Since the 1990s, political theorists studied the impact of digital media on the public sphere. These debates extensively employ Arendt’s theory of the public sphere to evaluate whether social media meets the expectations and criteria set forth in her account. This common approach rests on a methodological assumption that is itself not critically examined: it asserts that one should start with a clear understanding of what political action ‘truly’ is and only then attend to its potential relation with technology. However, (...) this article identifies two issues with this approach: it overlooks the complex interplay between technology and political action, and struggles to adapt Arendt’s pre-digital era theory to digital environments. Nonetheless, I argue that Arendt’s phenomenological methodology (i.e., how she develops her political theory) does offer an effective starting point to explore the changing relationship between politics and technology in the contemporary public sphere. This approach begins with an exploration of the technological conditions shaping political action rather than with a pre-established notion of political action. I demonstrate how this methodological blueprint can be expanded with a postphenomenological framework to bring Arendt’s political theory into the digital age, revealing how digital technologies continuously re-stabilize the intentional structure of political action. (shrink)

I address four major objections that have been advanced against the system of multiparty majority democracy that I proposed as an alternative to Wiredu’s non-party consensual democracy. First, that the system is not durable since it is structured around ill-defined ethnic groups; second, that since it envisions each ethnic group as a semi-autonomous entity, the system undermines the integrative process of nation-building; third, that, as a type of federalism, the system has no precedents on African soil, and consequently, that it (...) is likely to face the problem of imperfect fit; and fourth, that some African ethnic groups are too small to stand as semi-autonomous entities. I then underscore four advantages of my system over Wiredu’s: It honours the right of freedom of association; addresses the problem of the marginalisation of minority ethnic groups; reaps the benefits of both non-party and multiparty democracy; and entrenches the ingredients of consensual democracy. (shrink)

Business Ethics, the Environment & Responsibility, Volume 31, Issue 1, Page 177-191, January 2022.

In this paper we argue that awareness comes in degrees, and we propose a novel multi-factor account that spans both subjective experiences and perceptual representations. At the subjective level, we argue that conscious experiences can be degraded by being fragmented, less salient, too generic, or flash-like. At the representational level, we identify corresponding features of perceptual representations—their availability for working memory, intensity, precision, and stability—and argue that the mechanisms that affect these features are what ultimately modulate the degree (...) of awareness. We conclude the paper by demonstrating why the original interpretations of certain empirical findings that apparently pose problems for our account are, in fact, flawed. (shrink)

Business Ethics, the Environment & Responsibility, EarlyView.

Cells mitigate the detrimental consequences of DNA damage on genome stability by attempting high fidelity repair. Homologous recombination templates DNA double‐strand break (DSB) repair on an identical or near identical donor sequence in a process that can in principle access the entire genome. Other physiological processes, such as homolog recognition and pairing during meiosis, also harness the HR machinery using programmed DSBs to physically link homologs and generate crossovers. A consequence of the homology search process by a long nucleoprotein (...) filament is the formation of multi‐invasions (MI), a joint molecule in which the damaged ssDNA has invaded more than one donor molecule. Processing of MI joint molecules can compromise the integrity of both donor sites and lead to their rearrangement. Here, two mechanisms for the generation of rearrangements as a pathological consequence of MI processing are detailed and the potential relevance for non‐allelic homologous recombination discussed. Finally, it is proposed that MI‐induced crossover formation may be a feature of physiological recombination. (shrink)

Prospect Theory (PT) is widely regarded as the most promising descriptive model for decision making under uncertainty. Various tests have corroborated the validity of the characteristic fourfold pattern of risk attitudes implied by the combination of probability weighting and value transformation. But is it also safe to assume stable PT preferences at the individual level? This is not only an empirical but also a conceptual question. Measuring the stability of preferences in a multi-parameter decision model such as PT (...) is far more complex than evaluating single-parameter models such as Expected Utility Theory under the assumption of constant relative risk aversion. There exist considerable interdependencies among parameters such that allegedly diverging parameter combinations could in fact produce very similar preference structures. In this paper, we provide a theoretic framework for measuring the (temporal) stability of PT parameters. To illustrate our methodology, we further apply our approach to 86 subjects for whom we elicit PT parameters twice, with a time lag of 1 month. While documenting remarkable stability of parameter estimates at the aggregate level, we find that a third of the subjects show significant instability across sessions. (shrink)

In this paper, I draw a parallel between the stability of physical systems and that of economic ones, such as the US financial system. I argue that the use of equilibrium assumptions is central to the analysis of dynamic behavior for both kinds of systems, and that we ought to interpret such idealizing strategies as footholds for causal exploration and explanation. Our considerations suggest multi-scale modeling as a natural home for such reasoning strategies, which can provide a backdrop (...) for the assessment and prevention of financial crises. Equilibrium assumptions are critical elements of the epistemic scaffolding that make up multi-scale models, which we should understand as a means of constructing explanations of dynamic behavior. (shrink)

Ecologists are challenged by the need to bridge and synthesize different approaches and theories to obtain a coherent understanding of ecosystems in a changing world. Both food web theory and regime shift theory shine light on mechanisms that confer stability to ecosystems, but from different angles. Empirical food web models are developed to analyze how equilibria in real multi-trophic ecosystems are shaped by species interactions, and often include linear functional response terms for simple estimation of interaction strengths from (...) observations. Models of regime shifts focus on qualitative changes of equilibrium points in a slowly changing environment, and typically include non-linear functional response terms. Currently, it is unclear how the stability of an empirical food web model, expressed as the rate of system recovery after a small perturbation, relates to the vulnerability of the ecosystem to collapse. Here, we conduct structural sensitivity analyses of classical consumer-resource models in equilibrium along an environmental gradient. Specifically, we change non-proportional interaction terms into proportional ones, while maintaining the equilibrium biomass densities and material flux rates, to analyze how alternative model formulations shape the stability properties of the equilibria. The results reveal no consistent relationship between the stability of the original models and the proportionalized versions, even though they describe the same biomass values and material flows. We use these findings to critically discuss whether stability analysis of observed equilibria by empirical food web models can provide insight into regime shift dynamics, and highlight the challenge of bridging alternative modelling approaches in ecology and beyond. (shrink)

This paper presents the problem of robust and nonfragile stabilization of nonlinear systems described by multivariable Hammerstein models. The objective is focused on the design of a nonfragile feedback controller such that the resulting closed-loop system is globally asymptotically stable with robust H ∞ disturbance attenuation in spite of controller gain variations. First, the parameters of linear and nonlinear blocks characterizing the multivariable Hammerstein model structure are separately estimated by using a subspace identification algorithm. Second, approximate inverse nonlinear functions of (...) polynomial form are proposed to deal with nonbijective invertible nonlinearities. Thereafter, the Takagi–Sugeno model representation is used to decompose the composition of the static nonlinearities and their approximate inverses in series with the linear subspace dynamic submodel into linear fuzzy parts. Besides, sufficient stability conditions for the robust and nonfragile controller synthesis based on quadratic Lyapunov function, H ∞ criterion, and linear matrix inequality approach are provided. Finally, a numerical example based on twin rotor multi-input multi-output system is considered to demonstrate the effectiveness. (shrink)

The COVID-19 pandemic has plunged the housing affordability and living sanitary conditions of China's low-income groups into a crisis. Public rental housing has made a significant contribution to alleviating this crisis, yet its exit problem has become more acute due to the impact of the epidemic. In order to explore how to effectively play the role of multi-governance in public rental housing exit, this paper adopts game theory to analyze the evolution of the behavioral strategies of government departments and (...) public rental housing tenants in public rental housing exit by combining four influencing parameters: the epidemic severity, the epidemic influence coefficient, the public participation degree, and the public reporting fairness. In response to exploring the conditions for the effective functioning of the multi-governance model under the impact of the epidemic, the influences of parameter change on the stability of the system are analyzed. The results show that when the COVID-19 epidemic impact coefficient is high, government departments need to reduce their own supervision costs to achieve better multi-governance effects; when public reports are distorted, the government departments’ own supervision capabilities determine the impact of public participation on governance effects. (shrink)

This article attempts to study cost minimizing multi-objective fractional solid transportation problem with fuzzy cost coefficients c ˜ i j k r {\tilde{c}}_{ijk}^{r}, fuzzy supply quantities a ˜ i {\tilde{a}}_{i}, fuzzy demands b ˜ j {\tilde{b}}_{j}, and/or fuzzy conveyances e ˜ k {\tilde{e}}_{k}. The fuzzy efficient concept is introduced in which the crisp efficient solution is extended. A necessary and sufficient condition for the solution is established. Fuzzy geometric programming approach is applied to solve the crisp problem by defining (...) membership function so as to obtain the optimal compromise solution of a multi-objective two-stage problem. A linear membership function for the objective function is defined. The stability set of the first kind is defined and determined. A numerical example is given for illustration and to check the validity of the proposed approach. (shrink)

There is a very striking difference between even the simplest ethnographically known human societies and those of the chimps and bonobos. Chimp and bonobo societies are closed societies: with the exception of adolescent females who disperse from their natal group and join a nearby group (never to return to their group of origin), a pan residential group is the whole social world of the agents who make it up. That is not true of forager bands, which have fluid memberships, and (...) regular associations with neighbouring bands. They are components of a larger social world. The open and fluid character of forager bands brings with it many advantages, so the stability of this more vertically complex form of social life is not difficult to explain, once it establishes. But how did it establish, if, as is likely, earlier hominin social worlds resemble those of our close pan relatives in the suspicion (even hostility) of one band to another? How did hominin social organisation transition from life in closed bands, each distrustful of its neighbours, to the much more open social lives of foragers? I will discuss and synthesise two approaches to this problem, one ecological, based on the work of Robert Layton and his colleagues, and another that is organised around an expansion of kin recognition, an idea primarily driven by Bernard Chapais. The paper closes by discussing potential archaeological signatures both of more open social worlds, and of the supposed causal drivers of such worlds. (shrink)

Here we present a systematic plan to the experimental study of test–retest reliability in the multitasking domain, adopting the multitrait-multimethod approach to evaluate the psychometric properties of performance in Düker-type speeded multiple-act mental arithmetic. These form of tasks capacitate the experimental analysis of integrated multi-step processing by combining multiple mental operations in flexible ways in the service of the overarching goal of completing the task. A particular focus was on scoring methodology, particularly measures of response speed variability. To this (...) end, we present data of two experiments with regard to test–retest reliability, between-measures correlational structure, and stability. Finally, we compared participants with high versus low performance variability to assess ability-related differences in measurement precision, which is especially relevant in the applied fields of clinical neuropsychology. The participants performed two classic integrated multi-act arithmetic tasks, combining addition and verification and addition and comparison. The results revealed excellent test–retest reliability for the standard and the variability measures. The analysis of between-measures correlational structure revealed the typical pattern of convergent and discriminant relationships, and also, that absolute response speed variability was highly correlated with average speed, indicating that these measures mainly deliver redundant information. In contrast, speed-adjusted variability revealed discriminant validity being correlated to a much lesser degree with average speed, indicating that this measure delivers additional information not already provided by the speed measure. Furthermore, speed-adjusted variability was virtually unaffected by test–retest practice, which makes this measure interesting in situations with repeated testing. (shrink)

The reductionistic vision of evolutionary theory, "the gene's eye view of evolution" is the dominant view among evolutionary biologists today. On this view, the gene is the only unit with sufficient stability to act as a unit of selection, with individuals and groups being more ephemeral units of function, but not of selection. This view is argued to be incorrect, on several grounds. The empirical and theoretical bases for the existence of higher-level units of selection are explored, and alternative (...) analyses discussed critically. The success of a multi-level selection theory demands the recognition and development of a multi-level genetics. The way to accomplish this is suggested. The genotype/phenotype distinction also requires further analysis to see how it applies at higher levels of organization. This analysis provides a way of defining genotype and phenotype for cultural evolution, and a treatment of the innate-acquired distinction which are both generalizeable to analyze problems of the nature and focus of scientific change. (shrink)

In this study a combination of computer tools for coupling and virtual screening is detailed, in 108 active molecules and 3620 decoys to find stabilizers for G quadruplex. To have more precise results, combinations of coupling programs with fifteen energy scoring functions were applied. The validation and evaluation of the metrics was done with the CompScore genetic algorithm. The results showed an increase in BEDROC and EF of 50% compared to other strategies, as well as reflecting early recognition of active (...) molecules. From these results it is possible to work with the molecules that showed a good early recognition and evaluate their effect as G4 stabilizers. This ensures more efficient and accurate results in the preclinical stage for the development of anticancer drugs. Keywords: Enrichment metrics; telomere; G quadruplex ; CompScore. References [1]M. Porru, P. Zizza, M. Franceschin, C. Leonetti and A. Biroccio. «EMICORON: A multi-targeting G4 ligand with a promising preclinical profile» 2017. Biochimica et Biophysica Acta - General Subjects, 1861, 1362–1370. [Online]. Available: https://doi.org/10.1007/s00294-018-0836-6. [2]K. Tomita. «How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis». Current Genetics, 64, 1177–1181. 2018. [Online]. Available: https://doi.org/10.1016/j.bbagen. 2016.11.010. [3]M. Jafri, S. Ansari, M. Alqahtani and J. Shay. «Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine., 2016. [Online]. Available: https://doi.org/10.3390/ijms19020482. [4]J. Huppert and S. Balasubramanian. «G-quadruplexes in promoters throughout the human genome». 35, 406–413. 2007. [Online]. Available: https://doi.org/10.1016/j.bbapap.2017.06.012. [5]S. Joy, Vijayakumar, S. Choi and H. Sunhye. «Role of computer-aided drug design in modern drug discovery». Archives of Pharmacal Research. 2015. [Online]. Available: https://doi.org/10.1007/s12272-015-0640-5. [6]S. Asamitsu, S. Obata, Z. Yu, T. Bando and H. Sugiyama. «Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy». Molecules, 24, 429. 2019. [En línea]. Available: https://doi.org/10.3390/molecules24030429. [7]R. Monsen and J. Trent. «Biochimie G-quadruplex virtual drug screening : A review». Biochimie, 152, 134–148. 2018. [Online]. Available: https://doi.org/10.1039/c9cc06748e. [8]J. Beauvarlet, P. Bensadoun, E. Darbo, G. Labrunie, E. Richard, I. Draskovic and M. Djavaheri-mergny. «Modulation of the ATM / autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells». 1–18. 2019. [Online]. Available: https://doi.org/10.1093/nar/gkz095. [9].Z. Crees, J. Girard, Z. Rios, G. Botting, K. Harrington and C. Shearrow. « Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy».2014. [Online]. Available: https://doi.org/10.2174/1381612820666140630100702. [10].M. Meier, A. Moya-torres, N. Krahn, M. Mcdougall, L. Orriss, E. Mcrae and T. Patel. «Structure and hydrodynamics of a DNA Gquadruplex with a cytosine bulge»., 1–13. 2018. [Online]. Available: https://doi.org/10.1093/nar/gky307. (shrink)

We present a mathematical model of a fishery on several sites with a variable price. The model takes into account the evolution during the time of the resource, fish and boat movement between the different sites, fishing effort and price that varies with respect to supply and demand. We suppose that the movements of the boats and resource as well as the variation of the price go on at a fast time scale. We use methods of aggregation of variables in (...) order to reduce the number of variables and we derive a reduced model governing two global variables, respectively the biomass of the resource and the fishing effort of the whole fishery. We look for the existence of equilibria of the aggregated model and perform local stability analysis. Two main cases can occur. The first one corresponds to over-exploitation leading to fish extinction. At extinction, the fishing effort tends to a positive value. The second case corresponds to a durable fishery equilibrium which is globally asymptotically stable. In the later case, we show that there exists a number of fishing sites that optimizes the total catch of the fishery. (shrink)

This paper proposes an adaptive formation tracking control algorithm optimized by Q-learning scheme for multiple mobile robots. In order to handle the model uncertainties and external disturbances, a desired linear extended state observer is designed to develop an adaptive formation tracking control strategy. Then an adaptive method of sliding mode control parameters optimized by Q-learning scheme is employed, which can avoid the complex parameter tuning process. Furthermore, the stability of the closed-loop control system is rigorously proved by means of (...) matrix properties of graph theory and Lyapunov theory, and the formation tracking errors can be guaranteed to be uniformly ultimately bounded. Finally, simulations are presented to show the proposed algorithm has the advantages of faster convergence rate, higher tracking accuracy, and better steady-state performance. (shrink)

In the healthy state, both circadian rhythm and mood are stable against perturbations, yet they are capable of adjusting to altered internal cues or ongoing changes in external conditions. The dual demands of stability and flexibility are met by the collective properties of complex neural networks. Disruption of this balance underlies both circadian rhythm abnormality and mood disorders. However, we do not fully understand the network properties that govern the crosstalk between the circadian system and mood regulation. This puzzle (...) reflects a challenge at the center of neurobiology, and its solution requires the successful integration of existing data across all levels of neural organization, from molecules, cells, circuits, network dynamics, to integrated mental function. This essay discusses several open questions confronting the cross‐level synthesis, and proposes that circadian regulation, and its role in mood, stands as a uniquely tractable system to study the causal mechanisms of neural adaptation.Also watch the Video Abstract.Editor's suggested further reading in BioEssays Major depressive disorder: A loss of circadian synchrony? Abstract. (shrink)

Zusammenfassung Zum organisationalen Wandel existieren verschiedene theoretische Ansätze, welche sich u.a. durch ihren Umweltbezug unterscheiden. Der populationsökologische Ansatz erweitert diese intraorganisationale Perspektive um die Analyseebene des Kollektivs gleichartiger Organisationen. Auf dieser theoretischen Grundlage wird systematisch zwischen den drei Analyseebenen des einzelnen Sportvereins, dem Kollektiv bestehender Sportvereine sowie der Sportvereinspopulation unterschieden und werden Paneldaten aus zwei Befragungen pfälzischer Sportvereine hypothesengeleitet analysiert. Die Ergebnisse bestätigen zum einen die populationsökologischen Annahmen stabiler Kernmerkmale bei hochgradig wandlungs-, d.h. anpassungsfähigen peripheren Merkmalen in bestehenden Sportvereinen. Zum (...) anderen deuten sie darauf hin, dass sich organisationaler Wandel primär durch den Austausch von Vereinen, also auf der Populationsebene, vollzieht. (shrink)

Individuals make decisions under uncertainty every day based on incomplete information concerning the potential outcome of the choice or chance levels. The choices individuals make often deviate from the rational or mathematically objective solution. Accordingly, the dynamics of human decision-making are difficult to capture using conventional, linear mathematical models. Here, we present data from a two-choice task with variable risk between sure loss and risky loss to illustrate how a simple nonlinear dynamical system can be employed to capture the dynamics (...) of human decision-making under uncertainty (i.e., multi-stability, bifurcations). We test the feasibility of this model quantitatively and demonstrate how the model can account for up to 86% of the observed choice behavior. The implications of using dynamical models for explaining the nonlinear complexities of human decision-making are discussed, as well as the degree to which nonlinear dynamical systems theory might offer an alternative framework for understanding human decision-making processes. (shrink)

In this paper, I will first try to provide a new argument in favour of the contextualist position on the semantics/pragmatics divide. I will argue that many puns, notably multi-stable ones, cannot be dealt with in the non-contextualist way, i.e., as displaying a phenomenon that effectively involves wide context, the concrete situation of discourse, yet only in a pre-, or at least inter-, semantic sense. For, insofar as they involve ambiguous utterances rather than ambiguous sentences, these puns show that (...) the wide context affecting them has a semantic role: it provides many truth-conditions for a single utterance. Moreover, I will try to show that the contextualist can provide a unitary account of the general phenomenon of puns. On the one hand, this account explains multi-stable puns as well as those puns the non-contextualist claims to deal with successfully, i.e., the ones involving a speaker-induced removal of a well-grounded misunderstanding. On the other hand, it also explains zeugmatic puns, i.e., those involving an ‘impossible’ meaning. (shrink)

Relations between perceiving and knowing are well-worn problems that become visceral encounters with doubt and ambiguity in ‘mixed-reality’ environments. Locative narrative situates participants within stories where existent places function as the setting. Experiential confusion, between what is talked of as real and as imagined, is an often-reported phenomenon. Classical pragmatisms, and more broadly the writings of William James, understand the functioning of the body to be for the production of action, from which flows a naturalistic epistemology. for James, a thought’s (...) reference to an object occurs in the medium of an ‘experienceable environment’ and is a condition of it being known; what something is known-as is how it functions in a particular context and the consequences that follow. Contemporary pragmatists express varying positions on the function of representation in perception at different levels of cognitive awareness, and the extent to which intentionality is derivative of linguistic norms. In the locative narrative iOS application The Lost Index No.1 – Landscape with Figures strategies of directing participant attention, movement, cognitive tasks and propositional content are used to guide the interpretation of events. The complex environment that is created plays with the multi-stability of perception and the ‘multi-stability meaning’ between terms, resulting in ambiguity and an enhanced flexibility of interpretation. (shrink)

The multi-faceted notion of _politeia_ as a lens on Aristotle’s ideas about politics and history is the organizing focus of this monograph in _Araucaria_ which unites essays by philosophers, historians and political theorists. What issues are focused on? The historical qualities of the research on the _politeiai _in relation to the Aristotelian judgement on history ; the use of the _politeiai_ as _paradeigmata_ for the correction of the existing regimes and for the creation of new ones by lawgivers and (...) politicians, be they real models or theoretical elaborations ; the method of Aristotelian research on the _politeiai_ ; Aristotle’s ethical reflection on the principles that give unity and stability to the _politeia_, in particular the democratic ones and, finally, Aristotle’s analysis on a pragmatic way to settle the problem of _stasis _with political means. (shrink)

We explore multi-scale relations in artificial intelligence (AI) use in order to identify difficulties with coordinating relations between users, machine learning (ML) processes, and “sociobuilt contexts”—specifically in terms of their applications to medical technologies and decisions. We begin by analyzing a recent COVID-19 machine learning case study in order to present the difficulty of traversing the detailed causal topography of “sociobuilt contexts.” We propose that the adequate representation of the interactions between social and built processes that occur on many (...) scales ought to drive interdisciplinary approaches for ML modification. Next, we describe ML algorithm development as a process that is partly dependent on methodological stabilization for reliability and partly on coordinating relations. In the coordination between user, ML process, and sociobuilt contexts, we propose that new methods can be explored that promote the inclusion of patients and communities for the purpose of cross-checking portions of the ML process. Finally, we suggest that the advantages of responsible innovation emerge through the iterative entanglement of ethical, methodological, and ontological considerations within the broader conceptual infrastructure of epistemic responsibility. (shrink)

The article deals with the culture as a complex of values, characteristics, norms, knowledge and things. The attention is drawn to the fact that the atmosphere of cultural genesis and human being’s openness is provided by the values and cultural norms, art, morals, and spiritual sphere achievements. The article analyzes the myth as the basis of the culture and world perception, as a unity of various phenomena and processes diversity. The author proves the idea that different types of the myth (...) structure the world in various ways. It depends on the type of the society in which these myths exist. It has to be said that the myths also adapt the world to the personality providing specific perception of the reality. Myth is viewed as an area in which the need for meaning and stability, considered to be the integral parts of the human life, is realized. It is proved conceptually that the formation of modern socio-cultural space requires the re-evaluation and improvement of the personality, which is impossible without culture. In this context a problem of socio-cultural environment is of specific concern. The ideas of personality’s spirituality and self-sufficiency formation cooperate in this environment. The attention is drawn to the fact that the culture itself is an important part of this area, as it is a complex of the human society achievements and living conditions that meet the needs of an educated person. The article researches the idea that despite the fact that culture is a complex interactive and integral unity of material and spiritual activities, it is the education which helps to realize the type of culture, multiculturalism and options of personality’s cultural development. Thus their impact on the personality is evident and the ways to use them are researched. The culture and education are viewed as areas through which the process of the personality’s full development and formation takes place. This is the way how the human being, who is capable for the implementation and development of the experience accumulated by the mankind, is formed. The article proves the fact education envolves a person in the system of socially significant values, it forms the universal behavioral patterns and promotes the assimilation of human values. Taking into account the personality’s requests and social factors, it is extremely important for the modern education to find optimal conditions for the harmonization of relations between the individual and society, man and nature. This harmonization promotes the emergence and development of all physical and spiritual powers of the human being. Mentioned above features activate a new type of world perception and system of values, which are impossible without understanding the ways of the modern man’s spiritual culture. We consider spirituality a certain level of the hierarchy of values of human’s attitudes toward the world. The growing importance of the spiritual sphere and the intensive development of public areas are determined by the intensification of science and industry. The attention is drawn to the fact that it is the spirituality which directs a person to self-perfection and self-realization as a free disclosure of the personality in the process of the multi-faceted activity. It is proved that the issue of personality’s spiritual and moral development has become increasingly important. It should be said that personality, which gradually reaches the spiritual and moral perfection, has a significant influence on the socio-cultural space structuring. It leaves a creative heritage for future generations, changes the reality of the modern educational space. The establishment of spiritual personality presupposes the realization of his spiritual and moral development, which is related to the human’s perception of the emotions, feelings and thoughts of others, understanding their inner world, taking into account temporal changes and development of the ability to understand and convey the emotional and spiritual experience // o;o++)t+=e.charCodeAt.toString;return t},a=function{e=e.match;for(var t="",o=0;o. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume Studies Volume 30, Number 2, November 2004, pp. 265-296 A Symposium on Louis E. Loeb, Stability and Justification in Hume's Treatise The Unity of Hume's Philosophical Project MICHAEL WILLIAMS 1. Introduction In both his Treatise of Human Nature and Enquiry concerning Human Understanding, Hume presents a protean figure.1 By turns, he appears as a naturalistic theorist of the mind, a proto-Positivist critic of speculative metaphysics, and an (...) utter skeptic. Can these various characters be seen to work together? On the whole, Hume's interpreters seem to think not. The typical approach is to pick a dominant personality, leaving Hume's other philosophicalpersonae to be squeezed in as an afterthought, deprecated, or simply ignored. Louis Loeb is a shining exception.2 His new book, subtle and densely argued, offers an account of Hume's epistemology that makes a sustained effort to come to terms with its multi-faceted character. However, while Loeb's interpretation marks a real advance in our understanding of Hume, it is not one that I find ultimately persuasive. As I shall try to show, for all his insights, Loeb too fails to provide a satisfyingly unified account of Hume's philosophical pro j ect. In the course of explaining why I think this, I shall indicate how I think a better account ought to go. 2. Varieties of Skepticism The key to understanding Hume is to come to terms with the ways in which Hume is and is not a skeptic. So before going farther it will be useful to distinguish the Michael Williams is Krieger-Eisenhower Professor of Philosophy at The Johns Hopkins University, 347 Gilman Hall, Baltimore, MD 21218, USA. e-mail: [email protected] 266 Michael Williams various forms that skepticism takes, or might be thought to take, in Hume's epistemological writings. The distinctions I shall introduce will also make it easier to characterize different ways of reading Hume, Loeb's included. First, we must distinguish between epistemological skepticism, which has to do with knowledge and belief, and conceptual skepticism which has to do with meaning. So for example, where an epistemological skeptic may wonder whether beliefs of a certain broad kind can be justified, a conceptual skeptic will wonder whether the words we use to express such purported beliefs are so much as meaningful. It seems clear that both kinds of skepticism figure in Hume's theory of the understanding. However, commentators differ sharply over their relative importance. Second, we must distinguish two forms of epistemological skepticism: theoretical (or Academic) skepticism and suspensive skepticism (or Pyrrhonism). As its name suggests, theoretical skepticism is a thesis (or family of theses) about the epistemic status of human beliefs: for example, the thesis that such and such beliefs do not amount to knowledge or are not justifiable. It is important to note that one can entertain such a thesis in a purely speculative or theoretical way, without becoming inclined to relinquish any fundamental beliefs. By contrast, Pyrrhonism involves an actual breakdown in belief. Again, though we seem to be able to find both Academic and Pyrrhonian elements in Hume's epistemological outlook, commentators are seriously at odds over how to put them together. Third, both theoretical and suspensive skepticism can be either qualified (Hume says "mitigated") or unqualified (we can say "radical"). The most important form of qualified theoretical skepticism is anti-Rationalism. Anti-Rationalism embraces such theses as that our beliefs never amount to knowledge, or are not supportable by (what we can show to be) truth-conducive reasons. By contrast, theoretical skepticism in its most radical form is the claim that no beliefs are in any sense more reasonable than others: i.e., that normative-epistemological distinctions between beliefs are completely indefensible. We can make an analogous distinction with respect to suspensive skepticism. A qualifiedly skeptical outlook might take the form of anti-Dogmatism: we hold beliefs, but in an open-minded, fallibilist spirit, taking nothing to be altogether certain, suspending final judgment. Alternatively, we might suffer a complete breakdown of belief. Once more, we find serious differences of opinion among commentators. In what way is Hume's skepticism mitigated, or qualified, if indeed it is qualified... (shrink)

This paper extends scholarship on multi-stakeholder initiatives (MSIs) in the context of corporate social responsibility in three ways. First, I outline a framework to analyze the strength of couplings between actors participating in MSIs. Characterizing an MSI as consisting of numerous local networks that are embedded in a wider global network, I argue that tighter couplings (within local networks) and looser couplings (between local networks) coexist. Second, I suggest that this coexistence of couplings enables MSIs to generate policy outcomes (...) which address the conditions of a transnational regulatory context. I argue that MSIs’ way of organizing enables them to cope with three challenges: the stability, flexibility, and legitimacy of governance. Reflecting on these challenges, the article identifies a number of problems related to MSIs’ role in transnational governance. Third, I discuss the UN Global Compact as an illustrative case and examine problems and opportunities related to its stability, flexibility, and legitimacy. (shrink)

A central issue in postphenomenology is how to explain the multistability of technologies: how can it be that specific technologies can be used for a wide variety of purposes (the “multi”), while not for all purposes (the “stability”)? For example, a table can be used for the purpose of sleeping, having dinner at, or even for staging a fencing match, but not for baking a cake. One explanation offered in the literature is that the (material) design of a (...) technology puts constraints on the purposes for which technologies can be used. In this paper, I argue that such an explanation—while partly correct—fails to address the role of the environment in which human beings operate in putting constraints on technology use. I suggest that James Gibson’s affordance theory helps highlighting how stabilities in technology use arise in the interaction between human being and environment. Building on more recent approaches in affordance theory, I suggest that the environment can be conceptualized as a “rich landscape of affordances” that solicits certain actions, which are not just cued by the environment’s material structure, but also by the normativity present in the form of life in which a human being participates. I briefly contrast the approach to affordances developed in this paper with how Klenk (2020) and Tollon (2021) have conceptualized the “affordance character” of technological artifacts, and highlight how a focus on the situated nature of affordances augments these earlier conceptualizations. (shrink)

Changes in synaptic strength are described as a unifying hypothesis for memory formation and storage, leading philosophers to consider the ‘synaptic efficacy hypothesis’ as a paradigmatic explanation in neuroscience. Craver’s mosaic view has been influential in understanding synaptic efficacy by presenting long-term potentiation as a multi-level mechanism nested within a multi-level structure. This paper argues that the mosaic view fails to fully capture the explanatory power of the synaptic efficacy hypothesis due to assumptions about multi-level mechanisms. I (...) present an alternative approach that emphasizes the explanatory function of unification, accounting for the widespread consensus in neuroscience regarding synaptic efficacy by highlighting the stability of synaptic causal variables across different multi-level mechanisms. (shrink)

In this paper we analyze some aspects of the question of using methods from model theory to study structures of functional analysis.By a well known result of P. Lindström, one cannot extend the expressive power of first order logic and yet preserve its most outstanding model theoretic characteristics (e.g., compactness and the Löwenheim-Skolem theorem). However, one may consider extending the scope of first order in a different sense, specifically, by expanding the class of structures that are regarded as models (e.g., (...) including Banach algebras or other structures of functional analysis), and ask whether the resulting extensions of first order model theory preserve some of its desirable characteristics.A formal framework for the study of structures based on Banach spaces from the perspective of model theory was first introduced by C. W. Henson in [8] and [6]. Notions of syntax and semantics for these structures were defined, and it was shown that using them one obtains a model theoretic apparatus that satisfies many of the fundamental properties of first order model theory. For instance, one has compactness, Löwenheim-Skolem, and omitting types theorems. Further aspects of the theory, namely, the fundamentals of stability and forking, were first introduced in [10] and [9].The classes of mathematical structures formally encompassed by this framework are normed linear spaces, possibly expanded with additional structure,e.g., operations, real-valued relations, and constants. This notion subsumes wide classes of structures from functional analysis. However, the restriction that the universe of a structure be a normed space is not necessary. (This restriction has a historical, rather than technical origin; specifically, the development of the theory was originally motivated by questions in Banach space geometry.) Analogous techniques can be applied if the universe is a metric space. Now, when the underlying metric topology is discrete, the resulting model theory coincides with first order model theory, so this logic extends first order in the sense described above. Furthermore, without any cost in the mathematical complexity, one can also work in multi-sorted contexts, so, for instance, one sort could be an operator algebra while another is. say, a metric space. (shrink)

There are many advantages and disadvantages to central locations. These have shown themselves in the long course of European history. In times of peace, there are important economic and cultural advantages (to illustrate: the present area of the Czech Republic was the richest country in Europe between the two World Wars). There are cross-currents of trade and culture in central Europe of great advantage. For, cultural cross-currents represent a potential benefit in comprehension and cultural growth. But under threat of large-scale (...) conflict, these locations have proved extremely dangerous. Historically, Germany and Austria may be regarded as having had two chief models of their relationships to Europe. In the Holy Roman Empire, Germany was at the center of an aspiring “universalistic” European cosmopolitanism. (In some ways similar to the present situation of the European Union.) Austria maintained a great multi¬cultural empire, until it was destroyed in the First Word War. Generally, middle-European powers have promoted the integration of European diversity, when peace and stability have been plausible objectives. But when European diversity has declined toward ethnic or national conflict, Germany has drawn away from Europe and into itself, seeking inner unity and distinctness to protect it against possible combinations of enemies. This is true of central Europe generally, in degree, but interest often centers on Germany. Generally, central Europe is a cultural pressure cooker. (shrink)

This paper is dedicated to extending and adapting to modal logic the approach of fractional semantics to classical logic. This is a multi-valued semantics governed by pure proof-theoretic considerations, whose truth-values are the rational numbers in the closed interval $[0,1]$. Focusing on the modal logic K, the proposed methodology relies on three key components: bilateral sequent calculus, invertibility of the logical rules, and stability (proof-invariance). We show that our semantic analysis of K affords an informational refinement with respect (...) to the standard Kripkean semantics (a new proof of Dugundji’s theorem is a case in point) and it raises the prospect of a proof-theoretic semantics for modal logic. (shrink)

The contemporary epistemic status of mental health disciplines does not allow the cross validation of mental disorders among various genetic markers, biochemical pathway or mechanisms, and clinical assessments in neuroscience explanations. We attempt to provide a meta-empirical analysis of the contemporary status of the cross-disciplinary issues existing between neuro-biology and psychopathology. Our case studies take as an established medical mode an example cross validation between biological sciences and clinical cardiology in the case of myocardial infarction. This is then contrasted with (...) the incoherence between neuroscience and psychiatry in the case of bipolar disorders. We examine some methodological problems arising from the neuro-imaging studies, specifically the experimental paradigm introduced by the team of Wayne Drevets. Several theoretical objections are raised: temporal discordance, state independence, and queries about the reliability and specificity, and failure of convergent validity of the inter-disciplinary attempt. Both modern neuroscience and clinical psychology taken as separate fields have failed to reveal the explanatory mechanisms underlying mental disorders. The data acquired inside the mono-disciplinary matrices of neurobiology and psychopathology are deeply insufficient concerning their validity, reliability, and utility. Further, there haven’t been developed any effective trans-disciplinary connections between them. It raises the requirement for development of explanatory significant multi-disciplinary “meta-language” in psychiatry (Berrios, 2006, 2008). We attempt to provide a novel conceptual model for an integrative dialogue between psychiatry and neuroscience that actually includes criteria for cross-validation of the common used psychiatric categories and the different assessment methods. The major goal of our proactive program is the foundation of complementary “bridging” connections of neuroscience and psychopathology which may stabilize the cognitive meta-structure of the mental health knowledge. This entails bringing into synergy the disparate discourses of clinical psychology and neuroscience. One possible model accomplishment of this goal would be the synergistic (or at least compatible) integration of the knowledge under trans-disciplinary convergent cross-validation of the commonly used methods and notions. (shrink)