Recognition that biological systems are stabilized far from equilibrium by self-organizing, informed, autocatalytic cycles and structures that dissipate unusable energy and matter has led to recent attempts to reformulate evolutionary theory. We hold that such insights are consistent with the broad development of the Darwinian Tradition and with the concept of natural selection. Biological systems are selected that re not only more efficient than competitors but also enhance the integrity of the web of energetic relations in which they are embedded. (...) But the expansion of the informational phase space, upon which selection acts, is also guaranteed by the properties of open informational-energetic systems. This provides a directionality and irreversibility to evolutionary processes that are not reflected in current theory.For this thermodynamically-based program to progress, we believe that biological information should not be treated in isolation from energy flows, and that the ecological perspective must be given descriptive and explanatory primacy. Levels of the ecological hierarchy are relational parts of ecological systems in which there are stable, informed patterns of energy flow and entropic dissipation. Isomorphies between developmental patterns and ecological succession are revealing because they suggest that much of the encoded metabolic information in biological systems is internalized ecological information. The geneological hierarchy, to the extent that its information content reflects internalized ecological information, can therefore be redescribed as an ecological hierarchy. (shrink)

Two experiments examined how affective values from visual and auditory modalities are integrated. Experiment 1 paired music and videos drawn from three levels of valence while holding arousal constant. Experiment 2 included a parallel combination of three levels of arousal while holding valence constant. In each experiment, participants rated their affective states after unimodal and multimodal presentations. Experiment 1 revealed a congruency effect in which stimulus combinations of the same extreme valence resulted in more extreme state ratings than component stimuli (...) presented in isolation. An interaction between music and video valence reflected the greater influence of negative affect. Video valence was found to have a significantly greater effect on combined ratings than music valence. The pattern of data was explained by a five parameter differential weight averaging model that attributed greater weight to the visual modality and increased weight with decreasing values of valence. Experiment 2 revealed a congruency effect only for high arousal combinations and no interaction effects. This pattern was explained by a three parameter constant weight averaging model with greater weight for the auditory modality and a very low arousal value for the initial state. These results demonstrate key differences in audiovisual integration between valence and arousal. (shrink)

The design argument was rebutted by David Hume. He argued that the world and its contents (such as organisms) were not analogous to human artifacts. Hume further suggested that there were equally plausible alternatives to design to explain the organized complexity of the cosmos, such as random processes in multiple universes, or that matter could have inherent properties to self-organize, absent any external crafting. William Paley, writing after Hume, argued that the functional complexity of living beings, however, defied naturalistic explanations. (...) In effect he dared anyone to come up with an alternative to his inference to design, and hence a designer, outside of nature. Charles Darwin explained the apparent design of functional complexity by his theory of natural selection. Asa Gray, however, in essays as well as in correspondence with Darwin argued that natural selection allowed for a type of ' evolutionary teleology' in which design at most could be considered the result of universal principles. F. E. Hicks updated Hume by specifically objecting to the use of design arguments by Paley. Hicks argued that the apparent design seen in nature reflected order at a deep level in nature. The design argument was briefly revived by Lawrence Henderson early in the twentieth century but he ultimately concluded that design and teleology were not necessarily mutually entailing and he retracted his design argument in favor of one that he termed ' natural teleology'. The current claims of ' intelligent design' have the same logical problems that have beset previous design arguments. If design is divorced from teleology and its discontents put behind us, then there is a possibility that the latter can have a place in the development of theories to explain the phenomena of emergent complexity. (shrink)

The design argument was rebutted by David Hume. He argued that the world and its contents (such as organisms) were not analogous to human artifacts. Hume further suggested that there were equally plausible alternatives to design to explain the organized complexity of the cosmos, such as random processes in multiple universes, or that matter could have inherent properties to self-organize, absent any external crafting. William Paley, writing after Hume, argued that the functional complexity of living beings, however, defied naturalistic explanations. (...) In effect he dared anyone to come up with an alternative to his inference to design, and hence a designer, outside of nature. Charles Darwin explained the apparent design of functional complexity by his theory of natural selection. Asa Gray, however, in essays as well as in correspondence with Darwin argued that natural selection allowed for a type of ‘evolutionary teleology’ in which design at most could be considered the result of universal principles. F.E. Hicks updated Hume by specifically objecting to the use of design arguments by Paley. Hicks argued that the apparent design seen in nature reflected order at a deep level in nature. The design argument was briefly revived by Lawrence Henderson early in the twentieth century but he ultimately concluded that design and teleology were not necessarily mutually entailing and he retracted his design argument in favor of one that he termed ‘natural teleology’. The current claims of ‘intelligent design’ have the same logical problems that have beset previous design arguments. If design is divorced from teleology and its discontents put behind us, then there is a possibility that the latter can have a place in the development of theories to explain the phenomena of emergent complexity. (shrink)

In the same year, 1961, Peter D. Mitchell and Robert R.J.P. Williams both put forward hypotheses for the mechanism of oxidative phosphorylation in mitochondria and photophosphorylation in chloroplasts. Mitchell's proposal was ultimately adopted and became known as the chemiosmotic theory. Both hypotheses were based on protons and differed markedly from the then prevailing chemical theory originally proposed by E.C. Slater in 1953, which by 1961 was failing to account for a number of experimental observations. Immediately following the publication of Williams's (...) hypothesis and before his own was published, Mitchell initiated a correspondence. Examination of the letters shows the development of a dispute based on the validity of the proposals, who should have priority and particularly whether Mitchell had drawn on Williams's work without acknowledgement. We have concluded that Mitchell's proposals were original although it is evident that prior to the correspondence Williams had considered and rejected a proposition similar to Mitchell's theory. However, a major cause of the dispute was the difference in disciplinary backgrounds of Mitchell, a microbial biochemist and Williams, a chemist. (shrink)

In the same year, 1961, Peter D. Mitchell and Robert R.J.P. Williams both put forward hypotheses for the mechanism of oxidative phosphorylation in mitochondria and photophosphorylation in chloroplasts. Mitchell's proposal was ultimately adopted and became known as the chemiosmotic theory. Both hypotheses were based on protons and differed markedly from the then prevailing chemical theory originally proposed by E.C. Slater in 1953, which by 1961 was failing to account for a number of experimental observations. Immediately following the publication of Williams (...) 's hypothesis and before his own was published, Mitchell initiated a correspondence. Examination of the letters shows the development of a dispute based on the validity of the proposals, who should have priority and particularly whether Mitchell had drawn on Williams 's work without acknowledgement. We have concluded that Mitchell's proposals were original although it is evident that prior to the correspondence Williams had considered and rejected a proposition similar to Mitchell's theory. However, a major cause of the dispute was the difference in disciplinary backgrounds of Mitchell, a microbial biochemist and Williams, a chemist. (shrink)

Physicists regularly invoke universal laws, such as those of motion and electromagnetism, to explain events. Biological and medical scientists have no such laws. How then do they acquire a reliable body of knowledge about biological organisms and human disease? One way is by repeatedly returning to, manipulating, observing, interpreting, and reinterpreting certain subjects—such as flies, mice, worms, or microbes—or, as they are known in biology, “model systems.” Across the natural and social sciences, other disciplinary fields have developed canonical examples that (...) have played a role comparable to that of biology’s model systems, serving not only as points of reference and illustrations of general principles or values but also as sites of continued investigation and reinterpretation. The essays in this collection assess the scope and function of model objects in domains as diverse as biology, geology, and history, attending to differences between fields as well as to epistemological commonalities. Contributors examine the role of the fruit fly Drosophila and nematode worms in biology, troops of baboons in primatology, box and digital simulations of the movement of the earth’s crust in geology, and meteorological models in climatology. They analyze the intensive study of the prisoner’s dilemma in game theory, ritual in anthropology, the individual case in psychoanalytic research, and Athenian democracy in political theory. The contributors illuminate the processes through which particular organisms, cases, materials, or narratives become foundational to their fields, and they examine how these foundational exemplars—from the fruit fly to Freud’s Dora—shape the knowledge produced within their disciplines. Contributors Rachel A. Ankeny Angela N. H. Creager Amy Dahan Dalmedico John Forrester Clifford Geertz Carlo Ginzburg E. Jane Albert Hubbard Elizabeth Lunbeck Mary S. Morgan Josiah Ober Naomi Oreskes Susan Sperling Marcel Weber M. Norton Wise. (shrink)

The Scottish physician James Lind is the most celebrated name in the history of research into the causes and cures of scurvy. This is due to the famous experiment he conducted in 1747 on H.M.S. Salisbury in order to compare the efficiency of six popular treatments for scurvy. This experiment is generally regarded as the first controlled trial in clinical science (see e.g. Carpenter 1986, p. 52).

O artigo apresenta os elementos filosóficos constitutivos da crítica, lançada por Jacobi a Fichte em sua Carta a Fichte, segundo a qual “Idealismo é niilismo”. Para tanto, reconstitui a crítica de Jacobi à pretensão idealista de estabelecer um sistema absoluto do conhecimento que, partindo da atividade originária e infinita do pensamento, põe a objetividade do mundo na medida em que o pensa; dá atenção à centralidade do problema do absoluto/de Deus na argumentação de Jacobi e sua relação com as noções (...) de não-filosofia, não-saber e crença, além de apontar para as conexões destas noções com o emergente problema do niilismo na modernidade. Por fim, estabelece um breve contraponto com a filosofia de Nietzsche. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:"An Encyclopedic Pico della Mirandola"?Rethinking Aquinas on Christ's Infused KnowledgeJoshua H. LimIntroductionIn what has come to be known as Thomas's account of the triple knowledge of Christ, the infused knowledge holds a tenuous place. It stands awkwardly between two kinds of knowledge, beatific and acquired, which are explicitly linked to the fulfillment of Christ's redemptive mission.1 Christ's earthly [End Page 147] beatific knowledge, controverted though it may be, nevertheless (...) has for Thomas a definite soteriological end.2 As the author of salvation, Christ, from the moment of conception, had to possess in actu the very knowledge to which he was to lead the rest of humanity, namely, the supernatural and beatific knowledge of the divine essence and of all things in it. Christ's acquired knowledge is also ordered to our salvation; it is necessary on account of exigencies arising from the integrity of human nature. In the assumption of a complete human nature, it was necessary for Christ to possess acquired knowledge, for without an agent intellect having its proper operation (i.e., abstracting intelligible species from phantasms arising from the senses), Christ's humanity would have been incomplete, imperfect.3 Thus, according to the patristic dictum that what is not assumed is not redeemed, Christ's redemption of human nature would have been imperfect. In contrast to these two types of knowledge, it is not clear whether and how the infused knowledge contributes to human salvation. Unlike the beatific knowledge, the infused knowledge does not belong intrinsically to the state of the comprehensor, for beatitude does not consist in a knowledge of created things in themselves, but in God;4 and unlike the acquired knowledge, the infused knowledge is not necessary for the assumption of an integral human nature.5 Add to this Thomas's passing description of Christ's infused knowledge as "proportioned to the angelic nature," encompassing all intelligible species of things knowable through nature and through the light of grace. In this vein, the infused knowledge threatens to transform Christ into a caricature of a man—turning Christ into what É. H. Wéber has disparagingly called an "encyclopedic Pico della Mirandola."6 [End Page 148]Herein lies the problem. Given the acquired and beatific knowledge, what use is there for the infused knowledge? The knowledge of all that can be known by nature is already attributed to Christ through his acquired knowledge; further, the knowledge of all the mysteries of grace is accessible to Christ through his beatific knowledge of God and all things in Verbo. While humans, as viatores, gain knowledge through the senses, and, as comprehensores, behold God through an elevation of the soul through glory, it is unclear whether a third kind of knowledge, the infused knowledge, is necessary and, if so, to what end. If, according to the Scholastic dictum, God and nature do nothing in vain, what sense can be made of Christ's infused knowledge?At least since the seventeenth century, Thomists have typically sought to resolve this tension by appealing to the unique role of infused knowledge in Christ's earthly transmission of knowledge. Thus, the infused knowledge fills a gap between the beatific and acquired modes of knowing, providing Christ's soul with a mode of knowledge which enables him to communicate supernatural truths, the mysteria gratiae,7 otherwise known in the blessed vision of the Word, through created and, therefore, humanly communicable intelligible species. Christ's acquired knowledge, restricted to what is naturally knowable, is insufficient to lead "many brothers to glory,'" while the beatific knowledge, though saving, nevertheless remains unconceptualizable and therefore incommunicable in mode.8 According to this view, therefore, the necessity of the infused knowledge arises as a bridge of continuity between the beatific and acquired knowledge, enabling Christ to communicate the truth of the kingdom of God in a way that is proportioned to the human nature in via.Such an account has two clear points in its favor. First, by highlighting the gulf between the beatific and acquired modes of knowledge, it makes room for a distinct, third mode of knowledge. Second, and related to the first point, by accounting for the... (shrink)

Given its close ties with Confucianism, East Asian exceptionalism could be defined as the inversion of Max Weber's doctrine that Confucian values inhibit rationality and lead to economic stagnation. That revaluation, which has contributed to an inversion of `Orientalism' as it relates to East Asia, becomes a core premise of what may be called the Singapore model of East Asian development theory. Another premise of that model is the primacy given to economic over political development, i.e., over democracy. In opposition (...) to this reactionary turn, and in the light of current revisionism in Japanese studies, this article follows Kim Dae Jung in positing a `Korean model' which challenges prevailing assumptions of East Asian exceptionalism. It is argued that Korea's record of democratic development over the last 15 years deserves a more affirmative response than has been allowed by some of the most vocal American Koreanists. This model, moreover, affirms Kim's belief in an organic rather than exogenous explanation of Korea's political development. It is argued that Korea, rather than Japan, offers the best available prototype for Asian political development in its `post-exceptional' phase, and that Korea's emerging political culture - in striking contrast to Singapore's - bears witness to the fact that economic development can be consistent with liberal-democratic objectives. In Kim Dae Jung's opposition politics, and now in his presidency, one finds a rare balance of political and economic priorities. In the long run the `Korean Model' could prove far more important for East Asia than anything the IMF has to offer. (shrink)

There can be few other uses in the Latin language which afford us so great an insight into the mental attitude of a writer at the moment of his writing, or which endow writing with so much of that personal colour which the voice alone gives in perfection, as does the singular use of the pronoun nos. All forms of this word which occur in the speeches of individuals, who are at the moment speaking independently, are either wholly singular uses, (...) or partly plural uses with more or less justification for the plural form according to the extent to which the speaker is identifying himself with his surroundings. Thus we find all degrees of plurality in such forms, and it is those instances in which the plural form can be least definitely justified which we call ‘singular’ or ‘unreal plural’ uses, and which prove to be the most fascinating from a psychological point of view. The object of the present essay is to inquire how far the varieties of meaning in the singular use of nos, which Professor R. S. Conway has pointed out in Cicero, appear also in Vergil. (shrink)

Upshot: In our response we focus on five questions that point to important common themes in the commentaries: why start in wicked problems, what kind of system is a scientific perspective, what is the nature of second-order research processes, what does this mean for understanding interdisciplinary work, and how may polyocular research help make real-world decisions.

To the historian of art, it is evident that the two authors’ notion of ‘art’ is of very recent date, and not shared by everybody. They claim: ‘The purpose of art, surely, is not merely to depict or represent reality -- for that can be accomplished very easily with a camera -- but to enhance, transcend, or even to distort reality’ . They do not explain how one could photograph Paradise or Hell, the Creation of the World, the Passion of (...) Christ, or the escapades of the ancient gods -- all subjects that can be found represented in our museums. Nor is it more legitimate to generalize from certain Indian conventions of representing the female nude than it is for the academic tradition to take the Venus de Medici for the same purpose. Even a fleeting visit to one of the great museums might serve to convince the authors that few of the exhibits conform to the laws of art they postulate. [followed by response from V.S. Ramachandran]. (shrink)

Upshot: In our response we focus on how different types of systems are related from a constructivist perspective, and specifically on the relation between communicational social systems and embodied agency.

Open peer commentary on the article “Social Autopoiesis?” by Hugo Urrestarazu. Upshot: We agree on the need to explore a concept of social autopoiesis that goes beyond a strictly human-centered concept of social systems as autopoietic communicative systems. But both Hugo Urrestarazu and Niklas Luhmann neglect the importance of semiosis in understanding communication, and this has important implications for the question of a more general approach to social systems.

This article proposes a geostatistical solution for area-to-point spatial prediction (downscaling) taking into account boundary effects. Such effects are often poorly considered in downscaling, even though they often have significant impact on the results. The geostatistical approach proposed in this article considers two types of boundary conditions (BC), that is, a Dirichlet-type condition and a Neumann-type condition, while satisfying several critical issues in downscaling: the coherence of predictions, the explicit consideration of support differences, and the assessment of uncertainty regarding the (...) point predictions. An updating algorithm is used to reduce the computational cost of area-to-point prediction under a given BC. In a case study, area-to-point prediction under a Dirichlet-type BC and a Neumann-type BC is illustrated using simulated data, and the resulting predictions and error variances are compared with those obtained without considering such conditions. (shrink)