There is an increasing emphasis on clear disclosure of conflict of interest in medical communities, following repeated scientific frauds in clinical trials. However, incomplete COI statements continue to be prevalent in the medical community, as appears to have occurred in the Capecitabine for Residual Cancer as Adjuvant Therapy trial, which was recently published in the New England Journal of Medicine. The authors of the article did not clearly report the roles of the Japan Breast Cancer Research Group, a sponsor and (...) funder of the study, although a majority of the Japanese authors served in important positions in the organization. Furthermore, the conflict of interest related to Chugai Pharmaceutical Company, a Japanese distributor of capecitabine, was not correctly disclosed. More transparent statements of conflict of interest and clarification of sponsors and funders’ roles, as well as rigorous review by academic journals are required to fairly interpret the findings of clinical trials, including and beyond the single case of the CREATE-X trial. (shrink)

Translated text is chapt. 7, pt. 2 of Kirisutokyō no benshō.

Some researchers claim that uncertainty prolongs the duration of emotional experiences because uncertainty toward an emotion-eliciting event prolongs attention to that event. However, some results contradict this claim. We assumed that curiosity rather than uncertainty prolongs the duration of emotional experience via attention, and that attention and emotional experience are prolonged only when uncertainty elicits curiosity. This assumption is based on the information gap theory, which proposes that curiosity increases with uncertainty, but that curiosity decreases at a certain level of (...) uncertainty. We conducted a survey study to investigate the relationships among curiosity, uncertainty, attention and duration of positive and negative emotional experiences. The results showed that curiosity, but not uncertainty, prolonged the duration of emotional experiences and the process was completely mediated by attention both for positive and negative emotions. Moreover, uncertainty prolonged the duration of emotional experiences only when uncertainty elicited curiosity, which in turn prolonged attention to the emotion-eliciting event. (shrink)

As Hegel suggests, there is no philosophy apart from the history of philosophy. Each philosophy represents the spirit peculiar to its own period. Heidegger, too, holds that every philosophy is the sound of Being, and the history of philosophy is the history of Being. This is true for the Kyoto School philosophy of modern Japan represented by Kitaro Nishida, Hajime Tanabe, and Tetsuro Watsuji, who made to endeavor to construct a new synthesis of Western and Eastern philosophy in the critical, (...) confrontational, and creative ways in the given historical contexts. In particular, Tanabe attempts at the dialectical unification of Christianity and Buddhism in the last resort from the standpoint of Absolute Nothingness. As, in Whitehead’s conception of process, actuality is composed of the past objective being as the given data and the present subjective act of becoming, so it might be highly significant to analyze the constitutive elements of Tanabe’s system of thought from the historical and comparative contexts. (shrink)

In this collection on the Kyoto School of Philosophy, the author offers the reader Tanabe's religious philosophy, but also, and for the first time, his ...

Hajime Tanabe (1885-1962), the Kyoto- School philosopher of modern Japan, attempts to interpret Aristotle's ontology as being involved in the logic of self-identical being without self-negative conversion in action from his own dialectical perspective. For Tanabe, the eternal essence or Form is to be mediated by the dynamic character of matter, i.e., the temporality pertinent to the changing movement. For Aristotle, however, the essence or pure activity as the principle of being is devoid of such a dynamic mediation, but is (...) rather regarded as the past being, i.e., what it should be originally and eternally. In other words, for Aristotle, evil and matter are the lacks of goodness and the eternal Form that are identical with the essence of the individual substance. Evil is to be self-negatively mediated to goodness in free action through conversion in Tanabe's perspective. Movement pertaining to matter is not simply an incompletion of pure activity, but is rather self-negatively converted into the activity as the transcendent principle of the dialectical unification of time and eternity, matter and Form, evil and Goodness. The individual existence has freedom to unify the self-contradistinctive opposed moments, i.e., subjective action and objective being in a way of mutually negating conversion. The difference between Tanabe and Aristotle lies in that for Tanabe practice is relevant to the future, whereas for Aristotle contemplation is concerned with eternity as invariable and imperishable being since the past. While Aristotle's logic is confined to the self-identity of being in contemplation, Tanabe's logic is structured by the triadic elements of individuality, species as the relative universal, and genus as the absolute universal in terms of the negative conversion in action. (shrink)

The historical origins of the Kyoto School of Philosophy of modern Japan, represented by Kitaro Nishida and Hajime Tanabe, may be derived from both the ancient Chinese idea of Change and the ancient Indian Upanishadic idea of the mutual identity of Brahman and Atman. The ancient Chinese idea of Change signifies change as well as non-change, and even their dialectical unification. Both origins are structured by the self-identity of the opposed in logic, and these historical prototypes have been developed into (...) the various forms of Confucian, Taoist, and Buddhist philosophy. The notion of Nothingness or Emptiness rather than Being has been set up as the fundamental principle. The principle of Nothingness as ultimate reality has been connected with the logic of self-identity of theopposed, and this is evident in Nishida’s concept of the self-identity in absolute contradistinction that is equivalent to the Place of Absolute Nothingness. Even though Nishida’s idea of Place is directly and explicitly influenced by the ancient Greek idea of Topos, it has indirectly and implicitly been affected by the traditional agricultural society as well, in which the land is regarded as the self-identical substratum despite the cyclic time of the four-seasons change. The ancient Chinese idea of Change also reflects the agricultural society in which the cyclic time plays an important role on the basis of the unchanging self-identical land as the underlying substratum. Nishida succeeds in establishing the new logical expression of Eastern traditional thought, deeply hidden in consciousness, in relation toWestern philosophy. The uniqueness of Nishida’s idea of Place may have its main source in the traditional agricultural background, and in this sense his way of thinking may be rural in character. On the other hand, Tanabe, though following Nishida at first, turns to making criticism of the mentor with the establishment of the triadic logic of species as the dialectic, which is characterized by the perpetual self-negating conversion in action. In contrast to Nishida, Tanabe represents the urban type of thinking, which is in pursuit of transforming in life. While Nishida’s idea of Absolute Nothingness has an affinity with the ancient Chinese philosopher Laotzu’s idea of Nothingness from and into which every entity comes and goes, Tanabe’s concept of Absolute Nothingness as the principle ofconversion is more closed to the Buddhist idea of sunyata, i.e., Emptiness, which is devoid of any substance in itself. As regards evil, the difference between them is obvious in that for Nishida evil and time or history disappear into the ultimate horizon or place of Nothingness with the tendency toward a kind of monism of goodness, whereas for Tanabe evil copes with goodness and retains its own status throughout, never being reduced to the opposed. Even if so, both of them, however, fail to construct a philosophy of history from the epochal or durational viewpoint, compared to Heidegger and Jaspers. (shrink)

In June 2017, Japanese and Korean authors published the results of the CREATE‐X trial in the New England Journal of Medicine (NEJM). After we identified their inadequate disclosures of Financial Conflict of Interests (FCOIs), the authors made a post‐publication correction of their FCOIs. The purpose of this study is to evaluate the accuracy of the post‐publication corrections by the Japanese authors of the CREATE‐X trial. All the Japanese authors of the CREATE‐X trial were included in the study. We determined the (...) payments received by these authors in 2016 using publicly available data published by 78 pharmaceutical companies based on the stipulated Japanese transparency guidelines. We retrieved the original and revised versions of the FCOI disclosures as published on the NEJM website, and compared the payments reported by the pharmaceutical companies and the original and revised FCOI disclosures of the authors. Of the 12 authors, nine received payments made by the drug manufacturer involved in the CREATE‐X trial. Of these nine, only three (33.3%) originally disclosed their relationships, and another three (33.3%) later disclosed such relationships in the post‐publication corrections. Similarly, of the 11 receiving at least one payment from other manufacturers of breast cancer products, none correctly disclosed the payments in the original or the revised disclosure. In the CREATE‐X trial, FCOIs with pharmaceutical companies were not properly disclosed by 11 of the 12 Japanese authors, even after the post‐publication corrections, which highlights the need to pay more attention to the accuracy of FCOI disclosures in academic publications. (shrink)

Recent climate change statistics attribute over a quarter of carbon emissions to residential energy use in the United Kingdom. To address this, a building standard was introduced to aim to reduce the levels of carbon dioxide emissions and energy consumption. This paper analyzes how such an environmental standard reconfigures the sociotechnological relations and practices of housing professionals that design, construct, and manage social housing. We focus on how actors engage with the standard’s recommendation for incorporating low and zero carbon technologies (...) into new buildings. We identify diverse practices that emerge from these engagements, which, we contend, have significant consequences for the working relationships of professional actors and for renewable energy provision. By being entwined in, and generative of actors’ practices, we argue that the Code becomes part of the sociotechnological relationships and infrastructures that shape energy provision. (shrink)

For a prime k, the embeddability of finite lattices are discussed for various kind of the MODkP degrees of recursive sets. In particular, all finite lattices are embeddable into the MODkP Turing degrees, whereas the non distributive lattice M3 is embeddable into the MOD2P many-one degrees but N5 is not.

Hajime Tanabe (1885-1962), the Kyoto- School philosopher of modern Japan, attempts to interpret Aristotle's ontology as being involved in the logic of self-identical being without self-negative conversion in action from his own dialectical perspective. For Tanabe, the eternal essence or Form is to be mediated by the dynamic character of matter, i.e., the temporality pertinent to the changing movement. For Aristotle, however, the essence or pure activity as the principle of being is devoid of such a dynamic mediation, but is (...) rather regarded as the past being, i.e., what it should be originally and eternally. In other words, for Aristotle, evil and matter are the lacks of goodness and the eternal Form that are identical with the essence of the individual substance. Evil is to be self-negatively mediated to goodness in free action through conversion in Tanabe's perspective. Movement pertaining to matter is not simply an incompletion of pure activity, but is rather self-negatively converted into the activity as the transcendent principle of the dialectical unification of time and eternity, matter and Form, evil and Goodness. The individual existence has freedom to unify the self-contradistinctive opposed moments, i.e., subjective action and objective being in a way of mutually negating conversion. The difference between Tanabe and Aristotle lies in that for Tanabe practice is relevant to the future, whereas for Aristotle contemplation is concerned with eternity as invariable and imperishable being since the past. While Aristotle's logic is confined to the self-identity of being in contemplation, Tanabe's logic is structured by the triadic elements of individuality, species as the relative universal, and genus as the absolute universal in terms of the negative conversion in action. (shrink)

Tanabe Hajime, another pole of the so-called Kyoto-School of Philosophy of modern Japan, attempts to construct a dialectical, triadic logic of genus, species and individual as a creative synthesis between Eastern and Western philosophy. Although the formal pattern of his method is influenced by the Hegelian dialectic, the way of his thinking is rather prevailed by Kantian dualism. This makes a sharp contrast to his mentor Nishida Kitaro, whose logic of Topos or Place qua Absolute Nothingness is criticized as all-embracing (...) and static in character by him. The difference between them might be parallel to that of Greek and Latin theology concerning the Trinity. Tanabe never presupposes any preexistent entity as the primordial One in the eternal dimension, but rather maintains the individuality as the free subjective agent in the field of history. The dichotomy between the universal and the individual is overcome in and through the mediation of the third term— the species — as the negatively self-realized, specific form of the genus. The species, however, turns out to be the self-estrangement, when it loses the perpetually negative mediation of the free subjective activity of the individual. (shrink)

Tanabe Hajime, the Kyoto School philosopher of modern Japan, proposes a new idea of the relationship between religion and politics in terms of the triadic logic of species that is motivated by the religious moment of repentance. Even the state existence has the inherently radical evil as in the case of the individual person, due to its duality of the species level of being. This means that the state existence is on the way of actualization of the genus like universality, (...) while always involving in the regression into the past substrative being which prevents it from realizing its own universality. In other words, the state existence is not absolute as such but rather a balanced being between ideality and reality, absolute and relative. This entails that politics is in need of perpetual reformation in connection with the religious act of repentance for sin and evil deeply lurked in human beings from time immemorial. Tanabe’s Logic of Species as the dialectic elucidates the negative mediation of politics and religion from the metanoetic perspective and sheds a new light on the relation of world religion and politics today. (shrink)

In this philosophically sophisticated and historically significant work, John H. Zammito reconstructs Kant's composition of The Critique of Judgment and reveals that it underwent three major transformations before publication. He shows that Kant not only made his "cognitive" turn, expanding the project from a "Critique of Taste" to a Critique of Judgment but he also made an "ethical" turn. This "ethical" turn was provoked by controversies in German philosophical and religious culture, in particular the writings of Johann Herder and the (...) Sturm und Drang movement in art and science, as well as the related pantheism controversy. Such topicality made the Third Critique pivotal in creating a "Kantian" movement in the 1790s, leading directly to German Idealism and Romanticism. The austerity and grandeur of Kant's philosophical writings sometimes make it hard to recognize them as the products of a historical individual situated in the particular constellation of his time and society. Here Kant emerges as a concrete historical figure struggling to preserve the achievements of cosmopolitan Aufkl-rung against challenges in natural science, religion, and politics in the late 1780s. More specifically Zammito suggests that Kant's Third Critique was animated throughout by a fierce personal rivalry with Herder and by a strong commitment to traditional Christian ideas of God and human moral freedom. "A work of extraordinary erudition. Zammito's study is both comprehensive and novel, connecting Kant's work with the aesthetic and religious controversies of the late eighteenth century. He seems to have read everything. I know of no comparable historical study of Kant's Third Critique."-Arnulf Zweig, translator and editor of Kant's ;IPhilosophical Correspondence, 1759-1799;X "An intricate, subtle, and exciting explanation of how Kant's thinking developed and adjusted to new challenges over the decade from the first edition of the Critique of Pure Reason to the appearance of the Critique of Judgment. "--John W. Burbidge, Review of Metaphysics "There has been for a long time a serious gap in English commentary on Kant's Critique of Judgment Zammito's book finally fills it. All students and scholars of Kant will want to consult it."--Frederick Beiser, Times Literary Supplement. (shrink)

The members of the Six gene family were identified as homologues of Drosophila sine oculis which is essential for compound-eye formation. The Six proteins are characterized by the Six domain and the Six-type homeodomain, both of which are essential for specific DNA binding and for cooperative interactions with Eya proteins. Mammals possess six Six genes which can be subdivided into three subclasses, and mutations of Six genes have been identified in human genetic disorders. Characterization of Six genes from various animal (...) phyla revealed the antiquity of this gene family and roles of its members in several different developmental contexts. Some members retain conserved roles as components of the Pax-Six-Eya-Dach regulatory network, which may have been established in the common ancestor of all bilaterians as a toolbox controlling cell proliferation and cell movement during embryogenesis. Gene duplications and cis-regulatory changes may have provided a basis for diverse functions of Six genes in different animal lineages. (shrink)

KM (Knowledge Management) systems have recently been adopted within the realm of enterprise management. On the other hand, data mining technology is widely acknowledged within Information systems' R&D Divisions. Specially, acquisition of meaningful information from Web usage data has become one of the most exciting eras. In this paper, we employ a Web based KM system and propose a framework for applying Web Usage Mining technology to KM data. As it turns out, task duration varies according to different user operations (...) such as referencing a table-of-contents page, down-loading a target file, and writing to a bulletin board. This in turn makes it possible to easily predict the purpose of the user's task. By taking these observations into account, we segmented access log data manually. These results were compared with results abstained by applying the constant interval method. Next, we obtained a segmentation rule of Web access logs by applying a machine-learning algorithm to manually segmented access logs as training data. Then, the newly obtained segmentation rule was compared with other known methods including the time interval method by evaluating their segmentation results in terms of recall and precision rates and it was shown that our rule attained the best results in both measures. Furthermore, the segmented data were fed to an association rule miner and the obtained association rules were utilized to modify the Web structure. (shrink)

Introduction: Platonic dramatology -- The political and philosophical problems. Using pre-Socratic philosophy to support political reform: the Athenian stranger ; Plato's Parmenides: Parmenides' critique of Socrates and Plato's critique of Parmenides ; Becoming Socrates ; Socrates interrogates his contemporaries about the noble and good -- Paradigms of philosophy. Socrates' positive teaching ; Timaeus-Critias: completing or challenging Socratic political philosophy? ; Socratic practice -- The trial and death of Socrates. The limits of human intelligence ; The Eleatic challenge ; The trial (...) and death of Socrates -- Conclusion: Why Plato made Socrates his hero. (shrink)

In 'Een handvol filosofen' staan de filosofen centraal die sinds de oprichting van de Vrije Universiteit in 1880 aan deze instelling verbonden zijn geweest. Het gaat hierbij niet alleen om de inhoud van hun werk, maar ook om de personen zelf. Er waren filosofiedocenten die zich met de universiteit identificeerden en zich volledig konden ontplooien. Er waren er echter ook voor wie dit niet gold, die geïsoleerd of in gewetensnood raakten. Veel filosofiestudenten waren actief betrokken bij wat er in hun (...) faculteit gebeurde. Zij namen initiatieven, protesteerden soms tegen de gang van zaken en kozen partij in conflictsituaties. Sinds het eind van de jaren zestig van de twintigste eeuw verloor de Vrije Universiteit geleidelijk haar christelijk karakter. Tegenwoordig werken alle stafleden vanuit hun eigen motivatie mee aan een hoofdzakelijk seculier geworden universiteit, die ruimte biedt voor religieuze en levensbeschouwelijke diversiteit. (shrink)

Abstract:During recent years, the principle and practice of employment-at-will have been under attack. While progress has been made in eroding the practice, the principle still governs the philosophical assumptions underlying employment practices in the United States, and, indeed, EAW has been promulgated as one of the ways to address economic ills in other countries. This paper will briefly review the major critiques of EAW. Given the failure of these arguments to erode the underpinnings of EAW, we shall suggest new avenues (...) for approaching employment issues to achieve the desirable goal of employee dignity and respect. (shrink)

This groundbreaking volume casts light on the long shadow of naturalistic monism in modern thought and culture. When monism's philosophical proposition - the unity of all matter and thought in a single, universal substance - fused with scientific empiricism and Darwinism in the mid-nineteenth century, it led to the formation of a powerful worldview articulated in the work of figures such as Ernst Haeckel. The compelling essays collected here, written by leading international scholars, investigate the articulation of monism in science, (...) philosophy, and religion and its impact on a range of social movements, from socialism and early feminism to imperialism and eugenics. The result is a broad and comprehensive chronological, disciplinary, and geographic map of a century of monism, as well as a bellwether for innovative new directions in the interdisciplinary study of science, religion, philosophy, and culture. (shrink)

This article presents a response to Richard Rorty's paper "Is Philosophy Relevant to Business Ethics?" The author questions Rorty's views on the depreciation of the role of philosophy in applied ethics, and outlines four reasons why philosophy retains its relevance. The author addresses the role of moral reasoning in the development of the moral imagination. The author also concludes that humans have the means necessary to make moral progress and are capable of moral reasoning, and need only to develop a (...) strong moral imagination. (shrink)

The introduction of novel diagnostic techniques in clinical domains such as genomics and radiology has led to a rich ethical debate on how to handle unsolicited findings that result from these innovations. Yet while unsolicited findings arise in both genomics and radiology, most of the relevant literature to date has tended to focus on only one of these domains. In this article, we synthesize and critically assess similarities and differences between “scanning the body” and “sequencing the genome” from an ethical (...) perspective. After briefly describing the novel diagnostic contexts leading to unsolicited findings, we synthesize and reflect on six core ethical issues that relate to both specialties: terminology; benefits and risks; autonomy; disclosure of unsolicited findings to children; uncertainty; and filters and routine screening. We identify ethical rationales that pertain to both fields and may contribute to more ethically sound policies. Considerations of preserving public trust and ensuring that people perceive healthcare policies as fair also support the need for a combined debate. (shrink)

Human nature is enigmatic. Are we cruel, selfish creatures or good merciful Samaritans? This book takes you on a journey into the complexities of human mind and kind, from altruism, sharing, and large-scale cooperation, to cheating, distrust, and warfare. What are the building blocks of morality and sociality? Featuring contributions from leading researchers, such as Christophe Boesch, Leda Cosmides and John Tooby, Azar Gat, Dennis Krebs, Ara Norenzayan, and Frans B. M. de Waal, this fascinating interdisciplinary reader draws on evolutionary (...) and comparative perspectives, and is essential reading for any students interested in the unique characteristics that define humanity and society. (shrink)

This is the first sustained, whole-Bible treatment on the theme of meeting God face to face. Starting with Genesis and ending with Revelation, the author systematically covers the major events in salvation history, all of which reveal the beauty of encountering God's grace in abundance.

Both Carnap and Quine made significant contributions to the philosophy of mathematics despite their diversedviews. Carnap endorsed the dichotomy between analytic and synthetic knowledge and classified certainmathematical questions as internal questions appealing to logic and convention. On the contrary, Quine wasopposed to the analytic-synthetic distinction and promoted a holistic view of scientific inquiry. The purpose of thispaper is to argue that in light of the recent advancement of experimental mathematics such as Monte Carlosimulations, limiting mathematical inquiry to the domain of (...) logic is unjustified. Robustness studies implemented inMonte Carlo Studies demonstrate that mathematics is on par with other experimental-based sciences. (shrink)