Kant's philosophy of arithmetic / by Charles Parsons -- Visual geometry / by James Hopkins -- The proof-structure of Kant's transcendental deduction / by Dieter Henrich -- Imagination and perception / by P.F. Strawson -- Kant's categories and their schematism / by Lauchlan Chipman -- Transcendental arguments / by Barry Stroud -- Strawson on transcendental idealism / by H.E. Matthews -- Self-knowledge / by W.H. Walsh -- The age and size of the world / by Jonathan Bennett.

Nucleosomes are the basic elements of chromatin structure. Polyamines, such as spermine and spermidine, are small ubiquitous molecules absolutely required for cell growth. Photoaffinity polyamines bind to specific locations in nucleosomes and can change the helical twist of DNA in nucleosomes. Acetylation of polyamines reduces their affinity for DNA and nucleosomes, thus the helical twist of DNA in nucleosomes could be regulated by cells through acetylation. I suggest that histone and polyamine acetylation act synergistically to modulate chromatin structure. On naked (...) DNA, the photoaffinity spermine bound preferentially to a specific ‘TATA’ sequence element, suggesting that polyamines may be involved in the unusual chromatin structure in this region. Further work is needed to test whether the specificities shown by photoaffinity polyamines are also shown by cellular polyamines; such experiments are now feasible. (shrink)

. Power Games and Moral Territories: Ethical Dilemmas when Working with Children and Young People. Ethics, Place & Environment: Vol. 4, No. 2, pp. 117-118.

. Power Games and Moral Territories: Ethical Dilemmas when Working with Children and Young People. Ethics, Place & Environment: Vol. 4, No. 2, pp. 117-118.

Youth forums are a favoured means for encouraging youth participation. Taking many forms, they usually describe groups of young people who come together in committees to discuss issues relating to their communities. Adults establish many youth forums largely because they are perceived to provide tangible opportunities deemed to enable ongoing participation rather than because of demand from young people themselves. Recent evidence suggests, however, that youth forums are often an inappropriate way of engaging many young people, especially those who are (...) traditionally hardest to reach. This paper explores the ethical and methodological challenges facing those agencies who wish to behave in an inclusive manner, yet in so doing establish structures and bureaucracies that sideline many young people, further obfuscating their voices in local decision making. Alternative ways forward for engaging young people are suggested. (shrink)

Youth forums are a favoured means for encouraging youth participation. Taking many forms, they usually describe groups of young people who come together in committees to discuss issues relating to...

Light adaptation is modulated almost exclusively by changes in intracellular Ca2+ concentration, and other Ca2+-independent mechanisms are likely to play only a minor role. Changes in Ca2+i may be not only necessary for light adaptation to take place but sufficient to cause it.

Graphical AbstractTo metastasize, cancer cells must be able to complete cell division in environments very different from their tissue of origin. We suggest that mitotic cell rounding, aided by several actin-regulatory oncogenes, may facilitate this process in a robust, context-independent manner.