November 4th-5th, 2012 at Kyoto University. Organizers: Hisashi Nakao & Pierre-Alain Braillard.

A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.

pt. 1. Gaston Bachelard's historical epistemology.--pt. 2. For a critique of epistemology.

Qu'un interet renouvele se manifeste aujourd'hui pour la versant epistemologique de l'oeuvre de Gaston Bachelard peut se comprendre au regard de l'histoire contemporaine de la philosophie des sciences. Cette histoire a ete dominee durant la plus grande partie du XXe siecle par une doctrine - celle de l'empirisme (ou positivisme) logique - promue a Vienne a la fin des annees 1920 par une institution originale, le Cercle de Vienne qui publie son manifeste en 1929, et s'organise comme un mouvement a (...) visee universelle et progressiste - celui de la conception scientifique du monde. La tradition francaise de la philosophie des sciences a pris d'entree de jeu un tout autre chemin. Si elle ne les a pas ignorees, elle a refuse de souscrire aux theses majeures du positivisme logique lorsqu'il s'est presente a elle. Elle a toujours lie etroitement philosophie et histoire des sciences. Dans le titre de ce petit livre ecrit durant l'annee universitaire 1967-1968 sous la direction de Georges Canquilhem, Dominique Lecourt a avance l'expression d'epistemologie historique pour signaler, a propos de Gaston Bachelard, cette particularite. (shrink)

The tacit standard view that development ends once reproductive capacity is acquired (reproductive boundary, or ‘‘RB,’’ thesis) has recently been challenged by biologists and philosophers of biology arguing that development continues until death (death boundary, or ‘‘DB,’’ thesis). The relevance of these two theses is difficult to assess because the fact that there is no precise definition of development makes the determination of its temporal boundaries problematic. Taking into account this difficulty, this article tries to develop a new species-dependent perspective (...) on temporal boundaries of development. This species-dependent account stands against both RB and DB theses since neither of them reflects the differences between species in the temporality of their development. In this perspective, I propose to use stem cells as a tool to analyze (1) the different developmental capacities of an organism during its life; and (2) the different developmental temporal capacities between species. In particular, I will show that stem cells enable four distinct temporal developmental patterns to be distinguished, i.e., four distinct temporal boundaries of development in the living. I show how these four patterns can be interpreted differently depending on the perspective one has on the definition of development. (shrink)

The clonal evolution model and the cancer stem cell model are two independent models of cancers, yet recent data shows intersections between the two models. This article explores the impacts of the CSC model on the CE model. I show that CSC restriction, which depends on CSC frequency in cancer cell populations and on the probability of dedifferentiation of cancer non-stem cells into CSCs, can favor or impede some patterns of evolution and some processes of evolution. Taking CSC restriction into (...) account for the CE model thus has implications for the way in which we understand the patterns and processes of evolution, and can also provide new leads for therapeutic interventions. (shrink)

Reprogramming technologies show that cellular identity can be reprogrammed, challenging the classical conception of cell differentiation as an irreversible process. If non-stem cells can be reprogrammed into stem cells, then what is it to be a stem cell, and what kind of property is stemness? This article addresses this question both philosophically and biologically, states the different possibilities, and illustrates their potential consequences for science with the example of anti-cancer therapies.

This chapter brings a philosophical perspective to the concept of stem cell. Three general questions both clarify the concept of stem cell and emphasize its ambiguities: (1) How should we define stem cells? (2) What makes them different from non-stem cells? (3) What is their ontology? (i.e. what kind of property is “stemness”?) Following this last question, the Chapter distinguishes four conceptions of stem cells and highlights their respective consequences for the cancer stem cell theory. Determining what kind of property (...) stemness is, in what context, is an urgent question, at least for therapeutic strategies against cancers. I hope that this chapter also illustrates how philosophy can be useful to biology. -/- The Chapter starts by clarifying the notions of self-renewal and differentiation. This leads to the question “can we (and if so, how) distinguish stem cells from non-stem cells through these two properties?”. From that will follow an interrogation on whether stem cells belong to a natural kind. On this issue, biologists and philosophers have framed the following alternative: either the concept of stem cell refers to entities (the cells that belong to the stem cell natural kind) or it refers to a transient and reversible cell state. I will argue that four conceptions of stemness should be distinguished rather than two. Finally, I will develop the case of the cancer stem cell (CSC) theory in order to show why it is crucial to answer the ontological question: some therapies might or might not be efficient depending on what stemness is. (shrink)

The demonstration that pluripotent stem cells could be generated by somatic cell reprogramming led to wonder if these so-called induced pluripotent stem (iPS) cells would extend our investigation capabilities in the cancer research field. The first iPS cells derived from cancer cells have now revealed the benefits and potential pitfalls of this new model. iPS cells appear to be an innovative approach to decipher the steps of cell transformation as well as to screen the activity and toxicity of anticancer drugs. (...) A better understanding of the impact of reprogramming on cancer cell-specific features as well as improvements in culture conditions to integrate the role of the microenvironment in their behavior may strengthen the epistemic interest of iPS cells as model systems in oncology. (shrink)

Der Beitrag fragt danach, was einem Subjekt durch ein psychisches Trauma angetan wird. In diesem Zusammenhang setzt er sich mit Tendenzen auseinander, die derzeit in der Psychoanalyse im Umgang mit Traumata zu beobachten sind: Steht ein Trauma im Zentrum ihrer Aufmerksamkeit, tendierten Psychoanalytiker dazu, darin ein für ihre klinische Arbeit spezielles oder gar außergewöhnliches Problem zu sehen, das nach »etwas Anderem« als der grundlegenden Methode der Psychoanalyse verlangt. Demgegenüber wird die Auffassung vertreten, dass ein Trauma untrennbar mit dem Seelenleben verwoben (...) ist. So etwas wie eine nichttraumatische Psychopathologie, so der Autor, gibt es nicht. Jede traumatisierte Psyche, unabhängig von der Intensität des Traumas, stehe darum im Grunde vor demselben Problem: Wie lässt sich der grundsätzliche Mechanismus der Wiederholung überwinden und eine ergebnisoffene Symbolisierung erreichen? Um diese Prozesse beschreiben zu können – die auch anhand einer Vignette illustriert werden –, schlägt der Autor die Unterscheidung zwischen »Subjektivität« und »Subjektalität« vor. (shrink)

In response to Germain argument that evolution by natural selection has a limited explanatory power in cancer, Lean and Plutynski have recently argued that many adaptations in cancer only make sense at the tumor level, and that cancer progression mirrors the major evolutionary transitions. While we agree that selection could potentially act at various levels of organization in cancers, we argue that tumor-level selection is unlikely to actually play a relevant role in our understanding of the somatic evolution of human (...) cancers. (shrink)

This special issue of Biological Theory is focused on development; it raises the problem of the temporal and spatial boundaries of development. From a temporal point of view, when does development start and stop? From a spatial point of view, what is it exactly that "develops", and is it possible to delineate clearly the developing entity? This issue explores the possible answers to these questions, and thus sheds light on the definition of development itself.

Immunological mechanisms and therapy approaches in psychotic syndromes were recently supported by the discovery of autoantibody-associated limbic and non-limbic encephalitis. However, how clinical diagnostic procedures in psychiatry should be adapted to these new insights is still unclear. In this study, we analyzed the cerebrospinal fluid (CSF) and neuroimmunological alterations and their association with cerebral MRI (cMRI) and electroencephalographic (EEG) findings. From 2006 until 2013, we acquired 180 CSF samples from psychotic patients. Between 2006 and 2009, CSF examinations were only performed (...) in cases in which organic brain disease was suspected. Since then, this procedure has been integrated into our routine diagnostic workup. CSF basic diagnostics were supplemented by measuring antineuronal antibodies against intracellular synaptic antigens, antibodies against intracellular onconeural antigens, antibodies against neuronal cell surface antigens and thyroid antibodies. In addition, cMRIs and EEGs were conducted. We found white cell counts elevated in 3.4% of the cases, albumin quotient elevated in 21.8%, and protein concentration elevated in 42.2%. Evidence of intrathecal immunoglobulin synthesis was found in 7.2% of the cases. Antibodies measured against neuronal cell surface antigens were positive in 3.2%. Reactivity on antibodies against intracellular onconeural antigens were detected in 3.5%. Serum thyroid antibodies were elevated in 24.7%. Abnormalities were found in 39.5% of cMRIs and in 34.3% of EEGs. The main finding of our study was the high prevalence of CSF and autoantibody abnormalities in 54.4% of psychotic patients. In combination with cMRIs and EEGs, 75.6% showed abnormal findings. Our results are discussed with regard to the concept of immunological encephalopathy. Future studies should analyze the efficacy of immunomodulatory therapies. (shrink)

The analysis of identity in cases of memory loss, particularly in Alzheimer’s disease, sheds light on relevant philosophical and practical concerns, such as decision-making processes, autonomy, and the improvement of interaction with patients. Literature on psychological continuity recognizes identity when there are no disruptions in memory, which is certainly not the case in Alzheimer´s disease. Narrative identity, particularly in its relational and non-relational versions, delivers tools which are not exempt from difficulties. Either the caregivers’ narrative or the patient’s narrative is (...) dismissed. Furthermore, if there is a contradiction of narratives in relational theories, we are advised to either find the best narrative or seek agreement. However, one option rejects one narrative, while the other is unattainable in practice for the case in question. Hence, we propose drawing from ironism (Rorty, 1989), which suggests duality of dialogues when dealing with problems. This will be used to defend that the narratives of both, a person with Alzheimer and those close to them, are valid when constituting identity of the former. In this case, we will articulate and defend relational ironism, which allows us to embrace inconsistent narratives without seeking agreements. According to this, personal identity in this case is in constant tension between the narratives of those who suffer Alzheimer’s disease and the narratives of those close to them. We close illustrating possible benefits for how best to interact with patients. (shrink)

Public surveys conducted in many countries report widespread willingness of individuals to donate a kidney while alive to a family member or close friend, yet thousands suffer and many die each year while waiting for a kidney transplant. Advocates of financial incentive programs or “regulated markets” in kidneys present the problem of the kidney shortage as one of insufficient public motivation to donate, arguing that incentives will increase the number of donors. Others believe the solutions lie—at least in part—in facilitating (...) so-called “altruistic donation;” harnessing the willingness of relatives and friends to donate by addressing the many barriers which serve as disincentives to living donation. Strategies designed to minimize financial barriers to donation and the use of paired kidney exchange programs are increasingly enabling donation, and now, an innovative program designed to address what has been termed “chronologically incompatible donation” is being piloted at the University of California, Los Angeles, and elsewhere in the United States. In this program, a person whose kidney is not currently required for transplantation in a specific recipient may instead donate to the paired exchange program; in return, a commitment is made to the specified recipient that priority access for a living-donor transplant in a paired exchange program will be offered when or if the need arises in the future. We address here potential ethical concerns related to this form of organ “banking” from living donors, and argue that it offers significant benefits without undermining the well-established ethical principles and values currently underpinning living donation programs. (shrink)

During dialog, references are presented, accepted, and potentially reused. Two experiments were conducted to examine reuse in a naturalistic setting. In Experiment 1, where the participants interacted face to face, self-presented references and references accepted through verbatim repetition were reused more. Such biases persisted after the end of the interaction. In Experiment 2, where the participants interacted over the phone, reference reuse mainly depended on whether the participant could see the landmarks being referred to, although this bias seemed to be (...) only transient. Consistent with the memory-based approach to dialog, these results shed light on how differences in accessibility in memory affect the unfolding of the interaction. (shrink)

Alors que la guerre était associée au masculin, quelques femmes en France ont combattu au cours des guerres civiles des XVIe-XVIIe siècles ou ont servi dans les armées royales, qu’accompagnaient de plus de nombreuses civiles. Avec la Révolution française, le service dans la garde nationale et, moins directement, dans l’armée est lié à la citoyenneté. En réclamant le port des armes au sein de la garde nationale, des militantes révolutionnaires revendiquaient ainsi un des droits politiques du citoyen, ce qui provoqua (...) un ferme refus. Mues par le désir de défendre la République et de partager avec les hommes la gloire de se battre pour elle, des citoyennes s’engagèrent par ailleurs individuellement dans les armées, où elles continuèrent à servir après le décret du 30 avril 1793 qui les en chassait. Les demandes d’armement des militantes et les réponses qui leur sont apportées, ainsi que les histoires, les propos des soldates et les réactions qu’elles ont suscitées permettent d’analyser l’association entre masculin, armes et citoyenneté et d’étudier les mécanismes de l’exclusion des femmes des armées. (shrink)

Is it possible, and in the first place is it even desirable, to define what "development" means and to determine the scope of the field called "developmental biology"? Though these questions appeared crucial for the founders of "developmental biology" in the 1950s, there seems to be no consensus today about the need to address them. Here, in a combined biological, philosophical, and historical approach, we ask whether it is possible and useful to define biological development, and, if such a definition (...) is indeed possible and useful, which definition can be considered as the most satisfactory. (shrink)

In response to Adam’s concern that when one tries to articulate a moral commitment, the commitment is ‘falsified,’ I examine the importance of a particular articulation in the process of moral development and look for a way to engage in this articulation, while avoiding the pitfalls Adams identified. Via the example of moral formation, and more specifically, exemplarity, I show the role of articulation in moral growth. Moreover, I attempt to show that partial and imperfect articulation can lead to moral (...) growth. For if this articulation is understood as inherently partial, it does not fall into the pitfall of ‘falsification,’ nor other well-known pitfalls in the process of moral formation through exemplarity. (shrink)

. We start from the geometrical-logical extension of Aristotle’s square in [6,15] and [14], and study them from both syntactic and semantic points of view. Recall that Aristotle’s square under its modal form has the following four vertices: A is □α, E is , I is and O is , where α is a logical formula and □ is a modality which can be defined axiomatically within a particular logic known as S5 (classical or intuitionistic, depending on whether is involutive (...) or not) modal logic. [3] has proposed extensions which can be interpreted respectively within paraconsistent and paracomplete logical frameworks. [15] has shown that these extensions are subfigures of a tetraicosahedron whose vertices are actually obtained by closure of by the logical operations , under the assumption of classical S5 modal logic. We pursue these researches on the geometrical-logical extensions of Aristotle’s square: first we list all modal squares of opposition. We show that if the vertices of that geometrical figure are logical formulae and if the sub-alternation edges are interpreted as logical implication relations, then the underlying logic is none other than classical logic. Then we consider a higher-order extension introduced by [14], and we show that the same tetraicosahedron plays a key role when additional modal operators are introduced. Finally we discuss the relation between the logic underlying these extensions and the resulting geometrical-logical figures. (shrink)

Cet ouvrage propose une approche globale des reconstructions érudites et des utilisations polémiques de la philosophie de la Renaissance dans la France du XIXe siècle en centrant l’attention sur une relecture politique de la pratique historiographique à l’époque de Victor Cousin. This book offers a comprehensive approach to scholarly reconstructions and polemical uses of Renaissance philosophy in nineteenth-century France by focusing on the political implications of historiographical practice in Victor Cousin’s time.

De nombreuses répliques du satyre à l'outre conservé au musée du Caire étaient connues jusqu'à présent, provenant d'Alexandrie, de Syracuse, de Kertch et de Phanagoria. Il convient de leur joindre un nouvel exemplaire fragmentaire du musée du Louvre provenant d'Amisos. Il est probable que nous ayons affaire dans chaque cas à une fabrication locale. Un passage des Dionysiaca de Nonnos de Panopolis (XXIII, 148) permet sans doute de voir dans cet objet un satyre voguant sur son outre : en effet (...) les fantassins de Dionysos sont décrits traversant l'Hydaspe, confluent de l'Indus, sur des outres gonflées d'air, mode de navigation connu par ailleurs. On peut supposer que le prototype était un satyre en bronze (peut-être un ornement de fontaine), créé sous l'influence pergaménienne, à la fin du IIIe s. ou au début du IIe s. av. J.-C. à Alexandrie, où l'expédition d'Alexandre aux Indes avait été transposée en une épopée de Dionysos. Suffisamment célèbre, il a pu donner lieu à des répliques en terre cuite, à la fois à Alexandrie, et dans divers centres liés à cette cité. (shrink)

This paper investigates the literal, metaphorical and ideological implications of ‘hybrid’ texts/genres for criticism in general, and for the workshopping of creative work in particular. The question underlying this investigation concerns the place of poetic discourse in fictocriticism. This is consonant with my understanding of genre as ‘index and mark’ representing ‘the site of the nonsubstitutable positioning of the I and the you and of their modalities of expression’ and of poetic discourse as ‘an unsettling process … of identity of (...) meaning and speaking subject’. (shrink)

This paper investigates the literal, metaphorical and ideological implications of ‘hybrid’ texts/genres for criticism in general, and for the workshopping of creative work in particular. The question underlying this investigation concerns the place of poetic discourse in fictocriticism. This is consonant with my understanding of genre as ‘index and mark’ representing ‘the site of the nonsubstitutable positioning of the I and the you and of their modalities of expression’ and of poetic discourse as ‘an unsettling process … of identity of (...) meaning and speaking subject’. (shrink)

lack.” Lacan’s conception of Eros revolves around “a presentification of 1 It is my contention that King Lear invites a theoretical reading of kinship as such “presentification of lack.” Indeed, the dialectic of desire in the text derives from King Lear’s discovering that his own kingly signifier signifies nothing. This error of judgment, which stems from a confusion between desire and jouissance, leads him to misappropriate the rules of bothkingship and kinship. Interestingly enough, it is Cordelia, the daughter andsubject with (...) whom he is erotically involved, who brings home to him thetruth of his error. As an incestuous drama of signification, then, King Learnot only relates to the Phallus as master signifier, but also to the Name-ofthe-Father as referent of the law. Moreover, the truth Cordelia speaks is “a half-said” that leads to the “abolition of discourse”: muteness, madness anddeath. 2 Thus, if the violence implicit in the erotics of the play strikes at “the self-contained character of the participators,” it strikes first at the core of language. 3. (shrink)

While the mainstream media continues to narrowly define justice and reduce the site of its presence or absence to murder scenes and court cases, justice is often foreclosed long before someone is murdered and we must #SayHerName. To expand the project of Black mattering beyond race and physical death, this essay animates how body policing through school dress code policy sanctions racial-sexual violence and provide girls with an ultimatum: either abandon body sovereignty and self-expression, or accept the consequences of being (...) read as a distraction, a problem. membering classic Black feminist theory and the 2013 case of Vanessa Van Dyke, this essay locates these underrecognized facets of state violence as an extension of the #SayHerName project. Through a Black girlhood studies framework, the author underscores embodiment as an essential measure of justice and reframes mattering through the importance of Black girls’ crowns. (shrink)

The present paper reports a set of experimental studies concerning the comprehension of French argumentative operators and connectives.The first part is a presentation of the theoretical framework, the methodological problems and some of the most general results. Experiments were carried out in the perspective of the linguistic theory of argumentation developed by Anscombre and Ducrot. According to this theory, a number of devices in language are mainly defined by their argumentation function, i.e. by the types of discursive sequences and conclusions (...) they involve. Three categories of such devices were examined: (1) operators like “presque” (almost), “à peine” (hardly), “au moins” (at least), etc. which give an argumentative orientation to the statement; (2) co-orientation connectives, like “même” (even), which relate two statements oriented towards the same conclusion; (3) counter-orientation connectives, like the concessive ones (“mais” (but), “quand même” (even so), etc.), which relate two statements oriented towards opposite conclusions. The data shed light on issues such as: What is the nature of the relationship between the informative and argumentative functions of different operators? Is there a hierarchical relation between the argumentative processes of “co-orientation” and “counter-orientation”? What is the role of negation in the processing of argumentative sequences?The second part of the paper focuses specifically on the study of how 8 and 10 year-old children process “counter-oriented” statements. Five concessive connectives were studied: “mais”, “pourtant”, “quand même”, “même si”, “bien que”. The test was composed of two successive completion tasks: in one task the children had to choose the relevant context of complex sentences involving concessive connectives; in the other task they had to choose their relevant conclusion. Main results show a clear evolution in the performance of children between 8 and 10, suggesting that concessive strategies are not completely mastered at the age of 8. Differences among the concessive connectives studied were brought out: the item “quand même” obtained much better results than the other items with 8-year-old subjects; statements with “mais” seemed to be better processed in the conclusion task than in the context task, especially by 10-year-old subjects. These results are compared with other data obtained in some of the numerous studies on the production and comprehension of concessive connectives in various languages, and discussed from the point of view of argumentative theory. (shrink)

This study focuses on the essential difference between Kant’s and Husserl’s transcendental Idealism. In fact, Husserl describes in the «Cartesian Meditations» his own ontological thesis as a «transcendental idealism», in which all sorts of entities have to be constituted by an activity of the transcendental subjectivity, so that we have to regard pure consciousness as the ontological origin of all entities in the world. But this study is interested in the two opposite signications of the Kantian copernican inversion. On the (...) one hand, the Copernican inversion has the same sense as the phenomenological reduction, which implies that Husserl can’t agree with Kant’s presupposition of absolute things in themselves; on the second hand, it involves a relativistic and anthropologistic orientation, so that the aprioristic structures of given objects are founded on the universal structures of finite subjectivity, on pure forms and faculties of human consciousness. At the opposite, Husserl enounces a methodological prescription for any phenomenological elucidation: it is not allowed to presuppose in phenomenology any given faculty or given nature of transcendental subjectivity. This prescription has important consequences on which this study focuses. First the ontological difference between intuitus originarius and intuitus derivatus, in nite and nite type of intuition, doesn’t have any validity: the difference between factual and rational truths only depends on the essence of the truth itself, and doesn’t have its foundation on the ontological difference between creative and receptive sort of intuition. Secondly, this first thesis admits an immediate application on the level of subjective constitution of objects: the modality in which an object appears to the subjectivity doesn’t depend on the universal structure of finite subject, but is exclusively founded on the essence of the object itself, so that it is impossible to consider the aprioristic constitutive structure as a merely subjective structure. Thirdly, in this transcendental phenomenology everything has to be constituted by subjectivity: the aprioristic character of the pure forms of sensibility is not founded on the structure of finite subjectivity, but rather on the essential connection between sensual material and form; so that it is not allowed to presuppose any facticity of time and space; the pure forms of sensibility have to be constituted by a special type of synthesis that we have to elucidate in opposition to other types of higher levels. The profound signication of Husserl’s anticopernican inversion is that the field of transcendental phenomenology consists of the essential form of an eidos ego, which is «more objective than any objectivity», as Levinas said; and that transcendental phenomenology is completely dominated by the principium reddendae rationis. (shrink)