Apoptotic pathways have always been regarded as a key‐player in preserving tissue and organ homeostasis. Excessive activation or resistance to activation of cell death signaling may indeed be responsible for several mechanisms of disease, including malignancy and chronic degenerative diseases. Therefore, targeting apoptotic factors gained more and more attention in the scientific community and novel strategies emerged aimed at selectively blocking or stimulating cell death signaling. This is also the case for the TMEM219 death receptor, which is activated by a (...) circulating ligand, the Insulin‐like growth factor binding protein 3 (IGFBP3) and induces a caspase‐8‐dependent apoptosis of the target cells. Interestingly, stimulation of the IGFBP3/TMEM219 axis exerts an anti‐proliferative effect, while blockade of the TMEM219 deleterious signal protects TMEM219‐expressing cells of the endocrine pancreas, lung, and intestine from damage and death. Here, we summarize the most updated reports on the role of the IGFBP3/TMEM219 apoptotic axis in disease conditions, including intestinal disorders and diabetes, and we describe the advancements in designing and testing novel TMEM219‐based targeting approaches in emerging potential clinical applications. (shrink)

O texto seleccionado e que se apresenta agora em tradução portuguesa pode ser considerado como uma síntese exemplar das ideias de Hegel relativamente ao ensino da filosofia a nível secundário. Sobre a exposição da filosofia em Ginásios é um texto redigido como resposta a Immanuel Niethammer, na altura Conselheiro escolar da Baviera, que solicitara a Hegel uma apreciação sobre a reforma geral do sistema de ensino cuja aplicação estava em curso nas escolas bávaras e que tinha a sua expressão legal (...) no documento de 3 de Novembro de 1808, Allgemeines Normativ der Einrichtung der öffentlichen Unterrichtsanstalten [Directiva geral para a organização dos estabelecimentos públicos de ensino]. (shrink)

This work employs Elizabeth Cripps’ collectivist account of responsibility for climate change in order to ground an individual duty to reduce one’s GHG emissions. This is significant not only as a critique of Cripps, but also as an indication that even on some collectivist footings, individuals can be assigned primary duties to reduce their emissions. Following Cripps, this work holds the unstructured group of GHG emitters weakly collectively responsible for climate change harms. However, it argues against Cripps that what follows (...) from this is a corresponding collective duty to act qua group to bring about an end to the harm and a derivative duty for each emitter to promote the required organization of a group capable of this. Instead, this work argues that acts of GHG emission, to the extent that they are avoidable and performed with requisite knowledge, make one into a member of a group that is morally responsible for climate-related harms. Thus, individual emitters who can do otherwise should recognize themselves as members of a group that collectively harms. Subsequently, they should take all possible steps in order to renounce their membership (e.g. by reducing their GHG emissions). (shrink)

It appears at least intuitively appropriate to claim that we owe it to victims to punish those who have wronged them. It also seems plausible to state that we owe it to society to punish those who have violated its norms. However, do we also owe punishment to perpetrators themselves? In other words, do those who commit crimes have a moral right to be punished? This work examines the sustainability of the right to be punished from the standpoint of the (...) two main theories of rights—the will and the interest conceptions. The right to be punished is shown to be largely indefensible on both accounts: on the will theory, the right to be punished conflicts with autonomy, and it can neither be claimed nor waived by a perpetrator; on the interest theory, a perpetrator’s interest in punishment, inasmuch as it exists, is not sufficient to ground a duty on the part of the state. (shrink)

The contribution of recent theories of sound and audition has been extremely significant for the development of a philosophy of auditory perception; however, none tackle the question of how our consciousness of auditory states arises. My goal is to show how consciousness about our auditory experience gets triggered. I examine a range of auditory mental phenomena to show how we are able to capture qualitative distinctions of auditory sensations. I argue that our consciousness of auditory states consists in having thoughts (...) that organize our experience. Although my proposals could be adapted to fit with other theories of consciousness, here I expand David Rosenthal’s high-order-thought theory and his quality-space theory, and show their usefulness for analyzing our auditory experience. I use quality-space to account for pitch, timbre, loudness, and sound location. I further show that our high-order-thoughts capture qualitative aspects of our auditory sensations. I conclude by demonstrating how a hypothetical listener in possession of a refined vocabulary describes and reports her high-order-thoughts about her musical experience. (shrink)

The Nietzsche’s writings of the period of The birth of tragedy informs about the young philosopher’s concerns with the requisite political conditions for a true culture. The pair Apollo and Dionysus, in opposition and harmonized in Greek religiosity, as powers of the nature, results aesthetically in the tragic art, and politically results in a warlike State. Nietzsche assigns to Greeks the capacity to create a culture: art, state and religion jointed by the artistic will of nature, which impels the life (...) of a nation. (shrink)

In his unpublished 1979 Lectures on the Philosophy of Mind, Saul Kripke offers a knowledge argument against materialism focusing on deaf people who lack knowledge of auditory experience. Kripke's argument is a precursor of Frank Jackson's better‐known knowledge argument against materialism (1982). The paper sets out Kripke's argument, brings out its interest and philosophical importance, and explores some similarities and differences between Kripke's knowledge argument and Jackson's.

This volume deals with collocations from a lexicographic perspective by addressing, in detail, the boundaries between collocations and other word combinations, the possibility of adapting the definition of collocation to the objectives of specific dictionaries, and approaches towards collocation extraction for lexicographic purposes.

Este artigo tem como objetivo estabelecer as relações entre as habilidades sociais e as vivências acadêmicas necessárias à adaptação ao contexto universitário. A pesquisa foi realizada com 200 estudantes do curso de Psicologia de instituições públicas e privadas. Os dois instrumentos utilizados (IHS-Del Prette, 2001 e QVA de Villar, 2003) foram aplicados em conjunto em consonância com as normas do QVA. Os resultados permitem aÞ rmar que os alunos de instituições públicas apresentam melhor adaptação acadêmica do que os de instituições (...) privadas. Foram encontradas correlações entre adaptação acadêmica e habilidades sociais. Para os alunos de instituições públicas as habilidades sociais se relacionam principalmente com as dimensões pessoal e contextual e para os de instituições particulares, com a dimensão de realização. (shrink)

Polyphony of Anxiety. The Interview with Stefano Micali about His Book Phenomenology of Anxiety.

This paper presents a series of 4 single subject experiments aimed to investigate whether children with autism show more social engagement when interacting with the Nao robot, compared to a human partner in a motor imitation task. The Nao robot imitates gross arm movements of the child in real-time. Different behavioral criteria (i.e. eye gaze, gaze shifting, free initiations and prompted initiations of arm movements, and smile/laughter) were analyzed based on the video data of the interaction. The results are mixed (...) and suggest a high variability in reactions to the Nao robot. The results are as follows: For Child2 and Child3, the results indicate no effect of the Nao robot in any of the target variables. Child1 and Child4 showed more eye gaze and smile/laughter in the interaction with the Nao robot compared to the human partner and Child1 showed a higher frequency of motor initiations in the interaction with the Nao robot compared to the baselines, but not with respect to the human-interaction. The robot proved to be a better facilitator of shared attention only for Child1. Keywords: human-robot interaction; assistive robotics; autism. (shrink)

This paper analyses how the Cold War influenced the discourses on basic research and on Science and Technology Policies of some leaders of the Argentine research community. It explores two key intersections to study the Cold War: the first between politics and policies; the second between the global and the regional/national. The basic assumption is that, just as there was no one Cold War, specific regional and national traits lent specific meanings to basic research. In dialogue with the literature on (...) Latin American history of STPs, on Cold War and on the conceptual history of science, the paper identifies three discursive configurations around S&T: the first refers to the semi-peripheral scientific context; the second is associated with the ‘democracy-totalitarianism’ dichotomy, and the third is linked to the ‘development-dependence’ dichotomy. Finally, the paper also traces some connections between these discourses and the institutional models proposed by different key actors of the research community to implement STPs. (shrink)

In this article, caring, remembering and sharing memory are presented as moral responses, the case study being Alzheimer’s disease (AD). Memory connects memories and images, while care connects individuals, which is an ethical issue. When a person’s memory is lost, the care of others becomes the only thread connecting them to the world. AD deprives a person of memories, body control, makes it impossible to remember, communicate, move, recognize the environment, and disrupts consciousness. Caring for a patient with a neurodegenerative (...) brain disease requires constant reminding and reiteration; the presence of a caring person reminds of what the patient themselves can no longer remember. Lost memories do not mean that life or relational values have also lost their meaning. The description of the memory movement emphasizes the importance of repetition in the moral act. Highlighting the matter of care, also in scientific work, is the aim of this text. To care is to remember, on behalf of the AD patient, about the patient’s life. Within bioethical research, moral responses are an important point for projects which seek to improve the condition of patients—not only the condition of health but also the comfort of life. This improvement will not be possible without attentive, committed caregivers and their responsible attitude in the face of the phenomenon of memory loss. (shrink)

This paper presents a series of 4 single subject experiments aimed to investigate whether children with autism show more social engagement when interacting with the Nao robot, compared to a human partner in a motor imitation task. The Nao robot imitates gross arm movements of the child in real-time. Different behavioral criteria were analyzed based on the video data of the interaction. The results are mixed and suggest a high variability in reactions to the Nao robot. The results are as (...) follows: For Child2 and Child3, the results indicate no effect of the Nao robot in any of the target variables. Child1 and Child4 showed more eye gaze and smile/laughter in the interaction with the Nao robot compared to the human partner and Child1 showed a higher frequency of motor initiations in the interaction with the Nao robot compared to the baselines, but not with respect to the human-interaction. The robot proved to be a better facilitator of shared attention only for Child1. Keywords: human-robot interaction; assistive robotics; autism. (shrink)

This essay answers two questions that continue to drive debate in moral and legal philosophy; namely, ‘Is a risk of harm a wrong?’ and ‘Is a risk of harm a harm?’. The essay’s central claim is that to risk harm can be both to wrong and to harm. This stands in contrast to the respective positions of Heidi Hurd and Stephen Perry, whose views represent prominent extremes in this debate about risks. The essay shows that there is at least one (...) category of risks – intentional impositions of risk on unconsenting agents – which can be both wrongful and harmful. The wrongfulness of these risks can be established when, on the balance of reasons, one ought not to impose them. The harmfulness of these risks can be established when the risks are shown to set back legitimate interests. In those cases where risks constitute a denial of the moral status of agents, risks set back agents’ interest in dignity. In these ways, the essay shows that there are instances when a risk can constitute both a wrong and a harm. (shrink)

Nos pouco mais de dois anos da gestão de Jair Bolsonaro, as questões ambiental e indígena e a Amazônia tiveram grande destaque entre os temas que mais mobilizaram ações de oposição ao governo, tanto em campanhas da sociedade civil em âmbito nacional e internacional, quanto em embates no Congresso Nacional e ações judiciais no Supremo Tribunal Federal. Neste texto apontamos alguns desses momentos, pontuando com o histórico de posicionamentos do presidente sobre essas questões ao longo de sua trajetória política, demonstrando (...) como sua visão conflita diretamente com as premissas da maior parte dos tratados internacionais, os fundamentos da Constituição Federal, o consenso científico e o histórico das políticas implementadas no Brasil nos últimos 30 anos. A partir da análise da política socioambiental para a Amazônia, é inevitável tratar do papel das Forças Armadas no atual governo, ainda que de modo superficial, sem a menor pretensão de esgotar todos os aspectos em que se relacionam. (shrink)

In a little over two years of the Jair Bolsonaro administration, questions related to the Amazon, to the environment, and to indigenous peoples have come to the fore among the themes that have mobilized the opposition to the government, both in national and international civil society campaigns as well as in struggles taking place in Congress and in lawsuits in the Supreme Court. In this article, I point out some of these moments, highlighting the history of the president's positions on (...) some of these questions. I demonstrate how his visions contrasts starkly with the premises of most international treaties, with the foundations of Brazil's constitution, with scientific consensus, and with the policies implemented in the country in the past thirty years. The analysis of his anti-environmental policies for the Amazon makes it inevitable to treat the role of the Armed Forces in his government, even though many of the aspects involved still remain to be addressed. (shrink)

This paper presents a series of 4 single subject experiments aimed to investigate whether children with autism show more social engagement when interacting with the Nao robot, compared to a human partner in a motor imitation task. The Nao robot imitates gross arm movements of the child in real-time. Different behavioral criteria were analyzed based on the video data of the interaction. The results are mixed and suggest a high variability in reactions to the Nao robot. The results are as (...) follows: For Child2 and Child3, the results indicate no effect of the Nao robot in any of the target variables. Child1 and Child4 showed more eye gaze and smile/laughter in the interaction with the Nao robot compared to the human partner and Child1 showed a higher frequency of motor initiations in the interaction with the Nao robot compared to the baselines, but not with respect to the human-interaction. The robot proved to be a better facilitator of shared attention only for Child1. Keywords: human-robot interaction; assistive robotics; autism. (shrink)

This essay focuses on anthropomorphism as both a form of hype and fallacy. As a form of hype, anthropomorphism is shown to exaggerate AI capabilities and performance by attributing human-like traits to systems that do not possess them. As a fallacy, anthropomorphism is shown to distort moral judgments about AI, such as those concerning its moral character and status, as well as judgments of responsibility and trust. By focusing on these two dimensions of anthropomorphism in AI, the essay highlights negative (...) ethical consequences of the phenomenon in this field. (shrink)

This short contribution is written on the occasion of the book discussion of Sophie Loidolt’s Phenomenology of Plurality: Hannah Arendt on Political Intersubjectivity at the Institute for Philosophy and Social Theory. It presents an attempt to read the two key notions Loidolt elaborates in her book – spaces of meaning and spaces of the public and private – from a critical perspective offered by Judith Butler’s taking up of Arendt’s work. Offering Butler’s conception of social ontology through several major points (...) of contestation with Arendt, I argue against an all too simple reduction of her understanding of the political and normativity to poststructuralist ones. (shrink)

Lexical alignment, a communication phenomenon where conversational partners adapt their word choices to become more similar, plays an important role in the development of language and social communication skills. While this has been studied extensively in the conversations of preschool‐aged children and their parents in Western, Educated, Industrialized, Rich, and Democratic (WEIRD) communities, research in other pediatric populations is sparse. This study makes significant expansions on the existing literature by focusing on alignment in naturalistic conversations of school‐aged children from a (...) non‐WEIRD population across multiple conversational tasks and with different types of adult partners. Typically developing children aged 5 to 8 years (n = 45) engaged in four semi‐structured conversations that differed by task (problem‐solving vs. play‐based) and by partner (parent vs. university student), resulting in a corpus of 180 conversations. Lexical alignment scores were calculated and compared to sham conversations, representing alignment occurring at the level of chance. Both children and adults coordinated their conversational utterances by re‐using or aligning each other's word choices. This alignment behavior persisted across conversational tasks and partners, although the degree of alignment was moderated by the conversational context. These findings suggest that lexical alignment is a robust phenomenon in conversations between school‐age children and adults. Furthermore, this study extends lexical alignment findings to a non‐WEIRD culture, suggesting that alignment may be a coordination strategy employed by adults and children across diverse linguistic and cultural backgrounds. (shrink)

La paz y la seguridad internacionales no sólo son el resultado de la ausencia de guerras, es decir, no son únicamente el fundamento de la preservación del orden o ausencia de violencia, sino que incluyen también, para ser alcanzadas, aspectos diversos, tales como la seguridad alimentaria. Dentro del abanico de los nuevos riesgos y amenazas a la paz y seguridad internacionales, cada vez más se está teniendo en consideración las repercusiones negativas que tienen las crisis alimentarias y el hambre que (...) sufren en torno a 800 millones de personas en todo el mundo. La preocupación y abordaje de estos temas hizo que por primera vez, el 30 de marzo de 2016, la FAO se dirigiese al Consejo de Seguridad con el objetivo de reafirmar la necesidad de mejorar la seguridad alimentaria como aspecto fundamental para la consolidación de una paz y seguridad internacional sostenibles. (shrink)

A corpus of 60 articles published in Spanish, English, and Portuguese was analyzed to account for the integrative literature review on the concept of vulnerability from bioethics, identifying the following thematic trends: risk, susceptibility, autonomy, and culture in people and communities. The methodological approach has been mainly qualitative. We found that the disciplines that most addressed the concept belong to the human and social sciences. The authors recommend conducting studies of the concept from people’s perspectives and that ethics committees review (...) the informed consent and information guides according to these results. The categories give way to the concept of vulnerability, which must be analyzed beyond principlism in bioethics. (shrink)

This article combines thoughts about childhood, visual culture and education. It is known that we live among multiple images that shape the way we see our reality, and researchers in the visual culture field investigate how this role is played out in our culture. The goal is to make some applications those ideas, to think about the relationship between the images and education. This article tries to grasp what visual culture is and in what ways presumptions about childhood generate and (...) are generated by this association. It also discusses the genesis of these presumptions and the images they generate through a philosophical approach, questioning the role of education in a culture tied to the media, and about how children, who are familiar with multiple screens, presage a new visual literacy. We see how images play a fundamental role in the way children give meaning to the world around them and to themselves, in the context of their local culture. Given this context, it is necessary to consider how visual culture is tied to the elementary school, and what challenges confront the generation of wider and more creative ways to approach visual framing in children’s education. (shrink)

The main purpose of this paper is to make a reflection on the war from the work both by Karl von Clausewitz and Raymond Aron. The hypothesis proposed herein is that a misunderstanding of the theories proposed by the Prussian General may have led to an erroneous recognition about him as father of some tactics employed by some totalitarian regimes of the 20th Century in order to crush their opponents. In an effort to corroborate this idea, the analysis will be (...) based on two seminal sources, the Vom Kriege and Thinking about the war, Clausewitz, which will be supplemented by secondary literature comprising books and articles. It is to avoid that local and international conflicts that are unleashed on the world stage be approaching the limits of absolute war is to practice moderation (an essential political understanding) when making decisions related to the military leadership of the confrontation. (shrink)

O espelho da arte clássica se multiplicou em fragmentos e influenciou a arquitetura grega e seus desdobramentos, verificados no decorrer do que rotulamos chamar de história da arte. A arquitetura e o urbanismo praticados pelos gregos, e mais tarde pelos romanos, foi elemento de inspiração para personalidades de liderança e artistas nos grandes períodos históricos da humanidade, onde a cidade era tida como elemento principal da vida política e social dos povos. Do clássico ao neoclássico, o desdobramento inspirado na estética (...) da antiguidade chega ao Brasil através da corte portuguesa e se fortalece com a missão artística francesa, tornando-se uma característica estilística no Brasil do século XIX. Unir, portanto, esses fragmentos estilísticos em busca do verdadeiro reflexo clássico é o objetivo deste artigo. (shrink)

Relating Narratives is a major new work by the philosopher and feminist thinker Adriana Cavarero. First published in Italian to widespread acclaim, Relating Narratives is a fascinating and challenging new account of the relationship between selfhood and narration. Drawing a diverse array of thinkers from both the philosophical and the literary tradition, from Sophocles and Homer to Hannah Arendt, Karen Blixen, Walter Benjamin and Borges, Adriana Cadarero's theory of the `narratable self' shows how narrative models in philosophy and (...) literature can open new ways of thinking about formation of human identities. By showing how each human being has a unique story that can be told about them, Adriana Cavarero inaugurates an important shift in thinking about subjectivity and identity which relies not upon categorical or discursive norms, but rather seeks to account for `who' each one of us uniquely is. (shrink)

The main purpose of this study is the scientific practice of Edgard Roquette-Pinto at the National Museum of Rio de Janeiro during the 1910’s and 1920’s in the XXth Century. The article examines the relationship between laboratory science and nation building. Driven by Physicians-Anthropologists like Edgard Roquette-Pinto among others, the investigations performed at the Anthropology Laboratory there reveal the dynamic of the borders between Laboratory and Field Sciences, and the new biological parameters adopted at that time. The investigative agenda involved (...) plants, animals and human bodies, and it was related to the current Anthropology concept aligned with the debate of Nation construction. The physiological studies amplified the scientific exchange with different institutions, emphasizing cultural exchange between Brazil and Paraguay, and the role played by Edgard Roquette-Pinto there as he inaugurated the Physiological course at Faculty of Medicine at University of Asunción. (shrink)

The paper focuses on the ethical teachings of Classical Antiquity philosophers in the poetry of Saint Gregory of Nazianzus, especially on the parallels between the author’s work and the Cynics and the Stoics. The syncretic nature of Gregory’s work, reflected in the assimilation of the teachings of ancient philosophical schools and the then expanding Christianity creates conditions for the explanation and highlighting of basic human virtues. Gregory of Nazianzus’ legacy also draws on the teachings of such philosophers as Plato and (...) Aristotle, but he always approaches them from the perspective of a strictly Christian worldview. He understands philosophy as a moral underlying basis from which one can draw inspiration for a virtuous and happy life. Gregory thinks that philosophy cannot harm Christians in the pursuit of a virtuous life. Nevertheless, Christian teachings and God are the highest authority. They stand above all philosophical schools or ideas advanced by specific philosophers. Gregory’s moral poetry thus directs his readers, if they are to deserve eternal life, to follow the commandments, which is possible only if one lives a practical and virtuous life. (shrink)

Adriana Ayers studies the evolution of kotex advertising, focusing specifically on the way in which African American women were figured into changing advertisers’ conceptions of womanhood. The article analyzes images featured in various women’s magazines to examine how ideas surrounding menstruation were packaged and sold to women.

Twinned 2H martensite is observed in copper-based shape memory alloys together with basal and non-basal plane stacking faults. Knowledge of the twin-boundary structure and its interaction with the faults is important to understand the deformation mechanism by twin coalescence. High-resolution electron microscopy coupled with image simulations have been used for these studies. The interface of the type I twinning in 2H martensite shows an atomic configuration with mirror antisymmetry. An atomic plane is shared by the twinned variants in such a (...) way that the distance between the planes, parallel to the interface, is unchanged at the boundary and the mean atomic volume is conserved. The interaction of the boundary with a basal plane fault generates a shift in the interface. A mirror antisymmetrical boundary is maintained by introducing an imperfect interface dislocation. (shrink)