The Motin family proteins (Motins) are a class of scaffolding proteins consisting of Angiomotin (AMOT), AMOT‐like protein 1 (AMOTL1), and AMOT‐like protein 2 (AMOTL2). Motins play a pivotal role in angiogenesis, tumorigenesis, and neurogenesis by modulating multiple cellular signaling pathways. Recent findings indicate that Motins are components of the Hippo pathway, a signaling cascade involved in development and cancer. This review discusses how Motins are integrated into the Hippo signaling network, as either upstream regulators or downstream effectors, to modulate cell (...) proliferation and migration. The repression of YAP/TAZ by Motins contributes to growth inhibition, whereas subcellular localization of Motins and their interactions with actin fibers are critical in regulating cell migration. The net effect of Motins on cell proliferation and migration may contribute to their diverse biological functions. (shrink)

Schizophrenia is a serious mental disease whose pathogenesis has not been fully elucidated. Its clinical evaluation and diagnosis still highly depend on the clinical experience of doctors. It is of great scientific value and clinical significance to study the inducing factors and neuropathological mechanism of schizophrenia. Based on the four research problems of schizophrenia, this paper analyzes the data types that need to be stored in clinical trials and scientific research, including basic information, case report data, neuropsychological and cognitive function (...) evaluation, magnetic resonance data, electroencephalogram data, and intestinal flora data. Through the demand analysis of the system, including the data management part, data analysis part, the functional demand of the system management part, and the overall nonfunctional demand of the system, the overall architecture design, functional module division, and database table structure design of the system are completed. Adopting Browser/Server architecture and front-end and back-end separation mode and applying Java and Python programming language, based on spring framework and database, a multidimensional information management system for schizophrenia is designed and implemented, which includes four modules: data analysis, data management, system management, and security control. In addition, each functional module of the system is designed and implemented in detail, and the software operation flow of each module is illustrated with the sequence diagram. Finally, the multidimensional data of schizophrenia collected in our laboratory were used for system test to verify whether the system can meet the needs of clinical big data management of schizophrenia and the multidimensional information management system of schizophrenia can meet the needs of clinical big data management. The information management system helps schizophrenic researchers to carry out data management and data analysis. It also has advantages that are easy to use, safe, and efficient and has strong scalability in data management, data analysis, and scalability. It reflects the innovation of the system and provides a good platform for the management, research, and analysis of clinical big data of schizophrenia. (shrink)

While studies of Chinese landscape literature usually focus on landscape poetry (shanshui shi), I wish to take Xie Lingyun’s “Rhapsody on Mountain Dwelling” as my point of departure to discuss how the rhapsody draws from the categorization of geographic designations and local products (mingwu leiju) at work in traditional geographical texts such the “Yu Gong [Tribute to Yu]” chapter in Shangshu and the “Diguan [Regional Offices]” chapter in Zhouli More broadly, I discuss how “landscape literature” participated in contemporaneous writings on (...) geography. Xie was part of an Eastern Jin discovery of the landscape that engaged it through bodily movement. This new embodied mode of experience altered the system of naming and explicating the terms of landscape. Xie Lingyun, hailed asthe great “landscape poet” of Chinese literature, might be better described as someone who helped construct a new geographical discourse. (shrink)

Partner selection is the primary aspect of the formation of knowledge collaboration teams. We propose a method of partner selection for KCTs based on a weighted social network analysis method in which the individual knowledge competence and the collaboration performance of candidates are both considered. To select the desired partners, a biobjective 0-1 model is built, integrating the knowledge competence and collaboration performance, which is an NP-hard problem. Then, a multiobjective genetic algorithm is developed to solve the proposed model. Finally, (...) a real-world example is provided to illustrate the applicability of the model, and the MOGA is implemented to search for Pareto solutions of partner selection for KCT in this case. Moreover, some simulation examples are used to test the efficiency of the algorithm. The results suggest that the proposed method can support effective and practical partner selection. (shrink)

Many previous studies have documented the detrimental effects of social loafing on others (_inter_personal impacts) at the between-person level. However, social loafing may carry underappreciated _intra_personal functional effects at the within-person level. Our research develops a novel theoretical framework to investigate _when_ and _how_ engaging in social loafing enhances one’s job performance. Drawing on the effort-recovery model and moral cleansing theory, we propose that social loafing may improve subsequent job performance by enhancing recovery and guilt. Specifically, we argue that among (...) employees who experience higher job demands or have higher moral identity, social loafing in the morning enhances their job performance in the afternoon by facilitating recovery or guilt in the morning. Two-wave daily data collected across ten consecutive workdays using the experience sampling method (ESM) supports this model. We discuss how this research identifies a functional basis for social loafing and provides implications for research and practice. (shrink)

本书收录的文章按照四个主题进行了编排,分别是:世界历史与世界交往、马克思主义全球化理论建构、全球化与社会主义以及全球化理论的全球化等。.

本书从史学、文化学的角度对中国儒家伦理与商人精神进行探讨,文章有:《中国近世宗教伦理与商人精神》、《工业文明之精神基础》等。.

As a comparative study of the virtue ethics of Aristotle and Confucius, this book explores how they each reflect upon human good and virtue out of their respective cultural assumptions, conceptual frameworks, and philosophical perspectives. It does not simply take one side as a framework to understand the other; rather, it takes them as mirrors for each other and seeks to develop new readings and perspectives of both ethics that would be unattainable if each were studied on its own.

Objective: This study aimed to test the psychometric properties of the suicide stroop task in a Chinese college population. Methods: College students who were in the 1st–4th grade, fluent in Chinese, and without color blindness were recruited from a university in Guangzhou, China from September to December 2019. Participants were administered the suicide stroop task at baseline and 1-month follow-up. Results: The suicide stroop task showed excellent internal reliability. However, the suicide stroop task did not reveal suicide-related attentional biases among (...) current suicide ideators and was not significantly associated with the severity of suicidal ideation, depression, hopelessness, nor anhedonia, indicating a lack of concurrent validity for the task. Additionally, the two-time data of interference scores could not generate intraclass correlation coefficients due to a negative average covariance among data, which indicated poor test–retest consistency for the task. Conclusion: The results of this study did not support the use of the suicide stroop task on the identification of suicidal risk among Chinese college students. It is crucial to assess the psychometric properties of behavioral measures rigorously as self-report measures before large applications in clinical and community settings. (shrink)

本书论文大多围绕对康德、黑格尔与马克思思想的反思而展开讨论,进行了“不应该把近代西方哲学与当代西方哲学简单地割裂开来,也不应该“将对西方哲学的研究和对马克思哲学的研究抽象地对立起来”的思考。.

中国现代哲学是20世纪中国哲学变革和发展的重要时期,不少哲学家建立了自己独特的思想体系,对智慧问题予以高度重视。本书以中国现代哲学对形上智慧的追问和求索为主题,对中国现代哲学关于形而上学问题的理论发展 作了深入而清晰的梳理,并展示了其中的逻辑脉络。主要内容有科玄之争、知识和智慧、存在与天道、理智和直觉、名言之域与超名言之域、自由和境界等,着力对理气之辩、心物之辩、逻辑思维的辩证法、理性的直觉、可说的 和不可说的、思辩地说和诗意地说、天道和境界、自由和真善美等话题进行理性沉思。全书资料翔实、结构严谨、见解独特,是一部很有价值的学术专著,适合大学文科师生、哲学社会科学爱好者和研究者阅读使用。.

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

本书汇集了著名科学家、人文学者在中国科学院研究生院所做的有关科学前沿方面代表性的报告和讲座,内容涉及生物学、化学、农学、生态环境建设、可持续发展战略等。.

Antibiotic allergies are commonly reported among patients, but most do not experience reactions on rechallenge with the same agents. These reported allergies complicate management of infections in patients labelled as having penicillin allergy, including serious infections where penicillin-based antibiotics are the first-line (most effective and least toxic) treatment option. Allergy labels are rarely questioned in clinical practice, with many clinicians opting for inferior second-line antibiotics to avoid a perceived risk of allergy. Reported allergies thereby can have significant impacts on patients (...) and public health, and present major ethical challenges. Antibiotic allergy testing has been described as a strategy to circumvent this dilemma, but it carries limitations that often make it less feasible in patients with acute infections or in community settings that lack access to allergy testing. This article provides an empirically informed ethical analysis of key considerations in this clinical dilemma, usingStaphylococcus aureusbacteraemia in patients with penicillin allergies as a case study. We argue that prescribing first-line penicillin-based antibiotics to patients with reported allergies may often present a more favourable ratio of benefits to risks, and may therefore be more ethically appropriate than using second-line drugs. We recommend changes to policy-making, clinical research and medical education, in order to promote more ethically acceptable responses to antibiotic allergies than the status quo. (shrink)

本书分为九章,内容包括中西伦理思想概述,道德原则的分析与评价,几个重要的道德范畴,体现伦理价值的道德规范,完善人的道德等。.

俞吾金(1948~ ),浙江萧山人,复旦大学哲学系教授、西方哲学学科点博士生导师.

本书作者通过对中国哲学史上的天、命、阴阳、五行、感应、时、经权、常变、新民、亲民等著名而重要的哲学概念、命题、观念的梳理,勾画出中国思维的基本品质。.

In September 2008, the European Organization for Nuclear Research (CERN) scientists successfully switched on the historic biggest physics device, the Large ...

本书共五章,介绍了全球化的基本内涵与实质、全球化对苏南可持续发展新文化模式的影响、苏南新旧文化模式的转换与创新等内容。.