dieu, il devient d'une urgente nécessité de réaffirmer les Droits de l'Homme. Qu'il s'agisse de procréation médicalement assistée, de thérapie génique ou d'expérimentation sur l'homme, une conclusion s'impose : lorsqu'elle menace la dignité de la personne, la liberté de la Science doit être limitée. L'avenir de l'espèce humaine est peut-être à ce prix... (shrink)

Innovative forms of green urban architecture aim to combine food, production, and design to produce food on a larger scale in and on buildings in urban areas. It includes rooftop gardens, rooftop greenhouses, indoor farms, and other building-related forms. This study uses the framework of sustainability to understand the role of ZFarming in future urban food production and to review the major benefits and limitations. The results are based on an analysis of 96 documents published in accessible international resources. The (...) analysis shows that ZFarming has multiple functions and produces a range of non-food and non-market goods that may have positive impacts on the urban setting. It promises environmental benefits resulting from the saving and recycling of resources and reduced food miles. Social advantages include improving community food security, the provision of educational facilities, linking consumers to food production, and serving as a design inspiration. In economic terms it provides potential public benefits and commodity outputs. However, managing ZFarming faces several challenges. For some applications, the required technologies are known but have not been used or combined in that way before; others will need entirely new materials or cultivation techniques. Further critical aspects are the problem of high investment costs, exclusionary effects, and a lack of acceptance. In conclusion, ZFarming is seen as an outside-the-box solution which has some potential in generating win–win scenarios in cities. Nevertheless, ZFarming practices are not in and of themselves sustainable and need to be managed properly. (shrink)

Unter den klassischen Vertretern der deutschen Geistesgeschichte ist Georg Simmel der eher unklassische Denker, der keiner Fachdisziplin eindeutig zugerechnet werden kann. Sein Denken reicht in viele Bereiche der Philosophie und der Wissenschaften, der geistigen Kultur und der Alltagswelt hinein. Dieser Band verfolgt das Ziel, den Philosophen Georg Simmel (wieder) zu entdecken. Im Zentrum der Forschungsarbeiten stehen bisher weitgehend vernachlässigte systematische Fragen, z.B.: Gibt es einen archimedischen Punkt im Denken Simmels oder organisiert sich Simmels Analyse der Phänomene des inneren und äußeren (...) Lebens je nach Gegenstandsbereich neu? (shrink)