No one can be a scientist, even in private, if he does not have independence of observation and of thought. But if in addition science is to become effective as a public practice, it must go further; it must protect independence.I was advised upon graduating from college in 1962 to apply to medical school rather than to graduate school, on the grounds that I could teach, perform research, and treat patients if I had a medical degree, while I would be (...) confined to teaching and research with a basic science doctorate degree. The implication was that research is research, the exploration of the unknown; basic and medical research were of the same ilk. Thus, I decided to obtain a basic science degree principally .. (shrink)

The vertebrate eye lens has been used extensively as a model for developmental processes such as determination, embryonic induction, cellular differentiation, transdifferentiation and regeneration, with the crystallin genes being a prime example of developmentally controlled, tissue‐preferred gene expression. Recent studies have shown that Pax‐6, a transcription factor containing both a paired domain and homeodomain, is a key protein regulating lens determination and crystallin gene expression in the lens. The use of Pax‐6 for expression of different crystallin genes provides a new (...) link at the developmental and transcriptional level among the diverse crystallins and may lead to new insights into their evolutionary recruitment as refractive proteins. (shrink)

Virginia Held, best known for her landmark book Rights and Goods, has made an indelible mark on the fields of ethics, feminist philosophy, and social and political thought. Her impact on a generation of feminist thinkers is unrivaled and she has been at the forfront of discussions about the way in which an ethic of care can affect social and political matters. These new essays by leading contemporary philosophers range over all of these areas. While each stands alone, the essays (...) together demonstrate the lasting value of Held's work to the field. Includes an afterword by Held. (shrink)

'A thorough examination of the nature and value of forgiveness....This book stays close to its subject matter and moves within a tight focus. It is well written and thoroughly researched.'.

Physician-assisted suicide is a novel idea having affinities with both suicide and euthanasia. It has affinities with suicide because it involves a self-inflicted death, and it has affinities with euthanasia because the physician is instrumental in the death. It is, however, not exactly either, making it the subject of an exciting debate.

The hope of this work is that these notes will help to convince more mathematicians that non-standard analysis can make a useful addition to the tools of their trade.

Virginia Held, best known for her landmark book Rights and Goods, has made an indelible mark on the fields of ethics, feminist philosophy, and social and political thought. Her impact on a generation of feminist thinkers is unrivaled and she has been at the forfront of discussions about the way in which an ethic of care can affect social and political matters. These new essays by leading contemporary philosophers range over all of these areas. While each stands alone, the essays (...) together demonstrate the lasting value of Held's work to the field. Includes an afterword by Held. (shrink)

Ramsey type theorems are theorems of the form: if certain sets are partitioned at least one of the parts has some particular property. In its finite form, Ramsey's theory will ask how big the partitioned set should be to assure this fact. Proofs of such theorems usually require a process of multiple choice, so that this apparently pure combinatoric field is rich in proofs that use ideal guides in making the choices. Typically they may be ultrafilters or points in the (...) compactification of the given set. It is, therefore, not surprising that nonstandard elements are much more natural guides in some of the proofs and in the general abstract treatment.In Section 1 we start off with some very natural examples of Ramsey type exercises that illustrate our idea. In Section 2 we give a nonstandard proof of the infinite Ramsey theorem. Section 3 tries to do the same for Hindman's theorem, and points out, where nonstandard analysis must use some hard standard facts to make the proof go through. (shrink)

We use the spaces T n and E n of complete types and of existential types to investigate various notions which appear in the theory of the algebraic structure of models.

'...a clear and sharp introduction which defines absolutism from both consequentialism and more moderate deontological views...' -ETHICS.

In grapheme-color synesthesia, a number or letter can evoke two different and possibly conflicting color sensations at the same time. In this study, we investigate the relationship between synesthesia and executive control functions. First, no general skill differences were obtained between synesthetes and non-synesthetes in classic executive control paradigms. Furthermore, classic executive control effects did not interact with synesthetic behavioral effects. Third, we found support for our hypothesis that inhibition of a synesthetic color takes effort and time. Finally, individual differences (...) analyses showed no relationship between the two skills; performance on a ‘normal’ Stroop task does not predict performance on a synesthetic Stroop task. Across four studies, the current results consistently show no clear relationship between executive control functions and synesthetic behavioral effects. This raises the question of which mechanisms are at play in synesthetic ‘management’ during the presence of two conflicting sensations. (shrink)

Dopamine is critically important in the neural manifestation of motivated behavior, and alterations in the human dopaminergic system have been implicated in the etiology of motivation-related psychiatric disorders, most prominently addiction. Patients with chronic addiction exhibit reduced dopamine D2 receptor (DRD2) availability in the striatum, and the DRD2 TaqIA (rs1800497) and C957T (rs6277) genetic polymorphisms have previously been linked to individual differences in striatal dopamine metabolism and clinical risk for alcohol and nicotine dependence. Here, we investigated the hypothesis that the (...) variants of these polymorphisms would show increased reward-related memory formation, which has previously been shown to jointly engage the mesolimbic dopaminergic system and the hippocampus, as a potential intermediate phenotype for addiction memory. To this end, we performed functional magnetic resonance imaging (fMRI) in 62 young, healthy individuals genotyped for DRD2 TaqIA and C957T variants. Participants performed an incentive delay task, followed by a recognition memory task 24 h later. We observed effects of both genotypes on the overall recognition performance with carriers of low-expressing variants, namely TaqIA A1 carriers and C957T C homozygotes, showing better performance than the other genotype groups. In addition to the better memory performance, C957T C homozygotes also exhibited a response bias for cues predicting monetary reward. At the neural level, the C957T polymorphism was associated with a genotype-related modulation of right hippocampal and striatal fMRI responses predictive of subsequent recognition confidence for reward-predicting items. Our results indicate that genetic variations associated with DRD2 expression affect explicit memory, specifically for rewarded stimuli. We suggest that the relatively better memory for rewarded stimuli in carriers of low-expressing DRD2 variants may reflect an intermediate phenotype of addiction memory. (shrink)

The present research investigates the role of voluntary, conscious processing in strategy change. In 2 experiments, we address whether the switch to a new strategy is the result of data - driven, automatic processes or of voluntary processes. Experiment 1 demonstrates that participants performing an alphabet verification task are able to transfer a newly adopted strategy to dissimilar information never encountered before, verbally describe the task regularity that allows for the generation and application of the new strategy immediately after the (...) strategy was adopted. Using the same experimental task, Experiment 2 shows that participants, and decide against adopting a new strategy when the available evidence suggests that the new strategy cannot be used for the entire range of problems encountered. Overall, the obtained results support the view that strategy change is mediated by voluntary controlled processing. They do not support the view that strategy change is an inevitable, automatic consequence of task practice. The present research thus highlights a potential function of conscious human processing. (shrink)

Alexander Moiseevich Piatigorsky was, as we can read from numerous sources, an internationally renowned Russian and English philosopher, buddhologist, indologist, translator and writer.

The paper is dedicated to the reconstruction of Alexander Piatigorsky’s observational philosophy within the context of the confrontation between two versions of the transcendental project of man-in-the-world. The first project accentuates the invariant functional organization of cognitive systems by abstracting from bodily, affective and phenomenological realization of this organization. On the contrary, the second project emphasizes the phenomenological perspective of the experience of givenness, always already dependent on whose experience this is and how the cognitive system living this experience (...) is organized. The first project can be called functionalist, and the second – phenomenological. Ontological and epistemological positions of these projects are specified in the problem of the observer, its status in the world and cognitive practice. The observational philosophy possesses an intermediate position between these two programs since, aiming to disclose the invariant structure of observation, it proceeds from the factual experience of the embodied subject placed into the situation of self-observation and observation of the other subject. It is concluded that Piatigorsky’s philosophy borrows from the functionalist project the commitment to self-objectivation and rejection from the spatiotemporal localization of cognitive activity. With the phenomenological project of enactivism Piatigorsky shares the aspiration to disclose the invariant cognitive structures during the empirical observation of the real enactment of cognitive agency, abandonment of substantialization of the self as well as the refusal from theoretical formulation of the problem of consciousness. (shrink)