Biomedical ontologies are emerging as critical tools in genomic and proteomic research where complex data in disparate resources need to be integrated. A number of ontologies exist that describe the properties that can be attributed to proteins; for example, protein functions are described by Gene Ontology, while human diseases are described by Disease Ontology. There is, however, a gap in the current set of ontologies—one that describes the protein entities themselves and their relationships. We have designed a PRotein Ontology (PRO) (...) to facilitate protein annotation and to guide new experiments. The components of PRO extend from the classification of proteins on the basis of evolutionary relationships to the representation of the multiple protein forms of a gene (products generated by genetic variation, alternative splicing, proteolytic cleavage, and other post-translational modification). PRO will allow the specification of relationships between PRO, GO and other OBO Foundry ontologies. Here we describe the initial development of PRO, illustrated using human proteins from the TGF-beta signaling pathway. (shrink)

The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)

The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

Representing species-specific proteins and protein complexes in ontologies that are both human and machine-readable facilitates the retrieval, analysis, and interpretation of genome-scale data sets. Although existing protin-centric informatics resources provide the biomedical research community with well-curated compendia of protein sequence and structure, these resources lack formal ontological representations of the relationships among the proteins themselves. The Protein Ontology (PRO) Consortium is filling this informatics resource gap by developing ontological representations and relationships among proteins and their variants and modified forms. Because (...) proteins are often functional only as members of stable protein complexes, the PRO Consortium, in collaboration with existing protein and pathway databases, has launched a new initiative to implement logical and consistent representation of protein complexes. We describe here how the PRO Consortium is meeting the challenge of representing species-specific protein complexes, how protein complex representation in PRO supports annotation of protein complexes and comparative biology, and how PRO is being integrated into existing community bioinformatics resources. The PRO resource is accessible at http://pir.georgetown.edu/pro/. (shrink)

The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the building, curation, usage and dissemination of PRO. PRO provides a framework (...) for the formal representation of protein classes and protein forms in the OBO Foundry. It is designed to enable data retrieval and integration and machine reasoning at the molecular level of proteins, thereby facilitating cross-species comparisons, pathway analysis, disease modeling and the generation of new hypotheses. (shrink)

Given the pain, discomfort, anxiety, heartbreak, and boredom that most humans experience in their lives, is it morally permissible to create them? Some philosophers lately have answered ‘No’, contending that it is wrong to create a new human life when one could avoid doing so, because it would be bad for the one created. This view is known as ‘anti-natalism’. Some contributors to this volume argue that anti-natalism is true because: agents have a prima facie duty to prevent (...) suffering; it is immoral to violate another’s right not to be harmed without having consented to it; and it is a serious wrong to exploit the weakness of a poorly off being to become a biological parent. Others here argue against anti-natalism on the ground, for instance, that many of our lives are not so bad and in fact are quite good and that the logic of anti-natalism absurdly entails pro-mortalism, the view that we should kill off as many people as possible. This book explores these and related issues concerning the evaluative question of how to judge the worthwhileness of lives and the normative question of what basic duties entail for the creation of new lives. Most chapters initially appeared as part of a special issue of the _South African Journal of Philosophy_ (2012) and are here reprinted along with two additional essays on the topic. (shrink)

According to the Asymmetry, adding lives that are not worth living to the population makes the outcome pro tanto worse, but adding lives that are well worth living to the population does not make the outcome pro tanto better. It has been argued that the Asymmetry entails the desirability of human extinction. However, this argument rests on a misunderstanding of the kind of neutrality attributed to the addition of lives worth living by the Asymmetry. A similar misunderstanding is shown to (...) underlie Benatar’s case for anti-natalism. GPI Working Paper No. 3-2021. (shrink)

This book is an important contribution to the Values literature on the meanings of work. These essays explore the philosophical, ethical, religious, and social foundations that underscore so much of the current thinking and concern about work satisfaction and the place of work in the search of meaning. Various points of view are presented and these include among others historical perspectives, empirical studies and cross-cultural explorations. The result is a compelling and critical volume which challenges many basic cultural and empirical (...) assumptions and raises many questions about values and value-based decisions. (shrink)

The object of the study is the university quarter as a socio-cultural phenomenon. The subject of the study is the forms of cultural interaction between the university quarter and the city. The use of comparative and typological methods made it possible to identify and describe four forms of university presence in the city space, grouped around two basic directions. The first direction assumes the priority of the university in relation to the city, which gives rise to such a form of (...) their interaction as a "university city". In this case, university activity, in fact, fulfills the role of the economic basis of urban life. The second direction, which is characterized by the leading role of the city, is represented by the student quarter, campus, university quarter. And in this case, we can talk about the "growing" of the university into the urban space, which has both its positive and negative sides. Special attention is paid to the university quarter, the need for which is associated with the expansion of the university's interaction with the urban community. Combining the project nature, openness, flexible targeting, it demonstrates greater potential compared to traditional options. In turn, the university quarter project can be represented by various complementary options. The analysis of the Samara experience of its design revealed two promising forms of its implementation: building a citywide university space and updating the historical past on the basis of available university resources. (shrink)

M. J. Dewar argues that in Georg. 1.511–4 Virgil may have been drawing a disquieting parallel between Orestes, evoked through an imitation of Aeschylus , and Octavian, present a few lines above . Pausanias probably supports this suggestion; he shows that the link Octavian-Orestes existed quite early and in a sense favourable to Octavian, even though it may soon have been used in a negative sense by anti-Caesarian propaganda on account of the dark side of the myth. In front of (...) the temple of Hera in Argos there was still visible in the second century a statue representing Orestes, but identified by the inscription as Augustus. Certainly this parallel Augustus-Orestes was not proposed-and preserved - with polemical purpose in a famous sanctuary and in the Augustan age. Given the resemblance between history and myth and the moral weight of the famous myth itself, it is unlikely that we have to do with the mere re-use of any old statue. (shrink)

Water, the most represented substance in the human body, is a trace of the primordial sea where life originated. Its virtues may be represented by the Venus of Botticelli coming out from the sea, as well as by Velasquezs water seller and by Aristophanes chant of the clouds. Water has been connected with medicine from time immemorial and is a common good.

Este artigo analisa a projeção continental do México revolucionário no pós 1917 a partir do caso brasileiro. Após a eclosão da Revolução Russa, o modelo bolchevique passou a rivalizar indiretamente com o protagonismo que o México revolucionário pretendia exercer no cenário latino-americano. Assim, a ideia de um “autoctonismo continental” passou a ser enfatizada na propaganda mexicana como elemento que faria da Revolução Mexicana um modelo mais apropriado de transformação social para os países latino-americanos. Discutimos neste artigo os aspectos tomados pela (...) propaganda mexicana e algumas apropriações da experiência revolucionária do México por parte dos brasileiros, com destaque para o caso dos socialistas. (shrink)

En su último trabajo el historiador Enzo Traverso afirma que las utopías del siglo XX han desaparecido dejando un presente cargado de memoria pero impotente a la hora de proyectarse en el futuro (Traverso, 2018: 34). La era actual del presentismo histórico, tal como lo denomina François Hartog, momifica toda experiencia pasada despojando el potencial revolucionario y, a su vez, anulando la posibilidad de un futuro emancipador ante la inmanencia de lo mismo. Esa fuerza histórica totalitaria se nos presenta como (...) un continuo inanimado carente de toda narración histórica. La historiografía dominante es producto de la adición de relatos inconexos, tanto que el principio de rekonstruktion actualiza el pasado en consonancia a la legitimación de los vencedores. Ante ello, la melancolía de izquierda es un ejercicio que busca “repensar un proyecto revolucionario en una era no revolucionaria” (Traverso, 2018: 55). En la melancolía, a diferencia del duelo, “el sujeto mantiene su fidelidad al objeto perdido, negándose a renunciar a su vínculo con él” (Žižek, 2019: 63). La cultura de la derrota recolectó las huellas del pasado sepultado y es ahora, en un presente uniforme, donde intenta recuperar del olvido aquel proyecto concluido de forma catastrófica. El objetivo del presente trabajo es repensar y construir el pasado a la luz de la recuperación de aquello que no ha acontecido. Recolectar los fragmentos inacabados por intermedio del principio de konstruktion es también dar un haz de luz a la potencia suspensiva del tiempo presente. (shrink)

The subject of our article is the identification of cultural codes of Eastern European shtetl towns in the play by Grigory Gorin "Memorial Prayer", the libretto of which was written by the author based on the works of the famous Yiddish writer Sholom Aleichem. The author of the article describes the history and conditions of localization of Jewish culture in Eastern Europe and the Russian Empire, the peculiarities of its transformation, the tragic history of the Jewish theater in the first (...) third of the twentieth century. After the disappearance of the towns and the disuse of the Yiddish language, the preservation of the history of the characteristic everyday and philosophical way of life of the shtetls became the goal of museum figures, historians, writers, playwrights, and artists. In the work, using the example of Tevye the milkman, his family and environment, characteristic images of the inhabitants of small towns, their habitat, types of thinking and actions are revealed. The article uses the methods of historicism in the retrospective of the culture of Shtetl towns, the method of analysis in the identification of Shtetl archetypes, the method of synthesis in the generalization of a set of characteristic cultural codes. The main conclusions of the study are: 1. Eastern European Jewish shtetl towns are small urban-type settlements with a predominantly Jewish population, whose unique culture was determined by the Jewish faith, everyday and religious traditions, the Yiddish language, as well as the localization of residence in a small area. 2. During the period of large-scale social upheavals of the early twentieth century and the subsequent expansion beyond the boundaries of the towns, their unique culture became a mythologeme, the foundation for writers, artists, musicians, and theater figures who emerged from it. One of the milestones in the preservation of this culture was the Jewish theater GOSET, whose existence was tragically cut short in the middle of the twentieth century. 3. The play "Memorial Prayer", written by Grigory Gorin based on the works of Sholem Aleichem and staged at the Lenkom Theater by Mark Zakharov, became the quintessence of the characteristic images of the shtetl, and at the same time the revival of authentic Jewish culture. The author's special contribution is to highlight in the play the images-the archetypes of the Shtetl, which have become cultural markers, or codes of Jewish Yiddish culture. (shrink)

This paper summarizes three major approaches to the problem of business ethics. Comparisons and contrasts are drawn between the moralistic approach of Berhman, the social contract theory of Nash, and a comprehensive systems approach as articulated by Elbing. In the final section, some attempt is made to indicate how these models may be implemented into managerial policy decision making process by the use of group work and ascending communication. Some consideration of using organizational structure to implement ethical concerns is indicated.

The recent global economic collapse brings new calls for reform and change as well as a re-examination of the ethical foundations underpining it. Most professors as well as students remain profoundly unhappy with the Business Curricula. The curricula appear to swing between technological training and academic theory. There is little genuine focus on the central issue of the problem: the students’ and faculty’s assumptive world which drives the selection of the materials chosen for presentation as well as the decision-making process. (...) In the pragmatic quest to achieve status within academe, business schools appear to have forgotten that their subject matter is not one cognate domain but a mixture of several areas including mathematics, economics, anthropology, sociology, psychology, logic and planning. Course structures must be redesigned as consilient. That is, each course contains in it the links to other courses and is not expected to be complete in themselves; the new structures proposed are no longer under the direct control of one instructor but each course is under the control of a committee. This creates a linkage between courses that together from a linked chain of knowledge where the strength of the curriculum is tied to the consilient strength of the courses. The result is an organic and developmental model for teaching and learning with a strong ethical foundation as well as developed moral links to effective decision making. (shrink)