In this article ethical issues are discussed which play a role in pharmacogenetics. Developments in pharmacogenetics have a large impact on many different practices such as clinical trials, the practice of medicine and society at large. In clinical trials, questions rise regarding the exclusion of genetic subgroups that may be non- or poor-responders to the experimental drug. Also, the question is asked how pharmaceutical companies should deal with their growing knowledge about the relations between genetic variation and adverse effects. Moreover, (...) pharmacogenetics may provide disease-specific predictive information which may have a significant impact on the relations between physicians, patients and their relatives in the practice of medicine. Here, issues also arise regarding responsibility of patients and physicians for health and disease. In the society at large, the high costs of new pharmacogenetic possibilities lead to questions concerning solidarity and fair distribution on a national as well as an international level. It is concluded that in the near future, ethical research should be focused on the themes responsibility, inclusion and exclusion and global justice. (shrink)

Dem hier präsentierten Band liegt die These zugrunde, daß die Anfänge der Praxis, kunstprogrammatische Texte als Manifest zu bezeichnen, und die anschließende Hoch-konjunktur in der avantgardistischen Nomenklatur vor dem Hintergrund der problematisch gewordenen Intentionalität im Dreieck Künstler, Kunstwerk und Publikum gesehen werden muß. Den Beleg dafür tritt der vorliegende Band von drei Ansätzen aus an: Interpretation, Funktionalität und Strategie. Dabei wird ein Korpus aus verschiedenen Kunstsparten behandelt, das von literarischen Deklarationen der russischen Moderne ab 1893 bis zu postmodernen Manifesten reicht, (...) mit einem besonderen Schwerpunkt auf den Manifesten der historischen Avantgarde. Damit ist das vorliegende Buch auch als ein Beitrag zur Historiographie der Bezeichnung von Texten der Avantgarde als Manifeste, der Rolle von Manifesten in der Avantgarde und letztlich auch der Textproduktion der Avantgarde insgesamt zu verstehen. (shrink)

New means of transport and communication allowed unprecedented mobility of people, goods and ideas in the late nineteenth and early twentieth century, which contributed to far-reaching economic, social and political changes in a first wave of globalisation. In its genuine transnationality, the European historical avant-garde can be seen as a product of this development. Cosmpolitanism, internationality and internationalism became emblems of the avant-garde in its pursuit of a 'new', modern international culture trangressing 'old' borders and limitations dictated by conceptions of (...) nationhood, linguistic restrictions, and state boundaries. Simultaneously, national and nationalist reflexes can be traced in the avant-garde as well - in a European context marked by a plethora of competing nationalisms. This collection of essays focuses on the transnationality and inter-nationalisms in the European avant-garde as well as on conflicts, paradoxes and debates in the avant-garde as genuinely transnational configuration of artistic movements, which possessed nevertheless many nationalist edges. The book presents a panorama of the historical avant-garde oscillating and operating between transnationality, internationalism and nationalisms of different kinds, both in national cultural fields and a transnational European arena - from Iceland to Greece and from the Pale of Settlement to the Atlantic. (shrink)

BackgroundTo prevent sexual boundary violations (SBV) in mental health care institutions overall governments require these institutions to report SBV incidents to a central registry and to develop institutional guidelines how to react. In Europe SBV policies are only recently developed or implemented, as is also the case in Flanders (Belgium). The implementation of a new institutional policy is always a challenge and can encounter resistance, especially when it concerns SBV, because they remain delicate and complex.MethodThis study evaluated the extent to (...) which mandatory policies on SBV have been implemented in mental health care institutions in Flanders, and possible factors for (non-)implementation of these policies. An online survey was sent to the executives of all mental health care institutions in Flanders (N = 162).ResultsIn total 56 executives of mental health care institutions filled out the survey (response rate 35%). Results showed that the implementation of an SBV policy in mental health care institutions is unfortunately inadequate and not all SBV incidents were reported to the central registry. Type of institution and opinions on the SBV policy were related to the (non-)implementation of the requirements.ConclusionsIt is recommended that governments regularly communicate with mental health care institutions to better understand the concerns and difficulties concerning implementation of the required SBV policy and to support/stimulate an organisational culture of more openness and safety on this topic. (shrink)

Using the Job Demands-Resources model literature and the life-span theory as scholarly frameworks, we examined the effects of job demands and job resources as mediators in the relationship between bundles of used HRM practices and employee outcomes. In addition, we tested for age differences in our research model. Findings confirmed the hypothesized original 2-factor structure representing maintenance and development HRM practices. Structural Equation Modeling analyses showed that the maintenance HRM bundle related directly and negatively to employee outcomes, without moderating effects (...) of age. However, job resources appeared to mediate this relationship in a positive way as it also did for the development HRM bundle. Whereas this study showed the ‘driving power’ of the actual use of HRM bundles through job resources, regardless of the employee’s age, this study also suggests a ‘dark side’ of HRM. In particular, we found that development HRM bundles may also increase job demands, which, in turn, may result in lower levels of beneficial employee outcomes. These empirical outcomes demonstrate the strength of the driving power eliciting from job resources preceded by any HRM bundle. Moreover, this effect appears to apply to employees of all ages. Our moderated-mediation model appeared robust for several control variables. Overall, this study provides an extension of the well-known Job Demands-Resources model by including maintenance and development bundles of HRM practices used by employees that have a differential effect on job demands and job resources which in turn have an impact on employee outcomes. (shrink)

Biographical note: Sascha Bru, Genth University, Belgium; Peter Nicholls, University of Sussex, UK.

_Internet_ is een van de eerste boeken waarin het filosofische inzicht -van Plato tot Kierkegaard - betrokken wordt op het debat over de mogelijkheden en onmogelijkheden van het internet. Dreyfus laat zien dat de onstoffelijke, 'vrij zwevende' websurfer zijn oorsprong vindt in Descartes' scheiding van geest en lichaam, en hoe Kierkegaards inzichten in de opkomst van het moderne leespubliek vooruitlopen op de nieuwsgierige, maar elk risico vermijdende internet-junkie. Uitgaande van recente onderzoeken naar het isolement dat veel internetgebruikers ervaren, toont Dreyfus (...) aan hoe het internet, door zijn nadruk op privé-ervaringen, gebruikers berooft van wezenlijke, belichaamde vermogens zoals vertrouwen, stemmingen en betrokkenheid bij met anderen gedeelde lokale aangelegenheden. _Internet_ is verplichte kost voor iedereen die on line is en is geïnteressseerd in onze plaats in de 'e-revolutie'. (shrink)

Dit boek is een hommage aan de filosoof Hubert Dethier (°21 juli 1933), die we zeker in de rij kunnen plaatsen van denkers als Jaap Kruithof, Hans Achterhuis en Etienne Vermeersch. Deze hommage is geen chronologische biografie. Het is daarentegen wel een verhaal waarin het leven van Hubert Dethier verweven wordt met de geschiedenis van zijn denken. Een denken dat zich situeert in de tweede helft van de vorige eeuw en het begin van de huidige eeuw en zich (...) moeiteloos projecteert naar de toekomst. Ontegensprekelijk een woelige en gewelddadige periode, maar ook een tijdgewricht van hoop en verwachting van het “nieuwe”.0. (shrink)

Les Journées maliotes organisées à l'École française d'Athènes les 2 et 3 novembre 2007 portaient sur l'organisation des espaces et l'exploitation des ressources, thèmes qui permettaient d'unir les approches effectuées ces dernières années selon deux échelles différentes, celle de l'agglomération et de l'urbanisme d'une part, celle de l'organisation du territoire d'autre part. Les contributions portent toutes sur des recherches en cours, dont la publication est récente ou proche. Elles sont publiées ici sous forme de résumés argumentés et reflètent fidèlement les (...) discussions qui les suivirent. (shrink)

1. Het averroïstisch-nominalistisch front en de leer van de dubbele waarheid.

"Leopold Flam (1912-1995) is samen met Leo Apostel wellicht de belangrijkste figuur van het filosofische gebeuren tussen de jaren vijftig en tachtig van de vorige eeuw. Toch is hij in de vergetelheid geraakt.

Since the emergence of the innovative field of artificial intelligence in the 1960s, the late Hubert Dreyfus insisted on the ontological distinction between man and machine, human and artificial intelligence. In the different editions of his classic and influential book What computers can’t do, he posits that an algorithmic machine can never fully simulate the complex functioning of the human mind—not now, nor in the future. Dreyfus’ categorical distinctions between man and machine are still relevant today, but their relation (...) has become more complex in our increasingly data-driven society. We, humans, are continuously immersed within a technological universe, while at the same time ubiquitous computing, in the words of computer scientist Mark Weiser, “forces computers to live out here in the world with people” The cell phone reader. Peter Lang Publishing, New York, 2006, p 20). Dreyfus’ ideas are therefore challenged by thinkers such as Weiser, Kevin Kelly, Bruno Latour, Philip Agre, and Peter Paul Verbeek, who all argue that humans are much more intrinsically linked to machines than the original dichotomy suggests—they have evolved in concert. Through a discussion of the classical concepts of individuum and ‘authenticity’ within Western civilization, this paper argues that within the ever-expanding data-sphere of the twenty-first century, a new concept of man as ‘aggregate of data’ has emerged, which further erodes and undermines the categorical distinction between man and machine. This raises political and ethical questions beyond the confines of technology and artificial intelligence. Moreover, this seemingly never-ending debate on what computers should do provokes the philosophical necessity to once again define the concept of what it is to be ‘human.’. (shrink)

This is a collection of articles clarifying the nature of Husserlian phenomenology. Dreyfus argues that, given that Husserl put intentionality at the centre of cognitive investigation and painstakingly analyzed it and related concepts in logic, linguistics and psychology he is the father of current research in cognitive science and artificial intelligence. The authors include Follesdal, Fodor, Mohanty and Searle among others.

In 'Descartes' droom' worden strip en filosofie met elkaar verbonden. Een idee van Hubert Dethier, die in zijn colleges aan de VUB het medium strip tot onderwerp van filosofische bezinning maakte. Filosofe en vroegere stripuitgeefster Margreet van Muijlwijk nam de fakkel van hem over en verbond ter gelegenheid van Hubert Dethiers tachtigste verjaardag diens gedachtegoed met de vele aspecten van wat intussen een volwassen kunst (de negende kunst) is geworden. Strip en filosofie passen goed bij elkaar. Terwijl filosofie (...) een eeuwenoude praktijk is, is het stripverhaal het oudste medium onder de nieuwe media. In tegenstelling tot die laatste is de tijdlijn van een stripverhaal op elk moment tot stilstand te brengen of om te keren. Dat is een eerste voorwaarde voor reflectie: bij de dingen kunnen stilstaan en afwegingen maken. De strip kan op die manier onvermoede inzichten bieden in talloze stromingen van de westerse filosofie en in onze maatschappij in het algemeen. (shrink)

Kaum einer hat die offene Gesellschaft in der politischen Philosophie des 20. Jahrhunderts so leidenschaftlich verteidigt wie Karl Popper. Sein Demokratieverstandnis ist eng gekoppelt an seine Wissenschaftstheorie und die Kritik an Platon, Hegel, Marx. Als Liberaler und sozialer Reformist wird er parteiubergreifend zum Stichwortgeber bundesdeutscher Politik seit den 70er Jahren. Popper-Rezeptionen finden sich bis in die Staatsrechtslehre (namentlich Peter Haberle) und das Bundesverfassungsgericht hinein. Noch heute lasst sich mit Popper gegen Diktaturen wie uberhaupt gegen Konzepte von "Gemeinschaft" Position beziehen - (...) aber auch gegen einen pseudo-liberalen, gnadenlosen Kapitalismus der "Ich-AGs". Mit Beitragen von Dorothea Frede, Peter Haberle, Herbert Keuth, Hubert Kiesewetter, Martin H. W. Mollers, Jurgen Nordmann, Harald Stelzer, Robert Chr. van Ooyen, Robert Zimmer. (shrink)

Nicolas-Claude Fabri de Peiresc was een geleerde die niet tot een bepaalde institutie hoorde. Hij streefde naar de vooruitgang van wetenschappelijke kennis, had een netwerk van geleerden, politici, kooplieden en anderen en had contacten in Goa en Ethiopië, in het Ottomaanse Rijk en in christelijk Europa. Hij bewoog zich onder meer op terreinen als astronomie en de kennis van bijbelhandschriften in oosterse talen en werkte samen met protestanten, joden en moslims. Gedachte-experiment: iemand als Peiresc die internet ter beschikking heeft. (...) Peiresc heeft geen publicaties nagelaten en postuum hebben zijn vrienden zijn brieven niet gepubliceerd. Maar de archiefnalatenschap van deze briljante spin in zijn web is in onze tijd beschikbaar. (shrink)

Existential phenomenologists hold that the two most basic forms of intelligent behavior, learning, and skillful action, can be described and explained without recourse to mind or brain representations. This claim is expressed in two central notions in Merleau-Ponty's Phenomenology of Perception: the intentional arc and the tendency to achieve a maximal grip. The intentional arc names the tight connection between body and world, such that, as the active body acquires skills, those skills are stored, not as representations in the mind, (...) but as dispositions to respond to the solicitations of situations in the world. A phenomenology of skill acquisition confirms that, as one acquires expertise, the acquired know-how is experienced as finer and finer discriminations of situations paired with the appropriate response to each. Maximal grip names the body's tendency to refine its responses so as to bring the current situation closer to an optimal gestalt. Thus, successful learning and action do not require propositional mental representations. They do not require semantically interpretable brain representations either.Simulated neural networks exhibit crucial structural features of the intentional arc, and Walter Freeman's account of the brain dynamics underlying perception and action is structurally isomorphic with Merleau-Ponty's account of the way a skilled agent is led by the situation to move towards obtaining a maximal grip. (shrink)

For Descartes, knowledge exists as ideas in the mind that represent the world. In a radical critique, Hubert Dreyfus and Charles Taylor argue that knowledge consists of much more than the representations we formulate in our minds. They affirm our direct contact with reality—both the physical and the social world—and our shared understanding of it.

Gödel once offered an argument for the general reflection principle in set theory that took the form of an analogy with Leibniz' Monadology. I discuss the mathematical and philosophical background to Gödel's argument, reconstruct the proposed analogy in detail, and argue that it has no justificatory force.

Existential phenomenologists hold that the two most basic forms of intelligent behavior, learning, and skillful action, can be described and explained without recourse to mind or brain representations. This claim is expressed in two central notions in Merleau-Ponty's Phenomenology of Perception: the intentional arc and the tendency to achieve a maximal grip. The intentional arc names the tight connection between body and world, such that, as the active body acquires skills, those skills are “stored”, not as representations in the mind, (...) but as dispositions to respond to the solicitations of situations in the world. A phenomenology of skill acquisition confirms that, as one acquires expertise, the acquired know-how is experienced as finer and finer discriminations of situations paired with the appropriate response to each. Maximal grip names the body's tendency to refine its responses so as to bring the current situation closer to an optimal gestalt. Thus, successful learning and action do not require propositional mental representations. They do not require semantically interpretable brain representations either.Simulated neural networks exhibit crucial structural features of the intentional arc, and Walter Freeman's account of the brain dynamics underlying perception and action is structurally isomorphic with Merleau-Ponty's account of the way a skilled agent is led by the situation to move towards obtaining a maximal grip. (shrink)

McDowell's claim that "in mature human beings, embodied coping is permeated with mindedness",1 suggests a new version of the mentalist myth which, like the others, is untrue to the phenomenon. The phenomena show that embodied skills, when we are fully absorbed in enacting them, have a kind of non-mental content that is non-conceptual, non-propositional, non-rational and non-linguistic. This is not to deny that we can monitor our activity while performing it. For solving problems, learning a new skill, receiving coaching, and (...) so forth, such monitoring is invaluable. But monitoring what we are doing as we are doing it degrades performance to at best competence. On McDowell's view, there is no way to account for such a degradation in performance since the same sort of content would be involved whether we were fully absorbed in or paying attention to what we were doing. McDowell claims that it is an advantage of his conceptualism that it avoids any foundationalist attempt to build up the objective world on the basis of an indubitable Given or any other ground-floor experience. And, indeed, if the world is all that is the case and our minds are unproblematically open to it, all experience is on the same footing. But one must distinguish motor intentionality, and the interrelated solicitations our coping body is intertwined with, from conceptual intentionality and the world of propositional structures it opens onto. The existential phenomenologist can then agree with McDowell in rejecting traditional foundationalisms, while yet affirming and describing the ground-floor role of motor intentionality in providing the support on which all forms of conceptual intentionality are based. (shrink)

While 4E approaches to cognition are increasingly introduced in educational contexts, little has been said about how 4E commitments can inform pedagogy aimed at fostering ethical competencies. Here, we evaluate a 4E-inspired ethics exercise that we developed at a technical university to enliven the moral imagination of engineering students. Our students participated in an interactive tinkering workshop, during which they materially redesigned a healthcare artifact. The aim of the workshop was twofold. Firstly, we wanted students to experience how material choices (...) at the levels of design and functionality can enable morally significant reimaginings of the affordances commonly associated with existing artifacts. We term this type of reimagining world-directed moral imagination. Secondly, through the design process, we wanted students to robustly place themselves in the lived embodied perspectives of (potential) users of their selected artifacts. We term this person-directed moral imagination. While student testimonies about the exercise indicate that both their world-directed and person-directed moral imagination were enlivened, we note that the fostering of robust person-directed moral imagination proved challenging. Using 4E insights, we diagnose this challenge and ask how it might be overcome. To this end, we engage extensively with a recent 4E-informed critique of person-directed moral imagination, raised by Clavel Vázquez and Clavel-Vázquez (2023). They argue that person-directed moral imagination is profoundly limited, if not fundamentally misguided, particularly when exercised in contexts marked by emphatic embodied situated difference between the imaginer and the imagined. Building upon insights from both the 4E field and testimonies from critical disability studies, we argue that, while their critique is valuable, it ultimately goes too far. We conclude that a 4E approach can take on board recent 4E warnings regarding the limits of person-directed moral imagination while contributing positively to the development of moral imagination in engineering ethics education. (shrink)

MICHAEL WHEELER Cambridge, MA: MIT Press, 2005432 pages, ISBN: 0262232405 (hbk); $35.001.When I was teaching at MIT in the 1960s, students from the Artificial Intelligence Laboratory would come to...

A Critique of Artificial Reason Hubert L. Dreyfus . HUBERT L. DREYFUS What Computers Still Can't Do Thi s One XZKQ-GSY-8KDG What. WHAT COMPUTERS STILL CAN'T DO Front Cover.