Short-term limb immobilization results in skeletal muscle decline, but the underlying mechanisms are incompletely understood. This study aimed to determine the neurophysiologic basis of immobilization-induced skeletal muscle decline, and whether repetitive Transcranial Magnetic Stimulation could prevent any decline. Twenty-four healthy young males underwent unilateral limb immobilization for 72 h. Subjects were randomized between daily rTMS using six 20 Hz pulse trains of 1.5 s duration with a 60 s inter-train-interval delivered at 90% resting Motor Threshold, or Sham rTMS throughout immobilization. (...) Maximal grip strength, EMG activity, arm volume, and composition were determined at 0 and 72 h. Motor Evoked Potentials were determined daily throughout immobilization to index motor excitability. Immobilization induced a significant reduction in motor excitability across time. The rTMS intervention increased motor excitability at 0 h. Despite daily rTMS treatment, there was still a significant reduction in motor excitability, loss in EMG activity, and a loss of maximal grip strength after immobilization. Interestingly, the increase in biceps and posterior forearm skinfold thickness with immobilization in Sham treatment was not observed following rTMS treatment. Reduced MEPs drive the loss of strength with immobilization. Repetitive Transcranial Magnetic Stimulation cannot prevent this loss of strength but further investigation and optimization of neuroplasticity protocols may have therapeutic benefit. (shrink)

Yes, Aristotle was named ‘Aristotle’. I want to show that since ‘Aristotle’ is a proper name, this is true by definition. My theory of proper names is a version of Russell's, a theory that a name is equivalent in meaning to definite description which single out the individual, if there is one, to which the name refers. Braithwaite at one time said that the proper name ‘Aristotle’ meant the description ‘the individual named “Aristotle” ’. This theory, which makes it (...) contradictory to suppose that Aristotle was not named ‘Aristotle’ I will argue is the correct one. This will involve some explanation of what naming is, which I will carry out in the first two sections. My contention is that naming is an activity that can be done either explicitly or non-explicitly. And names can be conferred either on the basis of acquaintance or by associating the name with descriptions. (shrink)

Dans la genese de sa constitution, la philosophie n'a pu faire l'economie d'une confrontation avec la musique qui fournissait aux anciens Grecs les schemes fondamentaux de la culture. De cette confrontation Platon est le temoin. Scindant la musique, il privilegie l'Harmonique, qui en est la partie theorique, sans toutefois lui reconnaitre la titre de science supreme. Correlativement, il condamne comme dysharmonie, tumulte fracassant et perturbateur de l'ordre cosmique, l'harmonie chromaticiste dont il s'emploie, non sans paradoxe, a decrire le detail. Par (...) cette lecture en filigrane des Dialogues de Platon, l'auteur se propose de reconstruire la pensee qui procede de l'harmonie chromaticiste et de montrer son importance dans l'elaboration de la philosophie fondatrice. Au carrefour des disciplines du savoir antique, ce livre s'adresse non seulement aux philosophes, mais aussi a tous ceux qui, musiciens ou stylisticiens, s'interessent a la forme musicale. (shrink)

In this paper, I take a critical look at Sartorio’s book Causation and Free Will (2016). Sartorio offers a rich defence of an actual-sequence view of freedom, which pays close attention to issues in the philosophy of causation and how they relate to freedom. I argue that although this focus on causation is illuminating, Sartorio’s project nevertheless runs into some serious difficulties. Perhaps most worrying amongst them is whether the agent-based reason-sensitivity account, offered by Sartorio, is consistent with Frankfurt-style cases (...) – the very cases which are provided as the sole reason to endorse an actual-sequence view of freedom. I suggest that given that powers and causation are so intimately bound together, the debate is skewed somewhat by thinking of these as rivals. (shrink)

_A portion of the revenue from this book’s sales will be donated to Doctors Without Borders to assist the humanitarian work of nurses, doctors, and other health care providers in the fight against COVID-19 and beyond._ _Concepts and Cases in Nursing Ethics_ is an introduction to contemporary ethical issues in health care, designed especially for Canadian audiences. The book is organized around six key concepts: beneficence, autonomy, truth-telling, confidentiality, justice, and integrity. Each of these concepts is explained and discussed with (...) reference to professional and legal norms. The discussion is then supplemented by case studies that exemplify the relevant concepts and show how each applies in health care and nursing practice. This new fourth edition includes an added chapter on end-of-life issues, and it is revised throughout to reflect the latest developments on topics such as global health ethics, cultural competence, social media, and palliative sedation, as well as ethical issues relating to COVID-19. (shrink)

This paper aims to identify some of the values held by physicians in the United States that are relevant to physician strikes and other collective actions, and to articulate a position about collective actions that is consistent with medical professionalism. The concept of medical professionalism includes several elements to which physicians should aspire, but the fundamental definition of professionalism is based on just one of these elements, the virtue of altruism. As stated by a committee project paper of the American (...) Board of Internal Medicine. (shrink)

Concepts and Cases in Nursing Ethics maps the ethical landscape of contemporary nursing. The book is the product of a collaboration between philosopher-ethicist Michael Yeo, nurse-ethicist Anne Moorhouse, and six representatives of various areas of professional nursing. It thus combines philosophical and ethical analysis with nursing knowledge and experience in a manner that is both understandable and relevant. The book is organized around six main concepts in nursing ethics: beneficence, autonomy, confidentiality, truth-telling, justice, and integrity. A chapter is devoted to (...) the elucidation of each of these concepts. In each chapter, historical background and conceptual analysis are supplemented by case studies that exemplify issues and show how the concept applies in nursing practice. In this new edition, the materials in each chapter have been updated to reflect recent developments in nursing and more generally in health care. In addition, a totally new chapter on ethical theory has been added. Complete with bibliographies and study questions for further analysis of cases, this book is ideally suited for textbook use. It will help both practitioners and students to deal better with the clinical problems and issues that are encountered in the field. However, it's simple prose and clear exposition of complex issues will make Concepts and Cases in Nursing Ethics attractive to anyone concerned about health care. (shrink)

Some theories of goodness are descriptively rich: they have much to say about what makes things good. Neo-Aristotelian accounts, for instance, detail the various features that make a human being, a dog, a bee good relative to facts about those forms of life. Famously, such theories of relative goodness tend to be comparatively poor: they have little or nothing to say about what makes one kind of being better than another kind. Other theories of goodness—those that take there to be (...) absolute goodness—are comparatively rich: they offer grounds for judging some types of things better than others because they have more absolute goodness. Moorean accounts, for example, can tell us that humans and human experiences are superior to bees and blades of grass. But such theories tend to be descriptively poor: they struggle to tell us in virtue of what this is so. In this essay we motivate and flesh out a view that splits the difference between accounts of goodness as relative and accounts of goodness as absolute. Such a view holds promise only if the mechanics of this kind of metaphysics of goodness can be worked out. Here we present a view on which the paradigm for absolute goodness is God and the paradigm for each kind of relative goodness is a divine idea. (shrink)

This book is an intercultural exploration of the full scope of evil. The problems of evil have beset humanity throughout the ages and continue to trouble us. The studies here examine evil in Asian thought, in Western theory, in the cosmic order, in human psychology, and in social practice. Insights are added to the philosophical discussions from religion, culture, history, law, technology, and literature.

La 4ème de couverture indique : "Cet ouvrage, qui réunit juristes, sociologues, anthropologue et psychanalyste, se propose de saisir la place du genre en bioéthique à l'heure de questions sociétales liées tant aux progrès de la médecine reproductive qu'aux rôles assignés aux femmes et aux hommes à l'intérieur de la famille ou en dehors de celle-ci. Il s'agit, au travers de regards croisés, d'éclairer le débat du genre au sein de la sphère bioéthique en identifiant, au sein et au-delà des (...) thèmes de la procréation, de la parentalité et du patrimoine, les questions juridiques qui peuvent naître de la rencontre de la bioéthique et du genre. Les sujets sont nombreux, regroupés autour d'interrogations telles que : le genre est-il reçu dans le droit du vivant? Que font les lois bioéthique au genre? Y a-t-il un âge pour procréer? Existe-t-il une égalité entre les femmes et les hommes en termes d'accès aux soins? Assiste-t-on à une désexualisation du couple? Peut-on parler de patrimoine sexuel?... Éventail d'interrogations, diversité des opinions : les meilleurs spécialistes de chaque question abordée y analysent les réponses fournies par le droit en livrant des pistes de réflexion sur le traitement des inégalités ou des différences existant entre hommes et femmes dans l'exercice, parfois l'existence, des droits et libertés qui sont les leurs en ce domaine.". (shrink)

COVID-19 vaccine refusal seems like a paradigm case of irrationality. Vaccines are supposed to be the best way to get us out of the COVID-19 pandemic. And yet many people believe that they should not be vaccinated even though they are dissatisfied with the current situation. In this paper, we analyze COVID-19 vaccine refusal with the tools of contemporary philosophical theories of responsibility and rationality. The main outcome of this analysis is that many vaccine-refusers are responsible for the belief that (...) they should not be vaccinated and epistemically rational in holding it. This is an important result because it provides insights into the legitimacy of certain public health policies. In particular, this result shows that a public health policy that would abandon the project of convincing certain vaccine-refusers with reasons – e.g., by simply making vaccination compulsory – is prima facie illegitimate. (shrink)

Baised upon the Tarner Lectures given by Braithwaite in 1946, Scientific Explanation aims to examine the logical features common to all the sciences. Scientific advancement is by means of testing the conclusions of proffered hypotheses by observation and experiment. Braithwaite attempts to explain how the implications of this process may throw light upon seemingly mysterious features of scientific procedure and should resolve many of the fundamentals of scientific procedures, including the function of mathematics, probability, and models in science (...) and the nature of theoretical concepts. (shrink)

First published in 1984, this book examines corporate crime in the pharmaceutical industry. Based on extensive research, including interviews with 131 senior executives of pharmaceutical companies in the United States, the United Kingdom, Australia, Mexico and Guatemala, the book is a major study of white-collar crime. Written in the 1980s, it covers topics such as international bribery and corruption, fraud in the testing of drugs and criminal negligence in the unsafe manufacturing of drugs. The author considers the implications of his (...) findings for a range of strategies to control corporate crime, nationally and internationally. (shrink)

A new approach to sentencing Not Just Deserts inaugurates a radical shift in the research agenda of criminology. The authors attack currently fashionable retributivist theories of punishment, arguing that the criminal justice system is so integrated that sentencing policy has to be considered in the system-wide context. They offer a comprehensive theory of criminal justice which draws on a philosophical view of the good and the right, and which points the way to practical intervention in the real world of incremental (...) reform. They put the case for a criminal justice system which maximizes freedom in the old republican sense of the term, and which they call `dominion'. (shrink)

The meaning of life and man's alienation from himself and his natural environment is examined in brief selections, illustrated with photographs, from the works of Albert Schweitzer.

Puisqu’elles sont considérées comme des produits du monde occidental et de son modèle libéral, les églises évangéliques en Russie sont soumises à un contrôle accru des autorités gouvernementales. L’engagement politique des membres de ces églises est de ce fait souvent subi ou forcé, et il s’inscrit dans une critique à peine voilée de la société russe dans son ensemble. Cela se traduit par le recours de la part des évangéliques à des réseaux socioprofessionnels qui se développent en dehors des réseaux (...) habituels et surtout, tournés vers l’extérieur. Les individus les plus en rupture optent souvent pour l’émigration vers les pays occidentaux. (shrink)

Pionnière dans la pénalisation du viol en 1980, la France a été en eurocrime qu’aurait entraîné l’unanimité dans l’acceptation de la nouvelle définition proposée par la Commission européenne. L’absence de consentement devient finalement pour tous le critère principal, et de nombreux pays ont aligné récemment leur législation avec la directive européenne. Sur le droit à l’avortement, la convergence est moins sensible, plusieurs pays mettent d’importantes restrictions. La constitutionnalisation de la liberté d’avorter et de sa garantie en France va peut-être conduire (...) à son inscription dans les droits humains. (shrink)

ZusammenfassungDer Beitrag fragt nach dem Stellenwert des Normalitätsbegriffs im Diskurs der Behinderung. Ausgangspunkt ist die These, dass Normalität und Normativität analytisch voneinander getrennt werden müssen. In der heutigen Normalisierungsgesellschaft existieren sowohl wertbezogene, präskriptive ("normative") als auch statistisch fundierte, deskriptive ("normalistische") Normen. Außerdem lassen sich zwei Normalisierungsstrategien kennzeichnen: ein starr ausgrenzender, normierender Ansatz ("Protonormalismus") und eine flexible, normalisierende Strategie ("flexibler Normalismus"). Auf dieser theoretischen Folie wird diskutiert, ob sich im behindertenpolitischen Diskurs und in sozialpolitischen Konzepten Tendenzen der flexiblen Normalisierung auffinden lassen. (...) Der Schwerpunkt des Beitrags liegt auf einer normalitätstheoretischen Analyse der beiden Klassifikationsmodelle der Weltgesundheitsorganisation. Die "International Classification of Impairments, Disabilities and Handicaps" (ICIDH 1980) blieb noch der wertbezogenen Normativität verhaftet. Dagegen stellt die "International Classification of Functioning, Disability and Health" (ICF 2001) die normalistische (Vergleichs-)Norm ins Zentrum und formuliert das Gebot der Selbstnormalisierung. (shrink)

Was passiert, wenn die Bevölkerung die Möglichkeit erhält, sich ungeschminkt und ungefiltert zu bioethischen Problemstellungen zu äußern?