Literature on maternal exposures and the risk of epigenetic changes or diseases in the offspring is growing. Paternal contributions are often not considered. However, some animal and epidemiologic studies on various contaminants, nutrition, and lifestyle‐related conditions suggest a paternal influence on the offspring's future health. The phenotypic outcomes may have been attributed to DNA damage or mutations, but increasing evidence shows that the inheritance of environmentally induced functional changes of the genome, and related disorders, are (also) driven by epigenetic components. (...) In this essay we suggest the existence of epigenetic windows of susceptibility to environmental insults during sperm development. Changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote. Inclusion of paternal factors in future research will ultimately improve the understanding of transgenerational epigenetic plasticity and health‐related effects in future generations. (shrink)

Idealism and relativism were designed to assess different ethical ideological views. Their relation with attitudes toward a variety of outgroups has not been previously studied. Understanding how concerns over ethical principles and consequences are related to prejudiced attitudes could provide some insight into these constructs and into the nature of prejudice. In two studies totaling 311 participants, participants completed measures on ethical ideologies, right-wing authoritarianism, and attitudes toward various outgroups. The differential predictive validities of ethical ideologies, in comparison to right-wing (...) authoritarianism, on prejudicial attitudes toward dangerous, derogated, and dissident outgroup members were examined. We found that both idealism and relativism contributed to predicting attitudes regarding outgroup members, over and above right-wing authoritarianism. As such, people’s personal moral standards and code of conduct for dealing with interpersonal problems and transgressions can partly explain their negative attitudes toward outgroup members. More research is required to determine the unique influence of ethical ideologies over other constructs previously shown to predict prejudice. (shrink)

L'idealisme radical de Jean-Michel Le Lannou conteste l'identification de la pensee et de la representation. Loin de soumettre a la vacuite et la mort, l'abstraction manifeste ses puissances d'exces. Plus rien ne nous oblige a persister dans notre amour du fini. Pourtant, la philosophie s'est longtemps meprise sur elle-meme. D'ou provient une telle mesentente sur le desir du penser? Montrer comment la pensee a pu ainsi se fourvoyer sur elle-meme doit permettre d'entreprendre sa liberation definitive. Les etudes reunies ici s'attachent (...) avec ambition a eclairer ce mouvement insurrectionnel d'une pensee qui refuse de se laisser retenir par la particularite et qui, dans son detachement meme, rejoint l'affirmation substantielle la plus intense. (shrink)

What are the effects of our environment on human development and the next generation? Numerous studies have provided ample evidence that a healthy environment and lifestyle of the mother is important for her offspring. Biological mechanisms underlying these environmental influences have been proposed to involve alterations in the epigenome. Is there enough evidence to suggest a similar contribution from the part of the father? Animal models provide proof of a transgenerational epigenetic effect through the paternal germ line, but can this (...) be translated to humans? To date, literature on fathers is scarce. Human studies do not always incorporate appropriate tools to evaluate paternal influences or epigenetic effects. In reviewing the literature, I stress the need to explore and recognize paternal contributions to offspring's health within the Developmental Origins of Health and Disease hypothesis, and coin this new concept the Paternal Origins of Health and Disease paradigm. A better understanding of preconceptional origins of disease through the totality of paternal exposures, or the paternal exposome, will provide evidence-based public health recommendations for future fathers. A father's hereditary contribution exceeds that of his DNA sequence. The environment can regulate systems such as the sperm epigenome, which is inheritable as well and may steer the genome and health status of his offspring. We here suggest a new concept, the Paternal Origins of Health and Disease, as part of the DOHaD theory. (shrink)

La métaphysique est l’affirmation de la priorité de l’Être sur la puissance. En toutes ses variations stratégiques, elle retient la pensée dans la prison de l’égalité à soi. Après la physique qui n’a pu arrêter la pensée à la seule évidence sensible, la métaphysique produit les catégories réflexives d’une présence désormais reconnue jusque dans les fondements mêmes de sa représentation rationnelle. Un même désir, une même sève irrigue tout l’arbre de l’Être. Sous le tronc de la physique, les...

Noncoding RNA has arrived at centre stage in recent years with the discovery of “hidden transcriptomes” in many higher organisms. Over two decades ago, noncoding transcripts were discovered in Drosophila Hox complexes, but their function has remained elusive. Recent studies1-3 have examined the role of these noncoding RNAs in Hox gene regulation, and have generated a fierce debate as to whether the noncoding transcripts are important for silencing or activation. Here we review the evidence, and show that, by taking developmental (...) timing into account, some of these apparently conflicting results can be resolved. We examine current models that explain these data and explore alternative interpretations. BioEssays 30:110–121, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Les innombrables interprétations de l’allégorie de la caverne, aussi réduc­trices ou spéculatives, aussi fidèles à la lettre ou à l'esprit du texte soient-elles, paraissent s'effacer les unes les autres, comme balayées par la souplesse d'un texte qui autorise les lectures les plus élémentaires comme les plus raffinées. Cet "étrange tableau" qu'expose Socrate s'insère immé­dia­tement entre deux pôles d'intelligibilité censés en assurer la compréhension : l'image de la ligne au...

Dans le temps même où elle transforme le donné en reflet, la pensée tend à se représenter sous ses actes la présence silencieuse d’un irréfléchi qui résiste à son activité de séparation. Dans sa protestation contre l’emprison­ne­ment de l’évidence, la réflexion peine à se départir de la croyance que son écart n’est que provisoire et qu’il précède une ferme appropriation. Nous ne réfléchirions que pour mieux nous attacher au monde, à la vie et à nous-mêmes. Mais le désir de la (...) réflexion n’est... (shrink)

Nous nous plaisons à faire varier nos représentations. Nous jouissons en elles du dépôt stupéfiant de notre activité consciente de délimitation. Toujours nous croyons, comme le réalisme spontané nous y enjoint, que la pensée ne s’éprouve qu’en dehors d’elle-même, absorbée par l’œuvre de re­connaissance de ce qui la précède, de ce qui lui est « donné ». En cette pseudo-évidence, la forme est d’emblée présentée comme ce qui, traçant le contour, fait apparaître du fini, conformément aux conditio...

This paper contributes to the (re-)conceptualisation of responsible innovation by proposing an evolutionary economic approach that focuses on the role of consumers in the innovation process. After a discussion of the philosophical foundations and ethical implications of this approach, which bears an explanatory potential that has not been adequately considered in previous discussions of responsible innovation, we present a first step towards capturing the important but often neglected role of consumers in innovation processes (including responsible innovation): We propose an agent-based (...) model that incorporates a multidimensional space of characteristics in which new products or services are represented by more than the mere aspect of price and quality. Instead, innovations are denoted by a large set of characteristics, including also negative or harmful ones. The model is used to illustrate that consumers’ heterogeneity and bounded rationality – even if considered in a simple manner – indeed play a crucial role in the creation and diffusion of responsible innovation which can and should be used for further work in this field and for possible extensions of the model. (shrink)

Philosopher Judith Butler has influenced how people talk about vulnerable bodies and sees vulnerability as universal, existential, and relational. Being vulnerable is part of the human condition. The main theoretical areas that run across Butler’s work; power, knowledge and subjectivity, performativity, and ethics—are of particular relevance to nursing practice. This review aims to explore how Butler’s theoretical work is reflected in research literature within a nursing context. We conducted a scoping review guided by Arksey and O’Malley’s methodological framework. A systematic (...) literature search of CINAHL (EBSCOhost), MEDLINE (Ovid), Embase (Ovid), PsycINFO (Ovid), and Web of Science identified 15 papers. Butler’s theoretical work was applied at an individual and social level in research literature within a nursing context. Nurses need to reflect on their clinical practice and role as health professionals in relation to power and performativity in encounters with patients who are marginalized. Nurses’ working conditions, recognition, and understanding are strongly influenced by society, and calling nurses heroes undermines their capacity to challenge and resist the hero identity. The healthcare system’s impact on patient-nurse encounters challenges patients’ and nurses’ subjectivity, performativity, and power relations. The review allowed us to describe how Butler’s theoretical work can facilitate a reflection on nursing practice which is a prerequisite for caring, ethical relationships, and working conditions within a nursing context. Butler’s concepts can provide useful perspectives on how nurses understand, communicate with, and care for patients, as well as a nuanced understanding of the nursing role and power relations and structures. (shrink)

Ideas surrounding mechanicism and materialism are so prevalent and fundamental in early modern and modern philosophy and critical theory that almost all key intellectual, political, and theological questions have been cast in their terms. From the 1730s onward, such questions were increasingly connected to the idea of the "man-machine" – the mechanical android. This was not least due to Jacques de Vaucanson's work from the 1730s, and the work of other artisans in the following decades, whose mechanical androids quickly became (...) well-known and provided actual manifestations of man-machines. Eighteenth-century mechanical androids were more sophisticated in regard to mechanical complexity and craftsmanship than those of... (shrink)

ArgumentIn 1877, a young mathematician named Joseph Boussinesq presented amémoireto theAcadémiedes sciences which demonstrated that some differential equations may have more than one solution. Boussinesq linked this fact to indeterminism and to a possible solution to the free will versus determinism debate. Boussinesq's main interest was to reconcile his philosophical and religious views with science by showing that matter and motion do not suffice to explain all there is in the world. His argument received mixed criticism that addressed both his (...) philosophical views and the scientific content of his work, pointing to the physical “realisticness” of multiple solutions. While Boussinesq proved to be able to face the philosophical criticism, the scientific objections became a serious problem, thus slowly moving the focus of the debate from the philosophical plane to the scientific one. This change of perspective implied a wide discussion on topics such as instability, the sensitivity to initial conditions, and the conservation of energy. The Boussinesq debate is an example of a philosophically motivated debate that transforms into a scientific one, an example of the influence of philosophy on the development of science. (shrink)