Oxycholesterols (OS) are formed from cholesterol or its immediate precursors by enzymatic or free radical action in vivo, or they may be derived from food. OS exhibit a wide spectrum of biological activities. In OS cytotoxicity, several mechanisms seem to be involved: e.g. inhibition of HMG‐CoA reductase activity, antiproliferative action, apoptosis induction, replacement of cholesterol by OS in membranes followed by changes in cellular membrane structure and functionality, and immune system functions alteration. Furthermore, OS may be mutagenic and carcinogenic and (...) may serve as intracellular signaling or regulatory molecules. Here we review OS cellular activities with special attention to the cytotoxic action in vivo and in vitro using experimental models. BioEssays 28: 387–398, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Biological individuality is without a doubt a key concept in philosophy of biology. Questions around the individuality of organisms, species, and biological systems can be traced throughout the philosophy of biology since the discipline’s inception, not to mention the sustained attention they have received in biology and philosophy more broadly. It’s high time the topic got its own Cambridge Element. McConwell’s Biological Individuality falls short of an authoritative overview of the debate on biological individuality. However, it sends a welcome message (...) to new and seasoned scholars to reorient the debate towards practically and politically relevant themes. (shrink)

To ensure ethical employee behavior, companies often utilize several forms of mostly one-way communication such as codes of conduct. The extent to which these efforts, in addition to informing about the company stance on ethics, are able to positively influence behavior is disputed. In contrast, research on business ethics communication and behavior indicates a relatively clear, positive link between open workplace dialogue about ethical issues and ethical conduct. In this article, I therefore address the question: What influences employee attitudes to (...) talking openly about ethical issues? Answers are proposed on the basis of focus group interviews with staff at the Denmark and Brazil affiliates of the global healthcare company Novo Nordisk. It was found that interest in discussing ethical issues was influenced by two main factors: employee conceptualizations of business ethics and the level of inter-collegial trust, credibility, and confidence. In this article, by examining these phenomena, I aim at providing insight that can both inform scholars in these fields as well as help managers in their attempts to promote open workplace dialogue about ethical issues. (shrink)

Niches and mechanisms are two important but contested elements in the study of organism-environment interactions. Although they are closely interrelated, with niches playing a crucial role in theorizing about ecological and evolutionary mechanisms such as niche construction, facilitation, and species invasion, philosophical discussions about each issue have been largely disconnected. This collection addresses this gap, bringing together contributions from philosophers and biologists about the niche concept, niche construction theory, and ecological and evolutionary mechanisms. In this introduction we provide some background (...) to the collection, which arose out of two workshops organized within an interdisciplinary research consortium. We also summarize each contribution, organized roughly into three groups with considerable overlap and interrelations: niche construction and evolutionary theory, niches, and ecological and evolutionary mechanisms. (shrink)

Heightened concern with global issues has led to shifts in corporate social responsibility (CSR) programs. To capture the distinct nature of this global focus, researchers have developed a three-generation CSR typology. In this paper, we first evaluate the usefulness of this typology for understanding corporate approaches to CSR by examining how several companies position themselves thematically in CEO introductions to sustainability reports. On the basis of this, we then evaluate the practical value of this typology for assisting those who work (...) with CSR strategy. The analysis revealed expressions of all three CSR generations, with third-generation thinking being apparent, but not dominant. It also verified that the three-generation CSR typology can be an instructive means of both evaluating as well as framing a company's approach to sustainability, though with modifications. On the basis of the identified strengths and weaknesses of the typology, we develop a practitioner-focused, three-tiered model that can strategically guide the development of CSR programs. (shrink)

This article’s central aim is to debunk the overly simplified, paradigmatic, and essentialist description of certain types of Muslim sexuality, arguing that such essentialist characterization of Muslims ignores the nonunique social determinants (poverty, education, and sociostructural exclusions) of HIV/aids risk in an increasingly globalized world. To support this argument, we rely on a thematic and comparative analysis. A reoccurring theme in this project is that issues of public health, human rights, justice, and social empowerment are inextricably intertwined. Having established a (...) conceptual framework linking health and human rights, we use a comparative analysis of the cases of Iran, Indonesia, and Bangladesh in an attempt to single out similarities and differences among these cases. All these cases hold a majority Muslim population (at 98%, 86%, and 89%, respectively) and are also representative of the two primary strands of Islam: Shi’a and Sunni. Additionally, each of these states has signed the Declaration of Commitment on HIV/aids and reports the progress of their HIV/aids treatment and prevention efforts to United Nations Program on HIV/aids, the United Nations organization tasked with monitoring and combating the spread of HIV/aids. (shrink)

Management accounting and control seeks to provide information that substantiates decision-making at all firm levels and thus may also foster ethical decision-making. Against this background, this article presents a systematic literature review of research on management accounting and control and business ethics that has been published in the Journal of Business Ethics. Through this review, we intend to bring to the forefront a research topic that has been widely neglected in broader literature reviews on accounting ethics research and that has (...) been covered by a small number of articles published by traditional leading accounting journals only. Our systematic literature review is guided by a theoretical framework that integrates the decision-facilitating and decision-influencing roles of management accounting and control information and the stages of the ethical decision-making process. Through this theoretical lens, we analyze 64 management accounting and control articles published in the Journal of Business Ethics over more than three decades. Synthesizing and structuring this research, we discuss prior accomplishments and elaborate on avenues for future research. (shrink)

The problem of identity in the world of art is relevant from many perspectives. This paper aims at discussing the identity of the work of art. The discussion is built in three steps: the problem of identification of an object as work of art, the problem of the relevant properties of a work of art and the question of the author of the work of art as decisive (or not) for the identification of a work of art. These issues are (...) raised with the evolution of artistic practice and art theory in the last century. The appearing of the “ready-made” destabilized the firm identity of a work of art and now we have to decide what the difference is between a work of art and its perceptually identical pair. Traditionally relevant perceptual features lost their importance in conceptual art, so we have to decide what relevant properties belong, even today, to works of art. Finally, the practice of appropriation in postmodern art challenges the notion of the artist and of the meaning of genuine creation. (shrink)

Problem identiteta u svijetu umjetnosti je važan iz mnogih perspektiva. Ovaj rad ima namjeru raspraviti identitet umjetničkih djela. Rasprava je izvedena u tri koraka: problem identifikacije predmeta kao umjetničkog djela, problem relevantnih svojstava umjetničkog djela i pitanje autora kao odlučujuće (ili ne) za identifikaciju umjetničkog djela. Ova pitanja su se otvorila evolucijom umjetničke prakse i teorije u prošlom stoljeću. Pojava ready-madea destabilizirala je čvrsti identitet umjetničkog djela te nametnula zadatak odluke o razlici između umjetničkog djela i njegovog perceptivno identičnog para. (...) Tradicionalna relevantna svojstva izgubila su svoj značaj u konceptualnoj umjetnosti, stoga moramo odlučiti koja se relevantna svojstva, čak i danas, pridaju umjetničkim djelima. Konačno, praksa posuđivanja u postmodernoj umjetnosti dovodi u pitanje pojam umjetnika i smisao izvornog stvaralaštva. (shrink)

Le problème de l’identité dans le monde de l’art est pertinent sous de nombreux aspects. Cet article vise à examiner l’identité de l’oeuvre d’art. L’examen est construit en trois étapes : le problème d’identification d’un objet en tant qu’oeuvre d’art, le problème des propriétés pertinentes d’une oeuvre d’art et la question de l’auteur de l’oeuvre comme décisive (ou pas) pour l’identification d’une oeuvre d’art. Ces questions se sont posées avec l’évolution de la pratique artistique et de la théorie de l’art (...) au siècle dernier. L’apparition du “readymade” a déstabilisé l’identité solide de l’oeuvre d’art de sorte que nous devons maintenant déterminer quelle est la différence entre une oeuvre d’art et son pendant perceptuellement identique. Les caractéristiques traditionnellement pertinentes ayant perdu leur importance dans l’art conceptuel, nous devons déterminer quelles sont les caractéristiques pertinentes, même aujourd’hui, des oeuvres d’art. Enfin, la pratique de l’appropriation dans l’art post-moderne défie la notion d’artiste et celle du sens de la création authentique. (shrink)

"Documenta fifteen in 2022 was par excellence the space for participatory art, so this edition can be seen as a touchstone for it. The research of the phenomenon of participatory art is based in this text on the one hand on the curatorial texts of ruangrupa, the collective that ensured the artistic direction of this edition of the documenta, and on the personal experience of the author as a visitor of the exhibition. Among the many issues raised by participatory art, (...) the present text focuses on the aspect of reception of art in the case of the projects presented at documenta fifteen, and by extension, reflects on the experience of the receiver and the artistic value of participatory art projects. Keywords: participatory art, documenta fifteen, lumbung, reception of art, evaluation of participatory art ". (shrink)

Die Problemstellung der Identität in der Welt der Kunst ist aus allerlei Perspektiven gewichtig. Dieser Artikel strebt eine Debatte über die Identität der Kunstwerke an. Die Diskussion wird in drei Schritten aufgebaut: die Frage der Identifizierung eines Objektes als Kunstwerk, das Problem der relevanten Eigenschaften eines Kunstwerks und letzten Endes die Frage des Autors als ausschlaggebend (oder nicht) für die Identifizierung des Kunstwerks. Diese Thematik wurde aufgeworfen gleichlaufend mit der Evolution der Kunstpraxis samt – theorie im vergangenen Jahrhundert. Die Erscheinung (...) des „Readymades“ hatte die feste Identität des Kunstwerks der Stabilität beraubt, und es gilt eben, die Kluft zwischen dem Kunstwerk und dessen perzeptiv identischem Paar zu detektieren. Traditionell bedeutsame perzeptive Charakteristika haben deren Tragweite in der konzeptuellen Kunst eingebüßt, sodass wir urteilen müssen, welch relevante Eigentümlichkeiten, sogar gegenwärtig, den Kunstwerken beizumessen sind. Im Endeffekt stellt die Praxis der Aneignung innerhalb der postmodernen Kunst den Begriff des Künstlers sowie des Sinns der authentischen Schaffung infrage. (shrink)

Biological individuality is a notoriously thorny topic for biologists and philosophers of biology. In this paper we argue that biological individuality presents multiple, interconnected questions for biologists and philosophers that together form a problem agenda. Using a case study of an interdisciplinary research group in ecology, behavioral and evolutionary biology, we claim that a debate on biological individuality that seeks to account for diverse practices in the biological sciences should be broadened to include and give prominence to questions about uniqueness (...) and temporality. We show that broadening the problem agenda of biological individuality draws attention to underrecognized philosophical issues and discussions and thereby organizes and enriches the existing debate. (shrink)

This article aims to present a discussion about childhood from the issues raised by the short film entitled Alma, directed, produced and scripted by the filmmaker André Morais. In the work, we experience a day in the life of a girl who lives with her grandmother and who, throughout the plot, weaves questions about her own existence, the senses of life and the dimensions of the relationships we establish with each other. It is discussed in this article, therefore, the power (...) of cinema and childhood as dimensions that invite a dialogue capable of converging art and life, also revitalizing the field of science, from the reflections that are dear to the dynamics of human experience. What conceptions of childhood are presented in the production? In what ways does the chosen approach broaden the discussion about childhood and cinema as potencies? To what extent do the questions raised by the child connect their childhood experience to the experiences of those who watch it on screen? In order to mobilize the discussion, the text is organized from scenes, which characterize the sequence of events that give meaning to what the film wants to express. In the first, the central theme is presented; in the second, the questions for which the short awakens us throughout the narrative; and in the third, it seeks to expand the possibilities of reading, rather than closing them. These scenes support the discussions brought here through Walter Benjamin, Mikhail Bakhtin, Antoine de Saint-Exupéry, Aristotle and Hannah Arendt. (shrink)

In this paper I develop a concept of behavioural ecological individuality. Using findings from a case study which employed qualitative methods, I argue that individuality in behavioural ecology should be defined as phenotypic and ecological uniqueness, a concept that is operationalised in terms of individual differences such as animal personality and individual specialisation. This account make sense of how the term “individuality” is used in relation to intrapopulation variation in behavioural ecology. The concept of behavioural ecological individuality can sometimes be (...) used to identify individuals. It also shapes research agendas and methodological choices in behavioural ecology, leading researchers to account for individuals as sources of variation. Overall, this paper draws attention to a field that has been largely overlooked in philosophical discussions of biological individuality and highlights the importance of individual differences and uniqueness for individuality in behavioural ecology. (shrink)

Niche construction theory (NCT) aims to transform and unite evolutionary biology and ecology. Much of the debate about NCT has focused on construction. Less attention has been accorded to the niche: what is it, exactly, that organisms are constructing? In this paper I compare and contrast the definition of the niche used in NCT with ecological niche definitions. NCT’s concept of the evolutionary niche is defined as the sum of selection pressures affecting a population. So defined, the evolutionary niche is (...) narrower than the ecological niche. Moreover, when contrasted with a more restricted ecological niche concept, it has a slightly different extension. I point out three kinds of cases in which the evolutionary niche does not coincide with realized ecological niches: extreme habitat degradation, commensalism, and non-limiting or super-abundant resources. These conceptual differences affect the role of NCT in unifying ecology and evolutionary biology. (shrink)

Tracking technology has been heralded as transformative for animal ecology. In this paper I examine what changes are taking place, showing how current animal movement research is a field ripe for philosophical investigation. I focus first on how the devices alter the limitations and biases of traditional field observation, making observation of animal movement and behaviour possible in more detail, for more varied species, and under a broader variety of conditions, as well as restricting the influence of human presence and (...) observer bias. I reconstruct these as shifts in scope, objectivity, accuracy and fruitfulness. The second transformation is slightly less obvious but equally significant for animal ecology. Tracking devices generate complex data that demands both statistical and biological expertise, which has led to increasingly frequent and intensive collaborations between statisticians and biologists. Based on interviews, I examine how researchers in these interdisciplinary collaborations negotiate the collection, analysis and interpretation of movement data, integrating research interests, methodological constraints, previous field observations, and background theory. Tracking technology is therefore also shifting which disciplinary considerations are brought to bear on research into animal movement and behaviour and how this research is conducted. (shrink)

Elizabeth Grosz's interpretation of Darwinian evolutionary theory to ground a feminist ontology of biology has been particularly controversial. Most critics have understood Grosz as supporting her theory with empirical evidence, and they criticize her for being either inaccurate or uncritical of and overly dependent on science. I argue that Grosz reads Darwin as a philosopher in a Deleuzian and Irigarayan sense, and that Grosz's project is therefore better understood in terms of its ethical and political goals rather than in terms (...) of empirical adequacy. Employing this evaluative framework leads to a novel route for critique of Grosz's ontology in terms of its reliance on the Darwinian distinction between organism and environment. I conclude that Grosz's work is valuable for the way it maintains ethical and political considerations in feminist ontological debates, and that introducing a more sensitive understanding of the organism–environment relation will lead us closer to a truly feminist ontology of biology. (shrink)

Ao longo desse texto intencionamos desenvolver a ideia segundo a qual há uma estreita conexão estrutural entre categorias como vontade, razão, autonomia, liberdade e causalidade no interior da filosofia prática de Kant. Assim, partindo da identificação de vontade e razão procuraremos demonstrar que esse paralelismo só é possível por meio da purificação da vontade e pela atribuição de uma função prática à razão. Entretanto, somente a purificação da vontade ainda não será suficiente para permitir a identificação entre vontade e razão. (...) Com efeito, para identificá-las devemos demonstrar como passar da liberdade da vontade, da liberdade considerada negativamente, portanto, para a liberdade da razão prática, enquanto liberdade em sentido positivo. (shrink)

A thorough analysis of the Golden Rule (GR) is given including formal investigations of its logical structure and essential implications. Starting with the general distinction of positive and negative forms of GR a set of sixteen formal implications, one for each variant of the rule, is presented. The moral acceptability of the output of the different versions of GR is assessed in various problem contexts and in discussing several objections to GR with the conclusion that GR is hopelessly inadequate as (...) a general criterion of moral choice. (shrink)

One of Hans Christian Andersen's most beautiful tales is "The Emperor's Nightingale." Its message—an exceptionally sobering one in the present context—is that nature is altogether finer and more enduring than art. It tells how a Chinese emperor, beguiled by a precious imitation bird that had been given him, forsook a natural songster he had once favored. But when that glittering counterfeit broke down, its clockwork sound silenced, the now aged ruler found welcome solace in the real bird's return, in its (...) more reliable and spiritually healing song. . . . Despite the artist's foregone defeat in any contest with nature , over the ages artists have been irresistibly drawn to the challenge of imitating nature. The persistence of these claims upon their skills and the inventive flight that have been elicited in the process testify to the extraordinary hold that the desire to mirror nature, or better still, to capture something of its essence, can exert over artists and their public. Accounts of imitative prowess go back to the most ancient days, beyond the fabled skills of Zeuxis and Apelles. There is no need here to summarize the complicated but almost domestically familiar history of illusionism. Rather, it is my present intention to reflect upon some contradictions inherent in the conception of art as illusion and to review some of the more exaggerated forms in which efforts have been made to break down the boundaries between art and nature. Frank Anderson Trapp, William Rutherford Mead Professor of Fine Arts, chairman of the department of art, and director of the Mead Art Museum at Amherst College, is the author of The Attainment of Delacroix and a number of essays on the history of art. (shrink)

The recent global pandemic has led to a shift to online conferences in philosophy. In this paper we argue that online conferences, more than a temporary replacement, should be considered a sustainable alternative to in-person conferences well into the future. We present three arguments for more online conferences, including their reduced impact on the environment, their enhanced accessibility for groups that are minorities in philosophy, and their lower financial burdens, especially important given likely future reductions in university budgets. We also (...) present results from two surveys of participants who attended one large and three small online philosophy conferences this year. We show that participants were in general very satisfied with presentations and discussions at the conferences, and that they reported greater accessibility. This indicates that online conferences can serve as a good alternative to in-person conferences. We also find that networking was less satisfactory in online conferences, indicating a point for improvement and further research. In general, we conclude that philosophers should continue to organize online conferences after the pandemic. We also provide some advice for those wishing to organize online conferences. (shrink)