Magnetic resonance imaging (MRI) is an imaging technique with a rapidly expanding application range. This methodology, which relies on quantum physics and substance magnetic properties, is now being routinely used in the clinics and medical research. With the advent of measuring functional brain activity with MRI (functional MRI), this methodology has reached a larger section of the neuroscience community (e.g. psychologists, neurobiologists). In the past, the use of MRI as a biomarker or as an assay to probe tissue pathophysiological condition (...) was limited. However, with the new applications of MRI: molecular imaging, contrast‐enhanced imaging and diffusion imaging, MRI is turning into a powerful tool for in vivo characterization of tissue pathophysiology. This review focuses on the diffusion MRI. Although it only measures the averaged Brownian translational motion of water molecules, using different analysis schemes, one can extract a wide range of quantitative indices that represent tissue morphology and compartmentalization. Statistical and visualization routines help to relate these indices to biologically relevant measures such as cell density, water content and size distribution. The aim of this review is to shed light on the potential of this methodology to be used in biological research. To that end, this review is intended for the non‐MRI specialists who wish to pursue biological research with this methodology. We will overview the current applications of diffusion MRI and its relation to cellular biology of brain tissue. BioEssays 30:1235–1245, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The history of productivity of the κ-chain condition in partial orders, topological spaces, or Boolean algebras is surveyed, and its connection to the set-theoretic notion of a weakly compact cardinal is highlighted. Then, it is proved that for every regular cardinal κ > א1, the principle □ is equivalent to the existence of a certain strong coloring c : [κ]2 → κ for which the family of fibers T is a nonspecial κ-Aronszajn tree. The theorem follows from an analysis of (...) a new characteristic function for walks on ordinals, and implies in particular that if the κ-chain condition is productive for a given regular cardinal κ > א1, then κ is weakly compact in some inner model of ZFC. This provides a partial converse to the fact that if κ is a weakly compact cardinal, then the κ-chain condition is productive. (shrink)

Shaul Magid's Meir Kahane: The Public Life and Political Thought of an American Jewish Radical (2021) stresses the American character of Kahane's thought. This review analyzes this claim in two ways. First, it offers a transnational perspective on Kahane's philosophy. Second, it examines Magid's concept of neo‐Kahanism in light of Kahane's legacy in Israel.

Perception can’t have disjunctive content. Whereas you can think that a box is blue or red, you can’t see a box as being blue or red. Based on this fact, I develop a new problem for the ambitious predictive processing theory, on which the brain is a machine for minimizing prediction error, which approximately implements Bayesian inference. I describe a simple case of updating a disjunctive belief given perceptual experience of one of the disjuncts, in which Bayesian inference and predictive (...) coding pull in opposite directions, with the former implying that one’s confidence in the belief should increase, and the latter implying that it should decrease. Thus, predictive coding fails to approximately implement Bayesian inference across the interface between belief and perception. (shrink)

According to the thesis of transparency, subjects can attend only to the representational content of perceptual experience, never to the intrinsic properties of experience that carry this representational content, i.e., to “mental paint.” So far, arguments for and against transparency were conducted from the armchair, relying mainly on introspective observations. In this paper, we argue in favor of transparency, relying on the cognitive neuroscience of attention. We present a trilemma to those who hold that attention can be directed to mental (...) paint. Such attention is either first-order sensory, higher-order cognitive, or higher-order sensory attention. We argue that the notion of first-order sensory attention to mental paint is incompatible with the neuroscience of sensory attention; that higher-order cognitive attention to mental paint is irrelevant to transparency; and that the notion of higher-order sensory attention to mental paint has an apparently incoherent prediction. Via elimination, these considerations support the thesis of transparency. (shrink)

This book offers a systematic account of Wittgenstein's unique ethical thought, both in his early and in his later writings.

According to an influential philosophical view I call “the relational properties view”, “perspectival” properties, such as the elliptical appearance of a tilted coin, are relational properties of external objects. Philosophers have assessed this view on the basis of phenomenological, epistemological or other purely philosophical considerations. My aim in this paper is to examine whether it is possible to evaluate RPV empirically. In the first, negative part of the paper I consider and reject a certain tempting way of doing so. In (...) the second, positive part of the paper I suggest a novel way of evaluating RPV empirically, relying on the influential object files framework. (shrink)

The paper argues that knowledge is not closed under logical inference. The argument proceeds from the openness of evidential support and the dependence of empirical knowledge on evidence, to the conclusion that knowledge is open. Without attempting to provide a full-fledged theory of evidence, we show that on the modest assumption that evidence cannot support both a proposition and its negation, or, alternatively, that information that reduces the probability of a proposition cannot constitute evidence for its truth, the relation of (...) evidential support is not closed under known entailment. Therefore the evidence-for relation is deductively open regardless of whether evidence is probabilistic or not. Given even a weak dependence of empirical knowledge on evidence, we argue that empirical knowledge is also open. On this basis, we also respond to the strongest argument in support of knowledge closure. Finally, we present a number of significant benefits of our position, namely, offering a unified explanation for a range of epistemological puzzles. (shrink)

Ten years after the enactment of the Biologics Price Competition and Innovation Act, competition in biologics markets remains scant and far from sufficient for lowering prices of biologics to the level of 80-90% price drops seen in generic drug markets. This reality is not a result of one or two cardinal reasons, but many. If lowering the price of biologics is the goal and competition is the means by which we seek to achieve that goal, then there does not seem (...) to be a quick fix to address all of the many impediments to competition that plague biologics markets. Yet, certain changes to how the Food and Drug Administration evaluates and approves biologics may go a long way toward the creation of meaningful competition in biologics markets. One such change would be making original biologics' manufacturing information available to follow-on manufacturers.As recognized by several commentators, access to biologics manufacturing information is key to increasing competition in biologics markets. Without access to such information, making follow-on biologics is difficult and expensive, if not outright impossible. This is expected to be especially true for the highly anticipated class of interchangeable biologics, none of which has been approved by the FDA to date. Yet, it has long been the position of the brand-name pharmaceutical industry that biologics manufacturing information is proprietary and, thus, may not be shared. Congress has subscribed to the Industry's position, prohibiting the FDA from disclosing regulatory filings submitted by developers of original biologics, including manufacturing information, to third parties. That prohibition not only undermines competition in biologics markets, but is also wasteful, potentially unethical, and poses unnecessary risks to the health and safety of patients.This article makes the case for FDA sharing of original biologics manufacturing information with follow-on biologics developers. It is informed by the similar legal and commercial circumstances in the area of pesticides and the regulatory regime established by Congress in the Federal Insecticide, Fungicide and Rodenticide Act, which is administered by the Environmental Protection Agency. The article reviews the FIFRA regime, including its upholding as constitutional by the United States Supreme Court, and then examines its applicability to the area of biologics. The article concludes with a proposal for a similar regime to be incorporated into the pathway for approval of follow-on biologics as a means of increasing competition in biologics markets. (shrink)

It takes courage to characterize feminist writings on tort law as "thin." Indeed, Professor Schwartz in his provocative and challenging article examines feminist writings in a unique and innovative way. In his analysis of a number of such writings, he attempts to demonstrate that they either have not done enough or could have done better. His provocative analysis of many issues invites vigorous discussion. One could write a separate comment on each and every one of the issues he raises; however, (...) I will limit my comment to two: the tension between the "reasonable man" and the "reasonable woman" standard and the duty to rescue rule. It takes courage to characterize feminist writings on tort law as "thin." Indeed, Professor Schwartz in his provocative and challenging article examines feminist writings in a unique and innovative way. In his analysis of a number of such writings, he attempts to demonstrate that they either have not done enough or could have done better. His provocative analysis of many issues invites vigorous discussion. One could write a separate comment on each and every one of the issues he raises; however, I will limit my comment to two: the tension between the "reasonable man" and the "reasonable woman" standard and the duty to rescue rule. (shrink)

A commonly-discussed feature of perceptual experience is that it has ‘assertoric’ or ‘phenomenal’ force. We will start by discussing various descriptions of the assertoricity of perceptual experience. We will then adopt a minimal characterization of assertoricity: a perceptual experience has assertoric force just in case it inclines the perceiver to believe its content. Adducing cases that show that visual experience is not always assertoric, we will argue that what renders these visual experiences non-assertoric is that they are penetrated by belief-like (...) imaginings. Lastly, we will explain why it is that when belief-like imaginings—as opposed to beliefs (and other cognitive states)—penetrate visual experience, they render visual experiences non-assertoric. (shrink)

We study the behaviour of stable types in rosy theories. The main technical result is that a non-þ-forking extension of an unstable type is unstable. We apply this to show that a rosy group with a þ-generic stable type is stable. In the context of super-rosy theories of finite rank we conclude that non-trivial stable types of U þ -rank 1 must arise from definable stable sets.

The idea that knowledge can be extended by inference from what is known seems highly plausible. Yet, as shown by familiar preface paradox and lottery-type cases, the possibility of aggregating uncertainty casts doubt on its tenability. We show that these considerations go much further than previously recognized and significantly restrict the kinds of closure ordinary theories of knowledge can endorse. Meeting the challenge of uncertainty aggregation requires either the restriction of knowledge-extending inferences to single premises, or eliminating epistemic uncertainty in (...) known premises. The first strategy, while effective, retains little of the original idea—conclusions even of modus ponens inferences from known premises are not always known. We then look at the second strategy, inspecting the most elaborate and promising attempt to secure the epistemic role of basic inferences, namely Timothy Williamson’s safety theory of knowledge. We argue that while it indeed has the merit of allowing basic inferences such as modus ponens to extend knowledge, Williamson’s theory faces formidable difficulties. These difficulties, moreover, arise from the very feature responsible for its virtue- the infallibilism of knowledge. (shrink)

This paper proposes and develops the feelings of goals hypothesis (FGH). It has two aims: first, to describe the evolutionary function of emotional feelings (EFs), and second, to describe the content and the format of EFs. According to FGH, the evolutionary function of EFs is to enable motoric flexibility. Specifically, EFs are a component of a psychological mechanism that permits differential motoric reactions to the same stimulus. Further, according to FGH, EF is a special type of mental representation with the (...) content of an action goal, and with a non-motoric, non-conceptual format. This paper thoroughly clarifies the assumptions underlying FGH and discusses its theoretical implications and empirical predictions. (shrink)

In a recent paper, Dylan Evans proposed that emotions could help solve what has been known as ‘the frame problem’. In the process, he first questioned the utility of using the frame problem as a framework. After tackling this issue, he provided an alternative terminology to the frame problem—termed ‘the search hypothesis of emotion’—in order to re-examine how emotions aid rational agents. His new terminology, however, opens itself to other critiques. While accepting the basic tenets of his analysis, I question (...) (i) whether a single search theory of emotion is adequate, and (ii) whether his theory would have been better termed ‘the search hypothesis of feeling’. Finally, I extend some of the ideas developed in Evans' paper. 1. Introduction 2. Emotion, reason and ends 3. The search hypothesis of emotion revisited 4. Conclusion. (shrink)

This paper provides an economic justification for the exemption from liability for omissions in torts and for the exceptions to this exemption. It interprets the differential treatment of acts and omissions under tort law as a proxy for a more fundamental distinction between harms caused by multiple injurers, where each one can single-handedly prevent the harm, and harms caused by a single injurer. Since the overall cost to which a group of injurers is exposed is constant, attributing liability to many (...) injurers reduces the part each has to pay and, consequently, reduces each one’s incentives to take precautions. Broad exemption from liability for omissions is a way of carving a simple, practical rule to distinguish between the typical cases in which an agent can be easily selected and provided with sufficient incentives and cases in which there is a serious problem of dilution of liability. The exceptions to the rule exempting from liability for omissions are explained in terms of efficiency. The imposition of liability for omissions depends on the ability to identify a salient agent, i.e., to single out one or few liable agents and differentiate their role from that of others. Tort law designs three types of "salience rules." It either creates salience directly, or it can exploit salience created "naturally," or it can induce injurers to create salience voluntarily. (shrink)

In these pages we seek to integrate two claims. First, we argue that, taken to their logical conclusions, the considerations that support a strict form of protection for tangible property rights do not call for a similar form of protection when applied to the case of copyright. More dramatically, these considerations demand, on pain of glaring inconsistency, a substantially weaker protection for copyright. In pursuing this claim, we show that the form of protecting property rights is, to an important extent, (...) a feature of certain normal, though contingent, facts about the human world. Second, the normative question concerning the selection of a desirable protection for creative works is most naturally pursued from a tort law perspective, in part because the normative structure of copyright law simply is that of tort law. (shrink)

Harman and Lewis credit Kripke with having formulated a puzzle that seems to show that knowledge entails dogmatism. The puzzle is widely regarded as having been solved. In this paper we argue that this standard solution, in its various versions, addresses only a limited aspect of the puzzle and holds no promise of fully resolving it. Analyzing this failure and the proper rendering of the puzzle, it is suggested that it poses a significant challenge for the defense of epistemic closure.

According to the influential thesis of attentional transparency, in having or reflecting on an ordinary visual experience, we can attend only outwards, to qualities the experience represents, never to intrinsic qualities of the experience itself, i.e., to “mental paint.” According to the competing view, attentional semitransparency, although we usually attend outwards, to qualities the experience represents, we can also attend inwards, to mental paint. So far, philosophers have debated this topic in strictly armchair means, especially phenomenological reflection. My aim in (...) this paper is to show how to design an experiment, using the change detection paradigm for studying visual working memory that, if yielding positive results, would support AS. The structure of the argument is as follows. In standard change detection tasks, which involve attention to qualities the experience represents, there exists a known object integration effect (Luck and Vogel in Nature 390(6657):279–281, 1997). I formulate a hypothesis I call “the turn-off hypothesis,” according to which this effect does not exist in change detection tasks where subjects are instructed to attend to mental paint. I argue that, given AS, we have some reason to expect the turn-off hypothesis to be true, but given AT, we do not. Consequently, the truth of the turn-off hypothesis would support AS. I further argue that one can straightforwardly test the turn-off hypothesis, taking the standard change detection paradigm and instructing participants to attend inwards. (shrink)

We survey the history of Shelah’s conjecture on strongly dependent fields, give an equivalent formulation in terms of a classification of strongly dependent fields and prove that the conjecture implies that every strongly dependent field has finite dp-rank.

Let λ denote a singular cardinal. Zeman, improving a previous result of Shelah, proved that $\square _{\lambda}^{\ast}$ together with 2 λ = λ⁺ implies $\lozenge _{S}$ for every S ⊆ λ⁺ that reflects stationarily often. In this paper, for a set S ⊆ λ⁺, a normal subideal of the weak approachability ideal is introduced, and denoted by I[S; λ]. We say that the ideal is fat if it contains a stationary set. It is proved: 1. if I[S; λ] is fat, (...) then $\text{NS}_{\lambda ^{+}}$ ↾ S is non-saturated; 2. if I[S; λ] is fat and 2 λ = λ⁺, then $\lozenge _{S}$ holds; 3. $\square _{\lambda}^{\ast}$ implies that I[S; λ] is fat for every S ⊆ λ⁺ that reflects stationarily often; 4. it is relatively consistent with the existence of a supercompact cardinal that $\square _{\lambda}^{\ast}$ fails, while I[S; λ] is fat for every stationary S ⊆ λ⁺ that reflects stationarily often. The stronger principle $\lozenge _{\lambda ^{+}}^{\ast}$ is studied as well. (shrink)

Timothy Williamson has famously argued that the principle should be rejected. We analyze Williamson's argument and show that its key premise is ambiguous, and that when it is properly stated this premise no longer supports the argument against. After canvassing possible objections to our argument, we reflect upon some conclusions that suggest significant epistemological ramifications pertaining to the acquisition of knowledge from prior knowledge by deduction.

May the same graph admit two different chromatic numbers in two different universes? How about infinitely many different values? and can this be achieved without changing the cardinals structure? In this paper, it is proved that in Gödel’s constructible universe, for every uncountable cardinal \ below the first fixed-point of the \-function, there exists a graph \ satisfying the following:\ has size and chromatic number \;for every infinite cardinal \, there exists a cofinality-preserving \-preserving forcing extension in which \=\kappa \).

There are few indulgences academics can crave more than to have their work considered and addressed by leading researchers in their field. We have been fortunate to have two outstanding philosophers from whose work we have learned a great deal give ours their thoughtful attention. Grappling with Stephen Yablo’s, and Juan Comesaña’s comments and criticisms has helped us gain a better understanding of our ideas as well as their shortcomings. We are extremely grateful to them for the attentiveness and seriousness (...) with which they have considered our arguments and to philosophical studies for giving us this opportunity. Given the substantive difference between the two response papers, there is not much beyond sincere gratitude that we can covey to them jointly. We will therefore address them in turn. (shrink)

This article examines whether a functionalist approach to emotion classification is a research program that can feasibly be implemented in an experimental environment. I suggest that this is a promise perhaps impossible to keep. The crux of the argument is that if functional taxonomy is to go the full distance and shape experimental conditions to the new boundaries, then stimuli/experimental manipulations must be selected based on functional principles. But this seems implausible or even impossible. I conclude that emotion taxonomy, and (...) thus the metastructure of emotion theory, is both constrained and determined by human emotional feelings, and suggest that feelings have a special epistemological status in emotion research. (shrink)

It is relatively consistent with the existence of two supercompact cardinals that a special Aronszajn tree of height ${\aleph_{\omega_1+1}}$ is introduced by a cofinality-preserving forcing of size ${\aleph_3}$.

This article argues that constitutional mixture should be regarded as an inherent, inevitable feature of constitutions, and to some degree all constitutions are mixed. Thus, “mixed constitutions” should not be regarded as a distinct category of constitutions. Instead of asking whether a constitution is mixed, it might therefore be more useful to ask in which characteristics and to what extent a constitution is mixed. To demonstrate this, the article provides a preliminary typology of constitutional mixture considering the form or system (...) of government; the nature or character of government; the religious or secular identity; the flexibility or rigidity of the constitution; and its model of judicial enforcement—judicial or parliamentary supremacy. Examining these constitutional features, allows to shed light on the three different dimensions of “constitutional mixture”: First, the various features of the constitutional order do not function in a binary yes-or-no manner but appear and move along a spectrum. Second, the various features of the constitution change with time. Third, the various features of the constitutional text may be in tension with the features of the society. (shrink)

ABSTRACT A common conclusion of lab dishonesty studies is that subjects cheat to a very modest extent even when they cannot get caught. The modest level of cheating is attributed to subjects’ moral feelings which restrict their cheating to a level that enables them to retain their self-image as honest individuals. The present paper questions this claim, reporting the results of two experiments which uncover a discrepancy between self-portrayed honesty and actual dishonest behavior. The experiments reveal, first, that self-portrayed honesty (...) is stricter than practical honesty, suggesting that when facing an opportunity to benefit from dishonest behavior, subjects trade off some of their self-image as honest persons for dishonestly-generated payoffs. Secondly, dishonesty out of lab, in subjects’ self-chosen environment, is greater than in the lab, with a considerable fraction of subjects cheating to the maximum extent possible. We suggest that it is not a concern about their self-image that holds subjects back from cheating maximally, but rather a concern about their social image. The modest level of dishonesty observed in the lab presumably reflects caution subjects exercise in an unsafe setup. Given an environment where they feel safe to reap the fruits of dishonesty without compromising their image as honest persons in the eyes of others, the image they have of themselves hardly plays a role in curbing their unethical behavior. (shrink)

Generalising Hrushovski's fusion technique we construct the free fusion of two strongly minimal theories T₁, T₂ intersecting in a totally categorical sub-theory T₀. We show that if, e.g., T₀ is the theory of infinite vector spaces over a finite field then the fusion theory Tω exists, is complete and ω-stable of rank ω. We give a detailed geometrical analysis of Tω, proving that if both T₁, T₂ are 1-based then, Tω can be collapsed into a strongly minimal theory, if some (...) additional technical conditions hold—all trivially satisfied if T₀ is the theory of infinite vector spaces over a finite field Fq. (shrink)

European Journal of Philosophy, EarlyView.