Both W9 and OP3‐4 were known to bind the receptor activator of NF‐κB ligand (RANKL), inhibiting osteoclastogenesis. Recently, both peptides were shown to stimulate osteoblast differentiation; however, the mechanism underlying the activity of these peptides remains to be clarified. A primary osteoblast culture showed that rapamycin, an mTORC1 inhibitor, which was recently demonstrated to be an important serine/threonine kinase for bone formation, inhibited the peptide‐induced alkaline phosphatase activity. Furthermore, both peptides promoted the phosphorylation of Akt and S6K1, an upstream molecule (...) of mTORC1 and the effector molecule of mTORC1, respectively. In the in vivo calvarial defect model, W9 and OP3‐4 accelerated BMP‐2‐induced bone formation to a similar extent, which was confirmed by histomorphometric analyses using fluorescence images of undecalcified sections. Our data suggest that these RANKL‐binding peptides could stimulate the mTORC1 activity, which might play a role in the acceleration of BMP‐2‐induced bone regeneration by the RANKL‐binding peptides. (shrink)

This essay will introduce the biography and works of Tsumura Kimiko (1902-1975), one of the first female professional Noh actors, who threw herself into the male-dominated world and fought against the biased conventions of traditional Noh theater. Not only has she successfully opened the gates to many other female Noh actors, but more importantly, she has reevaluated the artistic value of Noh through her original Noh plays. Precisely, she highlighted the role of natural environment created by the dance accompanied with (...) simple and familiar poetic phrases on the Noh sage. In addition, she redefined the categories of Woman Play (Kazura Mono) and of Warrior Play (Shura Mono) with the main characters in the modern context. Her biography will help us learn how Noh has come to earn its current status of a traditional art form, and explorations of her plays will broaden the canon of Noh plays. (shrink)

Dieses Buch prüft die allgemeine Forschungsmeinung, dass Kant ein Vertreter des absoluten Lügenverbots sei. Dabei verteidigt der Königsberger Philosoph aber ebenso den Standpunkt, dass die Moralität einer Handlung von der Maxime des Willens abhängt. Wenn Kant nun gleichzeitig behaupten würde, dass bestimmte Handlungen in jedem Fall verboten sind, würde er sich widersprechen. Indem das Buch die begriffliche Unterscheidung von 'Lügen' als pflichtwidrige Falschaussagen und "Unwahrheiten" als nicht pflichtwidrige Falschaussagen trifft, bietet es für dieses Paradox der Kant-Forschung als erste Monografie zum (...) Lügenproblem einen Lösungsansatz. So wird man mit Kant sogar sagen können: 'Manchmal musst du die Unwahrheit sagen.'. (shrink)

The Nyāyamukha by Dignāga, considered the founder of the Buddhist epistemological school, is known to have been studied intensively by East Asian Buddhists and scholars through Xuanzang’s Chinese translation. However, Jinendrabuddhi’s commentary on Dignāga’s Pramāṇasamuccaya offers a clue that helps to better understand the religio-philosophical and historical position of the Nyāyamukha in South and East Asia. The eighth-century commentator describes the Nyāyamukha as a work for highly intelligent persons and contrasts it to Dignāga’s Pramāṇasamuccaya. He also preserves fragments of the (...) Nyāyamukha’s final verse, which served as the basis for a Sanskrit reconstruction of the verse, published in 2005. The present paper first examines the historical implications of Jinendrabuddhi’s interest in the Nyāyamukha and then discusses the hitherto accepted and yet problematic interpretation of its final verse. An analysis of relevant materials will include East Asian Buddhist sources in Chinese to seek evidence related to Jinendrabuddhi’s text. A detailed examination of hermeneutic aspects will lead us to reinterpreting the poison simile, “intellect-poison”, as well as a discussion of how this term was used by Vasubandhu. This will show that it is possible that the Sanskrit reconstruction should be modified slightly. (shrink)

30th Nov. and 1st Dec. 2013 at Kyoto University. Organizer: Takeshi Sakon.

One criterion of constructive logics is the disjunction, property (DP). The Halldén-completeness is a weak DP, and is related to the relevance principle and variable separation. This concept is well-understood in the case of propositional logics. We extend this notion to predicate logics. Then three counterparts naturally arise. We discuss relationships between these properties and meet-irreducibility in the lattice of logics.

To become more broadly applicable, positions on AI ethics require perspectives from non-Western regions and cultures such as China and Japan. In this paper, we propose that the addition of the concept of harmony to the discussion on ethical AI would be highly beneficial due to its centrality in East Asian cultures and its applicability to the challenge of designing AI for social good. We first present a synopsis of different definitions of harmony in multiple contexts, such as music and (...) society, which reveals that the concept is, at its core, about well-balanced relationships and appropriate actions which give rise to order, balance, and aesthetically pleasing phenomena. The mediator for these well-balanced relationships isTaktwhich is an ability to act thoughtfully and sensibly according to the specific situation and to put things into proportion and order. We propose that the central challenge of building harmonizing AI is to make intelligent systems tactful and also to design and use them tactfully. For an AI system to become tactful, it needs to be able to have an advanced sensitivity to the specific contexts which it is in and their social and ethical implications and have the capability of approximately inferring the emotional and cognitive states of people with whom it is interacting. (shrink)

Extending techniques of Dowd and those of Poizat, we study computational complexity of in the case when is a generic oracle, where is a positive integer, and denotes the collection of all -query tautologies with respect to an oracle . We introduce the notion of ceiling-generic oracles, as a generalization of Dowd's notion of -generic oracles to arbitrary finitely testable arithmetical predicates. We study how existence of ceiling-generic oracles affects behavior of a generic oracle, by which we show that is (...) not a subset of is comeager in the Cantor space. Moreover, using ceiling-generic oracles, we present an alternative proof of the fact (Dowd) that the class of all -generic oracles has Lebesgue measure zero. (shrink)

This note is a continuation of our former paper ''Complexity of the r-query tautologies in the presence of a generic oracle.'' We give a very short direct proof of the nonexistence of t-generic oracles, a result obtained first by Dowd. We also reconstitute a proof of Dowd's result that the class of all r-generic oracles in his sense has Lebesgue measure one.

Feinberg and Mallatt, in their presentation of neurobiological naturalism, have suggested that visual consciousness was acquired by early vertebrates and inherited by a wide range of descendants, and that its neural basis has shifted to nonhomologous nervous structures during evolution. However, their evolutionary scenario of visual consciousness relies on the assumption that visual consciousness is closely linked with survival, which is not commonly accepted in current consciousness research. We suggest an alternative idea that visual consciousness is linked to a specific (...) class of agency, consequently justifying their phylogenetic claim. We also examine the implication of their phylogenetic claim: visual consciousness is homologous across vertebrates, but its neural basis is not. This apparent incongruence illustrates a general phenomenon of homology, and that the resulting hierarchical view of visual consciousness and its neural basis can be straightforwardly accommodated by neurobiological naturalism. Throughout these discussions, we aim to address the potential theoretical issues in neurobiological naturalism and refine the picture illustrated by Feinberg and Mallatt regarding phylogenetic distribution and trajectories of visual consciousness. (shrink)

This paper presents a cross-cultural study on peoples’ negative attitude toward robots. 467 participants from seven different countries filled in the negative attitude towards robots scale survey which consists of 14 questions in three clusters: attitude towards the interaction with robots, attitude towards social influence of robots and attitude towards emotions in interaction with robots. Around one half of them were recruited at local universities and the other half was approached through Aibo online communities. The participants’ cultural background had a (...) significant influence on their attitude and the Japanese were not as positive as stereotypically assumed. The US participants had the most positive attitude, while participants from Mexico had the most negative attitude. The participants from the online community were more positive towards robots than those not involved. Previous experience in interacting with Aibo also had a positive effect, but owning an Aibo did not improve their attitude. (shrink)

Targeted gene alteration (TGA) is a strategy for correcting single base mutations in the DNA of human cells that cause inherited disorders. TGA aims to reverse a phenotype by repairing the mutant base within the chromosome itself, avoiding the introduction of exogenous genes. The process of how to accurately repair a genetic mutation is elucidated through the use of single‐stranded DNA oligonucleotides (ODNs) that can enter the cell and migrate to the nucleus. These specifically designed ODNs hybridize to the target (...) sequence and act as a beacon for nucleotide exchange. The key to this reaction is the frequency with which the base is corrected; this will determine whether the approach becomes clinically relevant or not. Over the course of the last five years, workers have been uncovering the role played by the cells in regulating the gene repair process. In this essay, we discuss how the impact of the cell on TGA has evolved through the years and illustrate ways that inherent cellular pathways could be used to enhance TGA activity. We also describe the cost to cell metabolism and survival when certain processes are altered to achieve a higher frequency of repair. (shrink)

Shehtman and Skvortsov introduced Kripke bundles as semantics of non-classical first-order predicate logics. We show the structural equivalence between Kripke bundles for intermediate predicate lógics and Kripke-type frames for intuitionistic modal propositional logics. This equivalence enables us to develop the semantical study of relations between intermediate predicate logics and intuitionistic modal propositional logics. New examples of modal counterparts of intermediate predicate logics are given.

The idea that the thalamo-cortical system is the crucial constituent of the neurobiological mechanisms of consciousness has a long history. For the last few decades, however, consciousness research has to a large extent overlooked the interplay between the cortex and thalamus. Here we revive an integrated view of the neurobiology of consciousness by presenting and discussing several recent major findings about the role of the thalamocortical interactions in consciousness. Based on these findings we propose a specific cellular mechanism how thalamic (...) nuclei modulate the integration of different processing streams within single cortical pyramidal neurons. This theory is inspired by recent work done in rodents, but it integrates decades of work conducted on various species. We illustrate how this new view readily explains various properties and experimental phenomena associated with conscious experience. We discuss the implications of this idea and some of the experiments that need to be done in order to test it. Our view bridges two long-standing perspectives on the neural mechanisms of consciousness and proposes that cortical and thalamo-cortical processing interact at the level of single pyramidal cells. (shrink)

Japan has often been regarded as an ethnically homogeneous society whose restrictive immigration policies reflect the deep-seated cultural peculiarities of this ‘island nation’. By contrast, I shall argue that Japan’s post- 1945 cultural separation from the other countries of East Asia, and its strict border controls, were to a large extent products of Cold War politics. The postwar democratization of Japan went hand in hand with the introduction of tight restrictions on cross-border mobility: restrictions which had profound consequences for the (...) rights of ethnic minorities in Japan (particularly Koreans and Taiwanese). An exploration of the emergence and impact of this border control regime casts new light, not just on Japan’s role in the Northeast Asian region, but also on key limitations of nation-state centred notions of liberal democracy. (shrink)

The vestibulo-ocular reflex plays an important role in controlling the gaze at a visual target. Although patients with vestibular hypofunction aim to improve their VOR function, some retain dysfunction for a long time. Previous studies have explored the effects of direct current stimulation on vestibular function; however, the effects of random noise stimulation on eye–head coordination have not previously been tested. Therefore, we aimed to clarify the effects of high frequency noisy vestibular stimulation on eye–head coordination related to VOR function. (...) Thirteen healthy young adult participants with no serious disease took part in our study. The current amplitude and density used were 0.4 mA and 0.2 mA/cm2, respectively, with a random noise frequency of 100–640 Hz. The electrodes were located on both mastoid processes. The stimulus duration and fade in/out duration were 600 and 10 s, respectively. Subjects oscillated their head horizontally, gazing at the fixation point, at 1 Hz for 30 repetitions. The coordination of eye–head movements was measured by eye-tracking and a motion capture system. Peak-to-peak angles for eye and head movement and deviation of the visual line from the fixation target revealed no significant differences between HF-nVS and sham. The lag time between the eye and head movement with HF-nVS post-stimulation was significantly shorter than that of the sham. We found that HF-nVS can reduce the lag time between eye and head movement and improve coordination, contributing to a clear retinal image. This technique could be applied as a form of VOR training for patients with vestibular hypofunction. (shrink)

This book explores the construction of gender ideology in early modern England through an analysis of the querelle des femmes - the debate about the relationship between the sexes that originated on the continent during the middle ages and the Renaissance and developed in England into the Swetnam controversy, which revolved around the publication of Joseph Swetnam's The arraignment of lewd, forward, and inconstant women and the pamphlets which responded to its misogynist attacks. The volume contextualizes the debate in terms (...) of its continental antecedents and elite manuscript circulation in England, then moves to consider popular culture and printed texts from the Jacobean debate and its effects on women's writing and the developing discourse on gender, and concludes with an examination of the ramifications of the debate during the Civil War and Restoration. Essays focus attention on the implications of the gender debate for women writers and their literary relations, cultural ideology and the family, and political discourse and ideas of nationhood. (shrink)

The Bird Song Diamond project is a series of multifaceted and multidisciplinary installations with the aim of bringing contemporary research on bird communication to a large public audience. Using art and technology to create immersive experiences, BSD allows large audiences to embody bird communication rather than passively observe. In particular, BSD Mimic, a system for mimicking bird song, asks participants to grapple with both audition and vocalization of birdsong. The use of interactive installations for public outreach provides unique experiences to (...) a diverse audience, while providing direct feedback for artists and researchers interested in the success of such outreach. By following an iterative design process, both artists and researchers have been able to evaluate the effectiveness of each installation for promoting audience engagement with the subject matter. The execution and evaluation of each iteration of BSD is described throughout the paper. In addition, the process of interdisciplinary collaboration in our project has led to a more defined role of the artist as a facilitator of specialists. BSD Mimic has also led to further questions about the nature of audience collaboration for an engaged experience. (shrink)

Web-based learning resources provide learners with hyperspace where they can navigate in a self-directed way to learn the contents included in the Web pages. The navigation involves making a sequence of the pages visited, which is called navigation path. However, learners often fail in making the navigation path due to a cognitive overload, which is caused by diverse cognitive efforts at comprehending the contents in Web pages, and monitoring the navigation process such as planning and reflection of navigation path. In (...) the self-directed learning, in particular, it is difficult for learners to maintain the navigation monitoring. Focusing on navigation planning, this paper addresses the issue of how to facilitate learners' navigation monitoring to promote their learning in hyperspace provided by Web-based learning resources. Our approach to this issue is to provide learners with a space, in which they can see through the learning resources to plan a navigation path, apart from hyperspace. In this paper, we also demonstrate an assistant system for the navigation planning, which is composed of hyperspace map, page previewer, and path previewer. These facilities give learners an overview of Web pages and navigation path to help them make a navigation path plan without visiting Web pages in hyperspace. This paper also describes a case study with the assistant system. The results indicate that the system facilitates navigation particularly in a more complicated hyperspace. (shrink)

Negative attitudes toward robots are considered as one of the psychological factors preventing humans from interacting with robots in the daily life. To verify their influence on humans‘ behaviors toward robots, we designed and executed experiments where subjects interacted with Robovie, which is being developed as a platform for research on the possibility of communication robots. This paper reports and discusses the results of these experiments on correlation between subjects’ negative attitudes and their behaviors toward robots. Moreover, it discusses influences (...) of gender and experience of real robots on their negative attitudes and behaviors toward robots. (shrink)

In [STU 00, KUT 03] we introduced a family of ‘modal' languages intended for talking about distances. These languages are interpreted in ‘distance spaces' which satisfy some of the standard axioms of metric spaces. Among other things, we singled out decidable logics of distance spaces and proved expressive completeness results relating classical and modal languages. The aim of this paper is to axiomatize the modal fragments of the semantically defined distance logics of [KUT 03] and give a new proof of (...) their decidability. (shrink)

To investigate whether people with social anxiety have less actual and “anticipatory” anxiety when interacting with a robot compared to interacting with a person, we conducted a 2 × 2 psychological experiment with two factors: social anxiety and interaction partner. The experiment was conducted in a counseling setting where a participant played the role of a client and the robot or the confederate played the role of a counselor. First, we measured the participants’ social anxiety using the Social Avoidance and (...) Distress Scale, after which, we measured their anxiety at two specific moments: “anticipatory anxiety” was measured after they knew that they would be interacting with a robot or a human confederate, and actual anxiety was measured after they actually interacted with the robot or confederate. Measurements were performed using the Profile of Mood States and the State–Trait Anxiety Inventory. The results indicated that participants with higher social anxiety tended to feel less “anticipatory anxiety” and tension when they knew that they would be interacting with robots compared with humans. Moreover, we found that interaction with a robot elicited less tension compared with interaction with a person regardless of the level of social anxiety. (shrink)