In lieu of an abstract, here is a brief excerpt of the content:Judith Butler’s “New Humanism”A Thing or Not a Thing, and So What?Sina KramerA few thinkers in the last few years, such as Stefan Dolgert and Miriam Leonard, but especially political theorist Bonnie Honig, have argued that Judith Butler’s most recent work (Antigone’s Claim, 2000; Undoing Gender, 2004; Precarious Life, 2005; Frames of War, 2009) institutes a new form of humanism, based on the universality of grief, mourning, vulnerability, (...) and precariousness that Butler describes in these texts. These critiques call into question an incipient foundationalism in the feminist political theory Butler produces in these texts, one seemingly at odds with her previous antifoundationalist commitments. In this article I will argue that, while these critiques oversimplify the relationship between politics and ethics or politics and ontology in their critique of Butler’s new mortalist humanism, the problem of the relation of politics to ethics or ontology—or, more exactly, the problem of the relation of politics to its outside, or to its conditions—remains nevertheless a real problem in Butler’s work. This is because, without a clear account of a method of rendering foundations contingent, or of rendering ontologies provisional, we tend to repeat the political move to establish an apolitical ground on which we can found a politic. This foundationalist move thus shields that ground from political critique and transformation—a move that Butler herself has done so much work to expose and displace.In this article, I ask whether feminist theory must repeat a recourse to foundations by examining the charge that Butler does so her in most recent work. The article will proceed as follows: in the first section, I examine the [End Page 25] charge that Butler is instituting a new humanism. In the second section, I look at some of Butler’s discussion of humanism, and look more closely at the relation between ethics and politics the question of humanism opens up in her work. In the third, I explore whether or not the charge that Butler is instituting a new humanism is correct. And in the fourth, I question what is at stake in this charge. Essentially, the article asks of this new humanist charge: Is this a thing or not a thing, and so what? I argue that, while the charge is somewhat overdetermined, it does point to a larger problem in Butler’s work, and that is the recourse to foundations, or to gesturing to an outside of or beyond of politics as the condition for altering political conditions. I will conclude by arguing that a greater attention to method can help to avoid the reification of the distinction between politics and its conditions that leads to the recourse of foundations.Butler’s New Mortalist HumanismIn her 2010 article “Antigone’s Two Laws: Tragedy and the Politics of Humanism”—as well as in her 2013 book Antigone, Interrupted—Bonnie Honig argues that Butler’s ethical turn institutes a new mortalist humanism, predicated on the “ontological fact of mortality, not the capacity to reason but the vulnerability to suffering” (Honig 2010, 1). She differentiates this new mortalist humanism, which she also diagnoses in the work of Nicole Loraux and Stephen White, from earlier rationalist forms of humanism that are based on the universal principle of human rationality, and from forms of antihumanism based on the “signs of a monstrous, dehumanizing animality” (Honig 2010, 3). Either form is problematic, Honig argues, insofar as they both seek to settle essentially political questions by recourse to a position beyond politics: through a stable and recognizably human figure who either secures its belonging to the polity by means of its rationality, or an exclusion rendered through the dehumanization of otherwise ostensibly human figures.This new mortalist humanism Honig diagnoses in Butler’s recent work falls into the same problem: in this version, Butler settles political questions by recourse to a principle of mortality, or the universal experience of mourning. This would seem to be contrary to Butler’s earlier commitments to a radical critique of foundationalism, especially in her famous critique of the naturalization of sex as the grounds for a political understanding of gender. This is... (shrink)

Kristeva’s Revolution in Poetic Language offers a challenge to theories of the subject in psychoanalysis, linguistic theory, and in philosophy. Central to that challenge is Kristeva’s conception of negativity. In this article, I trace the development of the concept of negativity in Revolution in Poetic Language from its root in Hegel, to rejection, which Kristeva develops out of Freud. Both are crucial to the development of the material dialectic between the semiotic and the symbolic that makes up Kristeva’s subject-in-process/on trial. (...) I argue that a clearer understanding of Kristeva’s conception of negativity helps us to better appreciate the force of Kristeva’s challenge, both philosophically and politically. Finally I argue that Kristevan negativity also helps us to clarify the relation between the delimited space of politics and its conditions, laying the groundwork for constitutive exclusion as political critique and opening a space for the possibility of political re-constitutions. (shrink)

In this article, I rely both on Derrida's 1974 work Glas, as well as Derrida's 1971–72 lecture course, “La famille de Hegel,” to argue that the concept of the quasi-transcendental is central to Derrida's reading of Hegel and to trace its implications beyond the Hegelian system. I follow Derrida's analysis of the role of Antigone—or, as the lecture course has it, “Antigonanette”—in Hegel's thought to argue that the quasi-transcendental indicates a restriction of empirical difference into the transcendental, which is thereby (...) only ever provisionally transcendental. I then argue that the economy of difference indicated by the quasi-transcendental is neither a general economy, nor is it in each case singular, but rather it ambivalently oscillates between these two. Finally, I treat the temporality of the quasi-transcendental, arguing that the economy of difference indicated by the quasi-transcendental is not prior to the restriction of empirical difference, but is paradoxically produced by it by being retroactively constituted. I take up this analysis for the sake of describing what I contend is the quasi-transcendental structure of constitutive exclusion, a way of understanding the conceptual structure of political bodies, and the political structure of concepts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Continental and Feminist Philosophical PedagogiesConditionsSina KramerIn thinking through what it means to teach continental and feminist philosophy, I keep coming back to a somewhat enigmatic line from Adorno’s essay, “Why Still Philosophy?”: “Because philosophy is good for nothing, it is not yet obsolete” (Adorno 2005, 15). I believe that this dialectical aphorism has everything to do with the conditions under which we as teachers practice philosophy today, and continental (...) and feminist philosophy in particular.On the one hand, Adorno’s remark is made in the context of the specific conditions—political, economic, philosophical, etc.—of his own time. On the other hand, Adorno writes that if philosophy is still necessary (and we should always take seriously this “if,” as well as the “not yet” of the quote above) then it is for the same reasons that philosophy has always been necessary: as critique. Philosophy is thus both spatially and temporally specific in that it plays particular roles in particular places and times, and it is universal in that its operation as critique has always been the same. We must therefore spell out the particular conditions of our historical moment in order for philosophy to play the critical role that it has purportedly always played. What are the conditions under which we teach continental and feminist philosophy today?I would point here to a few phenomena. First, President Barack Obama announced in his 2011 “State of the Union” address that in order for America to “win the future” we must invest in education, to reach the goal of having the [End Page 68] highest proportion of college graduates in the world by the end of the decade (Obama 2011). The president described investment in education as part of the larger of goal of supporting the competitive advantage of American workers. The president cast education in entirely economic terms: a greater quantity of graduates for the sake of a more economically prosperous nation.At the same time, some universities, especially those that depend in part upon dwindling state resources, have chosen to cut programs in the humanities in general or in philosophy in particular: at UNLV, at the University of Louisiana at Lafayette, or at Middlesex University.1 Under the logic of fiscal austerity, universities are deciding that they can no longer “afford” to keep departments that are losing money or, which may amount to the same thing, programs that are no longer central to the mission of the university.Finally, recent research indicates that only about one-third of all teachers in higher education in the United States are tenured or on the tenure track; teaching has been farmed out, outsourced, or subcontracted to a contingent labor force with less job security, lower wages, and fewer benefits than those on the tenure track.2 And shortly after the president’s “State of the Union” address, the book Academically Adrift and accompanying articles in the Chronicle of Higher Education and the New York Times argued that college students are learning less, according to measurable metrics, even as they are paying more—that is, going into greater debt—for a degree that is less and less a guarantee of a stable middle-class income (Arum and Roksa 2011; Glenn 2011a, 2011b).In his dialectical aphorism, Adorno seems to set up a contradiction between philosophy and utility, between learning as an end in itself, and learning as an instrument toward some other end—a contradiction that goes back as far as philosophy’s stories about its own origins, to Thales and the olive-press. But this contradiction must be examined in each context in which it is raised. For instance, W. E. B. Du Bois seems to set up the same contradiction in The Souls of Black Folk, when he writes that “the true college will ever have one goal: not to earn meat, but to know the end and aim of that life which meat nourishes” (Du Bois 1997, 86). While this seems like the statement of a universal truth, it must be understood in the context of the larger argument in Souls, in which Du Bois argues that black people have a right to an education as... (shrink)

This collection of essays forms a lively debate over the fundamental characteristics of legal and moral rights. The essays examine whether rights fundamentally protect individuals' interests or whether they instead fundamentally enable individuals to make choices.

The research discussed in this paper centers around the convergence of extended reality (XR) platforms, computational design, digital fabrication, and critical urban study practices. Its aim is to cultivate interdisciplinary and multiscalar approaches within these domains. The research endeavor represents a collaborative effort between two primary disciplines: critical urban studies, which prioritize socio-environmental justice, and integrated digital design to production, which emphasize the realization of volumetric or voxel-based structural systems. Moreover, the exploration encompasses augmented reality to assess its utilization in (...) both the assembly process of the structures and the integration of phygital (physical and digital) data with the physical environment. Within the context of these research scopes, this paper introduces FabriCity-XR as an interactive phygital installation. In addition to presenting an overview of the integrated research driven and performative design to production methodologies, the project showcases the practical implementation of web-based augmented reality trails, eliminating the requirement for external applications for interaction. This approach allows users to seamlessly navigate and engage with phygital content overlaid on physical objects using their personal smart devices. The result is a captivating and immersive user experience that effectively merges the physical and digital realms. (shrink)

Populism is on the rise, especially in Western Europe. While it is often assumed that populist actors have a tendency for fallacious reasoning, this has not been systematically investigated. We analyze the use of informal fallacies by right-wing populist politicians and their representation in the media during election campaigns. We conduct a quantitative content analysis of press releases of right-wing populist parties and news articles in print media during the most recent elections in the United Kingdom and Switzerland in 2015. (...) The results show that fallacies are used in more than a third of all analyzed texts and overwhelmingly co-occur with populist key messages. Moreover, fallacies occur more often in populist parties’ press releases than in news articles and are more common in Switzerland compared to the United Kingdom. This study confirms the argument that populist actors use fallacies in combination with populist claims. (shrink)

Data‐driven algorithms are widely used to make or assist decisions in sensitive domains, including healthcare, social services, education, hiring, and criminal justice. In various cases, such algorithms have preserved or even exacerbated biases against vulnerable communities, sparking a vibrant field of research focused on so‐called algorithmic biases. This research includes work on identification, diagnosis, and response to biases in algorithm‐based decision‐making. This paper aims to facilitate the application of philosophical analysis to these contested issues by providing an overview of three (...) key topics: What is algorithmic bias? Why and how can it occur? What can and should be done about it? Throughout, we highlight connections—both actual and potential—with philosophical ideas and concerns. (shrink)

Previous simulation models have found positive effects of cognitive diversity on group performance, but have not explored effects of diversity in demographics (e.g., gender, ethnicity). In this paper, we present an agent-based model that captures two empirically supported hypotheses about how demographic diversity can improve group performance. The results of our simulations suggest that, even when social identities are not associated with distinctive task-related cognitive resources, demographic diversity can, in certain circumstances, benefit collective performance by counteracting two types of conformity (...) that can arise in homogeneous groups: those relating to group-based trust and those connected to normative expectations towards in-groups. (shrink)

Inspired by recent breakthroughs in predictive modeling, practitioners in both industry and government have turned to machine learning with hopes of operationalizing predictions to drive automated decisions. Unfortunately, many social desiderata concerning consequential decisions, such as justice or fairness, have no natural formulation within a purely predictive framework. In efforts to mitigate these problems, researchers have proposed a variety of metrics for quantifying deviations from various statistical parities that we might expect to observe in a fair world and offered a (...) variety of algorithms in attempts to satisfy subsets of these parities or to trade o the degree to which they are satised against utility. In this paper, we connect this approach to fair machine learning to the literature on ideal and non-ideal methodological approaches in political philosophy. The ideal approach requires positing the principles according to which a just world would operate. In the most straightforward application of ideal theory, one supports a proposed policy by arguing that it closes a discrepancy between the real and the perfectly just world. However, by failing to account for the mechanisms by which our non-ideal world arose, the responsibilities of various decision-makers, and the impacts of proposed policies, naive applications of ideal thinking can lead to misguided interventions. In this paper, we demonstrate a connection between the fair machine learning literature and the ideal approach in political philosophy, and argue that the increasingly apparent shortcomings of proposed fair machine learning algorithms reflect broader troubles faced by the ideal approach. We conclude with a critical discussion of the harms of misguided solutions, a reinterpretation of impossibility results, and directions for future research. (shrink)

Machine learning algorithms are increasingly used to shape high-stake allocations, sparking research efforts to orient algorithm design towards ideals of justice and fairness. In this research on algorithmic fairness, normative theorizing has primarily focused on identification of “ideally fair” target states. In this paper, we argue that this preoccupation with target states in abstraction from the situated dynamics of deployment is misguided. We propose a framework that takes dynamic trajectories as direct objects of moral appraisal, highlighting three respects in which (...) such trajectories can be subject to evaluation in relation to their temporal dynamics, robustness, and representation. (shrink)

Within the framework of 'Temporalities and the Urban Fabric: Co-Producing Liminal Spaces in Transitional Epochs,' this rigorous examination unravels the multilayered nuances of temporality and its intimate relationship with urban spaces in times of transition. The research delineates the intricate interplay between public exhibitions, urban realms, and socio-political paradigms, particularly within the dynamic settings of the metropolitan entities of Houston and Amsterdam. These cities, as epitomes of temporal urban flux, become fertile grounds for exploring the ephemeral essence of liminal spaces (...) and their transformative manifestations. By weaving together diverse academic domains – from Design Computation and Fabrication to Urban Communities and Spatial Justice – this study underscores the symbiotic fusion of Augmented Reality (AR) and Gamification within the broader canvas of urban temporalities. Crucially, the research accentuates the transformative potential of Extended Reality (XR) in augmenting the theoretical and methodological contours of urban studies within these transitional epochs. (shrink)

Diffusions in Architecture: Artificial Intelligence and Image Generators delves into the impact of Diffusion AI algorithms and generative image models on architecture design and aesthetics. The book presents an in-depth analysis of how these new technologies are revolutionizing the field of architecture. The architects presented in the book focus on the application of specific AI techniques and tools used in generative design, such as Diffusion models, Dall-E2, Stable Diffusion, and MidJourney. It discusses how these techniques can generate synthetic images that (...) are both realistic and imaginative, creating new possibilities for architectural design and aesthetics. This comprehensive overview of the impact of Diffusion AI algorithms and generative image models on the field of architecture shows how they are changing the way architects approach their work. With a foreword by Lev Manovich—artist, writer and one of the world's most influential digital culture theorists. Sharing the work and insights of a team of designers and theorists from a range of backgrounds, offering disciplinary depth, and covering the full impact of these tools and models on architecture, Diffusions in Architecture includes information on: Fresh perspectives on design and aesthetics, with designs, images, and commentary from 22 leading architects, theorists, and designersThe potential of prompt engineering and text-to-image models applicable to a broad interdisciplinary audienceWhether image generators, or AI in general, will be an aid for human design, or potentially displace humans from the market fundamentals of a larger debate in the architectural discourse (and practice) on the use of image generatorsCollecting the different ideas that have emerged in the field, Diffusions in Architecture provides architects, designers, concept artists, and theorists with an overview of this cornucopia of architectural imaginations produced in a common effort between humans and artificial intelligence. (shrink)

Community resilience entails the community’s ongoing and developing capacity to account for its vulnerabilities and function amid and recover from disturbance. A holistic and systematic approach of the community on how it uses material and energy resources or how a society educates the members' overtime is required to learn from the past and adapt to the present and future opportunities and threads. Community resilience has a long history in the local communities, which is embedded in their culture and history around (...) shared values and local knowledge based on a dedicated and robust collaboration among diverse groups of the community and the various actors from different backgrounds. The innovative partnership between various actors such as stakeholders, research entities, local communities, and third sector parties is required to overcome the complexities of resiliency building. Using local knowledge to understand the local needs better is crucial in developing local, sustainable solutions and building community resilience over time. (shrink)

This paper focuses on two highly publicized formal trade-offs in the field of responsible artificial intelligence (AI) -- between predictive accuracy and fairness and between predictive accuracy and interpretability. These formal trade-offs are often taken by researchers, practitioners, and policy-makers to directly imply corresponding tensions between underlying values. Thus interpreted, the trade-offs have formed a core focus of normative engagement in AI governance, accompanied by a particular division of labor along disciplinary lines. This paper argues against this prevalent interpretation by (...) drawing attention to three sets of considerations that are critical for bridging the gap between these formal trade-offs and their practical impacts on relevant values. I show how neglecting these considerations can distort our normative deliberations, and result in costly and misaligned interventions and justifications. Taken together, these considerations form a sociotechnical framework that could guide those involved in AI governance to assess how, in many cases, we can and should have higher aspirations than the prevalent interpretation of the trade-offs would suggest. I end by drawing out the normative opportunities and challenges that emerge out of these considerations, and highlighting the imperative of interdisciplinary collaboration in fostering responsible AI. (shrink)

This book brings together contributions from seventeen of the world's foremost legal and political philosophers to examine the lasting influence of H.L.A. Hart. The essays explore the major subjects of Hart's work: general jurisprudence, criminal responsibility, rights, justice, causation and the foundations of liberalism.

Self-disclosures on online social networks have received increased attention in the last two decades. Researchers from different disciplines investigated manifold influencing variables, and studies applied different theories to explain why many users share very sensitive and personal information despite potential risks and negative consequences, whereas others do not. Oftentimes, it is argued that self-disclosure decisions result from a kind of rational “calculus” of risks and benefits. However, such an assumption of rationality can and has been criticized. Nevertheless, fundamental cognitive and (...) affective mechanisms that underlie self-disclosure decision making on social networks are still under-explored. By building upon previous self-disclosure theories and models, dual-and tripartite-system perspectives of decision making, and former empirical findings, we propose a Tripartite Self-Disclosure Decision model that conceptualizes inner processes of online self-disclosure decision making. Central to this model is the proposed interaction of three neural and cognitive/affective systems: a reflective, an impulsive, and an interoceptive system. We further highlight individual and environmental features, which can impact individuals’ online self-disclosure decisions by influencing the proposed inner decision-making processes targeting the aforementioned three systems. Possible short- and long-term consequences are also discussed, which in turn can affect certain model components in subsequent self-disclosure decision situations. By taking such a neurocognitive perspective, we expand current research and models, which helps to better understand potentially risky information sharing on online social networks and can support attempts to prevent users from incautious self-disclosures. (shrink)

Diversity of social identities can improve the performance of groups through varied cognitive and communicative pathways. Recently, research efforts have focused on identifying when we should expect to see these potential benefits in real-world settings. While most research to date has studied this topic at individual and interpersonal levels, in this paper, we develop an agent-based model to explore how various aspects of homophily, the tendency of individuals to associate with similar others, affects performance at a larger scale. Study 1 (...) examines how two types of homophily---identity-driven and opinion-driven---impact collective performance on a sequential decision-making task via modulating network formation and trust relations. Study 2 considers how the presence of identity-based conformity pressure can affect the findings from the first study. Overall, we find that the effect of homophily on performance is complex, depending on the operative dimensions of similarity, mediating pathways, and the specific outcome of interest. Finally, we discuss the implications of our results for policy interventions aiming to improve group performance. (shrink)

Port Cities are historically the places for paradigm shifts, radical changes, and socio-economic transitions. In particular, the interaction zone between the port infrastructure and urban activities creates liminal spaces at the forefront of many contemporary challenges. In these liminal spaces, the port's flows, form, and function intertwine with urban contexts and conflict with the living conditions. Conceptualizing the portcityscape and harborscape as liminal space and urban thresholds leads to (re)thinking about innovative participatory methods and technologies for building community resilience in (...) port cities. Additionally, inevitable constant development in port cities requires adaptability and resilience from the waterfronts to the hinterlands and city centers. Such confrontation of port infrastructures and urbanization is socio-politically and spatially challenging, specifically in historic port cities. Therefore, as the approach to exploiting energy and human resources changes over time, the physicality of the built environment in port cities and how we (re)use the resources need to be redefined. This research investigates key socio-spatial features and challenges of port cities by examining how the port's proximity to the city requires coordination, collaboration, transparency, and community dialogue. The introduction and background literature discuss three domains and notions of port city studies, building community resiliency through participatory frameworks, and parasitic architecture. By building upon this analytical framework, the paper presents case studies developed within the research-led design studio focusing on building resilient communities in four port cities, including Amsterdam, Constanta, Alexandria, and Rio De Janeiro. This research focus on the community-enabled application of emerging technologies, innovative approaches, and co-designing and co-building participatory methods. The selected case studies introduce an integrative and multi-scalar pedagogical framework for building resilient communities in liminal spaces of port cities. (shrink)

Contemporary economic analysts of the law argue that certain legal institutions, such as contract law, ought to be designed to promote wealth maximization, while different legal institutions ought to seek to achieve non-wealth maximizing aims, such as distributive justice. In order to preserve the normative claim that the sole aim of any single legal institution should be the promotion of wealth maximization, economists rely on the “specialization principle”: each legal institution must be organized around a single normative criterion, partitioned from (...) and without regard to the normative aims of other legal institutions. I argue that this idea of a strict normative division of labour between institutions is problematic. On any instrumentalist view, the normative justification of the ends of a particular legal institution cannot ignore the normative aims of the legal system of which it is a part. I develop this argument by critically examining the economic analyst’s claim that commercial contract law should be limited to helping firms maximize profit. (shrink)

In the hopes of finding supporting evidence for various accounts of actual causation, many philosophers have recently turned to psychological findings about the influence of norms on counterfactual cognition. Surprisingly little philosophical attention has been paid, however, to the question of why considerations of normality should be relevant to counterfactual cognition to begin with. In this paper, I follow two aims. First, against the methodology of two prominent psychological accounts, I argue for a functional approach to understanding the selectivity of (...) counterfactual cognition. Second, I take some steps towards a systematic analysis by providing a qualitative, decision‐theoretic account of one important function of counterfactual thinking, namely, inferring, in the face of undesirable outcomes, corrective policies that prevent the occurrence of similar outcomes in future circumstances. I make a case for employing this analysis by (a) showing its value for assessing the rationality of imagination‐driven counterfactual generation, (b) highlighting its use for making sense of practices in history and policy analysis where counterfactual selection plays a central role, and (c) demonstrating its diagnostic value for identifying areas where counterfactual generation may lead us into epistemic and ethical troubles. (shrink)

In this essay an attempt is made to transcend the divide between realists and anti-realists in the philosophy of history by proposing an alternative account of understanding the past, one based on the nature of testimonies, specifically theirscopeanddepth. This is done through a critical engagement with the works of prominent realist and anti-realist philosophers of history ; other philosophers working on relevant topics such as epistemology, and historians who have written on historical method. The alternative account thus developed is then (...) tested by applying it to the case of theHistorikerstreit, the bitterly waged historian's struggle concerning the history and legacy of Nazism. On the surface it appears to affirm the anti-realist position that posits historical narratives as being inherently normative/aesthetic given the inadequacies of the ‘thick’ realist position, but upon closer scrutiny it demonstrates the merit of my alternative, testimony-based ‘thin’ realist account. (shrink)

This paper defends JN Keynes’s argument that normative economics can be objective. It begins by exploring Keynes’s view on the positive/normative distinction in economics. After discussing its originality and advantages, the paper recognizes that the Keynesian distinction does not explain the exact nature of the relationship between positive and normative economics. Thus, it tries to improve Keynes’s position using Popper’s contributions to economics. It shows that for Popper, advances in normative social science are the main steppingstone to resolving disagreements over (...) the choice of the norms underlying the reform of social situations. The final two parts of the paper draw on the contributions of Keynes and Popper to the study of norms to explain why normative economics can more easily approach objectivity by concentrating on highly delimited topics. The last part relies on Popper’s concept of avoidable unhappiness to offer one method of restraining the tasks of normative economics. (shrink)

§1. Introduction. Asymptotic cones of metric spaces were first invented by Gromov. They are metric spaces which capture the ‘large-scale structure’ of the underlying metric space. Later, van den Dries and Wilkie gave a more general construction of asymptotic cones using ultrapowers. Certain facts about asymptotic cones, like the completeness of the metric space, now follow rather easily from saturation properties of ultrapowers, and in this survey, we want to present two applications of the van den Dries-Wilkie approach. Using ultrapowers (...) we obtain an explicit description of the asymptotic cone of a semisimple Lie group. From this description, using semi-algebraic groups and non-standard methods, we can give a short proof of the Margulis Conjecture. In a second application, we use set theory to answer a question of Gromov.§2. Definitions. The intuitive idea behind Gromov's concept of an asymptotic cone was to look at a given metric space from an ‘infinite distance’, so that large-scale patterns should become visible. In his original definition this was done by gradually scaling down the metric by factors 1/nfornϵ ℕ. In the approach by van den Dries and Wilkie, this idea was captured by ultrapowers. Their construction is more general in the sense that the asymptotic cone exists for any metric space, whereas in Gromov's original definition, the asymptotic cone existed only for a rather restricted class of spaces. (shrink)

ZusammenfassungDie Entwicklung einer „personalisierten Medizin“ ist zurzeit in aller Munde. Insbesondere die personalisierte Arzneimitteltherapie gewinnt infolge der pharmakologischen und molekulargenetischen Entwicklungen immer mehr an Bedeutung. Dies macht es erforderlich, die Auswirkungen der personalisierten Arzneimitteltherapie auf die gesetzliche Krankenversicherung (GKV) und die Patientenversorgung zu untersuchen. In diesem Zusammenhang stellt sich die Frage nach einer „Orphanisierung“: Könnten Arzneimittel der personalisierten Medizin regelmäßig als Orphan Drugs, also als Arzneimittel für seltene Leiden, ausgewiesen werden, würde für sie nach dem Arzneimittelneuordnungsgesetz (AMNOG) grundsätzlich kein Nachweis (...) des Zusatznutzens im Rahmen der vom Gemeinsamen Bundesausschuss (GBA) vorzunehmenden frühen Nutzenbewertung erforderlich werden. Entscheidend für die Ausweisung des Arzneimittels als Orphan Drug ist unter anderem die Prävalenzrate der Patientengruppe, deren Erkrankung mit dem Arzneimittel behandelt werden soll. In diesem Zusammenhang kommt der Stratifizierung von Patientengruppen im Rahmen der personalisierten Arzneimitteltherapie eine besondere Bedeutung zu. Eine solche „Orphanisierung“ hätte für die GKV wegen der mangelnden Kenntnis von dem Zusatznutzen des Arzneimittels insbesondere preisrechtliche Konsequenzen; für die Patienten sind die Folgen durchaus differenzierter zu betrachten. (shrink)

Die Entwicklung einer „personalisierten Medizin“ ist zurzeit in aller Munde. Insbesondere die personalisierte Arzneimitteltherapie gewinnt infolge der pharmakologischen und molekulargenetischen Entwicklungen immer mehr an Bedeutung. Dies macht es erforderlich, die Auswirkungen der personalisierten Arzneimitteltherapie auf die gesetzliche Krankenversicherung (GKV) und die Patientenversorgung zu untersuchen. In diesem Zusammenhang stellt sich die Frage nach einer „Orphanisierung“: Könnten Arzneimittel der personalisierten Medizin regelmäßig als Orphan Drugs, also als Arzneimittel für seltene Leiden, ausgewiesen werden, würde für sie nach dem Arzneimittelneuordnungsgesetz (AMNOG) grundsätzlich kein Nachweis (...) des Zusatznutzens im Rahmen der vom Gemeinsamen Bundesausschuss (GBA) vorzunehmenden frühen Nutzenbewertung erforderlich werden. Entscheidend für die Ausweisung des Arzneimittels als Orphan Drug ist unter anderem die Prävalenzrate der Patientengruppe, deren Erkrankung mit dem Arzneimittel behandelt werden soll. In diesem Zusammenhang kommt der Stratifizierung von Patientengruppen im Rahmen der personalisierten Arzneimitteltherapie eine besondere Bedeutung zu. Eine solche „Orphanisierung“ hätte für die GKV wegen der mangelnden Kenntnis von dem Zusatznutzen des Arzneimittels insbesondere preisrechtliche Konsequenzen; für die Patienten sind die Folgen durchaus differenzierter zu betrachten. (shrink)

The myriad controversies embroiling the mental health field—heightened in the lead-up to the release of DSM-5 —merit a close analysis of the field and its epistemological underpinnings. By using DSM as a starting point, this paper develops to overview the entire mental health field. Beginning with a history of the field and its recent crises, the troubles of the past “external crisis” are compared to the contemporary “internal crisis.” In an effort to examine why crises have recurred, the internal dynamics (...) of the field are assessed: applying Kuhn’s paradigmatic framework, crises are appraised to situate the differences between the natural sciences and the mental health field. Next, a Foucauldian analysis examines the functioning of the field’s power over the body, which is disproportionate in comparison to its scientific grounding. This is followed by investigating the field’s combination of contested scientific grounding and significant power, through a Latourian consideration of the assumptions and meaning behind the mental health field’s deployment of science. This includes scrutinizing the history of the classification of Post-Traumatic Stress Disorder. The paper closes by assessing the field’s potential to address these issues effectively. (shrink)