Bromodomain‐containing 4 (BRD4), a member of Bromo and Extra‐Terminal (BET) family, recognizes acetylated histones and is of importance in transcription, replication, and DNA repair. It also binds non‐histone proteins, DNA and RNA, contributing to development, tissue growth, and various physiological processes. Additionally, BRD4 has been implicated in driving diverse diseases, ranging from cancer, viral infection, inflammation to neurological disorders. Inhibiting its functions with BET inhibitors (BETis) suppresses the progression of several types of cancer, creating an impetus for translating these chemicals (...) to the clinic. The diverse roles of BRD4 are largely dependent on its interaction partners in different contexts. In this review we discuss the molecular mechanisms of BRD4 with its interacting partners in physiology and pathology. Current development of BETis is also summarized. Further understanding the functions of BRD4 and its partners will facilitate resolving the liabilities of present BETis and accelerate their clinical translation. (shrink)

Gender roles are anti-dichotomous and malleable social constructs that should theoretically be constructed independently from biological sex. However, it is unclear whether and how the factor of sex is related to neural mechanisms involved in social constructions of gender roles. Thus, the present study aimed to investigate sex specificity in gender role constructions and the corresponding underlying neural mechanisms. We measured gender role orientation using the Bem Sex-Role Inventory, used a voxel-based global brain connectivity method based on resting-state functional magnetic (...) resonance imaging to characterize the within-network connectivity in the brain reward network, and analyzed how the integration of the reward network is related to gender role scores between sex groups. An omnibus analysis of voxel-wise global brain connectivity values within a two-level linear mixed model revealed that in female participants, femininity scores were positively associated with integration in the posterior orbitofrontal cortex and subcallosal cortex, whereas masculinity scores were positively associated with integration in the frontal pole. By contrast, in male participants, masculinity was negatively correlated with integration in the nucleus accumbens and subcallosal cortex. For the first time, the present study revealed the sex-specific neural mechanisms underlying distinct gender roles, which elucidates the process of gender construction from the perspective of the interaction between reward sensitivity and social reinforcement. (shrink)

Perception of time plays a fundamental role in human social activities, and it can be influenced in social situations by various factors, including facial attractiveness. However, in the eyes of observers of different genders, the attractiveness of a face varies. The current study aimed to explore whether gender modulates the effect of facial attractiveness on perception of time. To account for individual differences in aesthetic standards, the critical stimuli presented to each participant were selected from an image pool based on (...) the participant’s own attractiveness judgments. Using a temporal reproduction task, we measured the perception of time by men and women during viewing of faces of different attractiveness and gender. The results show that attractive opposite-sex faces elicited longer reproduced durations in men than unattractive opposite-sex faces, while facial attractiveness did not affect men’s reproduced durations in the case of same-sex faces. Conversely, women exhibited longer reproduced durations for attractive faces than for unattractive faces, regardless of facial gender. These results suggest that gender difference plays an important role in the effect of facial attractiveness on time perception. (shrink)

The COVID-19 pandemic has created an urgent need for volunteers to complement overwhelmed public health systems. This study aims to explore Chinese people’s attitudes toward volunteerism amid the COVID-19 pandemic. To this end, we identify the latent topics in volunteerism-related microblogs on Weibo, the Chinese equivalent of Twitter using the topic modeling analysis via Latent Dirichlet Allocation. To further investigate the public sentiment toward the topics generated by LDA, we also conducted sentiment analysis on the sample posts using the open-source (...) natural language processing technique from Baidu. Through an in-depth analysis of 91,933 Weibo posts, this study captures 10 topics that are, in turn, distributed into five factors associated with volunteerism in China as motive fulfillment, fear of COVID-19, individual characteristic, government support, and community effect. The results show that motive fulfillment, government support, and community effect are the factors that could enhance positive attitudes toward volunteerism since the topics related to these factors report high proportions of positive emotion. Fear of COVID-19 and individual characteristic are the factors inducing negative sentiment toward volunteerism as the topics related to these factors show relatively high proportions of negative emotion. The provision of tailored strategies based on the factors could potentially enhance Chinese people’s willingness to participate in volunteer activities during the COVID-19 pandemic. (shrink)

Understanding the neural basis of schizophrenia (SZ) is important for shedding light on the neurobiological mechanisms underlying this mental disorder. Structural and functional alterations in the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, and medial prefrontal cortex (MPFC) have been implicated in the neurobiology of SZ. However, the effective connectivity among them in SZ remains unclear. The current study investigated how neuronal pathways involving these regions were affected in first-episode SZ using functional magnetic resonance imaging (fMRI). Forty-nine patients (...) with a first-episode of psychosis and diagnosis of SZ—according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision—were studied. Fifty healthy controls (HCs) were included for comparison. All subjects underwent resting state fMRI. We used spectral dynamic causal modeling (DCM) to estimate directed connections among the bilateral ACC, DLPFC, hippocampus, and MPFC. We characterized the differences using Bayesian parameter averaging (BPA) in addition to classical inference (t-test). In addition to common effective connectivity in these two groups, HCs displayed widespread significant connections predominantly involved in ACC not detected in SZ patients, but SZ showed few connections. Based on BPA results, SZ patients exhibited anterior cingulate cortico-prefrontal-hippocampal hyperconnectivity, as well as ACC-related and hippocampal-dorsolateral prefrontal-medial prefrontal hypoconnectivity. In summary, spectral DCM revealed the pattern of effective connectivity involving ACC in patients with first-episode SZ. This study provides a potential link between SZ and dysfunction of ACC, creating an ideal situation to associate mechanisms behind SZ with aberrant connectivity among these cognition and emotion-related regions. (shrink)

Western scholars read "dialectical materialism" in Chinese Marxism within a Western philosophical frame. Some hold that Chinese Marxism is Chinese in some important sense, but fail to see what is involved; others see nothing particularly Chinese about Chinese Marxism. Similarly, Chinese Marxists identify bianzhengfa with Marxian dialectic, without adequately realizing the difficulties attending that concept. ;The dissertation shows tongbian as a distinct but not necessarily unique style of Chinese "thought" , which was formulated in ancient philosophical literature such as the (...) Yijing. I argue that Chinese intellectuals understand Marxist thought in terms of tongbian. What tong-bian sees is a "world as such," or ziran ; with no transcendence, every element is relative to every other and all elements are thus "correlative." Each particular is both self-determinate and determined by every other. An explanation of relationships requires a contexualist interpretation of the world in which events are strictly interdependent. "Polarity" implies a relationship of two events, each constituting a necessary condition for the other. Yin always suggests becoming-yang, and vice versa. Any two events constantly alternate each another, change into each other, exchange with each other, displace each other, and so on. The salient feature of tongbian philosophy is that the complementary and contradictory interactions of the two basic elements of a polarity like yin-yang constitute the forces, and produce change. ;Chinese Marxism finds its roots in Engels but reads him in a distinctly different way and, by drawing on tongbian, develops into a strong and useful strand of thought. I examine this in the writings of Cai Yuanpei, Qu Qiubai, Ai Siqi, and Mao Zedong. I show that juxtaposing dialectics with bianzhenga is a misunderstanding. The version of Chinese Marxism that I recover seems close to Marx on certain points, especially In terms of "internal relations." However, it is rather a third way as developed from a culture and tradition that can not be understood in Western terms. (shrink)

Ben shu jie shao le gong zi zhen, wei yuan, yan fu, kang you wei, tan si tong, liang qi chao, chen tian hua, zhang bing lin deng wan qing si xiang jia de zhe xue si xiang.

Huangdi Yin fu jing -- Tai bai yin jing -- Su shu --Tian shu -- Tong xun zhen jing.

Ben shu gong fen san bu: di yi bu hui gui zhen wo, di er bu hui gui tian di, di san bu hui gui tai ji. Nei rong bao kuo: lun sheng ming; sheng ming yu shi ge; sheng ming yu yin yue; xian dai ren sheng ming de yan bian; wo shi shui, tian di yu wo deng.

The notions of Di (Emperor), Shangdi (God in heaven), and Tian (Heaven) were endowed with a variety of meanings and were used to refer to different objects of worship in ancient Chinese religion. In different eras, Di referred to the earthly emperor as well as to the heavenly emperor; Tian referred to the physical sky as well as to a supreme personal god in different contexts. Hegel oversimplified these three notions when he characterized ancient Chinese religion as a (...) kind of natural religion. This article aims to clarify Hegel’s misunderstanding of ancient Chinese religion by clarifying the meanings and references of these three notions as they appeared in the Yin-Shang and the Zhou Dynasties. (shrink)

di 1 juan. Zheng lun pian -- di 2 juan. Zhe xue pian -- di 3juan. Wen hua pian -- di 4 juan. Shu xin yu sui bi pian.

In Toward a Good Society, the authors theorize a mutually empowering and growth-fostering society. They begin this journey in relational psychology, then depart along nine paths reconstructed from nine classic social science theories. This leads them to propose a new Golden Rule as simple as it is profound.

From reviews of the hardback edition: a deep study of 20th century field ... of the conceptual origins and development of twentieth century field theories, ...

本书包含了英美基本逻辑教程中应该包含的全部题材,用对话的形式对逻辑的应用、纯逻辑的训练等方面的问题进行了讲解。.

内容包括:中国神秘文化总论、阴阳五行类、天人感应类、气功类、中医类、易理类、象数类、推命术类、相术类、杂占类、占星术类、堪舆类、巫术类、图腾类、道教类、佛教类、诸神类、鬼魅类及怪异类等。.

Media guidelines on safe suicide-related reporting are within the suicide prevention armamentarium. However, implementation issues beleaguer real-world practice. This study evaluated the perspectives of the Malaysian media community, persons with lived experience of suicidal behavior, and mental health professionals on suicide-related reporting in terms of the impact, strategies, challenges, and the implementation of guidelines on safe reporting. Three focus group discussions of purposively sampled Malaysian media practitioners, PLE, and MHP were audio-recorded, transcribed, coded and thematically analyzed. Inclusion criteria were: English (...) fluency, no clinical depression or suicidal ideation, no recent previous suicide attempts or suicide bereavement. Three major themes emerged: Unsafe Reporting; Impact; and Safe Reporting. Most described current reporting as unsafe by being potentially triggering to media users and may contribute to contagion effect. Positive impacts identified included raised awareness toward suicide and its prevention. Unsafe reporting was attributed to inadequate awareness, knowledge, and guidance, lack of empathy and accountability, job-related factors, popularity-seeking, lack of monitoring and governance, and information source with unsafe content. Majority agreed on how suicide stories should be framed to produce a safe report. The media community diverged on how detailed a suicide story should be. Safe reporting challenges included difficulties in balancing beneficial versus harmful details, social media ubiquity and its citizen reporters. Participants suggested these safe reporting strategies: stakeholder engagement, educational approaches, improving governance and surveillance, and guidelines revision. Most acknowledged the relevance of guidelines but were unaware of the existence of local guidelines. Implementation challenges included the dilemma in balancing media industry needs vis-à-vis safe reporting requirements, stakeholder engagement difficulties and social media regulation. There is poor awareness regarding safe suicide-related reporting across all groups. PLE and MHP were negatively impacted by current unsafe messaging which aggravated trauma and grief reactions. Postvention support gaps for mental health professionals were highlighted. Safe reporting promotion strategies should include stakeholder engagement to increase awareness on minimizing Werther and maximizing Papageno effects. Strategic re-examination and dissemination of local media guidelines to address new media issues, and effective surveillance mechanisms, are crucial in sustainable improvement of safe reporting practices. (shrink)

本书是一本汇集古今中外法律名著经典论述并加以简单评点的书,传播先进的法治思想和理念,树立先进的、文明的执法理念。.

本书内容包括:晚年马克思历史观变的朝代背景;晚年马克思历史观变革的理论准备;晚年马克思历史观变革的深层意蕴等。.

The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct.

殷海光―― 臺灣自由主義的奠基者與啟迪者 他用他的筆，對抗一整個時代的黑暗； 更用他的生命，為知識分子留下最鮮明的形象。 臺大版《殷海光全集》蒐羅殷海光先生所有中英文著作、文章、譯作、書序、隨筆、書信，是殷先生所撰文字最完整的紀錄。殷海光畢生筆耕不輟，或以筆言志，或藉紙抒懷，他的眾多文字遺產，既是自身思想言行的展現，也是 後人理解探討他的生命思想的最主要依據。 正因為殷海光先生的撰述繁多，清查檢索，好似永無止境的學術工程。機緣巧合，編者從各種管道陸續發現殷海光的著述，尚未匯編，故特編印《殷海光全集‧補遺》，以彌補前此的闕失，履踐讓臺大版《殷海光全集》總匯殷海 光之一切著述的期望。我們更誠懇希望，學界方家繼續提供助力，讓臺大版《殷海光全集》愈趨理想之境。 本書分為三部分： 第一部分「補遺」。收錄新始發現之殷海光先生著作，包括十五篇中文著作、兩篇英文著作及三封殷海光致夏君璐之書信；整理編輯之原則，率皆依循前例。 第二部分「殷海光先生著述目錄」。依初次發表年排序，編錄殷海光先生生平著作。發表時間相同者，依文章篇名筆畫順序排列；僅知發表年代、未知月日者，置於該年最末；僅知發表年月、未知日者，置於該年該月最末；撰作 時間不詳者，置於本篇最末。 第三部分「《殷海光全集》簡目」。依序展列臺大版《殷海光全集》各卷目錄，以便查詢對照。.

This paper proposes an extended version of the interventionist account for causal inference in the practical context of biological mechanism research. This paper studies the details of biological mechanism researchers’ practices of assessing the evidential legitimacy of experimental data, arguing why quantity and variety are two important criteria for this assessment. Because of the nature of biological mechanism research, the epistemic values of these two criteria result from the independence both between the causation of data generation and the causation in (...) question and between different interventions, not techniques. The former independence ensures that the interventions in the causation in question are not affected by the causation that is responsible for data generation. The latter independence ensures the reliability of the final mechanisms not only in the empirical but also the formal aspects. This paper first explores how the researchers use quantity to check the effectiveness of interventions, where they at the same time determine the validity of the difference-making revealed by the results of interventions. Then, this paper draws a distinction between experimental interventions and experimental techniques, so that the reliability of mechanisms, as supported by the variety of evidence, can be safely ensured in the probabilistic sense. The latter process is where the researchers establish evidence of the mechanisms connecting the events of interest. By using case studies, this paper proposes to use ‘intervention’ as the fruitful connecting point of literature between evidence and mechanisms. (shrink)

In 1908, the first and second chapters of Kropotkin’s Mutual Aid were first translated into Chinese by Li Shizeng, greatly influencing Chinese anarchists. Li Shizeng followed Kropotkin’s scientific argument of anarchism and strengthened the viewpoint for praising “public” and suppressing “private”. When translating Kropotkin’s thoughts, Li Shizeng focused on political revolution, glossing over the criticism of the capitalist economy, and barely referenced Kropotkin’s original anarchist communist ideology.

本书是对由“教”而“学”的单向度教学,向教师引导与学生自主间的双向度转变进行的探索,论述了这种教育理想的生成、当代教育理想的建构等。.

Distinct from nominal metaphors, predicate metaphors entail metaphorical abstraction from concrete verbs, which generally involve more action and stronger motor simulation than nouns. It remains unclear whether and how the concrete, embodied aspects of verbs are connected with abstract, disembodied thinking in the brains of L2 learners. Since English predicate metaphors are unfamiliar to Chinese L2 learners, the study of embodiment effect on English predicate metaphor processing may provide new evidence for embodied cognition and categorization models that remain controversial, and (...) offer practical insights into L2 metaphor processing and pedagogy. Hence, we aim to investigate whether the embodiment of verbs, via the activation of sensorimotor information, influences two groups of L2 learners during their comprehension of conventional and novel predicate metaphors. The results show a significant effect of embodiment: a stronger facilitation for novel predicate metaphors in both higher-level and lower-level groups, and a weaker facilitation for conventional predicate metaphors in the lower-level group. The findings demonstrate preliminary evidence for a graded effect of embodiment on predicate metaphors processing, modulated by L2 proficiency and metaphor novelty. The study supports a hybrid view of embodied cognition and reveals that sensorimotor aspects of verbs may be the intermediate entity involved in the indirect categorization. (shrink)

Based on elaboration likelihood model, this paper introduces the central route and peripheral route of online comments and constructs a conceptual model affecting consumers’ clothing impulse buying behavior in live broadcast. A total of 737 questionnaires were collected, and 709 valid questionnaires were used for questionnaire analysis. According to the ELM, there are central route and peripheral route of online comments. The results show that in addition to the commentator credibility, the comment quality, comment comprehensiveness, and comment quantity have a (...) significant positive impact on impulse buying behavior. Fashion involvement plays a moderating role in the relationship between online comments and impulse buying behavior. This paper will provide theoretical support for live broadcast clothing marketing and provide suggestions for the development and design of live broadcast. (shrink)