The problem of how the brain produces consciousness, subjectivity and "something it is like to be" remains one of the greatest challenges to a complete science of the natural world. While various scientists and philosophers approach the problem from their own unique perspectives and in the terms of their own respective fields, Biophysics of Consciousness: A Foundational Approach attempts a consilience across disparate disciplines to explain how it is possible that an objective brain produces subjective experience. This volume unites the (...) cr me de la cr me of physicists, neuroscientists, and psychiatrists in the attempt to understand consciousness through a foundational approach encompassing ontological, evolutionary, neurobiological, and Freudian interpretations with the focus on conscious phenomena occurring in the brain. By integrating the perspectives of these diverse disciplines with the latest research and theories on the biophysics of the brain, the book tries to explain how what John Searle calls a "conscious field" can be an adaptive and causal element in the natural world. (shrink)

This paper explores the work of Nicolas Rashevsky, a Russian émigré theoretical physicist who developed a program in "mathematical biophysics" at the University of Chicago during the 1930s. Stressing the complexity of many biological phenomena, Rashevsky argued that the methods of theoretical physics -- namely mathematics -- were needed to "simplify" complex biological processes such as cell division and nerve conduction. A maverick of sorts, Rashevsky was a conspicuous figure in the biological community during the 1930s and early 1940s: (...) he participated in several Cold Spring Harbor symposia and received several years of funding from the Rockefeller Foundation. However, in contrast to many other physicists who moved into biology, Rashevsky's work was almost entirely theoretical, and he eventually faced resistance to his mathematical methods. Through an examination of the conceptual, institutional, and scientific context of Rashevsky's work, this paper seeks to understand some of the reasons behind this resistance. (shrink)

In studying various possible physico-chemical interpretations of biological phenomena we arrived by a systematical development of what we have called “Mathematical Biophysics” at the interpretation of even such complex phenomena, as those involved in learning, Gestalt-discrimination and Gestalt-transposition. Yet, in spite of the apparent progress made along this newly trodden road, a sophisticated mind may feel that we are advancing into a peculiar “cul-de-sac.” Indeed we are discussing possible physico-chemical mechanisms underlying the discrimination, recognition and constancy-properties of various (...) spatial forms. Yet we have not touched at all the much more fundamental question, which logically precedes all the above, namely, what can be the physicochemical interpretation of the general and primordial fact that we perceive those forms as spatial? Can we conceive any physicochemical model at all, which would illustrate how and why we experience everything as being in space? (shrink)

Set theory faces two difficulties: formal definitions of sets/subsets are incapable of assessing biophysical issues; formal axiomatic systems are complete/inconsistent or incomplete/consistent. To overtake these problems reminiscent of the old-fashioned principle of individuation, we provide formal treatment/validation/operationalization of a methodological weapon termed “outer approach” (OA). The observer’s attention shifts from the system under evaluation to its surroundings, so that objects are investigated from outside. Subsets become just “holes” devoid of information inside larger sets. Sets are no longer passive containers, (...) rather active structures enabling their content’s examination. Consequences/applications of OA include: a) operationalization of paraconsistent logics, anticipated by unexpected forerunners, in terms of advanced truth theories of natural language; b) assessment of embryonic craniocaudal migration in terms of Turing’s spots; c) evaluation of hominids’ social behaviors in terms of evolutionary modifications of facial expression’s musculature; d) treatment of cortical action potentials in terms of collective movements of extracellular currents, leaving apart what happens inside the neurons; e) a critique of Shannon’s information in terms of the Arabic thinkers’ active/potential intellects. Also, OA provides an outer view of a) humanistic issues such as the enigmatic Celestino of Verona’s letter, Dante Alighieri’s “Hell” and the puzzling Voynich manuscript; b) historical issues such as Aldo Moro’s death. Summarizing, we suggest that the safest methodology to quantify phenomena is to remove them from our observation and tackle an outer view, since mathematical/logical issues such as selective information deletion and set complement rescue incompleteness/inconsistency of biophysical systems. (shrink)

Introduction to complexity and complex systems -- Introduction to large linear systems -- Introduction to biochemical oscillators and nonlinear biochemical systems -- Modularity, redundancy, degeneracy, pleiotropy and robustness in complex biological systems -- The evolution of biological complexity; invertebrate immune systems -- Irreducible and specified complexity in living systems -- The complex adaptive and innate human immune systems -- Complexity in quasispecies : microRNAs -- Introduction to complexity in economic systems -- Complexity in quasispecies : micrornas -- Dealing with complexity.

Since the early 1990s, the extractive industries have increasingly valued corporate social responsibility in the communities where they operate. More recently, these industries have begun to recognize the importance of adapting CSR efforts to unique local contexts rather than applying a one-size-fits-all model. However, firms understand local context to mean culture and treat the physical properties of the host region—topography, geology, hydrology, and climate—as the exclusive purview of mineral geologists and engineers. In this article, we examine the organization of CSR (...) at two industrial-scale gold mines in Guatemala, owned by the same firm, which yielded starkly distinct levels of support among host community residents. We develop the idea of social terrain to convey the way in which the biophysical environment informs local social relations and imbues phenomena with particular social meanings. We argue that firms must account for social terrain in organizing for CSR. The literature struggles to provide guidelines for identifying and understanding stakeholders. Social terrain, we argue, can begin to bridge this gap between theory and practice. (shrink)

Climate change is one of the greatest challenges that human societies have ever faced. After a late start, it is by now rather intensely debated and analysed also in the social sciences and humanities, though mostly through overly generic explanations in terms of an instrumental relation to nature, of capitalist expansion drives or of the human longing for comfort. In contrast, this article concentrates on the socio-political transformations since the middle of the 20th century, which have been referred to as (...) the ‘Great Acceleration’ in the use of biophysical resources and in environmental degradation. It provides an analysis of the socio-political mechanisms that brought the resource-intensive path of social development about, showing how Western democratic societies tended to ‘solve’ difficult social problems by means of a triple displacement: onto other societies; onto nature and the planet; and into the future. As an unintended consequence, this displacement politics led to the globalization of resource-intensive development and to a planetary situation in which, at least as it appears in much of current debate, no further displacement is possible. The article concludes with insights for a more adequate approach to social phenomena of large scale and long duration in social theory. (shrink)

Modern socio?cultural studies of medicine demonstrate the symbolic character of much of medical reality. This symbolic reality can be appreciated as mediating the traditional division of medicine into biophysical and human sciences. Comparative studies of medical systems offer a general model for medicine as a human science. These studies document that medicine, from an historical and cross?cultural perspective, is constituted as a cultural system in which symbolic meanings take an active part in disease formation, the classification and cognitive management (...) of illness, and in therapy. Medicine's symbolic reality also forms a bridge between cultural and psychophysiological phenomena; the basis for psychosomatic and socioso?matic pathology and therapy. This in turn becomes a central problem for medical theory and for a philosophical reinvestigation of medicine. (shrink)

This book is divided in two parts, the first of which shows how, beyond paleontology and systematics, macroevolutionary theories apply key insights from ecology and biogeography, developmental biology, biophysics, molecular phylogenetics, and even the sociocultural sciences to explain evolution in deep time. In the second part, the phenomenon of macroevolution is examined with the help of real life-history case studies on the evolution of eukaryotic sex, the formation of anatomical form and body-plans, extinction and speciation events of marine invertebrates, hominin (...) evolution and species conservation ethics. The book brings together leading experts, who explain pivotal concepts such as Punctuated Equilibria, Stasis, Developmental Constraints, Adaptive Radiations, Habitat Tracking, Turnovers, (Mass) Extinctions, Species Sorting, Major Transitions, Trends, and Hierarchies – key premises that allow macroevolutionary epistemic frameworks to transcend microevolutionary theories that focus on genetic variation, selection, migration and fitness. Along the way, the contributing authors review ongoing debates and current scientific challenges; detail new and fascinating scientific tools and techniques that allow us to cross the classic borders between disciplines; demonstrate how their theories make it possible to extend the Modern Synthesis; present guidelines on how the macroevolutionary field could be further developed; and provide a rich view of just how it was that life evolved across time and space. In short, this book is a must-read for active scholars and, because the technical aspects are fully explained, it is also accessible for non-specialists. Understanding evolution requires a solid grasp of above-population phenomena. Species are real biological individuals, and abiotic factors impact the future course of evolution. Beyond observation, when the explanation of macroevolution is the goal, we need both evidence and theory that enable us to explain and interpret how life evolves at the grand scale. (shrink)

G. H. Mead developed an alternative "metaphysics" of selfhood and agency that underlies, but is seldom made explicit in discussions of, his social developmental psychology. This is an alternative metaphysics that rejects any pregiven, fixed foundations for being and knowing. It assumes the emergence of social psychological phenomena such as mind, self, and deliberative agency through the activity of human actors and interactors within their biophysical and sociocultural world. Of central importance to the emergence of self-consciousness and deliberative (...) forms of human agency is the ability of developing individuals to take the perspectives of others within their own conduct. However, precisely what is involved in this process, and whether or not it assumes the preexistence of exactly those forms of selfhood and agency, the emergence of which it seeks to explain, have been much disputed. In this essay, recent reinterpretations of Mead's "metaphysics" are used to argue that his overall theoretical program contains resources necessary to overcome charges of ontological and epistemological circularity. In particular, once his interactionism, perspectivism, emergentism, and compatibilism are explicated, it is possible to see that Mead's "taking the perspective of the other" is not primarily a process of internalization that requires a preexisting "internalizer," but a process of participation with others within conventionalized sequences of interactivity. This participatory process enables the development of prereflective forms of perspective taking and self-other differentiation that serve as necessary conditions for the further emergence of more reflective forms of perspective taking, self-consciousness, and deliberative agency. Compatibilist interpretations of deliberative agency, thus understood, also are discussed. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.1 (2002) 87-90 [Access article in PDF] Phenomenological and Biological Psychiatry:Complementary or Mutual? James Morley Keywords: phenomenology, psychiatry, psychoanalysis, ontology. We feel that even if all possible scientific questions be answered the problems of life have still not been touched at all. (Witgenstein, Tractatus, 6.52) IF ONE WAS TO PERFORM a thought experiment by imagining a scientifically explained universe, how would this explained universe resolve (...) my issues of value and meaning? Would it help me to live a better life? In one sentence, Witgenstein expressed exactly the issues dividing, and defining, the phenomenological and biophysical approaches to psychiatry. (Natural) scientific questions are concerned with relations of physical causality while phenomenology is aimed at the problems of life, i.e., the elucidation of lived personal meanings.Clarifying the relation between phenomenology and the general psychiatric literature is clearly a significant undertaking. At this juncture in the history of psychiatry where the biophysical model is so dominant, the authors' efforts are especially welcome, as I wholeheartedly appreciate, and thank the authors for this endeavor. I only wish to explicate a few issues latent within the article and perhaps add a few supportive points. Explicitly or implicitly, the need for phenomenology in psychiatry is long enduring and will always persist (Ellenberger 1981, 1993). The integration of phenomenology with general psychiatric practice would certainly serve the needs of patients and society generally. But, in the present state of affairs where the biological model is so preeminent, a full accounting of the dramatic divergences between the two approaches is necessary if there is to be authentic dialogue between them.Essentially, I want to stress that phenomenology and natural science medicine are genuinely distinct paradigms for construing reality and organizing knowledge. As distinct scientific paradigms, each one is holistically self-contained. Like soap bubbles, if pushed together too forcefully one or the other may burst. In this case, it is more likely that the smaller, less prevalent paradigm would burst by becoming absorbed into the more dominant paradigm. I believe that this is precisely the risk when phenomenology is introduced to conventional psychiatry as "complementary." Whereas one could hardly object to any application of empathy and understanding toward the experiences of patients, it would be tragic if the [End Page 87] full philosophical power of phenomenology were to be overlooked in favor of its mere utility as a preliminary stage of diagnosis and assessment, a framework for bedside manners, or worst of all, an appendage to neuroscience or pharmacology. This would not be phenomenology but the very symptomatology that the authors have has so clearly distinguished from true phenomenology.This equation of phenomenology with symptomatology is exactly the misunderstanding that the authors so effectively address. However, I would hesitate to join the authors' optimism in regard to phenomenology's potential complementary role to conventional psychiatric practice. Furthermore, in the process of paradigm mix, certain constituents of each paradigm may be taken out of context and the strength of each paradigm thus diluted. For example, the very power of the experimental method is its reduction of phenomena to measurable variables that can be altered in order to discern causality. Unmeasurable variables detract form the rigor of this entire approach. Then on the other hand, phenomenological empathy is only possible within a standpoint that is severed from the causal thinking of experimental science. This is the holistic perceptual shift that cannot be accomplished when one only appends phenomenological insights to an otherwise materialist approach to psychiatry. Thus, it is not at all clear how one can be both phenomenological and nonphenomenologically natural scientific. Instead of positioning phenomenology as a potential complimentary component of natural-science psychiatry, both world views need to be examined, on their own terms, in a framework of mutuality.Empathy or the understanding of other peoples subjective experience is indeed an essential component of the application of phenomenology to clinical assessment and especially therapeutic treatment. But, to limit phenomenology to this theme alone may not honor the profoundly radical character of this paradigm. As the authors point out, phenomenology asks the practitioner to... (shrink)

Long‐term potentiation and long‐term depression are thought to be cellular mechanisms contributing to learning and memory. Although the physiological phenomena have been well characterized, little consensus of their underlying molecular mechanisms has emerged. One reason for this may be the under‐appreciated complexity of the signaling pathways that can arise if key signaling molecules are discretely localized within the synapse. Recent findings suggest an unanticipated degree of structural organization at the synapse, and improved methods in cellular imaging of living tissue (...) have provided much‐needed information about the intracellular dynamics of Ca2+, thought to be critical for both LTP and LTD. In this review, we briefly summarize some of these developments, and show that a more complete understanding of cellular signaling depends on the successful integration of traditional biochemistry and molecular biology with the spatial and temporal details of synaptic ultrastructure. Biophysically realistic computer simulations can have an important role in bridging these disciplines. BioEssays 24:1130–1144, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

Technologies developed since the late eighteenth century differ from earlier forms of technology by being as dependent on world market prices of labour, land and other biophysical resources as on human inventiveness. Yet, whether their outlook is mainstream or heterodox, modern people tend to view technology simply as ingenuity applied to nature, while oblivious of the extent to which it is contingent on the asymmetric exchange of resources in global society. Although inextricably entwined in the real world, the (...) class='Hi'>phenomena studied by economics and engineering are kept conceptually separate. This is achieved by disregarding the materiality of world trade. Modern technologies are not just instruments for solving problems but social strategies for redistributing time and space in world society, displacing work and environmental loads to sectors of the world system where wages are lower and environmental legislation less rigorous. Technology should not remain extraneous to social theory. A sociometabolic reconceptualisation of technology is particularly essential for critics of global capitalism. (shrink)

Long since, people tried to solve the mystery of the way that led to the appearance and propagation of living entities. However, no harmonious understanding of this mystery existed, because neither the scientifically grounded source minerals nor the ambient conditions were proposed and because it was groundlessly taken that the process of living matter origination is endothermal. The Life Origination Hydrate Theory (LOH-Theory) first suggests the chemical way capable of leading from the specified abundant natural minerals to origination of multitudes (...) of multitudes of simplest living entities and gives an original explanation for the phenomena of chirality and racemization delay. The LOH-Theory covers the period up to origination of the genetic code. The LOH-Theory is grounded on the following three discoveries based on the available information and on the results of our experimental works performed using original instrumentation and computer simulations. (1) There is the only one triad of natural minerals applicable for exothermal thermodynamically possible chemical syntheses of simplest living-matter components. (2) N-base, ribose, and phosphdiester radicals and nucleic acids as whole are size-compatible with structural gas-hydrate cavities. (3) The gas-hydrate structure arises around amido-groups in cooled undisturbed systems consisting of water and highly-concentrated functional polymers with amido-groups.The natural conditions and historic periods favorable for simplest living matter origination are revealed. The LOH-Theory is supported by results of observations, biophysical and biochemical experiments, and wide application of original three-dimensional and two-dimensional computer simulations of biochemical structures within gas-hydrate matrix. The instrumentation and procedures for experimental verification of the LOH-Theory are suggested. If future experiments are successful, they, possibly, could be the first step on the way to industrial synthesis of food from minerals, i.e., to execution of the work that is performed by plants. (shrink)

In spite of their growing specialization, modern natural sciences intend to reduce their theories to some fundamental structures: Physics tries to unify the different physical forces in one fundamental force. Chemistry tries to explain the structure of chemical substances by the quantum mechanics of molecules. Biology tries to reduce the processes of life to biochemical and biophysical laws. Mathematically, the unification of natural science can be described by structures of symmetry, the specialization of science, the variety, and emergence of (...) new phenomena by symmetry breaking. In the following, the successes and lacks of the reductionistic program are shown in recent developments of physics, chemistry, and biology. Philosophical discussions on holism, reductionism, and unification of science can be clarified by structures of symmetry and symmetry breaking. Alternative non-reductionistic view-points are not only possible, but desirable for the lacks in the reductionistic program. Nevertheless, the categorical framework of symmetry and symmetry breaking supports interdisciplinary work and gives new insight in a common structure and theory of natural science. (shrink)

In spite of their growing specialization, modern natural sciences intend to reduce their theories to some fundamental structures: Physics tries to unify the different physical forces in one fundamental force. Chemistry tries to explain the structure of chemical substances by the quantum mechanics of molecules. Biology tries to reduce the processes of life to biochemical and biophysical laws. Mathematically, the unification of natural science can be described by structures of symmetry, the specialization of science, the variety, and emergence of (...) new phenomena by symmetry breaking. In the following, the successes and lacks of the reductionistic program are shown in recent developments of physics, chemistry, and biology. Philosophical discussions on holism, reductionism, and unification of science can be clarified by structures of symmetry and symmetry breaking. Alternative non-reductionistic view-points are not only possible, but desirable for the lacks in the reductionistic program. Nevertheless, the categorical framework of symmetry and symmetry breaking supports interdisciplinary work and gives new insight in a common structure and theory of natural science. (shrink)

Following the general program, outlined in a previous paper on the Foundations of Mathematical Biophysics, we shall outline some physico-mathematical aspects of the Gestalt-problem. Faithful to the principles laid down before, we shall not attempt to give a theory of such and such psycho-physiological phenomena connected with our problem, but we shall investigate in a preliminary way the abstract conceptual basis, which must underlie the construction of any concrete theory. To make our aim quite clear and to avoid at (...) the same time unnecessary repetition, we refer the reader to our previous paper. Furthermore we shall give here only an outline of the physico-mathematical aspects; and of necessity we must leave a number of details untouched and unanswered. (shrink)

INTRODUCTION: Philosophy is the unique science which considers all other sciences in systematically unity (Kant). The classical anthropology (Platon, Aristoteles, Descartes, Hume, Kant, etc.) considers the human and his "spheres" (biological, psychological, logical, philosophical, theological) and his interdependence with nature and society. A philosophical theology investigates spiritual phenomena, described by religions and parapsychology in context of ethics, epistemology (incl. metaphysics), aesthetics. A theological anthropology should consider these phenomena multidimensional in context of a holisticscience, i.e. physico- (Kant), bio- (Lüke), (...) psycho-, logico-, philosophical theology, etc. [Lit.: Neu, Michailov: Integralanthropology. In: Proc. 21st World Congr. Philos. Istanbul. Press FISP 280‐281, 2003; Theol. Anthrop. In: Book: New Pathways for Eur. Bioethics. Ed.: Eur. Ass. Med. Ethics, Leuven, p. 53/60, 2006; Med. Ethics, 21st Ann. Conf. EACME (Ed.) Zürich, p. 53, 2007]. CONCEPTION: Regrettably philosophical theology is reduced to nearly philosophical and theological ethics: Both ethics in the future should realize a common scientific integrated ethics based on philosophy, theology, and psychology incl. of great cultures - Brahmanism, Buddhism, Christianism-Mosaism, Confucianism, and Mohammedanism. The present moral philosophy is very pluralistic: Many views concerningnormative and metaethics (deontology, axiology), also relativism, absolutism (incl. utilitarism), noncognitivism are present. A similar situation exists in moral theology: Not only in context of philosophy (consequentialism, justice, protectionism), but more - of theology are existent contradictionary differences concerning ethics in the great religions (related to God, Spirit/Soul, reincarnation, etc.). A future philosophical theology needs a renewal of its scientific theoretical andexperimental fundamentals (controlled observations: criterion for intersubjectivity) concerning theological anthropology incl. not only occidental epistemology (metaphysics, scientific theory, etc.), but also oriental - esp. Brahmanistic and Buddhist (self realization by Yoga, Tibetan, Zen Buddhism) and scientific evaluation of spiritual phenomena by biophysics, physiology, psychology and formal (Aristoteles, Gautama), real, transcendental (Kant), metaphysical (Hegel) normal logic. Areconsideration of application of philosophy of arts, esp. aesthetics in philosophical theology is also necessary (incl. inspirations in music/Bach, Beethoven, Händel, painting/Leonardo da Vinci, sculpture/Michelangelo). CONCLUSION: Scientific and political support for a renovation of theological anthropology and philosophical theology could help essentially for a realization of UNO-Agenda 21 for better total (incl. spiritual) health and peaceful world. (shrink)

Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students.

The approach used by physics is based on the identification and study of ideal objects, which is also the basis of biophysics, in combination with von Neumann heuristic modeling and functional fractionation according to R.Rosen is discussed as a tool for studying the properties of consciousness. The object of the study is a kind of line of analog systems: the human brain, the vertebrate brain, the invertebrate brain and artificial neural networks capable of reflection, which is a key property characteristic (...) of consciousness. Reflection in the broad sense of the word, understood as an internal representation of the external world, is characteristic of a wide range of animals, and some of them (bumblebees, fish) even demonstrate reflection in the narrow sense of the word, understood as an inner self-representation. This complex behavior is realized by miniature brains of ~1 million neurons. The use of simple recurrent neural networks (RNNs) to obtain answers to general questions is illustrated. For example, it has been shown a small RNS is able to pass delayed matching to sample (DMTS) test, forming an individual dynamic representation of the received stimulus, allowing decoding by a special external neural detector.. It has been demonstrated in the reflexive game “even-odd”, the RNS has a huge advantage over a multi-layered neural network, with the same and a larger number of neurons – reflection defeats regression. It was found that the asymmetry of outcomes in the odd-even game, which was explained by various causes, including psychological ones – “it’s easier to catch up than to run away”, is reproduced in the game of two RNNs. Obviously, there are no psychological causes here and the advantage of the player playing for “even” is explained by the more complex strategy of the “odd” player – he needs to predict the opponent’s move and choose the opposite one. (shrink)

The approach used by physics is based on the identification and study of ideal objects, which is also the basis of biophysics, in combination with von Neumann heuristic modeling and functional fractionation according to R.Rosen is discussed as a tool for studying the properties of consciousness. The object of the study is a kind of line of analog systems: the human brain, the vertebrate brain, the invertebrate brain and artificial neural networks capable of reflection, which is a key property characteristic (...) of consciousness. Reflection in the broad sense of the word, understood as an internal representation of the external world, is characteristic of a wide range of animals, and some of them (bumblebees, fish) even demonstrate reflection in the narrow sense of the word, understood as an inner self-representation. This complex behavior is realized by miniature brains of ~1 million neurons. The use of simple recurrent neural networks (RNNs) to obtain answers to general questions is illustrated. For example, it has been shown a small RNS is able to pass delayed matching to sample (DMTS) test, forming an individual dynamic representation of the received stimulus, allowing decoding by a special external neural detector.. It has been demonstrated in the reflexive game “even-odd”, the RNS has a huge advantage over a multi-layered neural network, with the same and a larger number of neurons – reflection defeats regression. It was found that the asymmetry of outcomes in the odd-even game, which was explained by various causes, including psychological ones – “it’s easier to catch up than to run away”, is reproduced in the game of two RNNs. Obviously, there are no psychological causes here and the advantage of the player playing for “even” is explained by the more complex strategy of the “odd” player – he needs to predict the opponent’s move and choose the opposite one. (shrink)

Evolution exploits the physics of non‐neural bioelectricity to implement anatomical homeostasis: a process in which embryonic patterning, remodeling, and regeneration achieve invariant anatomical outcomes despite external interventions. Linear “developmental pathways” are often inadequate explanations for dynamic large‐scale pattern regulation, even when they accurately capture relationships between molecular components. Biophysical and computational aspects of collective cell activity toward a target morphology reveal interesting aspects of causation in biology. This is critical not only for unraveling evolutionary and developmental events, but also (...) for the design of effective strategies for biomedical intervention. Bioelectrical controls of growth and form, including stochastic behavior in such circuits, highlight the need for the formulation of nuanced views of pathways, drivers of system‐level outcomes, and modularity, borrowing from concepts in related disciplines such as cybernetics, control theory, computational neuroscience, and information theory. This approach has numerous practical implications for basic research and for applications in regenerative medicine and synthetic bioengineering. (shrink)

Biophysics has been either an independent discipline or an element of another discipline in the United States, but it has always been recognized as a stand-alone discipline in the People’s Republic of China since 1949. To inquire into this apparent divergence, this paper investigates the formational history of biophysics in China by examining the early institutional history of one of the best-known and prestigious science and technology universities in the PRC, the University of Science and Technology of China. By showing (...) how the university and its biophysics program co-evolved with national priorities from the school’s founding in 1958 to the eve of the Cultural Revolution in 1966, the purpose of this paper is to assess the development of a scientific discipline in the context of national demands and institutional politics. Specific materials for analysis include the school’s admission policies, curricula, students’ dissertations, and research program. To further contextualize the institutional setting of Chinese biophysics, this paper begins with a general history of proto-biophysical institutions in China during the Nationalist-Communist transitional years. This paper could be of interest to historians wanting to know more about the origin of the biophysics profession in China, and in particular how research areas that constitute biophysics changed in tandem with socio-political contingencies. (shrink)

We present a two-pronged criticism of Ramos's argument. Our main contention is that the logic of the author’s argument is flawed. As we demonstrate, the author conflates probability with necessity, in addition to conflating free will having causal efficacy with the merely illusory conscious experience of free will; such conflations undermine the claim that individual free will should be both exhibited on a social scale and necessarily cause a particular organized pattern to emerge. In addition, we will show that the (...) author makes a series of inadequately supported assertions concerning the relationship between, and degree of scholarly consensus upon, causally effective free will and mind-body interactionist dualism, which further undermine his argument. (shrink)

Radiobiology assesses the biological hazards of exposure to radioactive substances and nuclear radiation. This article explores the history of radiobiology in twentieth-century China by examining the overlapping of radium research and biophysics, from roughly the 1920s Nationalist period to the 1960s Communist period; from the foreign purchase of radium by the Rockefeller Foundation’s China Medical Board during the Republican era, to the institutional establishment of radiobiology as a subset of biophysics in the People’s Republic. Western historiography of radiobiology highlights the (...) connection between the military development of nuclear weapons and the civilian use of radiation in biology, as well as the international export of radioisotopes and nuclear reactors. Considering the exclusion of China from Western atomic diplomacy, I argue that the study of the Chinese history of bomb-making and radiobiology is necessary not just to fill an existing knowledge gap, but more importantly to elucidate the influence of the Chinese nuclear weapons program and Cold War atomic politics on Chinese life-science enterprises. Through examining the formational history of the radiobiology program in China, I hope to shed light on the implications of the atomic age for Chinese biology in the twentieth century. (shrink)

Radiobiology assesses the biological hazards of exposure to radioactive substances and nuclear radiation. This article explores the history of radiobiology in twentieth-century China by examining the overlapping of radium research and biophysics, from roughly the 1920s Nationalist period to the 1960s Communist period; from the foreign purchase of radium by the Rockefeller Foundation’s China Medical Board during the Republican era, to the institutional establishment of radiobiology as a subset of biophysics in the People’s Republic. Western historiography of radiobiology highlights the (...) connection between the military development of nuclear weapons and the civilian use of radiation in biology, as well as the international export of radioisotopes and nuclear reactors. Considering the exclusion of China from Western atomic diplomacy, I argue that the study of the Chinese history of bomb-making and radiobiology is necessary not just to fill an existing knowledge gap, but more importantly to elucidate the influence of the Chinese nuclear weapons program and Cold War atomic politics on Chinese life-science enterprises. Through examining the formational history of the radiobiology program in China, I hope to shed light on the implications of the atomic age for Chinese biology in the twentieth century. (shrink)

Consciousness has always been linked to the nervous system or rather the brain, but there recorded conscious behaviors in organisms without nerve cells have changed the perspective of consciousness. A living cell is a blend of resonant frequencies, due to degrees of freedom that make it vibrate as a harmonic oscillator supporting the progression of vibrations as waves in and out of the system; to the neighboring cells, to the body, to other bodies and ultimately to the Universe; all of (...) which connects. Quantum generated consciousness is energy; emerges in each and every living cell and traverses by means of resonating vibrations; which utilizes the cellular structures to flow by means of a coherent, obscured, robust, recoverable process. (shrink)

It remains to summarize the contributions which each of the three disciplines discussed here is making toward the development of a science of man. "Significs" makes a study of the effects on human behavior of the linguistic aspects of the evaluative process, the most distinctly human aspect of the behavior of the human organism. "Mathematical Biophysics" seeks to describe the events associated with evaluative processes in physico-mathematical terms. "Cybernetics" is discovering important invariants common to these processes and others, particularly those (...) observed in man-made machines and in situations which lend themselves to description in thermo-dynamic or statistical (order -- chaos) terms. (shrink)

It remains to summarize the contributions which each of the three disciplines discussed here is making toward the development of a science of man. "Significs" makes a study of the effects on human behavior of the linguistic aspects of the evaluative process, the most distinctly human aspect of the behavior of the human organism. "Mathematical Biophysics" seeks to describe the events associated with evaluative processes in physico-mathematical terms. "Cybernetics" is discovering important invariants common to these processes and others, particularly those (...) observed in man-made machines and in situations which lend themselves to description in thermo-dynamic or statistical terms. (shrink)

The contemporary physical description of the universe reflects the inanimate world only. Broadening this description by including life may limit the application of well?established physical laws and may find new forces of the universe governing living organizations. This may also require adoption of some new assumptions and methodological principles, such as a broader principle of uncertainty, and recognition of the fact that humans? ability to manifest biofield communication is distributed very unevenly in the population. Based on available body of scientific (...) literature it is suggested that at this time, before the theoretical basis of the biofield is developed, it is important to conduct a broad experimental study of highly psi?gifted individuals in order to accumulate scientific knowledge of humans? ability to interact with matter, i.e., known physical fields and living organisms by intent. One can expect that current studies of organisms? genomes and attempts to utilize stem cells in medicine will call for the recognition of the biofield and its operative control function in organisms. However, developing a from?the?top?down view on the organism by the suggested approach will shorten this process and it deserves appropriate investment of social resources. (shrink)

Book written to preserve the wisdom of the ancient healing sages of China, and to provide the conceptual tools needed for its practical application in healing diseases of the modern world.

The literature on the nature of understanding can be divided into two broad camps. Explanationists believe that it is knowledge of explanations that is key to understanding. In contrast, their manipulationist rivals maintain that understanding essentially involves an ability to manipulate certain representations. The aim of this paper is to provide a novel knowledge based account of understanding. More specifically, it proposes an account of maximal understanding of a given phenomenon in terms of fully comprehensive and maximally well-connected knowledge of (...) it and of degrees of understanding in terms of approximations to such knowledge. It is completed by a contextualist semantics for outright attributions of understanding according to which an attribution of understanding is true of one just in case one knows enough about it to perform some contextually determined task. It is argued that this account has an edge over both its explanationist and manipulationist competitors. (shrink)

When examining the human being as a conscious being, we are still to arrive at an understanding of, firstly, the conditions required whereby physical processes give rise to consciousness and secondly, how consciousness is something fundamental to life as an intrinsic part of nature. Humans are complex organisms with myriad interacting systems whereby the convergence of the activities toward the support and development of the whole organism requires a high level of organisation. Though what accounts for the dynamic unity of (...) the human being? From an empirical perspective the question remains unanswered. The aim of this paper is to conceptually establish a fundamental biophysical organising principle to account for the unity and organisation of the human being. To this end I draw from David Bohm’s interpretation of quantum theory to provide an adapted and adjunct conceptual scheme in the form of a Triple-Aspect-Theory (TAT) of Being as a grounding ontology. David Bohm presented a holistic view of two interwoven orders of existence defined as the Explicate material world and the Implicate (quantum) enfolded world from which the former materialises. Consistent with David Bohm’s idea that matter at a fundamental level consists of a kind of protointelligence, the TAT facilitates a perspective based on aspect conditions of the human organism intended to furnish an explanation of the constitutive mechanism (TAT) inherent in the evolving human being. The TAT operates as an organising principle by which evolution inherently proceeds and maintains itself in an interactive relation between the Implicate and Explicate orders. The accumulated effect of natural selection is to produce adaptations, but without an organising principle: ‘Consciousness’, ‘Body-of-Experience’ and ‘Intellect-Reflective’ (the terms for the engaged coexistent aspects of being) it is argued could not occur. (shrink)

이 글에서 나는 창발 현상에 호소하여 자유의지 문제를 해결하려는 뉴섬(Newsome)의 시도를 비판적으로 검토할 것이다. 대략적으로 말하여, 창발현상은 물리적 일원론, 체계적 속성, 공시적 결정, 환원불가능성, 그리고 하향적 인과로 정의된다. 자유의지 문제와 관련된 창발 현상은 정신사건이다. 언뜻, 정신사건을 창발현상으로 간주하는 것은 자유의지 문제에 대한 좋은 해법을 제공하는 듯이 보인다. 그러나 이 글에서 나는 정신사건을 창발현상으로 간주한다고 해도 자유의지 문제는 해결되지 않는다는 것을 보이려고 시도할 것이다.

Es wird einführungsweise zuerst auf den allgemeinen Zusammenhang zwischen theoretischer und experimenteller Forschung hingewiesen, insbesondere darauf, dass die theoretische Forschung dem Experimentator nicht nur neue Probleme stellt, sondern auch die Ergebnisse vieler Versuche sinnvoll macht, unabhängig davon, ob diese Ergebnisse positiv oder negativ ausfallen. — Danach wird ein kurzer Überblick über einige neuere Ergebnisse der mathematischen Biophysik gemacht und es werden einige fundamentale Probleme der Krebsforschung vom Standpunkte dieser Ergebnisse diskutiert. Es wird auf eine Reihe neuer möglicher Versuche hingewiesen, welche (...) im Lichte der mathematisch-biologischen Forschung wichtige Fragen über die Natur der Tumoren beantworten würden.A titre d'introduction la relation entre les recherches théoriques et expérimentales est soumise à une discussion générale. L'auteur souligne particulièrement la circonstance que les recherches théoriques donnent non seulement des nouveaux problèmes à l'expérimentateur, mais que ces recherches théoriques donnent de la significance aux résultats expérimentaux, même aux résultats négatifs. — Ensuite l'auteur donne une revue générale de quelques nouveaux résultats de la biophysique mathématique. Quelques problèmes fondamentales du cancer sont discutées du point de vue de ces résultats. Des nouvelles expériences possibles qui porteraient à notre connaissance du mécanique intime des tumeurs, sont proposées. (shrink)

We have now seen that, in what we call the mental world, Consciousness,- there are three grand classes of phenomena, the most familiar of all the facts with ...

Traditional explanations of multistable visual phenomena (e.g. ambiguous figures, perceptual rivalry) suggest that the basis for spontaneous reversals in perception lies in antagonistic connectivity within the visual system. In this review, we suggest an alternative, albeit speculative. explanation for visual multistability - that spontaneous alternations reflect responses to active, programmed events initiated by brain areas that integrate sensory and non-sensory information to coordinate a diversity of behaviors. Much evidence suggests that perceptual reversals are themselves more closely related to the (...) expression of a behavior than to passive sensory responses: (1) they are initiated spontaneously, often voluntarily, and are influenced by subjective variables such as attention and mood; (2) the alternation process is greatly facilitated with practice and compromised by lesions in non- visual cortical areas; (3) the alternation process has temporal dynamics similar to those of spontaneously initiated behaviors; (4) functional imaging reveals that brain areas associated with a variety of cognitive behaviors are specifically activated when vision becomes unstable. In this scheme, reorganizations of activity throughout the visual cortex, concurrent with perceptual reversals, are initiated by higher, largely non- sensory brain centers. Such direct intervention In the processing of the sensory input by brain structures associated with planning and motor programming might serve an important role in perceptual organization, particularly in aspects related to selective attention. (shrink)