During the course of evolution, variations of a protein sequence is an ongoing phenomenon however limited by the need to maintain its structural and functional integrity. Deciphering the evolutionary path of a protein is thus of fundamental interest. With the development of new methods to visualize high dimension spaces and the improvement of phylogenetic analysis tools, it is possible to study the evolutionary trajectories of proteins in the sequence space. Using the data-driven high-dimensional scaling method, we show that it is (...) possible to predict and represent potential evolutionary trajectories by representing phylogenetic trees into a 3D projection of the sequence space. With the case of the aminodeoxychorismate synthase, an enzyme involved in folate synthesis, we show that this representation raises interesting questions about the complexity of the evolution of a given biological function, in particular concerning its capacity to explore the sequence space. (shrink)

Here I consider the two most venerated arguments about the existence of God: the Ontological Argument and the Argument from Evil. The Ontological Argument purports to show that God’s nature guarantees that God exists. The Argument from Evil purports to show that God’s nature, combined with some plausible facts about the way the world is, guarantees (or is very compelling grounds for thinking) that God does not exist. Obviously, both arguments cannot be sound. But I argue here that they are (...) both unsound for the very same reason. (shrink)

There are many alleged problems with trusting another person’s moral testimony, perhaps the most prominent of which is that it fails to deliver moral understanding. Without moral understanding, one cannot do the right thing for the right reason, and so acting on trusted moral testimony lacks moral worth. This chapter, however, argues that moral advice differs from moral testimony, differs from it in a way that enables a defender of moral advice to parry this worry about moral worth. The basic (...) idea is that an advisor and an advisee can together constitute a joint agent, and that this joint agent’s action can indeed have moral worth. So while the advisee himself might not do the right thing for the right reason (this because all alone he lacks the right reason), and while the advisor herself might not do the right thing for the right reason (this because all alone she does not do the right thing), they together do the right for the right reason. (shrink)

This paper argues that the classification of propositional attitudes into the de re, de dicto, and de se is incomplete. De se attitudes are widely agreed to be closely connected to de re attitudes. But there is a species of belief that is linked to agent-centered action in the way that de se beliefs are, but is also associated with entities, places, and especially times, under a description. These mark out a fourth kind. One way to think about what makes (...) them distinctive is that, despite being ‘essentially indexical’ they can be retained across different contexts of evaluation without having diagonal content. The paper also discusses the connection between such beliefs and the kinds of utterances (like ‘Don't put off for tomorrow what you can do today’) that are contested as examples of what David Kaplan called ‘monsters.’. (shrink)

No citizen should be denied the right to vote due solely to her age. We can see this by showing that all objections to it fail. It might be objected that it is not unjust to so deprive children because children as a group are unintelligent or irrational, have their interests already represented by the parents, or are justly deprived of many other rights, among other reasons. But all these objections fail because there is no evidence to support it, even (...) if true, this would not justify disenfranchisement, or, most prominently argued here, they deprive individuals of political rights based upon their membership in a group. The voting age should be abolished. (shrink)

This paper argues that under some conditions, when one person acts on the direction of another person, the two of them thereby act together, and that this explains why both the director and the directee can be responsible for what is done. In other words, a director and a directee can be a joint agent, one whose members are responsible for what they together do. This is most clearly so when the directive is a command. But it is also sometimes (...) so when the directive is a bit of advice. (shrink)

This Element introduces the philosophical literature on models, with an emphasis on normative considerations relevant to models for decision-making. Chapter 1 gives an overview of core questions in the philosophy of modeling. Chapter 2 examines the concept of model adequacy for purpose, using three examples of models from the atmospheric sciences to describe how this sort of adequacy is determined in practice. Chapter 3 explores the significance of using models that are not adequate for purpose, including the purpose of informing (...) public decisions. Chapter 4 provides a basic framework for values in modelling, using a case study to highlight the ethical challenges in building models for decision making. It concludes by establishing the need for strategies to manage value judgments in modelling, including the potential for public participation in the process. (shrink)

Autant d'études classiques qui accompagnent les grands ouvrages d'Eric Weil, Logique de la philosophie, Philosophie morale, Philosophie politique.

Puisqu’elles sont considérées comme des produits du monde occidental et de son modèle libéral, les églises évangéliques en Russie sont soumises à un contrôle accru des autorités gouvernementales. L’engagement politique des membres de ces églises est de ce fait souvent subi ou forcé, et il s’inscrit dans une critique à peine voilée de la société russe dans son ensemble. Cela se traduit par le recours de la part des évangéliques à des réseaux socioprofessionnels qui se développent en dehors des réseaux (...) habituels et surtout, tournés vers l’extérieur. Les individus les plus en rupture optent souvent pour l’émigration vers les pays occidentaux. (shrink)

This is a book about Kant's views on causality as understood in their proper historical context. Specifically, Eric Watkins argues that a grasp of Leibnizian and anti-Leibnizian thought in eighteenth-century Germany helps one to see how the critical Kant argued for causal principles that have both metaphysical and epistemological elements. On this reading Kant's model of causality does not consist of events, but rather of substances endowed with causal powers that are exercised according to their natures and circumstances. This (...) innovative conception of Kant's view of causality casts a light on Kant's philosophical beliefs in general, such as his account of temporality, his explanation of the reconciliation of freedom and determinism, and his response to the skeptical arguments of Hume. (shrink)

Even though Kant’s theory of cognition (Erkenntnis) is central to his Critique of Pure Reason, it has rarely been asked what exactly Kant means by the term “cognition”. Against the widespread assumption that cognition (in the most relevant sense of that term) can be identified with knowledge or if not, that knowledge is at least a species of cognition, we argue that the concepts of cognition and knowledge in Kant are not only distinct, but even disjunct. To show this, we (...) first (I) investigate Kant’s explicit characterizations of the nature of cognition. As it turns out, he introduces several different notions that must be carefully distinguished before identifying the one that is central to his project in the first Critique. We then (II) consider the basic features of Kant’s conception of knowledge, indicating both how it involves assent and objective justification and how it relates to our contemporary conception. Next (III), we compare and contrast Kant’s understanding of cognition and his conception of knowledge in a way that allows us to present their fundamental differences and connections. We argue that while cognition, in the most relevant sense, is a species of representation that differs from other representations in that it involves the conceptual determination of a sensibly given object, knowledge (for Kant) is a kind of assent to a judgment that requires consciousness of a sufficient epistemic ground. Finally (IV), by appreciating the differences between cognition and knowledge, we explain several of the implications this conception of cognition has for some of Kant’s main claims in the Critique of Pure Reason as a whole. Among other things, we show how Kant can deny cognition of specific things in themselves while allowing philosophical knowledge about things in themselves in general (e.g. that they exist, are not in space and time, etc.). (shrink)

kant’s critique of pure reason undertakes a systematic investigation of the possibility of synthetic cognition a priori so as to determine whether this kind of cognition is possible in the case of traditional metaphysics.1 While much scholarly attention has been devoted to the distinction between analytic and synthetic judgments as well as to that between the a priori and the a posteriori, less attention has been devoted to understanding exactly what cognition is for Kant. In particular, it is often insufficiently (...) clear what kind of mental state cognition is, what the exact nature of the conditions on cognition is, and how they are satisfied in the case of human beings. To bring greater clarity to... (shrink)

This book focuses on the unity, diversity, and centrality of the notion of law as it is employed in Kant's theoretical and practical philosophy. Eric Watkins argues that, by thinking through a number of issues in various historical, scientific, and philosophical contexts over several decades, Kant is able to develop a univocal concept of law that can nonetheless be applied to a wide range of particular cases, despite the diverse demands that these contexts give rise to. In addition, Watkins (...) shows how Kant comes to view both the generic conception of law which he develops and its different particular instances as crucial components of his systematic philosophy as a whole. This volume's new and unified account of a major current running through Kant's work will be important for scholars interested in numerous aspects of his philosophy, from the theoretical and abstract to the practical and empirical. (shrink)

Standard animalists are committed to a stringent form of restricted composition, thereby denying the existence of brains, hands, and other proper parts of an organism . One reason for positing this near-nihilistic ontology comes from various challenges to animalism such as the Thinking Parts Argument, the Unity Argument, and the Argument from the Problem of the Many. In this paper, I show that these putatively distinct arguments are all instances of a more general problem, which I call the ‘Too Many (...) Candidates Problem’ . Given my formulation of the problem, it is evident that standard animalists are mistaken in believing that restricting composition is the only solution. I show that there is another option for solving the TMC. The advantage of such a position, which I call ‘unrestricted animalism’, is that it is compatible with unrestricted composition and the existence of brains and other proper parts of an organism. I conclude by sketching several strategies one can take regarding this latter solution to the TMC. (shrink)

This article provides a critical overview of competing theories of conceptual structure (definitional structure, probabilistic structure, theory structure), including the view that concepts have no structure (atomism). We argue that the explanatory demands that these different theories answer to are best accommodated by an organization in which concepts are taken to have atomic cores that are linked to differing types of conceptual structure.

In trying to establish the view that there are no non-living macrophysical objects, Trenton Merricks has produced an influential argument—the Overdetermination Argument—against the causal efficacy of composite objects. A serious problem for the Overdetermination Argument is the ambiguity in the notion of overdetermination that is being employed, which is due to the fact that Merricks does not provide any theory of causation to support his claims. Once we adopt a plausible theory of causation, viz. interventionism, problems with the Overdetermination will (...) become evident. After laying out the Overdetermination Argument and examining one extant objection to it, I will explicate the relevant aspects of an interventionist theory of causation and provide a characterization of overdetermination that follows from such an account. From this, I will argue that the Causal Principle that undergirds the Overdetermination Argument is false and hence the argument is invalid; and I claim that the only other available characterization of overdetermination would render a key premise in the argument false. Thus, the Overdetermination Argument fails to provide us with any reason to deny the causal efficacy of macrophysical objects, and therefore provides no reason to doubt their existence. (shrink)

This is the first complete, one-volume English translation of the ancient Chinese text Xunzi, one of the most extensive, sophisticated, and elegant works in the tradition of Confucian thought. Through essays, poetry, dialogues, and anecdotes, the Xunzi articulates a Confucian perspective on ethics, politics, warfare, language, psychology, human nature, ritual, and music, among other topics. Aimed at general readers and students of Chinese thought, Eric Hutton's translation makes the full text of this important work more accessible in English than (...) ever before. Named for its purported author, the Xunzi has long been neglected compared to works such as the Analects of Confucius and the Mencius. Yet interest in the Xunzi has grown in recent decades, and the text presents a much more systematic vision of the Confucian ideal than the fragmented sayings of Confucius and Mencius. In one famous, explicit contrast to them, the Xunzi argues that human nature is bad. However, it also allows that people can become good through rituals and institutions established by earlier sages. Indeed, the main purpose of the Xunzi is to urge people to become as good as possible, both for their own sakes and for the sake of peace and order in the world. In this edition, key terms are consistently translated to aid understanding and line numbers are provided for easy reference. Other features include a concise introduction, a timeline of early Chinese history, a list of important names and terms, cross-references, brief explanatory notes, a bibliography, and an index. (shrink)

According to Eric Olson, the Thinking Animal Argument (TAA) is the best reason to accept animalism, the view that we are identical to animals. A novel criticism has been advanced against TAA, suggesting that it implicitly employs a dubious epistemological principle. I will argue that other epistemological principles can do the trick of saving the TAA, principles that appeal to recent issues regarding disagreement with peers and experts. I conclude with some remarks about the consequence of accepting these modified (...) principles, drawing out some general morals in defending animalism. (shrink)

During the last twenty years, Kant's theory of biology has increasingly attracted the attention of scholars and developed into a field which is growing rapidly in importance within Kant studies. The volume presents fifteen interpretative essays written by experts working in the field, covering topics from seventeenth- and eighteenth-century biological theories, the development of the philosophy of biology in Kant's writings, the theory of organisms in Kant's Critique of the Power of Judgment, and current perspectives on the teleology of nature.

There is much to admire in this book. It is written in a pleasingly straightforward style, and offers insight on a wide range of important issues.

Climate change and justice are so closely associated that many people take it for granted that a global climate treaty should--indeed, must--directly address both issues together. But, in fact, this would be a serious mistake, one that, by dooming effective international limits on greenhouse gases, would actually make the world's poor and developing nations far worse off. This is the provocative and original argument of Climate Change Justice. Eric Posner and David Weisbach strongly favor both a climate change agreement (...) and efforts to improve economic justice. But they make a powerful case that the best--and possibly only--way to get an effective climate treaty is to exclude measures designed to redistribute wealth or address historical wrongs against underdeveloped countries. In clear language, Climate Change Justice proposes four basic principles for designing the only kind of climate treaty that will work--a forward-looking agreement that requires every country to make greenhouse--gas reductions but still makes every country better off in its own view. This kind of treaty has the best chance of actually controlling climate change and improving the welfare of people around the world. (shrink)

The historical debate on representation in cognitive science and neuroscience construes representations as theoretical posits and discusses the degree to which we have reason to posit them. We reject the premise of that debate. We argue that experimental neuroscientists routinely observe and manipulate neural representations in their laboratory. Therefore, neural representations are as real as neurons, action potentials, or any other well-established entities in our ontology.

Focusing on the breakthrough field of molecular engineering--a new technology enabling scientists to build tiny machines atom by atom--the author offers projections on how this technological revolution will affect the future of computer science, space travel, medicine, and manufacturing.

Kant and the Sciences aims to reveal the deep unity of Kant's conception of science as it bears on the particular sciences of his day and on his conception of ...

A recent solution to the Body-Minus problem, which is a problem of material constitution, claims that ordinary proper parts (such as left feet) exist, but the complements of these objects (such as left-foot complements) do not exist. In this paper, I examine a defense of this solution from the worry of arbitrariness and from its ineffectiveness against a revised version of the problem that focuses on the head, and I show that this defense fails.

This paper argues that Book 3 of Porphyry’s De abstinentia contains an overlooked argument in favor of vegetarianism for the sake of non-human animals themselves. The argument runs as follows: animals are essentially sentient creatures. Sentience (αἴσθησις) allows them to discern what is good for their survival and what is destructive to them, so that they can pursue the former and avoid the latter. As a result, animals (human and non-human) have preferences, desires, and hopes. Having purposeful strivings that can (...) be promoted or frustrated makes them recipients of justice and injustice. This means, for Porphyry, that animals, unlike plants, can be wronged since they are creatures that discern, and purposefully pursue, what is good or bad for them. This reading stands against interpretations that argue that Porphyry advocates vegetarianism only for our benefit, and not for the animals’ own sake. (shrink)

Social referencing informs and regulates one’s relation with the environment as a function of the perceived appraisals of social partners. Increased emphasis on relational and social contexts in the study of emotion makes this interpersonal process particularly relevant to the field. However, theoretical conceptualizations and empirical operationalizations of social referencing are disjointed across domains and populations of study. This article seeks to unite and refine the study of this construct by providing a clear and comprehensive definition of social referencing. Our (...) perspective presents social referencing and social appraisal as coterminous processes and emphasizes the importance of a relational and interpersonal approach to the study of emotion. We conclude by outlining possible lines of research on this construct. (shrink)

This volume provides English translations of texts that form the essential background to Kant's Critique of Pure Reason. Presenting the projects of Kant's predecessors and contemporaries in eighteenth-century Germany, it enables readers to understand the positions that Kant might have identified with 'pure reason', the criticisms of pure reason that had developed prior to Kant's, and alternative attempts at synthesizing empiricist elements within a rationalist framework. The volume contains chapters on Christian Wolff, Martin Knutzen, Alexander Baumgarten, Christian Crusius, Leonhard Euler, (...) Johann Lambert, Marcus Herz, Johann Eberhard, and Johann Tetens. Each chapter includes a brief introduction that provides succinct biographical and bibliographical information on these authors, a concise account of their projects, and information on the importance of these projects to Kant's First Critique. Extensive references to the First Critique, brought together in a concordance, highlight the potential relevance of each text. (shrink)

In the Philebus, Socrates argues that pleasures can be false in the same way that beliefs can be false. On the basis of Socrates' analysis of malicious pleasure, a mixed pleasure of the soul and a passion, I defend the view that, according to Socrates, pleasures can be false when they represent as pleasant something that is not worthy of our enjoyment, where that means that they represent as pleasant something that is not pleasant in its own right because it (...) is not fine. Since these pleasures misrepresent the value of their objects, they involve an evaluative error. In contrast, a pleasure is true when it correctly represents the actual value of things. (shrink)

This review of 122 research reports (184 independent samples, 14,900 subjects) found average r ϭ .274 for prediction of behavioral, judgment, and physiological measures by Implicit Association Test (IAT) measures. Parallel explicit (i.e., self-report) measures, available in 156 of these samples (13,068 subjects), also predicted effectively (average r ϭ .361), but with much greater variability of effect size. Predictive validity of self-report was impaired for socially sensitive topics, for which impression..

Name der Zeitschrift: Kant-Studien Jahrgang: 105 Heft: 4 Seiten: 471-490.

In Quod animi mores, Galen says both that there is an identity between the capacities of the soul and the mixtures of the body, and that the soul’s capacities ‘follow upon’ the bodily mixtures. The seeming tension in this text can be resolved by noting that the soul’s capacities are constituted by, and hence are nothing over and above, bodily mixtures, but bodily mixtures explain the soul’s capacities and not the other way around. Galen’s proposal represents a distinctive position in (...) the Ancient debate on the relationship between soul and body. (shrink)

In Nicomachean Ethics 7.7 (= Eudemian Ethics 6.7), Aristotle distinguishes softness (malakia) from lack of self-control (akrasia) and endurance (karteria) from self-control (enkrateia). This paper argues that unqualified softness consists of a disposition to give up acting to avoid the painful toil (ponos) required to execute practical resolutions, and (coincidentally) to enjoy the pleasures of rest and relaxation. The enduring person, in contrast, persists in her commitments despite the painful effort required to enact them. Along the way, I argue that (...) this interpretation qualifies our understanding of the pleasures and pains with which temperance and intemperance are concerned. (shrink)

Recent attempts to define being moved have difficulties agreeing on its eliciting conditions. The status quaestionis is often summarized as a question of whether the emotion is evoked by exemplifications of a wide range of positive core values or a more restricted set of values associated with attachment. This conclusion is premature. Study participants associate being moved with interactions with their loved ones not merely for what they exemplify but also for their affective bond to them. Being moved is elicited (...) when we apprehend the value of entities to which we are connected through basic as well as extended forms of affiliative attachment. These comprise people, certain objects, and even abstract entities, including the unshakable life-guiding ideas we call “core values.”. (shrink)

In the Phaedo, Socrates offers recommendations for living a philosophical life. We argue that those recommendations can be properly understood only in light of Socrates’ account of the soul’s true nature, considered separately from the body. Embodiment causes the soul to diverge from its proper end, the pursuit of knowledge. Bodily pleasures, pains, and desires divert the soul to other ends, distract its attention away from knowledge, and deceive it about what is true. Socrates’ recommended solutions to these obstacles are (...) diverse, reflecting the complexities of human psychology. He recommends avoidance of bodily experiences in many cases as well as reevaluation of the importance of the body, but he doesn’t recommend either the wholesale rejection or embrace of the bodily. We are our souls but, like it or not, we are temporarily embodied, and what happens to the body is thereby experienced by us. Socrates thus exhorts us to live in a way that recognizes both our temporary humanity and our lasting, true nature. Only so can we best pursue knowledge. (shrink)

We review and present a new meta‐analysis of research suggesting that ethicists in the United States appear to behave no morally better overall than do non‐ethicist professors. Measures include: returning library books, peer evaluation of overall moral behavior, voting participation, courteous and discourteous behavior at conferences, replying to student emails, paying conference registration fees and disciplinary society dues, staying in touch with one's mother, charitable giving, organ and blood donation, vegetarianism, and honesty in responding to survey questions. One multi‐measure study (...) found ethicists tending to embrace more stringent moral views, especially about meat eating and charitable donation. The same multi‐measure study found ethicists and other professors to show similarly small‐to‐medium correlations between their expressed normative attitudes and their self‐reported or directly measured behavior. (shrink)