The world’s first living donor liver transplant from an HIV-positive mother to her HIV-negative child, performed by our team in Johannesburg, South Africa in 2017, was necessitated by disease profile and health system challenges. In our country, we have a major shortage of donor organs, which compels us to consider innovative solutions to save lives. Simultaneously, the transition of the HIV pandemic, from a death sentence to a chronic illness with excellent survival on treatment required us to rethink our policies (...) regarding HIV infection and living donor liver transplantation. Although HIV infection in the donor is internationally considered an absolute contraindication for transplant to an HIV-negative recipient, there have been a very small number of unintentional transplants from HIV-positive deceased donors to HIV-negative recipients. These transplant recipients do well on antiretroviral medication and their graft survival is not compromised. We have had a number of HIV-positive parents in our setting express a desire to be living liver donors for their critically ill children. Declining these parents as living donors has become increasingly unjustifiable given the very small deceased donor pool in SA; and because many of these parents are virally suppressed and would otherwise fulfil our eligibility criteria as living donors. This paper discusses the evolution of HIV and transplantation in SA, highlights some of the primary ethical considerations for us when embarking on this case and considers the new ethical issues that have arisen since we undertook this transplant. (shrink)

Iris Murdoch's moral philosophy has long influenced contemporary ethics, yet it has not, in general, received the kind of sustained critical attention that it deserves. "Existentialists and Mystics" and "Metaphysics as a Guide to Morals" provide new access to most of Murdoch's philosophical writings and make possible a deeper appreciation of her contribution to current thought. After assessing the recent critical reception of Murdoch's thought, this review places her moral philosophy in the context of contemporary trends in ethics by tracing (...) her influence on the work of Charles Taylor, highlights the distinctive features of her moral philosophy, and suggests future directions for Murdochian ethics. (shrink)

F. Brencio (2023), Embodied Attention. A phenomenological hypothesis, in D. Stoyanov (Ed.), Contemporary Neuropsychiatry: Implications from Cognitive Neuroscience, Cambridge Scholars Publishing, Cambridge, pp. 26-42.

Graph-based frames have been introduced as a logical framework which internalises an inherent boundary to knowability (referred to as ‘informational entropy’), due, e.g. to perceptual, evidential or linguistic limits. They also support the interpretation of lattice-based (modal) logics as hyper-constructive logics of evidential reasoning. Conceptually, the present paper proposes graph-based frames as a formal framework suitable for generalising Pawlak's rough set theory to a setting in which inherent limits to knowability exist and need to be considered. Technically, the present paper (...) establishes systematic connections between the first-order correspondents of Sahlqvist modal reduction principles on Kripke frames, and on the more general relational environments of graph-based and polarity-based frames. This work is part of a research line aiming at: (a) comparing and inter-relating the various (first-order) conditions corresponding to a given (modal) axiom in different relational semantics; (b) recognising when first-order sentences in the frame-correspondence languages of different relational structures encode the same ‘modal content’; (c) meaningfully transferring relational properties across different semantic contexts. The present paper develops these results for the graph-based semantics, polarity-based semantics, and all Sahlqvist modal reduction principles. As an application, we study well known modal axioms in rough set theory (such as those corresponding to seriality, reflexivity, and transitivity) on graph-based frames and show that, although these axioms correspond to different first-order conditions on graph-based frames, their intuitive meaning is retained. This allows us to introduce the notion of hyperconstructivist approximation spaces as the subclass of graph-based frames defined by the first-order conditions corresponding to the same modal axioms defining classical generalised approximation spaces, and to transfer the properties and the intuitive understanding of different approximation spaces to the more general framework of graph-based frames. The approach presented in this paper provides a base for systematically comparing and connecting various formal frameworks in rough set theory, and for the transfer of insights across different frameworks. (shrink)

Conducting empirical research on gender in medical ethics is a challenge from a theoretical as well as a practical point of view. It still has to be clarified how gender aspects can be integrated without sustaining gender stereotypes. The developmental psychologist Carol Gilligan was among the first to question ethics from a gendered point of view. The notion of care introduced by her challenged conventional developmental psychology as well as moral philosophy. Gilligan was criticised, however, because her concept of ‘two (...) different voices’ may reinforce gender stereotypes. Moreover, although Gilligan stressed relatedness, this is not reflected in her own empirical approach, which still focuses on individual moral reflection. Concepts from social psychology can help overcome both problems. Social categories like gender shape moral identity and moral decisions. If morality is understood as being lived through actions of persons in social relationships, gender becomes a helpful category of moral analysis. Our findings will provide a conceptual basis for the question how empirical research in medical ethics can successfully embrace a gendered perspective. (shrink)

In this contribution, an overview of the distinct ways in which the interplay between knowledge, values, and beliefs took shape in the South African context since 1948 is offered. This is framed against the background of the paleontological significance of South Africa and an appreciation of indigenous knowledge systems, but also of the ideological distortion of knowledge and education during the apartheid era through the legacy of neo-Calvinism. The overview includes references to discourse on human rationality, on the use of (...) social sciences in theological reflection, on the teaching of evolution in public schools, on science and religion, and on religion and ecology. The essay concludes with a survey of some of the major voices regarding the interface between religion and science in South Africa. (shrink)

It is well known that Hermann Cohen was one of the first philosophers who engaged in the debate about non-Euclidean geometries and the concept of space. His relation to Hermann von Helmholtz, who played a major role in the same debate, is an illuminating example of how some of the leading ideas of Marburg neo-Kantianism, although motivated independently of scientific debates, naturally led to the examination of scientific works and scientists’ epistemological views. This paper deals with Cohen’s view of magnitudes (...) and measurement and with his – less known – review of Helmholtz’s paper “Zählen und Messen, erkenntnistheoretisch betrachtet”, which contains one of the first attempts to formulate a theory of measurement in the modern sense. The first part provides a brief introduction to this debate in its connection with the earlier discussion on geometrical axioms and the concept of space. The main sections deal with Helmholtz’s and Cohen’s approaches to the foundations of measurement. Cohen’s criticism of some of Helmholtz’s assumptions notwithstanding, my emphasis is on some unexpected affinities between these two approaches. In the concluding section, I rely on the constructive side of Cohen’s criticisms to reconsider the philosophical aspects of Helmholtz’s theory and draw a few comparisons with contemporary measurement theory. (shrink)

The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 19 (COVID-19) has led to the imposition of severely restrictive measures by governments in the Western hemisphere. We feel a contrast between these measures and our freedom. This contrast, we argue, is a false perception. It only appears to us because we look at the issue through our contemporary moral philosophy of utilitarianism and an understanding of freedom as absence of constraints. Both these views can be (...) substituted with more sophisticated alternatives, namely an ethics of virtue and a notion of freedom of the will. These offer a fuller picture of morality and enable us to cooperate with the current restrictions by consciously choosing to adhere to them instead of perceiving them as draconian and immoral. We ask whether we should collaborate with the restrictions and argue that considerations of virtue will lead to an affirmative answer. More broadly, virtue ethics permits to deal with the practical concerns about how an individual should behave during this pandemic, given the current lockdown measures or lack thereof. -/- In section 1, we present how utilitarianism and a notion of freedom as negative liberty support the opposition to restrictive measures. In section 2, we outline an alternative based on an ethics of virtue and a more elaborated notion of free will. In the concluding section 3, we argue that considerations of virtue should guide the individual and public response to the emergency. (shrink)

What is a gene? Does it represent a natural kind, or is it just a tool for genomics? A clear answer to these questions has been challenged by postgenomic discoveries. In response, I will argue that the gene can be deemed a natural kind as it satisfies some requirements for genuine kindhood. Specifically, natural kinds are projectible categories in our best scientific theories, and they represent nodes in the causal network of the world (as in Khalidi. Natural Categories and Human (...) Kinds: Classification in the Natural and Social Sciences. Cambridge University Press, Cambridge, 2013; Khalidi. Synthese 195: 1379–1396, 2018; Khalidi. Are Sexes Natural Kinds, In: Dasgupta S, Weslake B (eds) Current Controversies in Philoso-phy of Science. Routledge, New York, 2020; Khalidi. Philos Sci 88:1–21, 2021). In Sect. 2, I will present a brief history of the gene and the controversy over its status. In Sect. 3, I will introduce the account of natural kinds considered in this paper. In Sect. 4, I will first present the relevant definition of genes and how they can be classified. Then, I will argue that the gene can be considered a natural kind as it satisfies the criteria for natural kindhood. Section 5 concludes. (shrink)

A concise yet rigorous introduction to logic and discrete mathematics. This book features a unique combination of comprehensive coverage of logic with a solid exposition of the most important fields of discrete mathematics, presenting material that has been tested and refined by the authors in university courses taught over more than a decade. The chapters on logic - propositional and first-order - provide a robust toolkit for logical reasoning, emphasizing the conceptual understanding of the language and the semantics of classical (...) logic as well as practical applications through the easy to understand and use deductive systems of Semantic Tableaux and Resolution. The chapters on set theory, number theory, combinatorics and graph theory combine the necessary minimum of theory with numerous examples and selected applications. Written in a clear and reader-friendly style, each section ends with an extensive set of exercises, most of them provided with complete solutions which are available in the accompanying solutions manual. Key Features: Suitable for a variety of courses for students in both Mathematics and Computer Science. Extensive, in-depth coverage of classical logic, combined with a solid exposition of a selection of the most important fields of discrete mathematics Concise, clear and uncluttered presentation with numerous examples. Covers some applications including cryptographic systems, discrete probability and network algorithms. Logic and Discrete Mathematics: A Concise Introduction is aimed mainly at undergraduate courses for students in mathematics and computer science, but the book will also be a valuable resource for graduate modules and for self-study. (shrink)

An inquiry drawing on the presence of Hellenistic philosophy in Philo provides a better knowledge of the diffusion of Hellenistic philosophy since the late ...

The topic tackled in this book is Philo's account of the complex, double-sided nature of God's acting - the two-sided coin of God as transcendent yet immanent, ...

Robotic and artificially intelligent (AI) systems are becoming prevalent in our day-to-day lives. As human interaction is increasingly replaced by human–computer and human–robot interaction (HCI and HRI), we occasionally speak and act as though we are blaming or praising various technological devices. While such responses may arise naturally, they are still unusual. Indeed, for some authors, it is the programmers or users—and not the system itself—that we properly hold responsible in these cases. Furthermore, some argue that since directing blame or (...) praise at technology itself is unfitting, designing systems in ways that encourage such practices can only exacerbate the problem. On the other hand, there may be good moral reasons to continue engaging in our natural practices, even in cases involving AI systems or robots. In particular, daily interactions with technology may stand to impact the development of our moral practices in human-to-human interactions. In this paper, we put forward an empirically grounded argument in favor of some technologies being designed for social responsiveness. Although our usual practices will likely undergo adjustments in response to innovative technologies, some systems which we encounter can be designed to accommodate our natural moral responses. In short, fostering HCI and HRI that sustains and promotes our natural moral practices calls for a co-developmental process with some AI and robotic technologies. (shrink)

In terms of validity in Kripke frames, a modal formula expresses a universal monadic second-order condition. Those modal formulae which are equivalent to first-order conditions are called elementary. Modal formulae which have a certain persistence property which implies their validity in all canonical frames of modal logics axiomatized with them, and therefore their completeness, are called canonical. This is a survey of a recent and ongoing study of the class of elementary and canonical modal formulae. We summarize main ideas and (...) results, and outline further research perspectives. (shrink)

The introduction of Autonomous Military Systems (AMS) onto contemporary battlefields raises concerns that they will bring with them the possibility of a techno-responsibility gap, leaving insecurity about how to attribute responsibility in scenarios involving these systems. In this work I approach this problem in the domain of applied ethics with foundational conceptual work on autonomy and responsibility. I argue that concerns over the use of AMS can be assuaged by recognising the richly interrelated context in which these systems will most (...) likely be deployed. This will allow us to move beyond the solely individualist understandings of responsibility at work in most treatments of these cases, toward one that includes collective responsibility. This allows us to attribute collective responsibility to the collectives of which the AMS form a part, and to account for the distribution of burdens that follows from this attribution. I argue that this expansion of our responsibility practices will close at least some otherwise intractable techno-responsibility gaps. (shrink)

Despite the importance of commitment for distinctively human forms of sociality, it remains unclear how people prioritize and evaluate their own and others’ commitments - especially implicit commitments. Across two sets of online studies, we found evidence in support of the hypothesis that people’s judgments and attitudes about implicit commitments are governed by an implicit sense of commitment, which is modulated by cues to others’ expectations, and by cues to the costs others have invested on the basis of those expectations.

Function talk is a constant across different life sciences. From macro-evolution to genetics, functions are mentioned everywhere. For example, a limb’s function is to allow movement and RNA polymerases’ function is to transcribe DNA. Biochemistry is not immune from such a characterization; the biochemical world seems to be a chemical world embedded within biological processes. Specifically, biochemists commonly ascribe functions to biomolecules and classify them accordingly. This has been noticed in the recent philosophical literature on biochemical kinds. But while a (...) lot has been written on biological and psychological functions, little has been said explicitly about biochemical fuctions. Here, I explore functional attribution to biochemical molecules. I argue that if we accept this attribution, then biochemical functions are constituted by chemical dispositional properties that causally contribute to selected biological processes. In section 2, I discuss the controversy concerning the characterization of biochemical functions. In section 3, I consider whether a biological or a chemical under- standing of function can be applied to biochemical functions, illustrating the account with the example of vitamin B12. The result is that none of the theories on their own provides an adequate characterization. In section 4, I present an account of biochemical functions. In section 5, I assess this account taking into consideration common requirements for a theory of functions and an objection. (shrink)

F. Brencio (2023), Quel che resta delle cose. Riccardo de Biase lettore di Heidegger, in G. Giannini, P. Marangolo, M. Papa (eds.), Segni. Studi in memoria di Riccardo De Biase, TAB Edizioni, Roma 2023, pp. 171-182, ISBN: 978-88-9295-769-5.

Criminal liability for acts committed by AI systems has recently become a hot legal topic. This paper includes three different contributions. The first contribution is an analysis of the extent to which an AI system can satisfy the requirements for criminal liability: accomplishing an actus reus, having the corresponding mens rea, possessing the cognitive capacities needed for responsibility. The second contribution is a discussion of criminal activity accomplished by an AI entity, with reference to a recent case involving an online (...) bot, the Random Darknet Shopper. This discussion will provide the context for the analysis of commonalities and differences between criminal activities by humans and by artificial systems. The third contribution concerns the evaluation of different ways of addressing criminal activities by AI systems in a regulatory perspective. (shrink)

In recent years, bioethical discourse around the topic of ‘genetic enhancement’ has become increasingly politicized. We fear there is too much focus on the semantic question of whether we should call particular practices and emerging bio-technologies such as CRISPR ‘eugenics’, rather than the more important question of how we should view them from the perspective of ethics and policy. Here, we address the question of whether ‘eugenics’ can be defended and how proponents and critics of enhancement should engage with each (...) other. (shrink)

Through this contribution I aim to explore the horizons and limits of digital medicine in light of an embodied approach to the issue of care. I will sketch the historical background of digital medicine and show the contemporary status of this interdisciplinary field, as well as its applications and outcomes. Then, I will address a critique of the computational theory of mind (CTM) upon which many contemporary mental health apps are designed. This approach to the mind is inscribed into the (...) modern trend of neuromania, which conceives the embodied, living human being as a mere series of data analyses and algorithms, with the brain as the seat of the person. Drawing on continental philosophy and classical phenomenology I will develop a notion of health conceived as a moral enterprise, showing how wellbeing and vitality are not reducible to a product made by technologies or doctors, but rather they are the results of an embodied encounter. As such, empathy and person-centered care cannot be achieved by digital medicine. They are the result of a journey into the regions of recognition, embodied presence and the aliveness constituting the person. Finally, I will show how the issue of care cannot be separated from an embodied encounter between people, especially in case of dementia. (shrink)

Objects of knowledge exist within material, immaterial, and conceptual worlds. Once the world is conceived from the perspective of others, the physical ontology of modern science no longer functions as a standard by which to understand other orderings of reality, whether from ethnographical or historical sources. Because premodern and non-western sources attest to a plurality of sciences practiced in accordance with different ways of worldmaking from that of the modern West, their study belongs to the history of science, the philosophy (...) of science, and the sociology of science, as well as the anthropology of science. In Worldmaking and Cuneiform Antiquity, Francesca Rochberg extends an anthropology of science to the historical world of cuneiform texts of ancient Babylonia. Exploring how Babylonian science has been understood, she proposes a new direction for scholarship by recognizing the world of ancient science, not as a less developed form of modern science, but as legitimate and real in its own right. (shrink)

We provide syntactic necessary and sufficient conditions on the formulae reducible by the second-order quantifier elimination algorithm DLS. It is shown that DLS is compete for all modal Sahlqvist and Inductive formulae, and that all modal formulae in a single propositional variable on which DLS succeeds are canonical.

In this paper, we will explore the relation between molecular structure and functions displayed by biochemical molecules in complex physiological processes by using tools from the philosophy of science and the philosophy of scientific practice. We will argue that biochemical functions are weakly emergent from molecular structure by using an account of weak. In order to explore this thesis, we will consider the role of vitamin B12 in contributing to the process of erythropoiesis. The structure of the paper is the (...) following: First, we will consider biochemical functions and why they cannot be easily reduced to their chemical realisers. We will suggest weak emergence as an alternative while also accounting for the relevance of the context, in our case, systemic and organisational. The paper will conclude by considering (1) how the usage of tools from the philosophy of science, such as weak emergence, can aid our understanding of the relations between the components of complex phenomena, such as erythropoiesis, and (2) how the philosophy of scientific practice sheds light on the explanatory role of processes that are dynamically stabilised and the different levels of organisation implied. (shrink)

In his examination of the concepts of evil and impermanence, entitled “Evil and the Problem of Impermanence in Medieval Japanese Philosophy”, Yujin Nagasawa addresses four responses to the problem of impermanence, arguing that the only satisfactory response to the problem leads to an implication about supernaturalism. As Nagasawa puts it, “the problem of impermanence can be construed as a partial argument for supernaturalism and against naturalism”. In response to Nagasawa, I will take up the challenge of naturalism by trying to (...) deconstruct the arguments against indifferentism in order to reformulate and thus strengthen Nagasawa’s response to the problem of impermanence. I will then turn to the radicalization of this thesis by drawing out implications through a comparison with Dōgen’s thought. (shrink)

In terms of validity in Kripke frames, a modal formula expresses a universal monadic second-order condition. Those modal formulae which are equivalent to first-order conditions are called \emph{elementary}. Modal formulae which have a certain persistence property which implies their validity in all canonical frames of modal logics axiomatized with them, and therefore their completeness, are called \emph{canonical}. This is a survey of a recent and ongoing study of the class of elementary and canonical modal formulae. We summarize main ideas and (...) results, and outline further research perspectives. (shrink)

In a previous work we introduced the algorithm \SQEMA\ for computing first-order equivalents and proving canonicity of modal formulae, and thus established a very general correspondence and canonical completeness result. \SQEMA\ is based on transformation rules, the most important of which employs a modal version of a result by Ackermann that enables elimination of an existentially quantified predicate variable in a formula, provided a certain negative polarity condition on that variable is satisfied. In this paper we develop several extensions of (...) \SQEMA\ where that syntactic condition is replaced by a semantic one, viz. downward monotonicity. For the first, and most general, extension \SSQEMA\ we prove correctness for a large class of modal formulae containing an extension of the Sahlqvist formulae, defined by replacing polarity with monotonicity. By employing a special modal version of Lyndon's monotonicity theorem and imposing additional requirements on the Ackermann rule we obtain restricted versions of \SSQEMA\ which guarantee canonicity, too. (shrink)

In this contribution, the author engages in a conversation with Christopher Southgate on the relationship between social evil and what is called natural “evil.” Theologically, this centers around an understanding of creation and fall. It is argued that Southgate typically treats soteriology and eschatology as themes pertaining to an evolutionary theodicy, whereas an adequate ecotheology would discuss the problem of natural suffering under the rubric of the narrative of God's economy. The question is then how that story is best told.

Metaphor has been considered as a cognitive process, independent of the verbal versus visual mode, through which an unknown conceptual domain is understood in terms of another known conceptual domain. Metaphor might instead be viewed as a cognitive process, dependent on the mode, which leads to genuinely new knowledge via ignorance. First, I argue that there are two main senses of ignorance at stake when we understand a metaphor: we ignore some existing properties of the known domain in the sense (...) that we disregard or neglect them; we ignore some “non-existing” properties of the known domain in the sense that they are not a piece of information belonging to the known domain, but emerge in metaphor interpretation. Secondly, I consider a metaphor as a reasoning device, guiding the interpreters along a path of inferences to a conclusion, which attributes to the target some properties of the source. In this path, interpreters might discover the ignored existing properties of the known domain and/or recover the “non-existing” properties, inferring or imagining the missing piece of information. Finally, I argue that, especially in visual metaphors, this process is guided by a “sentiment of rationality”, tracking a disruption of existing familiar conceptualisations of objects and/or actions and a recovery of ignored properties. (shrink)