While neuroscientists often characterize brain activity as representational, many philosophers have construed these accounts as just theorists’ glosses on the mechanism. Moreover, philosophical discussions commonly focus on finished accounts of explanation, not research in progress. I adopt a different perspective, considering how characterizations of neural activity as representational contributes to the development of mechanistic accounts, guiding the investigations neuroscientists pursue as they work from an initial proposal to a more detailed understanding of a mechanism. I develop one illustrative example involving (...) research on the information-processing mechanisms mammals employ in navigating their environments. This research was galvanized by the discovery in the 1970s of place cells in the hippocampus. This discovery prompted research in what the activity of these cells represents and how place representations figure in navigation. It also led to the discovery of a host of other types of neurons—grid cells, head-direction cells, boundary cells—that carry other types of spatial information and interact with place cells in the mechanism underlying spatial navigation. As I will try to make clear, the research is explicitly devoted to identifying representations and determining how they are constructed and used in an information processing mechanism. Construals of neural activity as representations are not mere glosses but are characterizations to which neuroscientists are committed in the development of their explanatory accounts. (shrink)

The evidence grid representation was formulated at the CMU Mobile Robot Laboratory in 1983 to turn wide angle range measurements from cheap mobile robot-mounted sonar sensors into detailed spatial maps. It accumulates diffuse evidence about the occupancy of a grid of small volumes of nearby space from individual sensor readings into increasingly confident and detailed maps of a robot's surroundings. It worked surprisingly well in first implementation for sonar navigation in cluttered rooms. In the past decade its use (...) has been extended to range measurements from stereoscopic vision and other sensors, sonar in very difficult specular environments, and other contexts. The most dramatic extension yet, from 2D grid maps with thousands of cells to 3D grids with millions, is underway. (shrink)

Very encouraging results have been obtained from a new program that derives a dense three-dimensional evidence grid representation of a robot's surroundings from wide-angle stereoscopic images. The pro gram adds several spatial rays of evidence to a grid for each of about 2,500 local image features chosen per stereo pair. It was used to construct a 256x256x64 grid, representing 6 by 6 by 2 meters, from a hand- collected test set of twenty stereo image pairs of an (...) office scene. Fifty nine stereo pairs of an 8 by 8 meter laboratory were also processed. The positive (probably occupied) cells of the grids, viewed in perspec tive, resemble dollhouse scenes. Details as small as the curvature of chair armrests are discernible. The processing time, on a 100 MIPS Sparc 20, is less than five seconds per stereo pair, and total memory is under 16 megabytes. The results seem abundantly adequate for very reliable navigation of freely roaming mobile robots, and plausibly adequate for shape identification of objects bigger than 10 centimeters. The program is a first proof of concept, and awaits optimizations, enhancements, variations, extensions and applications. (shrink)

The comprehensive liberalisation of the electricity market at the end of the last century has initiated a dynamic development. The politically determined disjunction of the network operation from generation, commerce and distribution which broke open the value added chain concerning the business organisation is to induce competition and consequently lower prices. Thus, besides a secure electricity supply, profitability, efficiency, quality and environmental aspects constitute present aims and have led to an enormous increase of complexity in the power supply. Furthermore, the (...) imponderability and uncertainty of competition processes in a liberated market aggravate prognoses for future investment decisions. Not least the anymore rising electricity demand, the emerging of a single European power market as well as technically pushed changes in the production structure, due to the emergence of alternative forms of power generation such as wind or solar energy, biomass energy or fuel cells, account for electric networks which afford complex planning and regulation mechanisms. This article gives a survey of various requirements posed on electricity networks and concludes with a short description of solution approaches to safeguard a cost-saving and secured future electricity supply. (shrink)

Among emotions, surprise has been extensively studied in psychology. In linguistics, surprise, like other emotions, has mainly been studied through the syntactic patterns involving surprise lexemes. However, little has been done so far to correlate the reaction of surprise investigated in psychological approaches and the effects of surprise on language. This cross-disciplinary volume aims to bridge the gap between emotion, cognition and language by bringing together nine contributions on surprise from different backgrounds - psychology, human-agent interaction, linguistics. Using different methods (...) at different levels of analysis, all contributors concur in defining surprise as a cognitive operation and as a component of emotion rather than as a pure emotion. Surprise results from expectations not being met and is therefore related to epistemicity. Linguistically, there does not exist an unequivocal marker of surprise. Surprise may be either described by surprise lexemes, which are often associated with figurative language, or it may be expressed by grammatical and syntactic constructions. Originally published as a special issue of Review of Cognitive Linguistics 13:2 (2015). (shrink)

Nous étudions dans cet article les différentes formes de prédication seconde détachée en position initiale dans un corpus comparable composé de textes d’économie en anglais et en français. Ce corpus a été annoté sous le logiciel Analec. L’enjeu est de montrer en quoi un même phénomène syntaxique est exploité, sur le plan discursif, de façon divergente dans chacune des deux langues. Une étude qualitative et quantitative des prédications secondes du corpus montre que la prédication seconde prend le plus souvent la (...) forme d’une participiale en –ing en anglais, où elle se spécialise dans un rôle méta-énonciatif de balise textuelle pour le lecteur, ce qui n’est pas le cas en français. (shrink)

This study presents a sociological profile of Peruvian female industrialists and some narratives of their struggle for personal independence and entrepreneurial success within the context of global restructuring and local deindustrialization. The study adopts the classical definition of woman's economic independence as a result of women's participation in the world of paid labor.

Surprise is treated as an affect in Aristotelian philosophy as well as in Cartesian philosophy. In experimental psychology, surprise is considered to be an emotion. In phenomenology, it is only addressed indirectly (Husserl, Heidegger, Levinas), with the important exception of Ricoeur and Maldiney; it is reduced to a break in cognition by cognitivists (Dennett). Only recently was it broached in linguistics, with a focus on lexico-syntactic categories. As for the expression of surprise, it has been studied in connection with evidentiality (...) in languages that encode surprise morphosyntactically. However, how surprise is encoded in languages that lack an evidential morphosyntactic system has been largely unexplored. This book provides new insights into the dynamics of surprise based on a heuristic hypothesis tested against the investigation of time, language and emotion. It is intended to arouse the interest of a multidisciplinary audience keen on crossing the disciplinary borders of phenomenology, cognitive sciences, and pragmatics. The theoretical approaches adopted in this collection of articles rely on experiments and corpus data. They advance knowledge by building on robust empirical results coming from psychology, microphenomenology, linguistics and physiology. (shrink)

The study of spatial cognition has provided considerable insight into how animals (including humans) navigate on the horizontal plane. However, the real world is three-dimensional, having a complex topography including both horizontal and vertical features, which presents additional challenges for representation and navigation. The present article reviews the emerging behavioral and neurobiological literature on spatial cognition in non-horizontal environments. We suggest that three-dimensional spaces are represented in a quasi-planar fashion, with space in the plane of locomotion being computed separately and (...) represented differently from space in the orthogonal axis bicoded.” We argue that the mammalian spatial representation in surface-travelling animals comprises a mosaic of these locally planar fragments, rather than a fully integrated volumetric map. More generally, this may be true even for species that can move freely in all three dimensions, such as birds and fish. We outline the evidence supporting this view, together with the adaptive advantages of such a scheme. (shrink)

A common way to understand memory structures in the cognitive sciences is as a cognitive map​. Cognitive maps are representational systems organized by dimensions shared with physical space. The appeal to these maps begins literally: as an account of how spatial information is represented and used to inform spatial navigation. Invocations of cognitive maps, however, are often more ambitious; cognitive maps are meant to scale up and provide the basis for our more sophisticated memory capacities. The extension is not meant (...) to be metaphorical, but the way in which these richer mental structures are supposed to remain map-like is rarely made explicit. Here we investigate this missing link, asking: how do cognitive maps represent non-spatial information?​ We begin with a survey of foundational work on spatial cognitive maps and then provide a comparative review of alternative, non-spatial representational structures. We then turn to several cutting-edge projects that are engaged in the task of scaling up cognitive maps so as to accommodate non-spatial information: first, on the spatial-isometric approach​ , encoding content that is non-spatial but in some sense isomorphic to spatial content; second, on the ​ abstraction approach​ , encoding content that is an abstraction over first-order spatial information; and third, on the ​ embedding approach​ , embedding non-spatial information within a spatial context, a prominent example being the Method-of-Loci. Putting these cases alongside one another reveals the variety of options available for building cognitive maps, and the distinctive limitations of each. We conclude by reflecting on where these results take us in terms of understanding the place of cognitive maps in memory. (shrink)

In this commentary, we highlight a difficulty for metric navigation arising from recent data with grid and place cells: the integration of piecemeal representations of space in environments with repeated boundaries. Put simply, it is unclear how place and grid cells might provide a global representation of distance when their fields appear to represent repeated boundaries within an environment. One implication of this is that the capacity for spatial inferences may be limited.

"This wholeheartedly interdisciplinary book explores the possibility of domain specific cooperation between philosophy and psychology concerning questions on spatial representation. Its leitmotif is the importance of movement in concord with the workings of the body schema. Against the background of embodiment, situatedness, and Susan Hurley's notion of a ninety-degree shift it is spelled out how true, domain specific cooperation between the disciplines can be accomplished. By enriching Grush's naturalistic account of representation (emulation theory) with insights stemming from teleosemantics, the notion (...) of the body schema is clarified and connected to the notion of a nonconceptual point of view. Translating this latter notion into three key capacities allows to draw on insights from neuroscience concerning place cells, head-direction cells, and grid cells. These cell types can be mapped on our key capacities, which shows that the nonconceptual point of view already is apparent on a very low level of analysis. Elaborating on Evans's notion of a travel-based space allows to sketch an account of spatial representation underwritten by the importance of movement and emulation and helps us to grasp spatial content's special framework role. Moreover, it provides a satisfying answer to the question of how a representation of space might be built up that enables higher-level cognition, yet, stands in continuity to sensorimotor research."--Publisher's description. (shrink)

Reinvention of the form of expression is a conceptual approach characteristic for the evolution of all arts. This research study provides one such step forward in the advancement of scientific paper, a standard form of expression in natural sciences, toward more progressive terrains. The paper adopts the form of a theatrical play where a scientific family of four attempts to find the way around a writer’s block (Act I). Their idealess sense of confinement is overcome through arts or, more specifically, (...) through scientific research implementing the aesthetics of music as its key element. The characters record compositions differing in the degrees of consonance, rhythmicity and tonality, and play them to birds to observe their vocal and behavioral responses (Act II). They note that the birdsong volume drops significantly when the piano tunes, especially the compositionally complex ones, are played to the birds and increases signifcantly when the white noise of ocean waves is played. The bird count experiment proves indirectly that the birdsong volume reduction is an auditory response of the birds to music rather than the effect of their migrating to or away from the sound source. This science with the flavor of art elevates the characters beyond the limits of their confinement and they, exalted and uplifted, gain ideas for creative research in their own disciplines of biomedical science (Act III). They relinquish the newly gained freedom in favor of embracing love for humanity that underlies medical research and return to their confinement, where they conduct, in the coda of the paper, a series of experiments that venture beyond musicology and ornithology and fall in the domains of tissue engineering and drug delivery, but also psychology (Act III). First, sparrow nests are used as templates for tissue engineering constructs, which facilitate the growth of human fibroblastic cells better than their artificial, gridded replicas. Next, the shell of an Easter egg, predominantly calcite in composition, is used with success as a drug delivery carrier. Lastly, the bird nest drawing experiment demonstrates a greater mental health of children than that of the adults, correlating with one of the overarching points of the paper, which is to present children as a model for grownups to follow rather than the other way around. Over the course of the play, the characters discuss the value of the various fusions between art and science, question the limits of human language and repeatedly go off-topic to celebrate the freeness of the creative thinking process. The play reports on real-life research methods and scientific results through a narrative, without diminishing their empirical rigor and analytical accuracy. (shrink)

Cardiovascular modelling has been a major research subject for the last decade. Different cardiac models have been developed at a cellular level as well as at the whole organ level. Most of these models are defined by a comprehensive cellular modelling using continuous formalisms or by a tissue-level modelling often based on discrete formalisms. Nevertheless, both views still suffer from difficulties that reduce their clinical applications: the first approach requires heavy computational resources while the second one is not able to (...) reproduce certain pathologies.This paper presents an original methodology trying to gather advantages from both approaches, by means of a hybrid model mixing discrete and continuous formalisms. This method has been applied to define a hybrid model of cardiac action potential propagation on a 2D grid of endocardial cells, combining cellular automata and a set of cells defined by the Beeler-Reuter model. For simulations under physiological and ischemic conditions, results show that the action potential propagation as well as electrogram reconstructions are consistent with clinical diagnosis. Finally, the advantage of the proposed approach is discussed within the frame of cardiac modelling and simulation. (shrink)

Over many centuries, the homing pigeon has been selectively bred for returning home from a distant location. As a result of this strong selective pressure, homing pigeons have developed an excellent spatial navigation system. This system passes through the hippocampal formation, which shares many striking similarities to the mammalian hippocampus; there are a host of shared neuropeptides, interconnections, and its role in the storage and manipulation of spatial maps. There are some notable differences as well: there are unique connectivity patterns (...) and spatial encoding strategies. This review summarizes the comparisons between the avian and mammalian hippocampal systems, and the responses of single neurons in several general categories: location and place cells responding in specific areas, path and goal cells responding between goal locations, context-dependent cells that respond before or during a task, and pattern, grid, and boundary cells that increase firing at stable intervals. Head-direction cells, responding to a specific compass direction, are found in mammals and other birds but not to date in pigeons. By studying an animal that evolved under significant adaptive pressure to quickly develop a complex and efficient spatial memory system, we may better understand the comparative neurology of neurospatial systems, and plot new and potentially fruitful avenues of comparative research in the future. (shrink)

The acceptability of sentences in natural language is constrained not only grammaticality, but also by the relationship between what is being conveyed and such factors as context and the beliefs of interlocutors. In many languages the critical element in a sentence (its focus) must be given grammatical prominence. There are different accounts of the nature of focus marking. Some researchers treat it as the grammatical realization of a potentially arbitrary feature of universal grammar and do not provide an explicit account (...) of its origins; others have argued, however, that focus marking is a (grammaticalized) functional solution to the problem of efficiently transmitting information via a noisy channel. By adding redundancy to highlight critical elements in particular, focus protects key parts of the message from noise. If this information‐theoretic account is true, then we should expect focus‐like behavior to emerge even in non‐linguistic communication systems given sufficient noise and pressures for efficiency. We tested this in an experiment in which participants played a simple communication game in which they had to click cells on a grid to communicate one of two line figures drawn across the grid. We manipulated the noise, available time, and required effort, and measured patterns of redundancy. Because the lines in many cases overlapped, meaning that only some parts of each line could be used to distinguish it from the other, we were able to compare the extent to which effort was expended on adding redundancy to critical (non‐overlapping) and non‐critical (overlapping) parts of the message. The results supported the information‐theoretic account of focus and shed light on the emergence of information structure in language. (shrink)

Utilization of renewable energies in association with energy storage is increased in different applications such as electrical vehicles, electric boats, and smart grids. A robust controller strategy plays a significant role to optimally utilize the energy resources available in a power system. In this paper, a suitable controller for the energy resources of an EB which consists of a 5 kW solar power plant, 5 kW fuel cell, and 2 kW battery package is designed based on the linear parameter varying (...) controller design approach. Initially, all component dynamics are augmented, and by exploiting the sector-nonlinearity approach, the LPV representation is derived. Then, the LPV control method determines the suitable gains of the states’ feedbacks to provide the required pulse commands of the boost converters of the energy resources to regulate the DC-link voltage and supply the power of EB loads. Comparing with the state-of-the-art nonlinear control methods, the developed control approach assures the stability of the overall system, as it considers all component dynamics in the design procedure. The real-time simulation results demonstrate the performance of the designed controller in the creation of a constant DC-link voltage. (shrink)

Reinvention of the form of expression is a conceptual approach characteristic for the evolution of all arts. This research study provides one such step forward in the advancement of scientific paper, a standard form of expression in natural sciences, toward more progressive terrains. The paper adopts the form of a theatrical play where a scientific family of four attempts to find the way around a writer’s block (Act I). Their idealess sense of confinement is overcome through arts or, more specifically, (...) through scientific research implementing the aesthetics of music as its key element. The characters record compositions differing in the degrees of consonance, rhythmicity and tonality, and play them to birds to observe their vocal and behavioral responses (Act II). They note that the birdsong volume drops significantly when the piano tunes, especially the compositionally complex ones, are played to the birds and increases signifcantly when the white noise of ocean waves is played. The bird count experiment proves indirectly that the birdsong volume reduction is an auditory response of the birds to music rather than the effect of their migrating to or away from the sound source. This science with the flavor of art elevates the characters beyond the limits of their confinement and they, exalted and uplifted, gain ideas for creative research in their own disciplines of biomedical science (Act III). They relinquish the newly gained freedom in favor of embracing love for humanity that underlies medical research and return to their confinement, where they conduct, in the coda of the paper, a series of experiments that venture beyond musicology and ornithology and fall in the domains of tissue engineering and drug delivery, but also psychology (Act III). First, sparrow nests are used as templates for tissue engineering constructs, which facilitate the growth of human fibroblastic cells better than their artificial, gridded replicas. Next, the shell of an Easter egg, predominantly calcite in composition, is used with success as a drug delivery carrier. Lastly, the bird nest drawing experiment demonstrates a greater mental health of children than that of the adults, correlating with one of the overarching points of the paper, which is to present children as a model for grownups to follow rather than the other way around. Over the course of the play, the characters discuss the value of the various fusions between art and science, question the limits of human language and repeatedly go off-topic to celebrate the freeness of the creative thinking process. The play reports on real-life research methods and scientific results through a narrative, without diminishing their empirical rigor and analytical accuracy. (shrink)

Many ontologies posit levels of existence. A whole exists at a level above its parts; a set exists at a level above its members. Hardware objects are at the lowest level in a computational ontology. Software objects exist at higher levels. The game of life illustrates a stratified computational ontology. The cells in the life grid are the hardware objects. An event is a function from cells to values 0 or 1. A process is a series of (...) events. A process contains a software object iff its content is generated by some rule that is independent of the rule for cells. We give a precise existence axiom for software objects. As expected, blinkers, gliders, puffer trains, and so on are software objects. Software objects satisfy traditional conceptions of materiality. Our conception of software objects has intriguing links to modern conceptions of material particles in terms of symmetry groups and topological invariants. Software objects are not abstract. (shrink)

Background The first COVID-19 wave started in February 2020 in France. The influx of patients requiring emergency care and high-level technicity led healthcare professionals to fear saturation of available care. In that context, the multidisciplinary Ethics- Support Cell (EST) was created to help medical teams consider the decisions that could potentially be sources of ethical dilemmas. Objectives The primary objective was to prospectively collect information on requests for EST assistance from 23 March to 9 May 2020. The secondary aim was (...) to describe the Cell’s functions during that period. Research design This observational, real-time study of requests for Cell consultations concerned ethical dilemmas arising during a public health crisis. The EST created a grid to collect relevant information (clinical, patient’s/designated representative’s preferences and ethical principles strained by the situation), thereby assuring that each EST asked the same questions, in the same order. Participants and research context Only our university hospital’s clinicians could request EST intervention. Ethical considerations The hospital Research Ethics Committee approved this study (no. CER-2020-107). The patient, his/her family, or designated representative was informed of this ethics consultation and most met with EST members, which enabled them to express their preferences and/or opposition. Findings/results 33 requests (patients’ mean age: 80.8 years; 29 had COVID-19: 24 with dyspnea, 30 with comorbidities). 17 Emergency Department solicitations concerned ICU admission, without reference to resource constraints; others addressed therapeutic proportionality dilemmas. Discussion Intervention-request motives concerned limited resources and treatment intensity. Management revolved around three axes: the treatment option most appropriate for the patient, the feasibility of implementation, and dignified care for the patient. Conclusions COVID-19 crisis forced hospitals to envisage prioritization of ICU access. Established decision-making criteria and protocols do not enable healthcare professionals to escape ethical dilemmas. That acknowledgement highlights ethical risks, enhances the added-value of nursing and encourages all players to be vigilant to pursue collective deliberations to achieve clear and transparent decisions. (shrink)

We reviewed the output of research and innovation cooperation between Russia and the US, including publications and patents, in the four prospective areas of energy efficiency and renewable energy during 2007-2011. Joint US-Russia research groups appear to focus primarily on hydrogen energy (fuel cells), followed by solar photovoltaics. The upcoming areas of smart grid and biofuels were left out entirely both from research and innovation collaboration. Russian patents in green energy technologies registered in the US are very low (...) in comparison to those from Japan, Korea, and China. (shrink)

A model of face representation, inspired by the biology of the visual system, is compared to experimental data on the perception of facial similarity. The face representation model uses aggregate primary visual cortex (V1) cell responses topographically linked to a grid covering the face, allowing comparison of shape and texture at corresponding points in two facial images. When a set of relatively similar faces was used as stimuli, this Linked Aggregate Code (LAC) predicted human performance in similarity judgment experiments. (...) When faces of perceivable categories were used, dimensions such as apparent sex and race emerged from the LAC model without training. The dimensional structure of the LAC similarity measure for the mixed category task displayed some psychologically plausible features but also highlighted differences between the model and the human similarity judgements. The human judgements exhibited a racial perceptual bias that was not shared by the LAC model. The results suggest that the LAC based similarity measure may offer a fertile starting point for further modelling studies of face representation in higher visual areas, including studies of the development of biases in face perception. (shrink)

Il s’agira ici de faire apparaître la régressivité — possibilité perpétuelle d’adjoindre un degré supplémentaire à l’énoncé — comme le principe même de l’ironie, ce qui conduit à la concevoir non comme une grille sémiotique et axiologique, mais comme une dynamique.La réflexion part de la cellule de base qu’est le signe ironique en tant que structure hiérarchisée à deux degrés, selon la conception traditionnelle. Cette dualité est d’abord analysée du point de vue sémantique, dans le cadre tropologique, puis sur les (...) plans axiologique, actantiel et énonciatif, ce qui aboutit à l’hypothèse de l’ironie comme trope métadiscursif, cumulant l’usage et la mention . Dans ce cadre, l’ironie se conçoit comme une représentation de représentation, comme un processus d’auto-duplication agissant par réflexivité critique et comique, et donc capable de se perpétuer virtuellement à l’infini puisque, s’appliquant à lui-même, il peut toujours ajouter un degré au précédent, sans pour autant l’annuler : le signe à deux niveaux ne constitue que la réalisation minimale de l’ironie, dont le second degré peut lui-même être réfléchi par un troisième, etc. Le « pouvoir réfléchissant » de l’ironie fait ainsi sa « force ascensionnelle » régressive, selon deux expressions empruntées à Proust.Interne au signe, ce dynamisme permet aussi, à l’échelle d’une oeuvre, de greffer différentes sortes d’ironie les unes sur les autres : la puissance créatrice du processus régressif conduit à envisager son rôle dans l’oeuvre d’art, en l’occurrence À la recherche du temps perdu, dont le texte multiplie de façon exemplaire et retorse les strates d’ironie. La Recherche, qui aura préalablement servi de support à toutes les analyses, permettra, par l’intermédiaire de Bergotte — écrivain ironiste dont le génie consiste dans le « pouvoir réfléchissant » et l’énergie créatrice dans la « force ascensionnelle » —, de poser la question de l’actualisation de la régressivité ironique dans l’oeuvre littéraire.Regressivity, as the perpetual possibility of adding a further degree to an utterance is the very principle of irony, which is thus conceived not under a semiotic and axiological grid, but as a dynamics.Reflection starts from the ironic sign as the basic cell and as a two tiered hierarchical structure, according to the traditional conception. This duality is first analysed from a semantical point of view, within the tropological framework, then on the axiological, actancial and utterance theoretic levels. This leads us to the hypothesis that irony is a metadiscursive trope, bringing together use and mention . Within this framework, irony is a representation of representation, an auto-duplicative process which acts through critical and comical reflectivity, and which is liable to perpetuate itself indefinitely, since, being auto-applicative, a new degree can always be added to the previous one, without cancelling itself : the two tiered sign being only the minimal realisation of irony, whose second degree can itself be reflected through a third, and so on. The “reflective power” of irony thus produces its “ascending force”.This mechanism internal to the sign allows also, at the level of the work, to plug different kinds of ironies onto each other : the creative power of the regressive process allows us to envisage its role in the work of art, in the case at hand in Remembrance of Things Past, whose text multiplies the various layers of irony. Proust’s work, which is here the basis of all our analyses, allows Bergotte — the ironist writer whose genius consists in the “reflective power” and in the “ascending force” — to raise the question of the actualisation of the ironical regressivity of the literary work. (shrink)

The vast majority (> 95%) of single-gene mutations in yeast affect not only the expression of the mutant gene, but also the expression of many other genes. These data suggest the presence of a previously uncharacterized ‘gene expression network’—a set of interactions between genes which dictate gene expression in the native cell environment. Here, we quantitatively analyze the gene expression network revealed by microarray expression data from 273 different yeast gene deletion mutants.(1) We find that gene expression interactions form a (...) robust, error-tolerant ‘scale-free’ network, similar to metabolic pathways(2) and artificial networks such as power grids and the internet.(3-5) Because the connectivity between genes in the gene expression network is unevenly distributed, a scale-free organization helps make organisms resistant to the deleterious effects of mutation, and is thus highly adaptive. The existence of a gene expression network poses practical considerations for the study of gene function, since most mutant phenotypes are the result of changes in the expression of many genes. Using principles of scale-free network topology, we propose that fragmenting the gene expression network via ‘genome-engineering’ may be a viable and practical approach to isolating gene function. BioEssays 24:267–274, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10054. (shrink)

In the following we study the evolution of support networks among egoists who differ widely in their degree of neediness, are free to choose their partners, and do so in opportunistic ways. No central authority is involved. The question we address is to what degree and under what aspect it shapes the structure of emerging solidarity networks whether we model egoistic actors as rational actors in a game theoretical sense or as adaptive actors, i.e. learning beings following a simple learning (...) mechanism which is driven by success and failure.1 The central modelling ideas to address that question are: Support relationships are modelled by a 2-person support game. The social space in which a network can emerge is a 2-dimensional cellular grid. Actors can play the support game simultaneously with all their neighbours. Not all cells are occupied. From time to time players have the opportunities to migrate. In one model we make our actors rational beings, in a second one we make them adaptive agents. Obviously we use a cellular automata framework of modelling . Especially because of its simplicity that framework has often proved fruitful for analysing micro/macro relations. (shrink)

The Renaissance architect, moral philosopher, cryptographer, mathematician, Papal adviser, painter, city planner and land surveyor Leon Battista Alberti provided the theoretical foundations of modern perspective geometry. Alberti’s work on perspective exerted a powerful influence on painters of the stature of Albrecht Dürer, Leonardo da Vinci and Piero della Francesca. But his Della pittura of 1435–36 contains also a hitherto unrecognized ontology of pictorial projection. We sketch this ontology, and show how it can be generalized to apply to representative devices in (...) general, including maps and spatial and non-spatial databases. (shrink)

This book bridges the divide between the fields of power systems engineering and computer communication through the new field of power system information theory. Written by an expert with vast experience in the field, this book explores the smart grid from generation to consumption, both as it is planned today and how it will evolve tomorrow. The book focuses upon what differentiates the smart grid from the "traditional" power grid as it has been known for the last (...) century. Furthermore, the author provides the reader with a fundamental understanding of both power systems and communication networking. It shows the complexity and operational requirements of the evolving power grid, the so-called "smart grid," to the communication networking engineer; and similarly, it shows the complexity and operational requirements for communications to the power systems engineer. The book is divided into three parts. Part One discusses the basic operation of the electric power grid, covering fundamental knowledge that is assumed in Parts Two and Three. Part Two introduces communications and networking, which are critical enablers for the smart grid. It also considers how communication and networking will evolve as technology develops. This lays the foundation for Part Three, which utilizes communication within the power grid. Part Three draws heavily upon both the embedded intelligence within the power grid and current research, anticipating how and where computational intelligence will be implemented within the smart grid. Each part is divided into chapters and each chapter has a set of questions useful for exercising the readers' understanding of the material in that chapter. Key Features: Bridges the gap between power systems and communications experts Addresses the smart grid from generation to consumption, both as it is planned today and how it will likely evolve tomorrow Explores the smart grid from the perspective of traditional power systems as well as from communications Discusses power systems, communications, and machine learning that all define the smart grid It introduces the new field of power system information theory. (shrink)

IEEE Vision for Smart Grid Communications: 2030 and Beyond Reference Model, directly overlays events in the power grid with communication performance on the same spacetime model, it ensures a perspective that verifies that any of the myriad of communication technologies chosen will provide the required support for the Smart Grid. For Corporate or Institutional Access, request a custom quote for your organization at www.ieee.org/smartgridresearch.

This IEEE Vision for Smart Grid Communications: 2030 and Beyond Roadmap is a high-levelsupplement of the full vision document IEEE Vision for Smart Grid Communications: 2030 andBeyond. Communication is a major enabling technology for the Smart Grid. We believe that the powergrid will tend to utilize advances in communications since the data exchange requirements willscale up for the Smart Grid. Smart Grid communication will help to improve demand forecasting,enable self-healing from power disturbance events, facilitate active (...) participation by consumers in demand-response mechanisms, and provide resilience against physical and cyber attacks. Smart Grid communication will also help to improve quality of power, allow easy integration of renewable energy sources into the grid, foster innovation to enable new products, services, and markets, assist in optimization of assets, and improve operating efficiency. (shrink)

Between 1940 and 1970 pioneers in the new field of cell biology discovered the operative parts of cells and their contributions to cell life. They offered mechanistic accounts that explained cellular phenomena by identifying the relevant parts of cells, the biochemical operations they performed, and the way in which these parts and operations were organised to accomplish important functions. Cell biology was a revolutionary science but in this book it also provides fuel for yet another revolution, one that (...) focuses on the very conception of science itself. Laws have traditionally been regarded as the primary vehicle of explanation, but in the emerging philosophy of science it is mechanisms that do the explanatory work. Bechtel emphasises how mechanisms were discovered, focusing especially on the way in which new instruments made these inquiries possible. He also describes how new journals and societies provided institutional structure to this new enterprise. (shrink)

Examining stem cell biology from a philosophy of science perspective, this book clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. The first chapters discuss what stem cells are, how experiments identify them, and why these two issues cannot be completely separated. The basic concepts, methods and structure of the field are set out, as well as key limitations and challenges. The second part of the book shows how rigorous (...) explanations emerge from stem cell experiments, and compares these to other kinds of scientific explanation. Model organisms, the role of genes, and the significance of collaboration are also discussed. The last part of the book considers relations to systems biology and clinical medicine, arguing that both the mathematical models of the former, and ethical principles of the latter, are necessary for stem cell biology to deliver on its promises. (shrink)

This document provides a vision of the communications-related aspects of the Smart Grid in the year 2030, and lays out the technology roadmap that will lead us to the vision. This document starts with some basic knowledge of the power grid and follows up with fundamental building blocks for the communication infrastructure that will accompany the Smart Grid. Subsequently, network architectures, including overlays, are discussed at length. Also discussed, are important issues such as standards, regulations, security, and (...) disruptive technologies. The last part of this document discusses emerging technologies such as the solid state transformer, wireless beamed power, and quantum key distribution. Throughout the document, a careful distinction is made between communications capabilities and the specific technologies that are required to support those capabilities. (shrink)

A large number of modern communication technologies and sensing technologies are incorporated into the smart grid, which makes its structure unique. The centralized optimized dispatch method of traditional power grids is difficult to achieve effective dispatch of smart grids. Based on the analysis of power generation plan and maintenance plan optimization model, this paper establishes a smart grid power generation and maintenance collaborative optimization model with distributed renewable energy. The objective function of this collaborative optimization problem is the (...) operating cost of conventional units, the cost of wind power generation, and the cost of overhauling units; the constraints considered mainly include system constraints and overhaul constraints. The solution method of combinatorial optimization is analyzed, and the genetic optimization algorithm adopted in this paper is selected and discussed. According to the characteristics of the system, various loads are modeled, and power supply constraints are considered. By establishing an effective objective function, the adjustable load scheduling problem is transformed into a solvable optimal control problem. Taking into account the uncertain factors in the system, the advantage of the real-time control system is that it can realize the dynamic update scheduling of the load, so it is more in line with the requirements of the actual system. The real-time algorithm proposed in the paper is based on a distributed control strategy, which can not only realize dynamic compensation for random fluctuations in renewable energy power generation but also satisfy the load curve optimization under the premise of making full use of power supply resources. In addition, simulation experiments compare the load dispatching capabilities of the proposed algorithm with the existing algorithms, thereby verifying the performance of the proposed method. (shrink)

This article is a reflection of the project ‘Welcome Aboard’, which I collaborated on in 2011, with two scientists Nicola Armaroli (Ist. ISOF/CNR, Bologna and Molecular Photoscience Group, Bologna) and Vincenzo Balzani (Department of Chemistry G. Ciamician, University of Bologna). The video establishes a dialogue based on Buckminster Fuller’s ‘World Game’ where they offer possible scenarios for our planet running under renewable energy sources. Ultimately, a democratic system of energy sharing, between consumers and suppliers, was proposed to be put at (...) the forefront. The article begins with David Bohm’s focus on how a collective thought process can have drastic affects on our society. He proposes that we recognize the ‘whole’ in which we live to avoid becoming a society of fragmented incoherency. Similarly, as an engineer Buckminster Fuller has devoted himself to finding an effective action to change the world through a global approach, which he calls a whole-system perspective. The technology of the Smart Grid, proposed in the dialogue between the two scientists of ‘Welcome Aboard’ in which every individual produces, shares and consumes energy (electricity), seems to be a new tool that could be combined with other technologies to provide a connectivity between human beings. (shrink)

Between 1940 and 1970 pioneers in the new field of cell biology discovered the operative parts of cells and their contributions to cell life. They offered mechanistic accounts that explained cellular phenomena by identifying the relevant parts of cells, the biochemical operations they performed, and the way in which these parts and operations were organised to accomplish important functions. Cell biology was a revolutionary science but in this book it also provides fuel for yet another revolution, one that (...) focuses on the very conception of science itself. Laws have traditionally been regarded as the primary vehicle of explanation, but in the emerging philosophy of science it is mechanisms that do the explanatory work. Bechtel emphasises how mechanisms were discovered, focusing especially on the way in which new instruments made these inquiries possible. He also describes how new journals and societies provided institutional structure to this new enterprise. (shrink)

We show that, given extensive exploration of a three-dimensional volume, grid units can form with the approximate periodicity of a face-centered cubic crystal, as the spontaneous product of a self-organizing process at the single unit level, driven solely by firing rate adaptation.