Muscular dystrophies are associated with mutations in genes encoding several classes of proteins. These range from extracellular matrix and integral membrane proteins to cytoskeletal proteins, but also include a heterogeneous group of proteins including proteases, nuclear proteins, and signalling molecules. Muscular dystrophy phenotypes have also become evident in studies on various knockout mice defective in proteins not previously considered or known to be mutated in muscular dystrophies. Some unifying themes are beginning to emerge from all of these data. This review (...) will consider recent advances in our understanding of the molecules involved and bring together data that suggest a role for the cytoskeleton and cell adhesion in muscular dystrophies. BioEssays 24:542–552, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

This study compares the use of interactional metadiscourse in a British newspaper, the Daily Mail, and a British news magazine, The Economist, in reporting on the Brexit referendum. We adopted Hyland’s (2005a:48–54) framework to analyze hedges, boosters, attitude markers, engagements, and self-mentions. One hundred news articles were randomly selected from online archives from February to June in 2016, during which time the debatable issue was discussed ardently. Quantitative and qualitative results of this study revealed both similarities and differences between the (...) newspaper and the news magazine in the use of interactional metadiscourse. For example, quantitatively, the frequencies of boosters in both genres were similar; however, the newspaper used much more engagement markers and self-mentions whereas the magazine used more hedges and attitude markers. Qualitatively, while most self-mentions were the same in both genres, a unique choice of self-mentions was found in the news magazine. (shrink)

Happiness, defined as a state of well-being and contentment, is a central human goal. Despite advances in customer behavior research related to value co-creation, the link between customer happiness and these behaviors remains unclear. This study therefore examines customers’ in-role participation behavior and extra-role citizenship behavior to determine their influence on customers’ happiness. Customer participation and citizenship behaviors relate positively to customers’ perceptions of both service performance and their contributions to others’ welfare. In addition, collectivism moderates the relationship between perceived (...) contributions to others’ welfare and happiness; individualism instead moderates the relationship between perceived service performance and happiness. These findings provide both managerial implications and directions for business marketing ethics. (shrink)

Do liberals’ and conservatives’ brain processes differ in moral reasoning? This research explains these groups’ dissimilar moral stances when they face ethical transgressions in business. Research that explores the effects of ideological asymmetry on moral reasoning processes through moral foundations has been limited. We hypothesize two different moral reasoning processes and test them in the South Korean culture. Study 1 uses the neuroscientific method of event-related potentials to explore the dissociable neural mechanisms that underlie Korean liberals’ and conservatives’ moral reasoning (...) processes in business ethical transgressions. Liberals’ early frontal negative-going brain waves showed that they are quick to pass negative judgment by intuitively detecting violations of fairness, while conservatives’ temporoparietal positive-going brain waves showed that they have a higher motivation to respect authority. Both liberals’ and conservatives’ ERP components occur within the first second of the decision-making phase, suggesting the rapid and intuitive nature of moral reasoning processes. Study 2 tests a mediating process and confirms that Korean liberals exhibit the moral engagement strategy, through the fairness foundation. These findings from our interdisciplinary research deepen the knowledge of the complexity of human morality in business ethics research. (shrink)

Modern schooling in Korea, which was officially established by law in 1949, is well known for its function as an engine of economic success in modern Korea. Although this fact seems to be world-wid...

Background Ethical dilemmas that arise in the clinical setting often require the collaboration of multiple disciplines to be resolved. However, medical and nursing curricula do not prioritize communication among disciplines regarding this issue. A common teaching strategy, problem-based learning, could be used to enhance communication among disciplines. Therefore, a university in southern Taiwan developed an interprofessional ethics education program based on problem-based learning strategies. This study described tutors’ experience teaching in this program. Aim To explore the phenomenon of teaching and (...) learning in interprofessional ethics education for medical and nursing students from the perspectives of tutors. Design Phenomenological qualitative research. Methods Medical and nursing students completed a 6-week interprofessional ethics education program moderated by either physician or nurse tutors. At the conclusion of the ethics education program, all 14 tutors were invited to participate in focus group interviews. Among them, six tutors (three nursing tutors and three physician tutors) participated in additional individual interviews. All of the contents from the focus group interviews and individual interviews were recorded and transcribed. Using the phenomenological approach, the phenomenon of teaching and learning in interprofessional ethics education were generated. Ethical consideration The study was approved by the Institutional Review Board. Findings Three themes emerged from the tutors' teaching perspectives, including the instructor’s motivation to teach, the use of narrative case scenarios, and the emphasis on improving interprofessional ethics communication. Discussion Problem-based learning creates an interprofessional communication platform in interprofessional ethics education. The phenomenon of value convergence between tutors and students, between different students’ professions, and between different students’ professional maturities is observed. Conclusion Problem-based learning is an effective teaching strategy for creating a communication platform for interprofessional ethics education. Ethic curriculum should emphasize motivating instructor, use narrative case scenarios, and focus on interprofessional communication. (shrink)

本书内容包括:绪论:思想史的写法及其使命、法律应该是什么、法律的合法性、社会契约理论基本问题、法官与法律的关系等。.

ABSTRACT:Drawing upon John Rawls's framework inThe Law of Peoples,this paper argues that MNEs have a responsibility to promote well-ordered social and political institutions in host countries that lack them. This responsibility is grounded in a negative duty not to cause harm. In addition to addressing the objection that promoting well-ordered institutions represents unjustified interference by MNEs, the paper provides guidance for managers of MNEs operating in host countries that lack just institutions. The paper argues for understanding corporate responsibility in relation (...) to the specific institutional environment in which MNEs operate. (shrink)

Abstract:Building on John Rawls’s account of the Law of Peoples, this paper examines the grounds and scope of the obligations of transnational corporations (TNCs) that are owned by members of developed economies and operate in developing economies. The paper advances two broad claims. First, the paper argues that there are conditions under which TNCs have obligations to fulfill a limited duty of assistance toward those living in developing economies, even though the duty is normally understood to fall on the governments (...) of developed economies. Second, by extending Rawls’s account to include a right to protection against arbitrary interference, the paper argues that TNCs can be said to have negative and positive obligations in the areas of human rights, labor standards, and environmental protection, as outlined in the U.N. Global Compact. More generally, the paper aims to further our understanding of the implications of Rawls’s account of justice. (shrink)

Abstract:Building on John Rawls’s account of the Law of Peoples, this paper examines the grounds and scope of the obligations of transnational corporations (TNCs) that are owned by members of developed economies and operate in developing economies. The paper advances two broad claims. First, the paper argues that there are conditions under which TNCs have obligations to fulfill a limited duty of assistance toward those living in developing economies, even though the duty is normally understood to fall on the governments (...) of developed economies. Second, by extending Rawls’s account to include a right to protection against arbitrary interference, the paper argues that TNCs can be said to have negative and positive obligations in the areas of human rights, labor standards, and environmental protection, as outlined in the U.N. Global Compact. More generally, the paper aims to further our understanding of the implications of Rawls’s account of justice. (shrink)

Om Martin Heidegger, Karl Jaspers, Arnold Gehlen, Helmuth Plessner, Ernst Bloch, Theodor W. Adorno, Alexander Mitscherlich, Karl Löwith, Ludwig Wittgenstein, Hannah Arendt, Wolfgang Abendroth, Herbert Marcuse, Walter Benjamin, Gershom Scholem, Hans Georg Gadamer, Alfred Schütz, Max Horkheimer og Leo Löwenthal.

Der kommunikativen Alltagspraxis müssen kognitive Deutungen, moralische Erwartungen, Expressionen und Wertungen einander durchdringen. Die Verständigungsprozesse der Lebenswelt bedürfen deshalb einer kulturellen Überlieferung auf ganzer Breite, nicht nur der Segnungen von Wissenschaft und Technik. So könnte die Philosophie ihren Bezug zur Totalität in einer der Lebenswelt zugewandten Interpretenrolle aktualisieren. Sie könnte mindestens dabei helfen, das stillgestellte Zusammenspiel des Kognitiv-Instrumentellen mit dem Moralisch-Praktischen und dem Ästhetisch-Expressiven wie ein Mobile, das sich hartnäckig verhakt hat, wieder in Bewegung zu setzen.

本书详细论述智慧与思维的关系,同时对智慧的理解、智慧的类型,思维与思维科学,思维方式及基本类型,以及思维活动及其基本形式均有详细阐述。.

인간의 이성적 의식과 법의 관계를 밝히고 법의 해석 과 판단에 인간의 의식이 어떻게 작용하는가를 고찰 한 저술. 제1부에서는 법의 형이상학적인 측면에서 법의 실체, 그리스의 법, 데카르트의 법, 로크와 법, 칸트와 법, 헤겔과 법, 아담스미스의 법의 경제, 중국의 도덕과 법사상을 다루었다. 제2부에서는 심리학적 분석으로 헌법의 심리학적 해석, 법의 판결절차, 증거법, 형법과 죄, 청소년과 가족법, 조세법, 플라톤의 법, 칸트의 도덕론의 경험적 확인, 헤겔의 자아와 노동법, 법의 4차원에 대해 다뤘다.

Essays by Jurgen Habermas on religion and religious belief.

Das Zeitbewusstsein der Moderne und ihr Bedürfnis nach Selbstvergewisserung -- Hegels Begriff der Moderne -- Drei Perspektiven, Linkshegelianer, Rechtshegelianer und Nietzsche -- Eintritt in die Postmoderne -- Die Verschlingung von Mythos und Aufklärung -- Die metaphysikkritische Unterwanderung des okzidentalen Rationalismus -- Überbietung der temporalisierten Ursprungsphilosophie -- Zwischen Erotismus und allgemeiner Ökonomie -- Vernunftkritische Entlarvung der Humanwissenschaften -- Aporien einer Machttheorie -- Ein anderer Ausweg aus der Subjektphilosophie -- Der normative Gehalt der Moderne.

Over the last half decade or so, Jürgen Habermas has increasingly employed the interview format, both as a means of presenting his changing views on philosophical topics in an accessible way, and as a means of debating current social and political issues. This new, expanded edition of Autonomy and Solidarity includes an additional five interviews in which Habermas discusses such themes as the history and significance of the Frankfurt School, the social and political development of post-war Germany, the moral status (...) of civil disobedience, the implications of the "Historians' Dispute," and the function of national identity in the modern world. Never before published autobiographical material covering Habermas' early years at the Frankfurt Institute for Social Research is followed by an extended philosophical interrogation of his latest thinking on the relations between ethics, morality and law. With an extended introduction by Peter Dews, exploring the status and prospects of Critical Theory in the light of the recent revolutionary transformations in Europe, Autonomy and Solidarity should be of interest and value both to newcomers and those already familiar with Habermas' thought. (shrink)

Xunzi’s pessimistic understanding of human nature and his endorsement of the intrinsically valuable virtue of yi (義) put him in a vulnerable position. To defend this position, Xunzi needs to conquer what the essay calls “the compatibility problems,” the first of which concerns the compatibility between bad human nature and virtue, while the second is between Xunzi’s functional understanding of virtue and his understanding of virtue as possessing intrinsic value. If Xunzi’s moral philosophy were to fail to solve these two (...) problems, it would be guilty of inconsistency. In reconstructing a genealogy of Xunzi’s philosophy, I argue that he can successfully resolve the two compatibility problems, and his genealogy perspicuously shows that virtue can grow out of vicious human nature. (shrink)

Recent developments in biotechnology and genetic research are raising complex ethical questions concerning the legitimate scope and limits of genetic intervention. As we begin to contemplate the possibility of intervening in the human genome to prevent diseases, we cannot help but feel that the human species might soon be able to take its biological evolution in its own hands. 'Playing God' is the metaphor commonly used for this self-transformation of the species, which, it seems, might soon be within our grasp. (...) In this important new book, Jurgen Habermas - the most influential philosopher and social thinker in Germany today - takes up the question of genetic engineering and its ethical implications and subjects it to careful philosophical scrutiny. His analysis is guided by the view that genetic manipulation is bound up with the identity and self-understanding of the species. We cannot rule out the possibility that knowledge of one's own hereditary factors may prove to be restrictive for the choice of an individual's way of life and may undermine the symmetrical relations between free and equal human beings. In the concluding chapter - which was delivered as a lecture on receiving the Peace Prize of the German Book Trade for 2001 - Habermas broadens the discussion to examine the tension between science and religion in the modern world, a tension which exploded, with such tragic violence, on September 11th. (shrink)

Part 1. Eschatology and ethics. Introduction -- Apocalyptic eschatology -- Christological eschatology -- Separatist eschatology -- Transformative eschatology -- Part 2. An ethics of life. A culture of life -- Medical ethics -- Part 3. Earth ethics. In the space of the earth, what is the earth? -- The time of the earth -- Ecology -- Earth ethics -- Part 4. Ethics of just peace. Criteria for forming a judgment -- Divine and human righteousness and justice -- Dragon slaying and (...) peacemaking in Christianity -- Control is good, trust is better : liberty and security in the "free world" -- The righteousness of God and human and civil rights -- Part 5. Joy in God : aesthetic counterpoints. Sabbath : the feast of creation -- The jubilation of Christ's resurrection -- "And peace in the midst of strife.". (shrink)

全书分五个部分, 分别从经济秩序的伦理理论、经济学的秩序理论、经济秩序的法律问题、文化性质和关于秩序政策的第三条道路的可能性等观点, 研讨了经济秩序问题.

"Besonders der Anfang der,Phiinomenologie des Geistes', niimlich die Dialektik der sinnlichen Gew~heit, setzt dem Verstiindnis oft einen scheinbar uniiberwindlichen Widerstand entgegen.,,1 Ein Buch, das, wie das vorliegende, in die Idealistische Dia­ lektik (Hegels) vorrangig am Beispiel der beriihmten "Pha­ nomenologie des Geistes" (im folgenden: PhdG) einftihren will, am Beispiel also eines der schwierigsten Texte der philosophischen Literatur iiberhaupt: mu~ das auch ein besonders schwieriges Buch sein? Es ware unverantwortlich, in diesem Vorwort den Eindruck nahezulegen, da~ es - trotzdem - durchweg (...) "ganz leicht" zugehen wird, z. B. aufgrund der Darstellung. Unverant­ wortlich nicht nur, weil dem Text der PhdG yom besonders schwierigen Anfang her gefolgt wird - iiber eine weite Strecke. "Kein Problem!" sagt die Sprache des Alltagsja dort, wo es wahrhaftig urn keine philosophischen Probleme geht, urn keine philosophischen Problemstellungen. J edenfalls urn noch keine, bzw. urn so1che, die noch nicht als philosophi­ sches Problem bewu~t sind. Philo sophie - Dialektik zumal - ist kein bequemer Weg zum Ziel; keine bequeme Methode etwa (griech.: methodos heillt ja: der Weg)... Vermittlung", ein zentrales Motiv der Dialektik, ist kein "goldener Mittelweg" (Vermittlung, einmal populiir gespro­ chen: als "Synthese" von "These" und "Antithese"). Banalisierung darf nicht der Preis sein; Vereinfachung darf nicht Simplifizierung, Abkiirzung nicht Verklirzung be­ deuten. 1 W. Wieland: Hegels Dialektik der sinnl. GewUlheit, a.a.O., S. 69. (shrink)