Recent systematic studies using newly developed genomic approaches have revealed common mechanisms and principles that underpin the spatial organization of eukaryotic genomes and allow them to respond and adapt to diverse functional demands. Genomes harbor, interpret, and propagate genetic and epigenetic information, and the three‐dimensional (3D) organization of genomes in the nucleus should be intrinsically linked to their biological functions. However, our understanding of the mechanisms underlying both the topological organization of genomes and the various nuclear processes is still largely (...) incomplete. In this essay, we focus on the functional relevance as well as the biophysical properties of common organizational themes in genomes (e.g. looping, clustering, compartmentalization, and dynamics), and examine the interconnection between genome structure and function from this angle. Present evidence supports the idea that, in general, genome architecture reflects and influences genome function, and is relatively stable. However, the answer as to whether genome architecture is a hallmark of cell identity remains elusive. (shrink)

The security of the civil aviation network is closely related to flight safety. Security situation prediction is the advanced stage of situational awareness in the civil aviation network. In this article, a prediction approach of security situations for the air traffic management network is proposed on the basis of the wavelet neural network. The proposed approach adopts the wavelet theory and neural network, combining a time-series forecasting method for the prediction of security situations in the civil aviation network. The experimental (...) results show that this approach has the advantages of fast training and high prediction accuracy. (shrink)

This chapter contains section titled: Literary Revolution and its Meaning The Naturalistic Conception of the Universe and the Experimentalist Method History of Chinese Philosophy and Systematizing the National Heritage Political Philosophy and Liberalism Hu Shi as an Enlightenment Philosopher.

本书论述了艺术与想象力、艺术门类的相互关系、艺术与社会的参照分析、生活对艺术的启示、艺术欣赏三总体等。.

The COVID-19 pandemic has had a profound psychological and behavioral impact on people around the world. Consumer purchase behaviors have thus changed greatly, and consumer services companies need to adjust their business models to adapt to this change. From the perspective of consumer psychology, this paper explores the impact of consumer purchase behavior changes over the course of the pandemic on the business model design of consumer services companies using a representative survey of 1,742 individuals. Our results show that changes (...) in consumer purchase behavior have a significant impact on the design of consumer services firms’ business models. Specifically, changes in consumers’ purchase object, motive, and timeframe are more likely to spark a novelty-centered business model design, whereas changes in purchase method tend to inspire an efficiency-centered one. Our findings provide a theoretical reference for consumer services companies in designing business models when faced with unexpected crises. (shrink)

I first present a brief interpretation of Sosa’s virtue epistemology by showing how it is arguably better than Goldman’s process reliabilism, why Sosa distinguishes between animal knowledge and reflective knowledge, and how Sosa’s recent account of knowing full well can deal with pragmatic encroachment. Then, I raise two worries about Sosa’s account: (a) Sosa’s claim that one might have animal knowledge without knowing reflectively or knowing full well implies that one’s true belief might manifest both competence and luck, which seems (...) to pose a challenge to Sosa’s solution to the Gettier problem; (b) intellectual virtue or competence does not seem to be a necessary condition for knowledge: there are cases where one knows without possessing the relevant intellectual virtue or competence. Finally, I suggest a responsibilist account of knowledge and show how it can not only handle the cases that pose a problem for Sosa’s account but also explain our intuitions about different grades of knowledge. (shrink)

On December 3 last year, Comrade Zhao Fusan of the Research Institute of Religion of the Chinese Academy of Social Sciences wrote a letter to Comrade Hu Qiaomu outlining his personal reflections on the Party Center's Document 19 [1982].

The debate over the existence of a “public sphere” in China’s Late Qing/Early Republican era began nearly three decades ago, but it has yet to generate a special socio-cultural review on the “Confucian social imaginary” of the Chinese people. The article builds on existing “economic-political approach” and “idea-communication approach” to argue decisive factors hindering the development of a Habermasian “public sphere.” These includes (1) people’s traditional-collectivist lifestyle, (2) lack of understanding of “universal equality,” (3) conservative self-positioning during social transition, (4) (...) regionalist attitude toward outsiders, (5) lack of access to Enlightenment ideas, (6) disregard for parliamentary systems, and (7) ignorance of the rule of law. (shrink)

Science, the proud son of the era and the crystallization of man's wisdom, is inlaid in the crown of our times like a lustrous and brilliant pearl. Social science discloses to mankind the general law governing the development of society and leads it in marching forward to the higher stages of social system - socialist society and communist society. Natural science creates for mankind tremendous productive forces like miracles, enabling the human race to live a life in fairyland. Who is (...) there who does not praise the power of science and refuses to admit that science is the great force pushing history forward? Who is there that dares openly to set up forbidden zones in science, thus serving as an executioner to strangle science? In our times, people who dare openly to do this, perhaps, are increasingly few. However, this does not mean that science can completely extricate itself from disaster. Science has to pay dearly for every step of exploration and has to undergo a stern struggle for it. Science is an undertaking that is most creative and filled with the spirit of innovation. It openly declares that it will wage an irreconcilable struggle against all the old stuff which is reactionary, dark, ignorant and superstitious. Because of this, it is bound to suffer bans and buffets from the reactionary forces. Science has no forbidden zone! This is a call of reason; but there are forbidden zones in science, and that is what we see in the picture of history and reality. What are the forbidden zones? And how should we destroy the forbidden zones and set science free? For many years Lin Biao and the "gang of four" brought terrible disasters to science. In consequence, the aforementioned question is sharply raised before us, requiring us to deal with it strictly and try to resolve it correctly. (shrink)

Machine learning algorithms bring out an under-appreciated puzzle of discrimination, namely figuring out when a decision made on the basis of a factor correlated with race is a decision made on the basis of race. I argue that prevailing approaches, which are based on identifying and then distinguishing among causal effects of race, in their metaphysical timidity, fail to get off the ground. I suggest, instead, that adopting a constructivist theory of race answers this puzzle in a principled manner. On (...) what I call a “thick constructivist” account of race, to be raced is to be socially positioned in the way indicated by a certain set of statistical regularities on the basis of particular phenotypical traits. A thick constructivist sees that acting on the basis of correlations that constitute race qua social position just is acting on the basis of race, because races just are social positions that subject their member individuals to a particular matrix of social relations that define the raced position. This conclusion has considerable ramifications for our understanding of discrimination, algorithms and beyond. (shrink)

The importance of work stress on newcomers’ organizational socialization has been a topic of substantial interest. However, the impact mechanism of different stressors on newcomers’ organizational socialization is still in the early stages of theory development. This study, based on the theory of the dual work stress model, explored how to challenge stressors and hindrance stressors impact newcomers’ organizational socialization via the mediation of job crafting. Based on the empirical data from 247 newcomers, we found that challenge stressors positively affected (...) newcomers’ organizational socialization; on the contrary, hindrance stressors would result in negative influences. In addition, leader-member exchange enhanced the positive effect of challenge stressors on newcomers’ job crafting and further moderated the indirect influence of challenge stressors on newcomers’ organizational socialization via job crafting. These findings provide a practical guide for organizations to apply stress management and promote newcomers’ socialization. (shrink)

En este mundo no existen dos culturas iguales, la traducción es una actividad de comunicación intercultural. En la década de los noventa, Suan Bussnett propuso “la gira de la cultura”, y enfatizó que la traducción no se debe aislar de la cultura. Como un importante elemento cultural 妾 (Qiè) es llevada a la novela en Sueño en el Pabellón Rojo. Desde la perspectiva de “traducción cultural”, se pone enfoque en cómo se puede traducir el significado y también transmitir las informaciones (...) culturales de 妾 (Qiè)). (shrink)