Recent years have witnessed intensive efforts to specify which requirements ethical artificial intelligence (AI) must meet. General guidelines for ethical AI consider a varying number of principles important. A frequent novel element in these guidelines, that we have bundled together under the term explicability, aims to reduce the black-box character of machine learning algorithms. The centrality of this element invites reflection on the conceptual relation between explicability and the four bioethical principles. This is important because the application of general ethical (...) frameworks to clinical decision-making entails conceptual questions: Is explicability a free-standing principle? Is it already covered by the well-established four bioethical principles? Or is it an independent value that needs to be recognized as such in medical practice? We discuss these questions in a conceptual-ethical analysis, which builds upon the findings of an empirical document analysis. On the example of the medical specialty of radiology, we analyze the position of radiological associations on the ethical use of medical AI. We address three questions: Are there references to explicability or a similar concept? What are the reasons for such inclusion? Which ethical concepts are referred to? (shrink)

Employee shareholder associations (ESAs) have emerged as a novel, and widely underestimated actor in the European corporate arena, established to collect and pool the shares and voting power held by a company's employees. As such, they parallel existing institutions for employee representation, potentially empowering employees in their role as shareholders and possibly even providing a counterweight to traditional company owners. Unfortunately, we know little about the actual functioning, the inner workings, and, particularly, the ESAs' contributions to date. To address these (...) shortcomings this paper explores the limitations but also the potential of ESAs in large, German listed companies to contribute to employee share ownership (ESO), to organizational democracy (OD), and to corporate sustainability (CS). Our findings show that, as far as ESOs and OD are concerned, in the specific German context, ESAs usually do not offer alternatives to (or even to compete with) existing employee representation but are instead rather dependent on cooperation with them. Regarding CS, any contribution here is closely linked to the ESAs' own principles and depends on the extent to which the ESA management takes them seriously and prioritizes them over other objectives. (shrink)

This essay is part of a project that has set out, as one of its primary objectives, to observe perversions as important indicators of broader changes and developments within society. Both of the momenta I follow in this study meet all the requirements for such an inquiry. The first development to be examined is what I will call the decline of pornography. At a time when all of society is increasingly becoming pornographic in so many ways, it sounds strange to (...) talk about the decline of pornography. And yet pornography as a genre is, I believe, losing ground to something else – to a distinctly different system of unfolding sexuality and its economic exploitation. The second development to be discussed is the rise of masochism. In this context, I will analyse certain reports that show that, especially since the outbreak of the pandemic COVID-19, the number of people practicing masochistic “heavy play” has increased significantly. It appears that in a period when one would expect people to be dreaming of the lifting of restrictions, freedom, or whatever, many have chosen to undertake the cruel path of “servitude”. Eventually, I will show that these two developments are essentially connected, probably even consubstantial. (shrink)

The article is primarily a study of Nietzsche’s unpublished fragments from the period spring-autumn 1881, in which Nietzsche first developed his thought of the “eternal recurrence of the same.” In the article, I attempt to accomplish two goals: the first goal is to explain Nietzsche’s theses on the eternal recurrence, which at that time were still remarkably clear and coherent. And the second goal is to try to find in these same theses an explanation for their future silence. In other (...) words, the article examines the relationship between Nietzsche’s theses that he developed in 1881 and his book _Thus spoke Zarathustra_, which, in Nietzsche’s own words, relies on these theses as their “grounding thought,” but nevertheless never fully reveals them. Both lines of inquiry lead to the conclusion that the core of Nietzsche’s introduction of the idea of eternal recurrence is his concept of _Einverleibung_ or embodiment. Indeed, the analysis shows that Nietzsche’s main concern with the thought of eternal recurrence was not to set forth its clear articulation within consciousness, but rather to construct it in such a way that it could become an unconscious instinct capable of gradually displacing the “embodied mistakes” that dominate our thinking from within itself. (shrink)

The paper is primarily devoted to Nietzsche’s account of cruelty, which represents an indispensable key to understanding Nietzsche’s genealogical project in many of its essential aspects. This study is complemented by parallels with two other outstanding intellectual figures of the late nineteenth century: Fyodor Mikhailovich Dostoevsky and Leopold von Sacher-Masoch. Dostoevsky wrote that “civilisation has made mankind if not more bloodthirsty, at least more vilely, more loathsomely bloodthirsty.” Nietzsche went a step further in this assessment: not only does civilisation not (...) make us immune to cruelty, but it must itself be seen to emerge directly from cruelty at every significant step it has taken. What brings Nietzsche close to Masoch, on the other hand, is the fact that these historical or even prehistorical developments that have shaped humankind and civilisation are not only related to cruelty, but must be observed as various forms of the internalisation (“spiritualisation”, “deification”) of cruelty. The core of the study is devoted to analyses of different forms and aspects of Nietzsche’s concept of the internalisation of cruelty (in relation to power-relations, subject-object relations, mutations of pleasure, and perversions). (shrink)

The vertebrate eye lens has been used extensively as a model for developmental processes such as determination, embryonic induction, cellular differentiation, transdifferentiation and regeneration, with the crystallin genes being a prime example of developmentally controlled, tissue‐preferred gene expression. Recent studies have shown that Pax‐6, a transcription factor containing both a paired domain and homeodomain, is a key protein regulating lens determination and crystallin gene expression in the lens. The use of Pax‐6 for expression of different crystallin genes provides a new (...) link at the developmental and transcriptional level among the diverse crystallins and may lead to new insights into their evolutionary recruitment as refractive proteins. (shrink)

Knjiga vsebuje filozofske in estetiške študije, v katerih avtor obravnava nekatere osrednje sodobne probleme estetike, umetnosti in kulture.

This paper deals with the theoretical concepts of image and imagery as used by the foremost imaginal psychologists. Attributing primary epistemological status to image and imagery, imaginal psychology school developed a new theory of image and imagery, questioning the older thesis on the derivative and secondary epistemological status of the image. Using Jung’s concept of the autonomous psyche of an essentially archetypal nature, Hillman started to question Jung’s concept of the Self as a central archetype symbolizing a sort of disguised (...) traditional monotheism (the Christian God, the Jewish Yahweh etc.) like Freud’s sexuality (id) or central cultural myth (the Oedipus myth). Imaginal psychology defends essential sovereignty and the equality of all images and the resultant polytheist psychology. Jungian studies set out it this direction, giving birth to parallel developments to imaginal psychology in various fields. Derrida’s and Feyerabend’s rejection of an ultimate referential frame was not identical to but corresponds to Hillman’s and Vannoy Adam’s discovery that it is fantasy that rules the psyche. (shrink)

Biomarker-based predictive tests for subjectively asymptomatic Alzheimer’s disease (AD) are utilized in research today. Novel applications of artificial intelligence (AI) promise to predict the onset of AD several years in advance without determining biomarker thresholds. Until now, little attention has been paid to the new ethical challenges that AI brings to the early diagnosis in asymptomatic individuals, beyond contributing to research purposes, when we still lack adequate treatment. The aim of this paper is to explore the ethical arguments put forward (...) for AI aided AD prediction in subjectively asymptomatic individuals and their ethical implications. The ethical assessment is based on a systematic literature search. Thematic analysis was conducted inductively of 18 included publications. The ethical framework includes the principles of autonomy, beneficence, non-maleficence, and justice. Reasons for offering predictive tests to asymptomatic individuals are the right to know, a positive balance of the risk-benefit assessment, and the opportunity for future planning. Reasons against are the lack of disease modifying treatment, the accuracy and explicability of AI aided prediction, the right not to know, and threats to social rights. We conclude that there are serious ethical concerns in offering early diagnosis to asymptomatic individuals and the issues raised by the application of AI add to the already known issues. Nevertheless, pre-symptomatic testing should only be offered on request to avoid inflicted harm. We recommend developing training for physicians in communicating AI aided prediction. (shrink)

Since 1989, clinical ethics consultation in form of hospital ethics committees was established in most of the transition countries of Central and Eastern Europe. Up to now, the similarities and differences between HECs in Central and Eastern Europe and their counterparts in the U.S. and Western Europe have not been determined. Through search in literature databases, we have identified studies that document the implementation of clinical ethics consultation in Central and Eastern Europe. These studies have been analyzed under the following (...) aspects: mode of establishment of HECs, character of consultation they provide, and their composition. The results show that HECs in the transition countries of Central and Eastern Europe differ from their western-European or U.S. counterparts with regard to these three aspects. HECs were established because of centrally imposed legal regulations. Little initiatives in this area were taken by medical professionals interested in resolving emerging ethical issues. HECs in the transition countries concentrate mostly on review of research protocols or resolution of administrative conflicts in healthcare institutions. Moreover, integration of non-professional third parties in the workings of HECs is often neglected. We argue that these differences can be attributed to the historical background and the role of medicine in these countries under the communist regime. Political and organizational structures of healthcare as well as education of healthcare staff during this period influenced current functioning of clinical ethics consultation in the transition countries. (shrink)

During development of the anterior eye segment, cells that originate from the surface epithelium or the neuroepithelium need to interact with mesenchymal cells, which predominantly originate from the neural crest. Failures of proper interaction result in a complex of developmental disorders such Peters' anomaly, Axenfeld–Rieger's syndrome or aniridia. Here we review the role of transcription factors that have been identified to be involved in the coordination of anterior eye development. Among these factors is PAX6, which is active in both epithelial (...) and mesenchymal cells during ocular development, albeit at different doses and times. We propose that PAX6 is a key element that synchronizes the complex interaction of cell types of different origin, which are all needed for proper morphogenesis of the anterior eye. We discuss several molecular mechanisms that might explain the effects of haploinsufficiency of PAX6 and other transcription factors, and the broad variation of the resulting phenotypes. BioEssays 26:374–386, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

In order to build on the information that was obtained in the course of the first study, a follow-up survey was conducted first by phone and subsequently in a written form between August and October 2014. We contacted 1.858 hospitals in all of Germany for the follow-up survey by phone. In cases where a hospital had not participated in the first study, the willingness to participate in the follow-up survey was established in advance. The survey’s dispatch was ensured in the (...) case of acceptance. The same structured survey was used as a research tool. The data of the first study and the follow-up survey were merged and evaluated. 654 surveys could be evaluated altogether. Our survey by phone revealed that 912 hospitals in all of Germany have at least one form of clinical ethics consultation available. The health care ethics committee is the most frequently implemented structure of clinical ethics consultation. The implementation of clinical ethics consultation is dependent on sponsorship and hospital size. Recommendations to deliver structures of clinical ethics consultations have a smaller influence on the implementation compared to the certification by KTQ respectively proCum Cert. The rate of implementation in regard to the structures of clinical ethics consultation has steadily increased for years. The establishment of clinical ethics consultation in German hospitals should be further promoted. It would be desirable further to develop suitable juridical regulations in order to implement clinical ethics consultation as well as structural parameters. (shrink)

A tension between perspectives that emphasize deterministic versus stochastic processes has sparked controversy in ecology since pre-Darwinian times. The most recent manifestation of the contrasting perspectives arose with Hubbell’s proposed “neutral theory”, which hypothesizes a paramount role for stochasticity in ecological community composition. Here we shall refer to the deterministic and the stochastic perspectives as the niche-based and neutral-based research programs, respectively. Our goal is to represent these perspectives in the context of Lakatos’ notion of a scientific research program. We (...) argue that the niche-based program exhibits all the characteristics of a robust, progressive research program, including the ability to deal with disconfirming data by generating new testable predictions within the program. In contrast, the neutral-based program succeeds as a mathematical tool to capture, as epiphenomena, broad-scale patterns of ecological communities but appears to handle disconfirming data by incorporating hypotheses and assumptions from outside the program, specifically, from the niche-based program. We conclude that the neutral research program fits the Lakatosian characterization of a degenerate research program. (shrink)

This book proposes a new interpretative key for reading and overcoming the binary of idealism and realism. It explores the way human consciousness unfolds through the relationship between the I and the world-a field of phenomenological investigation that cannot and must not remain closed within the limits of its own disciplinary boundaries. The book focuses on the question of realism in contemporary debates, ultimately dismantling prejudices and automatisms that one finds therein. It shows that at the root of the controversy (...) between realism and idealism there often lie equivocations of a semantic nature. By returning to the origins of modern phenomenology this study mines the Husserlian concept of transcendental idealism. Following this path, and neutralizing the extreme positions of an acritical idealism and a naïve realism, the book proposes a "transcendental realism": the horizon of a dynamic unity that embraces the process of cognition and that grounds the relation, and not the subordination, of subject and object. The close reading of this reciprocity offered here allows one to surpass the limits of the domain of knowing, leading one to fundamental questions about the ultimate sense of things and their origin. (shrink)

German medical schools have not yet sufficiently introduced students to the field of good scientific practice. In order to prevent scientific misconduct and to foster scientific integrity, courses on GSP must be an integral part of the curriculum of medical students. Based on a review of the literature, teaching units and materials for two courses on GSP were developed and tested in a pilot course. The pilot course was accompanied by a pre-post evaluation that assessed students’ knowledge and attitudes towards (...) scientific integrity and scientific misconduct. A syllabus was designed that comprised the following six topics: theoretical foundations of GSP; scientific publishing; empirical data; scientific supervision and teamwork; clinical research; personal interests. The comparison pre versus post-intervention yielded statistically significant changes in regard to the participants’ knowledge and attitude toward all forms of scientific misconduct treated in the course. As the majority of participants was not familiar with the fundamental regulations or guidelines of GSP, it seems crucial to train students in actively applying such norms to real-world conflicts. Students’ unfamiliarity with the fundamentals of GSP can be linked to the fact that many students have already experienced forms of scientific misconduct. Thus, GSP syllabi should be closely adjusted to a student’s realm of experience. All in all, courses on GSP can be seen as a potential means to increase the number of young scholars. (shrink)

Der Unterricht in Medizinethik soll Medizinstudierenden die Grundlagen dafür vermitteln, in ihrer zukünftigen ärztlichen Tätigkeit gute Entscheidungen treffen zu können. Im Rahmen einer Panelstudie wird derzeit die Entwicklung moralischer Positionen, medizinethischer Kenntnisse und Motivationen von Medizinstudierenden der Ludwig-Maximilians-Universität München über den Verlauf des Studiums untersucht. Für die Datenerhebung wurde ein Fragebogen entwickelt, der medizinethische Positionen und Kenntnisse sowie Motivationen erfasst. Im Wintersemester 2009/10 wurde die erste Querschnittsuntersuchung mit Studierenden im 1., 3. und 8. Semester sowie im Praktischen Jahr durchgeführt. Die (...) Mehrzahl der Befragten verfügte über einen geringen Kenntnisstand in verschiedenen Themenbereichen des Unterrichtsfachs GTE. Rechtliche Grundlagen und praktische Umsetzung von Therapiebegrenzungsmaßnahmen waren bis ins PJ-Semester vielen Studierenden nicht bekannt. Im Verlauf des Studiums veränderten sich die Motivationen weg von der Motivation, Menschen helfen zu wollen, hin zu Wissenserwerb und dem Ergreifen eines sicheren Berufs. Obwohl viele Befragte ein hohes Interesse an medizinethischen Fragestellungen und Unterricht im Bereich GTE angaben, zeigte sich kein nachhaltiger Zuwachs an medizinethischen Kenntnissen im Laufe des Studiums. In der Zusammenschau werfen die Ergebnisse die Frage auf, inwieweit verschiedene Ausbildungskonzepte Einfluss auf die individuelle ethische Entwicklung Medizinstudierender nehmen können. Eine Untersuchung dieser Fragestellung bleibt Gegenstand weitergehender Forschung. (shrink)

The article draws attention to a certain multi-layered parallel between Nietzsche and Badiou’s theory of the event, which the author argues Badiou evaded by a kind of strategic relocation. The article does not focus so much on (and certainly not against) Badiou’s philosophy, but attempts to assess the possible implications of this relocation for Badiou’s interpretation of Nietzsche. In the first part of the article, the key concepts of Badiou’s account of Nietzsche are introduced, such as “archi-politics”, “antiphilosophy”, and the (...) “event Nietzsche”. Later, it is shown that, despite some fundamental differences, there is a strong resemblance between some key concepts of Badiou’s theory of the event, especially those related to the notion of “intervention”, and some concepts found in Nietzsche. Finally, the paper focuses on the problem of the “death of God”, which is somehow absent in Badiou’s interpretation, even though the term itself resonates strongly in various aspects of Badiou’s philosophy. (shrink)

V příspěvku připomínáme originální spolupráci s prof. P. Maternou, která začala v 60. letech minulého století a vedla ke vzniku třísložkové teorie jazyka, jejímiž autory jsou spolu s Pavlem Maternou Karel Pala a Aleš Svoboda. Články o třísložkové teorii byly publikovány v r. 1976 a 1979, ovšem jméno P. Materny se v titulcích článků ne­smělo objevit, byl tak komunistickým režimem trestán za vyloučení z KSČ v r. 1969. Třísložková teorie jazyka, jak název naznačuje, pokrývá tři základní komponenty sys­tému jazyka, (...) tedy syntax, sémantiku a pragmatiku, a je plně srovnatelná s podobnými pokusy u nás i v zahraničí. Stala se východiskem pro další propojení logiky, lingvistiky a informatiky díky působení K. Paly a P. Materny na Fakultě informatiky od roku 1995. Do této spolupráce se zapojili studenti Fakulty informatiky, zejména Aleš Horák, jehož zásadním příspěvkem je počítačová implementace systému transparentní intenzionální logiky (TILu) ve vztahu ke zpracování přirozeného jazyka (češtiny). (shrink)

The goal of this article is to analyze the way in which Edith Stein describes the human subject throughout her research, including her phenomenological phaseand the period of her Christian philosophy. In order to do this, I trace essential moments in Husserl’s philosophy, showing both Stein’s reliance upon Husserl andher originality. Both thinkers believe that an analysis of the human being can be carried out by examining consciousness and its lived experiences. Through suchan examination Stein arrives at the same conclusion (...) as Husserl, namely, that the human subject is formed of body, psyche, and spirit (Geist). Stein’s originalityconsists in a further development of the complexity of the human being. She maps this out, providing detailed analyses of the I, the soul, the spirit, and, ultimately,the person. She makes use of medieval philosophical anthropology, including that of Thomas Aquinas and Augustine of Hippo. (shrink)

In the study of the soul between psychology and phenomenology in Edith Stein works it becomes clearer that it is only phenomenology that really comes to gripswith the question of psychic causality by correlating the two moments and it is therefore only phenomenology that can respond to Hume’s objections while yetremaining on his selfsame terrain. It is very important to distinguish between psychology and phenomenology and also to clarify the relationship between psyche and consciousness; there is thus reproposed the distinction (...) already made by Husserl, who stressed that when one sets out to look for the causes that determine psychic life, they must not be sought in life feelings (Lebensgefühle) but rather in the „modes” of a life force (Lebenskraft) that is announced in them. All this is indicated here within limits because psychology in itself is undoubtedly not a science of the spirit, though the psychic states, on the other hand, will not be validly understood unless and until one arrives, as is demonstrated in the essay under consideration, at the motivation and therefore the spiritual sphere. We would say that our body is animated by a psyche and further enlivened by the spirit. (shrink)

This book reflects on Indonesia's recent experience with REDD (Reducing Emissions from Deforestation and forest Degradation), all set within a broader discussion of neoliberal environmentalism, hyper-capitalism and Indonesian carbon politics. Drawing on the author's political ethnographic fieldwork conducted in Jakarta, Central Sulawesi and Oslo, where the author examined Norway's interests and role in implementing REDD, this book discusses the long evolution of the idea that foreign state and private financing can be used to protect tropical forests and the carbon stored (...) within them, resulting in both local economic development and global climate benefits. It shows how neoliberal environmental approaches to climate change, of which REDD is a leading example, increases the severity of political contestations that must be overcome to reach global climate mitigation goals, and how recent incarnations of REDD have tended to forget earlier scholarly advice to couple anti-deforestation approaches with policies that reduce industrial carbon emissions. In Indonesia, tectonic political and economic forces are shown to have negatively impacted REDD implementation. Using a political ecology approach, the book links the literature on REDD with that covering Indonesia's recent democratic regression, highlighting how the country's environmental performance is inextricably linked to the timbre of its political governance. Given the severity of the political contestations that must be overcome to reach its stated goals, REDD cannot replace global policies that drastically reduce industrial carbon emissions. This book will be of great interests to students and scholars of political ecology, deforestation, climate change, environmental politics, natural resource management and environmental conservation. (shrink)

The article takes as its venture-point the thesis that – whilst speaking of Nietzsche’s critique of objectivity – it is impossible to avoid the following fundamental problem: according to Nietzsche, objectivity and criticism are two facets of the same tendency that the “philosophy of the future” will have to overcome in the higher form of the philosophical “creation of new values”. From this perspective, it also becomes possible to explain Nietzsche’s decision to focus his critique in an attempt to intervene (...) against what he calls Rangverschiebung, the “shift in rank ordering,” of the relationship between philosophy and science. Namely, by doing so, he immediately positioned the philosophical critique on a terrain that does not allow for the critique to follow its spontaneous tendency towards the ideal of objectivity. The first part of the article addresses the epistemological aspect of Nietzsche’s critique of objectivity, i.e. it explains why Nietzsche rejected all philosophical criteria of the foundation of objective understanding. The second part, by contrast, explains how it is possible, according to Nietzsche, to intervene against the ongoing process of the “shift in rank ordering” within the relationship between philosophy and science, which ultimately leads to a harmful complete monopolisation of truth by the ideal of scientific objectivity. (shrink)

This paper aims to analyze the ethical challenges in experimental drug use during the early stage of the COVID-19 pandemic, using Germany as a case study. In Germany uniform ethical guidelines were available early on nationwide, which was considered as desirable by other states to reduce uncertainties and convey a message of unity. The purpose of this ethical analysis is to assist the preparation of future guidelines on the use of medicines during public health emergencies. The use of hydroxychloroquine, remdesivir (...) and COVID-19 convalescent plasma in clinical settings was analyzed from the perspective of the ethical principles of beneficence, non-maleficence, justice and autonomy. We observed that drug safety and drug distribution during the pandemic affects all four ethical principles. We therefore recommend to establish ethical guidelines (i) to discuss experimental treatment options with patients from all population groups who are in urgent need, (ii) to facilitate the recording of patient reactions to drugs in off-label use, (iii) to expand inclusion criteria for clinical studies to avoid missing potentially negative effects on excluded groups, and (iv) to maintain sufficient access to repurposed drugs for patients with prior conditions. (shrink)

The article examines the relation between Nietzsche’s and Hegel’s concepts of nothing and negativity. Both concepts have to be understood as two radical answers to the metaphysical constitution of reality. Namely, if metaphysics constitutes reality through the exclusion of nothing from being, then for Hegel it is actually impossible to recognize reality if it hasn’t been understood in its equality with negation, or in other words, if being hasn’t been beheld in its sameness with nothing. On the other hand, the (...) essence of Nietzsche’s critique of metaphysics lies exactly in the accusation that metaphysics remains unable not to think of being as nothing. There are several reasons for this incapacity, the crucial aspect can however only be grasped through an analysis of Nietzsche’s "double affirmation" as an answer to Hegel’s "negation of negation". (shrink)