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When first published twenty years ago, The Logic of Medicine presented a new way of thinking about clinical medicine as a scholarly discipline as well as a profession. Since then, advances in research and technology have revolutionized both the practice and theory of medicine. In this new, extensively rewritten edition, Dr. Murphy includes changes to show how these different areas of scholarship may affect details of "the logic of medicine" without compromising its fundamental coherence. New to this edition are discussions (...) of the challenge of the flood of new empirical data, new ideas in genetics, molecular biology, homeostasis, pathogenesis, cancer, aging, and Alzheimer's disease. Murphy also comments on such new theoretical topics as dynamic systems, chaos, and fractals and their impact on the burgeoning fields of philosophy and practice of medicine. Written with medical students in mind, the book includes a glossary, many new examples, and problems for solutions with comments on each. An entirely new chapter deals with modeling. Clinicians and researchers will also find the principles thought-provoking and illuminating. (shrink)

On 25th October 1946, in a crowded room in Cambridge, Ludwig Wittgenstein and Karl Popper came face to face for the first and only time. The meeting was a disaster, their loud and aggressive confrontation became the stuff of legend. This book tells what really went on in that room.

Plato and the Power of Images addresses ways Plato has used images and the ways to understand their status as images, particularly how an image resembles what it represents and how to avoid mistaking that image for what it represents.

There are many algorithm texts that provide lots of well-polished code and proofs of correctness. Instead, this book presents insights, notations, and analogies to help the novice describe and think about algorithms like an expert. By looking at both the big picture and easy step-by-step methods for developing algorithms, the author helps students avoid the common pitfalls. He stresses paradigms such as loop invariants and recursion to unify a huge range of algorithms into a few meta-algorithms. Part of the goal (...) is to teach the students to think abstractly. Without getting bogged with formal proofs, the book fosters a deeper understanding of how and why each algorithm works. These insights are presented in a slow and clear manner accessible to second- or third-year students of computer science, preparing them to find their own innovative ways to solve problems. (shrink)

Twenty-seven of today's leading philosophers each introduce and explore ideas from one of history's greatest minds." -- Cover.

In 1766 philosopher, novelist, composer, and political provocateur Jean-Jacques Rousseau was a fugitive, decried by his enemies as a dangerous madman. Meanwhile David Hume—now recognized as the foremost philosopher in the English language—was being universally lauded as a paragon of decency. And so Rousseau came to England with his beloved dog, Sultan, and willingly took refuge with his more respected counterpart. But within months, the exile was loudly accusing his benefactor of plotting to dishonor him—which prompted a most uncharacteristically violent (...) response from Hume. And so began a remarkable war of words and actions that ensnared many of the leading figures in British and French society, and became the talk of intellectual Europe. Rousseau's Dog is the fascinating true story of the bitter and very public quarrel that turned the Age of Enlightenment's two most influential thinkers into deadliest of foes—a most human tale of compassion, treachery, anger, and revenge; of celebrity and its price; of shameless spin; of destroyed reputations and shattered friendships. (shrink)

Fields of enquiry. Rome Harré on What is social science -- Toby Miller on Cultural studies -- Lawrence Sherman on Criminology -- Jonathan Haidt on Moral psychology -- Robert J. Shiller on Behavioural economics -- Births, deaths and human population. Sarah Franklin on the Sociology of reproductive technology -- Ann Oakley on Women's experience of childbirth -- Sarah Harper on the Population challenge for the 21st century -- Steven Pinker on Violence and human nature -- Social science through different lenses. (...) Gregory Clark on Names -- Robin Dunbar on Dunbar numbers -- David Goldblatt on the Sociology of football -- Trevor Marchand on Craft -- Bruce Hood on the Supernatural -- Doreen Massey on Space -- Politics and social science. Craig Calhoun on Protest movements -- Danny Dorling on Inequality -- Kate Pickett on the Case for equality. (shrink)

La 4e de couverture indique : "Cet ouvrage est écrit à quatre mains et porte sur la relation entre création artistique et sciences de la cognition. L'ouvrage propose deux approches de l'expérience esthétique. Une approche en troisième personne mobilisant des modèles propres aux systèmes dits auto-organisateurs issus de la biologie dédiée à la réception des œuvres d'art et une approche en première personne rendant compte par auto-analyse d'une pratique artistique vécue qui s'appuie également sur de tels systèmes, systèmes eux-mêmes liés (...) aux concepts d'émergence et de complexité". (shrink)

Dans un passage de Physique iii (7, 207b15-21), Aristote s’exprime d’une manière qui suppose valide l’implication suivante : « Si une grandeur peut être infinie en puissance, une telle grandeur peut aussi être infinie en acte ». Cette implication a intrigué les commentateurs tant anciens et médiévaux que modernes. Ces derniers se sont en général bornés à constater que l’implication n’est pas logiquement valide, sans expliquer comment et en quel sens Aristote avait pu la tenir pour telle. En rapprochant le (...) passage précité d’un autre passage de Physique iii (6, 206b16-27), le présent article en propose une interprétation qui semble lever toutes les difficultés. Au Moyen Age, le sens de l’implication a été très discuté, et l’interprétation proposée ici a été vue et soutenue par plusieurs commentateurs : on l’étudie chez quelques-uns de ceux-ci en situant leur position dans le cadre du débat médiéval sur la question, notamment en référence aux deux interprétations alors fameuses proposées par Averroès. (shrink)

This book reflects upon the manner in which medical research is performed and interpreted.

Given the adverse consequences of destructive leadership at work, we examine leader favoritism prevalent in contemporary organizations. Our study builds on previous research on unethical leadership behaviors and extends social exchange theory by assessing whether leader favoritism contributes to employee psychological withdrawal behavior at work and whether perceived unfairness explains this link, addressing a gap in the literature on this topic. In addition, we investigate the condition of perceived employability to seek whether the influence of perceived unfairness due to leader (...) favoritism on psychological withdrawal behavior at work is strengthened when employees think they can secure alternative employment elsewhere. The study utilizes a two-wave data collection approach to gather responses from 206 front end customer service employees working in the hospitality and tourism firms in the United Arab Emirates (UAE). The study findings offer empirical support for the proposed mediated moderation model. Specifically, the results demonstrate that leader favoritism directly, indirectly (via perceived unfairness), and positively influence employee withdrawal behaviors. This influence is stronger among employees who believe they can easily find alternative employment options. Our findings highlight the relevance of incorporating social exchange theory into the unethical leadership behaviors and withdrawal behaviors literature and provide valuable insights for managers into how to mitigate the practice of leader favoritism because of its adverse consequences on employees' work attitudes and behavior. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

A system of semigroup identities is hereditarily finitely based if it defines a variety all semigroups of which are finitely based. Two new types of hereditarily finitely based identity systems are presented. Two of these systems, together with eight existing systems, establish the hereditary finite basis property of every semigroup of order five or less with one possible exception.

It is shown that given any finite system of monoid identities, it is decidable if the class of locally finite monoids that satisfy the system is a variety. This answers an open problem of Mark V. Sapir.

Voilà un ouvrage d’une grande originalité, si grande qu’un spécialiste aussi consommé de la biologie aristotélicienne que Pierre Pellegrin – qui préface le livre – peut écrire (p. 10) : « Mes années d’études ne me donnent pas plus de compétence que n’en a n’importe quel lecteur nouveau du corpus biologique aristotélicien pour apprécier un travail aussi neuf ». Quant à moi, je ne saurais mieux faire, pour en donner une première idée, que d’emprunter quelques phrases à cette préface : (...) « […] l.. (shrink)

On se souvient peut-être de la parution au début de l’année 2008 du livre de Sylvain Gougenheim, Aristote au Mont Saint-Michel – Les racines grecques de l’Europe chrétienne (Le Seuil, Paris, 2008), des recensions laudatives dont cet ouvrage fit l’objet dans de grands quotidiens (le Monde, le Figaro), et de la polémique qui s’ensuivit. Cette polémique et l’ouvrage qui l’a suscitée semblent aujourd’hui déjà oubliés, les projecteurs de l’actualité, comme on dit, s’étant braqués sur d’autres obje..

Examen de la philosophie de l'analyse structurale, analysant terme à terme les rapports entre la forme et le sens et débouchant sur une réflexion concernant les concepts annexes d'expression, de signal, de signe, de symbole, de langage et de discours.

Some properties are discussed of regular polygons that may result from angular homeostatic processes in stable orbit. To characterize these homeostatic polygons we need to discuss the winding number, the sidedness (integer, fractional and irrational), multiplicity, envelopes, and density. A regular (i.e., equilateral, equiangular) polygon may be closed in one revolution about its unique center, in multiple revolutions, or not at all. A homeostatic polygon can be generated only if all vertices are included in a single polygon, which occurs if (...) and only if the number of vertices and the number of revolutions required to complete the polygon are relatively prime. For the homeostatic polygon to have a finite number of sides (without repeating itself) the angle subtended by any two successive vertices at the center must be a rational multiple of 2. Biological implications of these properties are illustrated. (shrink)

From the standpoint of the theory of medicine, a formulation is given of three types of reasoning used by physicians. The first is deduction from probability models (as in prognosis or genetic counseling for Mendelian disorders). It is a branch of mathematics that leads to predictive statements about outcomes of individual events in terms of known formal assumptions and parameters. The second type is inference (as in interpreting clinical trials). In it the arguments from replications of the same process (data) (...) lead to conclusions about the parameters of a system, without calling into question either the probabilistic model or the criteria of evidence. The third is illation (as in the elucidation of symptoms in a patient). It is a process whereby, in the light of the total evidence and the conclusions from the other types of reasoning, one may modify, expand, simplify or demolish a conceptual framework proposed for deductions, and modify the nature of the evidence sought, the criteriology, the axioms, and the surmised complexity of the scientific theory. (The process of diagnosis as applied to a patient may in extreme cases lead to the discovery of an entirely new disease with its own, quite new, set of diagnostic criteria. This course cannot be accommodated inside either of the other two types of reasoning.) Illation has something of the character of Kuhn's scientific revolution in physics; but it differs in that it is the nature, not the degree or frequency of change that distinguishes it from Kuhn's normal science. (shrink)

The skewness of a distribution, a poorly-defined term, is conventionally deemed to be invariant under linear transformations. A comparison is made of three criteria of it: the sign of odd central moments; the several relationships of the mean, the median and the mode; and asymmetry proper which is the set of ratios of the probability densities of all pairs of points equidistant above and below some arbitrary point, usually the principal mode. Some useful general relationships are discussed. The skeness of (...) convolutions is briefly discussed. A class of distributions is identified for which the skewness of the minimum ofk competing processes is independent ofk. It has importance in the parametric study of survivorship. (shrink)

SummaryCertain revolutionary changes in medicine—measurement, chemistry, genetics—have led to recasting both the criteriology and the conceptualization of the terms of discourse. But advances along this path rest no longer on naive observation but intimately and inextricably involve modeling, that is, a system of inference which derives no immediate warrant from the primordial data of the senses. This system is not totally new in quality, since all “fact” involves interpretation of data; nor is it entirely new in having heuristic value in (...) unearthing, or calling attention to, unsuspected evidence. But it differs in two major respects. First, it requires patterns of surmise which can no longer be immediately corroborated at all stages by naive means but rest more and more on internal theoretical consistency and confirmatory predictions to be verified by other sophisticated and indirect means. Second, it is leading to fundamental upheavals in even the broad perception of human biology, undermining well-established groupings and exposing certain classical fields of inquiry as meaningless. The problem yet to be confronted in this field is how an epistemology of the model (in this sense) is to be constructed. The model is useless (as the whole scientific endeavor is useless) if it has not a more economical structure than the totality of the raw data, even if the success of this economy is in some degree factitious (“robustness”). On the other hand, the model is also useless unless it has heuristic value and helps in adjudicating among competing interpretations (“power”). A good model will help also to distinguish relevant aspects of the data from the irrelevancies ascribed to error. The paradigmatic function of the model, then, defines certain “sufficient statistics” which condense the relevant features of the data. In fact a close analogy can be developed between the methodology of statistical inference and nosology. Both are necessarily tentative, and healthy development of both, in practice, is iterative; that is, the evidence and the model are mutually correcting and lead to advancement one of another. (shrink)

The meaning of consciousness, has interested thinkers throughout recorded time, and yet it is quite obvious that its understanding is still exceedingly remote. This is evident from the fact that even the presently used definitions give rise to contradictions. As implied by the title, the purpose of this paper is to remove some of the main difficulties concerned with this definition by using epistemological methods which have recently been developed. It is hoped that by clarifying the definition of consciousness, or, (...) more accurately, by clarifying the process leading to a scientifically rigorous definition of consciousness, some of the paradoxes surrounding the concept might be removed. (shrink)