The DNA‐passage activity of topoisomerase II accidentally produces DNA knots and interlinks within and between chromatin fibers. Fortunately, these unwanted DNA entanglements are actively removed by some mechanism. Here we present an outline on DNA knot formation and discuss recent studies that have investigated how intracellular DNA knots are removed. First, although topoisomerase II is able to minimize DNA entanglements in vitro to below equilibrium values, it is unclear whether such capacity performs equally in vivo in chromatinized DNA. Second, DNA (...) supercoiling could bias topoisomerase II to untangle the DNA. However, experimental evidence indicates that transcriptional supercoiling of intracellular DNA boosts knot formation. Last, cohesin and condensin could tighten DNA entanglements via DNA loop extrusion (LE) and force their dissolution by topoisomerase II. Recent observations indicate that condensin activity promotes the removal of DNA knots during interphase and mitosis. This activity might facilitate the spatial organization and dynamics of chromatin. (shrink)

CONTENIDO: Fenomenología / Daniel Herrera Restrepo / - La hermenéutica y su naturaleza analógica: necesidad de una hermenéutica analógica / Mauricio Beuchot / - La filosofía analítica / Margarita M. Valdés / - Filosofía de la ciencia en el siglo XX / Ana Rosa Pérez Ransanz / - El liberalismo en la segunda mitad del siglo XX / Jesús Antonio Serrano Sánchez / - Filosofía y cultura / Dora Elvira García G. / - Filosofía e interculturalidad en América (...) Latina: intento de introducción no filosófica / Raúl Fornet-Betancourt. (shrink)

Most theories about virtue cultivation fall under the general umbrella of the role model approach, according to which virtue is acquired by emulating role models, and where those role models are usually conceived of as superior in some relevant respect to the learners. I argue that although we need role models to cultivate virtue, we also need good and close relationships with people who are not our superiors. The overemphasis on role models is misguided and misleading, and a good antidote (...) draws on the Aristotelian concept of character friendship. Character friendship constitutes a unique form of experience in which we share a substantial way of seeing with a close other; facilitates a unique form of knowledge, the knowledge of a particular person ; develops other emotions important for virtue cultivation besides admiration, such as love, shame, trust, and hope; and is a praxis in which cooperative interactions and discussions function as a bridge between habituation of virtue at home and the public life. Character friendship provides necessary elements for human cultivation of virtue that the sole experience of having a role model does not. (shrink)

Inhaltsverzeichnis/Table of Contents:IntroductionAntónio ZILHÃO: Folk-Psychology, Rationality and Human ActionJoão BRANQUINHO: The Problem of Cognitive DynamicsJ.P. MONTEIRO: Hume, Induction and Single ExperimentsMarco RUFFINO: The Primacy of Concepts and the Priority of Judgments in Frege's LogicJoão Vergílio Gallerani CUTER: Die unanwendbare Arithmetik des TractatusSílvio PINTO: Wittgenstein's Anti-PlatonismFernando FERREIRA: A Substitutional Framework for Arithmetical ValidityJ.R. CROCA & R.N. MOREIRA: Indeterminism Versus CausalismLuíz MONIZ PEREIRA: The Logical Impingement of Artifical Intelligence.

INCONTINENCE, HONOURING SUNK COSTS AND RATIONALITY According to a basic principle of rationality, the decision to engage in a course of action should be determined solely by the analysis of its consequences. Thus, considerations associated with previous use of resources should have no bearing on an agent’s decision-making process. Frequently, however, agents persist carrying on an activity they themselves judge to be nonoptimal under the circumstances because they have already allocated resources to that activity. When this is the case, agents (...) are said to be honouring sunk costs. Honouring sunk costs is thus typically viewed as irrational economic behaviour. Two striking findings of the psychological literature on the sunk cost effect are that it is, in general, not lessened by having taken previously courses in economics, and that agents who did take such courses and that do honour sunk costs seem to be frequently aware of a cognitive dissonance in their behaviour. Davidson’s account of the possibility conditions of incontinent action renders continent action materially unfeasible. The very idea of incontinent action becomes thus a hollow one. I’ll present an alternative description of these possibility conditions that renders continent action materially feasible, and both, continent and incontinent action, cognitively plausible. In a nutshell, my proposal rests upon the drawing of an essential cognitive contrast between explicit processes of deliberative reasoning and lower level heuristic procedures. I conclude the paper arguing that my redescription of incontinent action accounts for the above mentioned cognitive dissonance effect better than the alternatives and that viewing at least an important subset of behaviours of honouring sunk costs as incontinent actions will enable us to consider them as peculiar manifestations of a more general and meaningful pattern in human behaviour. (shrink)

En este artículo examino el problema de si la concepción socrática de la eudaimonia entraña el egoísmo. Esto es, si, según Sócrates, un hombre que actúa teniendo como criterio final su felicidad es un egoísta. Este punto de vista parece entrar en contradicción con lo que pensamos comúnmente acerca de lo que debe decir una teoría moral. Clasifico los intentos que se han hecho por resolver el problema en dos grupos: los formalistas y los sustantivistas, con base en sus objetivos (...) generales. Argumento que la segunda clase de enfoque es más efectiva, puesto que trata de interpretar la teoría de Sócrates como un todo y la hace más coherente. Asume que Sócrates ofrece una teoría de la motivación humana para actuar en la que el agente busca su felicidad, pero otorgando también una función central a la amistad, el amor y la justicia. (shrink)

Se trata de mostrar y analizar algunas de las lecturas que se han hecho de la obra de Mohandas Gandhi en América Latina en las últimas décadas, a través de un escrito que se balancea entre una investigación empírica y el estudio de un caso que permite presentar dos problemas teóricos. Para esto se abordan autores y autoras de diversos países de la región, que permiten aludir a dos problemas teóricos que se formulan en este trabajo: la circulación de las (...) ideas entre regiones Sur-Sur, la reelaboración de las ideas en la región receptora. Estos problemas son claves en el desarrollo de los estudios eidéticos como disciplina. Se realiza una introducción respecto a la recepción de las ideas de Gandhi en la región hacia 1930, estudiando las articulaciones del pensamiento de éste con otros autores y tendencias de pensamiento y señalando algunas recepciones y cruzamientos posteriores. Luego el trabajo se focaliza en estudiosos de Argentina, Brasil, Chile, México, Nicaragua, Puerto Rico y Venezuela, tratando de presentar varios casos diferentes y que cubran numerosos países de la región, apuntando a un muestreo válido, aunque sin suficiente afirmación metodológica. The intention of this work is to show and analyze some of the readings that have been done about Mohandas Gandhi’s work in Latin America in the last decades, by means of a writing that swings between an empirical research and the study of a case that allows to present two theoretical problems. For this there are approached authors and authoresses of diverse countries of the region, who allow to allude to two theoretical problems that are formulated in this work: the flow of the ideas between South-South regions, the reformulation of the ideas in the receiving region. These issues are key to the development of the eidéticos studies as a discipline. An introduction is made regarding the reception of the ideas of Gandhi in the region by 1930, studying the joints of his thought and of those of other authors and trends of thought, pointing out some receptions and later crosses. Then the work focuses in experts of Argentina, Brazil, Chile, Mexico, Nicaragua, Puerto Rico and Venezuela, trying to present several different cases covering numerous countries of the region, pointing at a valid sampling, though without sufficient methodological affirmation. (shrink)

Que se ha llamado “ética del cuidado”de si tal ética podría remplazar la éticason razonables. Al final del artículofundamental para la construcción de unabuena teoría ética.

El artículo muestra la forma en que laepistemología de las virtudes puederesolver algunos de los problemasepistemológicos clásicos, y la manera enque puede lograrse una concepciónintegrada de las variantes confiabilistay responsabilista de la epistemología delas virtudesThis paper shows the way in which Virtue Epistemology can solve some ofthe classical epistemological problems,and the way in which an integrated approach of the Reliabilist and Responsibilist variants of Virtue Epistemology can be achieved.

La realidad social, política, económica y sanitaria que experimentamos hoy denota que vivimos una crisis planetaria que convulsa al conjunto de las relaciones sociales. Es un imperativo teórico, retomar la fecundidad del concepto de persona y la crítica de Emmanuel Mounier al positivismo y al marxismo del siglo XX. Su crítica se basó en la noción de persona, de profunda raíz en la teología cristiana occidental y hoy considerado Patrimonio Cultural de la Humanidad al permitir fundamentar la validez global de (...) los Derechos Humanos y la posibilidad de la creación de una Ética Universal. En la presente investigación se propone redimensionar el valor de la filosofía personalista de Mounier y su activismo evangélico hacia los pobres, como un nuevo humanismo de una dimensión más que teórica, práctica. A través de una revisión cronológica y bibliográfica de los momentos más relevantes del personalismo, esta investigación se propone en su conclusión, comprender la fecundidad de la reflexión del concepto de persona, como de la vigencia de la crítica de este pensador al positivismo y al marxismo; para contribuir a situar el eje ético y político- social de la actual situación sociosanitaria que atraviesa la humanidad. (shrink)

Este artículo reconstruye panorámicamente la posición de Agustín de Hipona con respecto a la filosofía en la obra De civitate Dei. Sostiene que la valoración y el reproche que le hace Agustín a los platonici descansan en último término en un concepto de filosofía tomado del mismo platonismo y reinterpretado según textos bíblicos que enfatizan la centralidad de la mediación y el culto para alcanzar la beata vita.

Introducción: las tecnologías de la información y las comunicaciones se utilizan cada vez más en las universidades como medios de enseñanza. Se ha optado por el uso de los objetos de aprendizaje para lograr la reutilización, accesibilidad, durabilidad e interoperabilidad en sus recursos educativos. Objetivo: enunciar algunos de los valores humanos que se que se manifiestan en el proceso de autoformación con los objetos de aprendizaje. Método: se utilizó la observación como método científico durante el proceso enseñanza-aprendizaje con los objetos (...) de aprendizaje para la autoformación de los estudiantes. Resultados: se enunciaron algunos valores intelectuales, éticos, estéticos, físicos, morales y sociales, que se revelan en el proceso de autoformación con los objetos de aprendizaje. Conclusiones: Los valores humanos que manifiestan los estudiantes durante el proceso de autoformación con los objetos de aprendizaje sirven para establecer juicios de valor consistentes, derivados de modos de pensar y sentir que les permitan enfrentar sus decisiones vitales. Introduction: Information technology and communications are increasingly used in universities as teaching means in the teaching-learning process. The use of learning objects has been opted to achieve reusability, accessibility, durability and interoperability in its educational resources. Objective: To enunciate some human values occurring in the process of self-education with learning objects. Method: The observation as a scientific method for the teaching-learning process with learning objects for independent self-training of students was used. Results: There have been enunciated some intellectual, ethical, aesthetic, physical, moral and social values that are revealed in the process of self-training with learning objects. Conclusions: The human values that students showed during self-training with learning objects serve to establish consistent value judgments derived from modes of thinking and feeling that enable them to cope with their vital decisions. (shrink)

El cuerpo se presenta en una doble perspectiva como mediación en la configuración de la realidad y como elemento de alienación para el sujeto. Esta condición estudiada ya en autores como Marcel, Sartre y Merleau Ponty es retomada aquí como posibilidad para entender mejor las relaciones del hombre con el mundo y las diferentes vivencias que el ser humano experimenta en el proceso de su existencia. Para la Antropología filosófica entender la mediación cuerpo humano — mundo se convierte en punto (...) de partida y eje de estudios interdisciplinares que generan y facilitan un conocimiento integral del hombre como es el caso del estudio fenomenológico de la enfermedad y el dolor. (shrink)

Sartre considers the rise of spontaneous not cognitive consciousness or prereflexive cogito as a subject. Without any conditions, without any nature or essence can be determined. The awareness event as an absolute necessity is indeed unjustifiable that refers to the world, is pure intentionality. The abstract ideal of freedom for Sartre is a conscience without any determination. Man is free because it is free of any determination by precognitive structure of consciousness.

Derecho natural y positivismo jurídico.--Derecho y poder.--Ley y conciencia.--Hans Welzel.--Obras de Hans Welzel.

Caro leitor! Em busca de sempre mais apresentar reflexões consistentes e relevantes para o pensar teológico, em conexão com o mundo e às urgências da Igreja, a presente edição trás importantes temas que ajudam refletir a realidade humana à luz do mistério de Deus. Por isso, os artigos oferecidos nas mais variadas áreas, a saber: bíblico-teológica, dogmática, moral, pastoral, antropologia teológica, filosofia e eclesiologia, dão suporte científico e metodológico para a reflexão teológica. Antes de conferir as novidades desta edição, gostaria (...) de comunicar que esta Revista Eletrônica conquistou um espaço ainda maior de publicação, ao tornar-se indexada na base de dados do Directory of Open Access Journals (DOAJ). (shrink)

En este trabajo presentamos el proceso del ordenamiento, catalogación y curaduría de los materiales fotográficos de un antropólogo estadounidense que realizó trabajo de campo en Atlixco, Puebla, México, con indígenas de la etnia nahua en las décadas de 1970 y 1980La metodología utilizada para este trabajo se basó en una propuesta propia de catalogación mínima de materiales fotográficos.Concluimos que la catalogación mínima es adecuada para la interoperabilidad con los estándares internacionales y resulta fácil de aplicar en los contextos universitarios y (...) de archivos locales. (shrink)

The paper contains a conceptual analysis of “act of toleration” and the property of “being tolerant”. Being tolerant is understood as a dispositional property of persons manifested in what the author calls the “circumstances of toleration”. The main circumstances distinguished are: a tendency to prohibit a certain behaviour and the competence to determine the deontic status of the behaviour in question. An act of toleration, then, consists in not prohibiting (or cancelling the prohibition of) that behaviour. It is argued that (...) this requires the existence of two different normative systems, the “basic system”, and the “justifying system”. Acts of toleration must be based on reasons coming from the latter. This insight enables one to establish a difference between reasonable and unreasonable toleration, as well as between toleration and related concepts like indifference, acquiescence, etc. The analysis also introduces the distinction between “vertical” and “horizontal” toleration. Acceptance of this last category implies that toleration does not necessarily require hierarchical relationships between those who tolerate and those whose actions are tolerated. (shrink)

The article analyses the distinction between the private and the public sphere from a conceptual and from a normative point of view. On the conceptual level, it is argued that the common dichotomous view is incomplete, giving rise to conceptual confusions which can be overcome by a careful distinction between the intimate and the private sphere. While the boundary between the private and the public is a conventional matter, the sphere of intimacy, including thoughts as well as a certain type (...) of actions, is empirically delimited. On the normative level, a number of arguments for or against the extension or restriction of the private sphere as well as for or against the intervention of the state in its citizens’ spheres of intimacy is discussed from a liberal point of view. (shrink)

Un problema puede ser viejo por persistente, porque todavía no se ha encontrado la respuesta adecuada. Pero también puede ser viejo por recurrente, por reaparecer cuando se eliminan las condiciones que hicieron posible su solución en el pasado. Y un problema es nuevo cuando es el resultado de desafíos inéditos o hasta ahora desconocidos. El Estado de Derecho y Terrorismo es un viejo problema recurrente. El impacto de las investigaciones neurológicas en el concepto de responsabilidad es un viejo problema persistente. (...) La erosión de las estructuras institucionales a nivel internacional es un viejo problema persistente. Un nuevo problema es la relación entre ética, política y derecho desde el punto de vista de una fi losofía analítica. Enfrentarse a estos viejos y nuevos problemas de la fi losofía del derecho desde una perspectiva analítica en el contexto de América Latina es una tarea doblemente difi cultosa. (shrink)

This article aims to propose some connections between the conceptions of poetry of the Mexican poet Octavio Paz and the German philosopher Martin Heidegger. Both see in poetry the element of recognition of the original condition of the human being, not as an interpretation, but as a perception and affectation of the existential reality of human beings. So that the event of the "poetic saying" is configured as a call to the possibility of glimpsing the being of each entity, inhabiting (...) oneself and, thus, learning to be with others, establishing the poetic field as the clearing of perception and of existential affectation. Poetic speech goes beyond the limits of language, creating and establishing meanings and representations to the affectations that poetry provides. Thus, through poetry man recognizes himself in his worldliness, in search of his own being and in his relationship with other beings. (shrink)

Columbia University Press's multivolume _Prison Notebooks_ is the only complete critical edition of Antonio Gramsci's seminal writings in English. Based on the authoritative Italian edition of Gramsci's work, _Quaderni del Carcere_, this comprehensive translation presents the intellectual as he ought to be read and understood, with critical notes that clarify Gramsci's history, culture, and sources; an index of names; and a contextualization of the thinker's ideas against his earlier writings and letters. This set includes notebooks 1 through 8 with (...) all attendant notes and materials and is an indispensible resource for scholars in the humanities and social sciences. (shrink)