Background: Individuals’ information processing includes automatic and effortful processes and the latter require sustained concentration or attention and larger amounts of cognitive “capacity.” Event-related potentials reflect all neural activities that are related to a certain stimulus. Investigating ERP characteristics of effortful cognitive processing in people with schizophrenia would be helpful in further understanding the neural mechanism of schizophrenia.Methods: Both schizophrenia patients and health controls completed ERP measurements during the performance of the basic facial emotion identification test and the face-vignette task. (...) Data of ERP components, BFEIT and FVT performances were analyzed.Results: Schizophrenia patients’ accuracies of face emotion detection in the BFEIT and vignette emotion detection in the FVT were both significantly worse than the performance of the HC group. Repeated-measures ANOVAs performed on mean amplitudes and latencies revealed that the interaction effect for group × experiment × site was significant for N250 amplitude. In FVT experiment, N250 amplitudes at prefrontal and frontal sites in schizophrenia group were larger than those of HC group; the maximum N250 amplitude was present at the prefrontal site in both the groups. For N250 latency, the interaction effect for group × experiment was significant; N250 latencies in the schizophrenia group were longer than those of the HC group.Conclusion: Schizophrenia patients present effortful cognitive processing dysfunctions which reflect in abnormal ERP components, especially N250 at prefrontal cortex and frontal cortex sites. These findings have important implications for further clarifying the neural mechanism of effortful cognitive processing deficits in schizophrenia. (shrink)

Each Olympic Games will offer fresh research material in the fields of social and sports philosophy. This article uses Beijing 2022 Winter Olympic Games (B2022WOG) as an illustration to discuss the difficulty in viewing sports as contributors to social progress. We have examined the phenomena of fusing classical Chinese philosophy with social sports philosophy, as exemplified by the current Olympic movement. The key finding is that the fusion of Eastern and Western cultures and civilizations is responsible for sports revival as (...) a social force in the modern era. As a result, new social cognition emerges. The leadership of the nations hosting the Olympic Games gains knowledge and the chance to showcase their own political, economic, and solid philosophical underpinnings. The B2022WOG, taking place in a completely new societal environment (COVID-19 pandemic, world power realignment), is used as a case study for analysis. Using this example, the artіcle shows the social significance of the Olympic Games and emphasizes that the social value of sports and the Olympic movement is reflected in the "spirit of fair competition" and the "spirit of peace", "human intelligence". This is a relatively new direction in the development of researcհ in the field of physical education and social philosophy, and the special contrіbutіon of this study is to study one of the promising trends in the development of sports, that is, the modern Olympic movement, integrated with the national culture of different countries, B2022WOG were utilized as a case study for research since they are taking place in a totally new social context (COVID-19 pandemic, realignment of global power). By using this illustration, the article highlights the social significance of the Olympic Games and stresses how the "spirit of fair competition", "spirit of peace" and "human intelligence" are reflections of the social worth of sports and the Olympic movement. This is a relatively new area of study in the fields of physical education and social philosophy, and the focus of this research is to examine one of the most encouraging developments in the field of sports — the modern Olympic movement — as it interacts with various national cultures. (shrink)

Each Olympic Games will provide new material for research in the field of sports philosophy and social philosophy. This article raises the problem of understanding sports as a participant in social development on the example of the 2022 Winter Olympics in Beijing. The author analyzes the phenomenon of combining the philosophy of social sports, represented by the modern Olympic movement, and traditional Chinese philosophy. The main conclusion is that sport, as a social force, is reborn in the modern era due (...) to the combination of Eastern and Western cultures and civilizations. This gives rise to new social cognition. The leadership of the countries hosting the Olympic Games gain experience and the opportunity to demonstrate their own political and economic strength and deep mental foundations. The Beijing 2022 Winter Olympics, taking place in a completely new societal environment (COVID-19 pandemic, world power realignment) is used as a case study for analysis. Using this example, the article shows the social significance of the Olympic Games and emphasizes that the social value of sports and the Olympic movement is reflected in the "spirit of fair competition" and the "spirit of peace", "human intelligence". This is a relatively new direction in the development of research in the field of physical education and social philosophy, and the special contribution of this study is to study one of the promising trends in the development of sports, that is, the modern Olympic movement, integrated with the national culture of different countries. (shrink)

Ribonucleotide reductase (RNR) catalyzes the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. In addition to the well documented allosteric regulation, the synthesis of the enzyme is also tightly regulated at the level of transcription. mRNAs for both subunits are cell cycle regulated and inducible by DNA damage in all organisms examined, including E. coli, S. cerevisiae and H. sapiens. This DNA damage regulation is thought to provide a metabolic state that facilitates DNA replicational repair processes. (...) S. cerevisiae also encodes a second large subunit gene, RNR3, that is expressed only in the presence of DNA damage. Genetic analysis of the DNA damage response in S. cerevisiae has shown that RNR expression is under both positive and negative control. Among mutants constitutive for RNR expression are the general transcriptional repression genes, SSN6 and TUP1. Mutations in POL1 and POL3 also activate RNR expression, indicating that the DNA damage sensory network may respond directly to blocks in DNA synthesis. A protein kinase, Dun1, has been identified that controls inducibility of RNR1, RNR2 and RNR3 in response to DNA damage and replication blocks. This result suggests that the RNR genes in S. cerevisiae form a regulon that is coordinately regulated by protein phosphorylation in response to DNA damage. (shrink)

The signals in numerous complex systems of engineering can be regarded as nonlinear parameter trend with noise which is identically distributed random signals or deterministic stationary chaotic signals. The commonly used methods for parameter estimation of nonlinear trend in signals are mainly based on least squares. It can cause inaccurate estimation results when the noise is complex. This paper proposes a calibration method for this issue in the case of single parameter via nonstationarity measure from the perspective of the stationarity (...) of residual sequence. Some numerical studies are conducted for validation. Results of numerical studies show that the proposed calibration method performs well for various models with different noise strengths and types and can significantly improve the accuracy of initial estimates obtained by least squares method. This is the first time that the nonstationarity measure is applied to the parameter calibration. All these results will be a guide for future studies of other parameter calibrations. (shrink)

本书包括绪论、定义、论证、谬误、命题逻辑、归纳推理和类比推理、科学和假说等八章,每章后都附有思考题和练习题。.

In recent years there has been a boom in the study of the Yi Jing (the Book of Changes) and ancient Chinese forms of physical exercise in European countries such as Germany, Belgium and France, with research themes focusing on psychotherapeutic and medical clinical experimental studies, such as a study conducted at the Institute of Psychology at the University of Tübingen in Germany that emphasised that moderate general physiological activation, exercise-dependent regulation of the heart rhythm ANS can induce a typical (...) state of calm to regulate Qi. There are few theoretical studies on the metaphysical aspects of the existence of such healthful and beneficial underlying psychophysiological mechanisms of mind-body exercise Florens（2021）, so this paper chooses to use the practice of Qi as a case study, where Qi practice refers to the classical and systematic use in Chinese martial arts’ internal styles and systems such as Taijiquan (Taichi), Qigong and shaolinquan(Shaolin Boxing). A primarily documentary research approach is adopted, this paper using classical theories from the Yi Jing to analyse a metaphysical analysis of the physical exercises associated with Qi. The conclusions of the study show that: Firstly, Chinese traditional methods and practical experience can be drawn upon. Secondly, the classical theory of the Yi Jing, which uses Qi as the core of practice, enriches the ontology of human life perception in the field of philosophy. Thirdly, the ultimate pursuit of life through the practice of Qi is a concrete manifestation of the metaphysical holistic view of life in traditional Chinese physical exercises. (shrink)

[1]. Xian Qin liang Han juan -- [2]. Wei Jin Nan Bei chao juan -- [3-4]. Sui Tang Wu dai juan -- [5-6]. Song Liao Jin Yuan juan -- [7-8]. Ming Qing juan -- [9]. Jin dai juan.