Cancer drugs are broadly classified into two categories: cytotoxic chemotherapies and targeted therapies that specifically modulate the activity of one or more proteins involved in cancer. Major advances have been achieved in targeted cancer therapies in the past few decades, which is ascribed to the increasing understanding of molecular mechanisms for cancer initiation and progression. Consequently, monoclonal antibodies and small molecules have been developed to interfere with a specific molecular oncogenic target. Targeting gain‐of‐function mutations, in general, has been productive. However, (...) it has been a major challenge to use standard pharmacologic approaches to target loss‐of‐function mutations of tumor suppressor genes. Novel approaches, including synthetic lethality and collateral vulnerability screens, are now being developed to target gene defects in p53, PTEN, and BRCA1/2. Here, we review and summarize the recent findings in cancer genomics, drug development, and molecular cancer biology, which show promise in targeting tumor suppressors in cancer therapeutics. (shrink)

This paper discusses four diagrams in the Archimedes Palimpsest, a manuscript that provides among other texts the only extant witness to Archimedes’ Method. My study of the two diagrams for Method 12 aims to open up discussions about the following two questions. First, I want to question the assumed relationship between diagram and geometric configuration. Rather than a representation-represented relation, I argue that the two diagrams for Method 12 have a stronger independence from the geometric configuration they are related to. (...) Their connection with the theorem rather lies in their role in shaping the way in which the proof is written. Secondly, I want to examine the connection between geometric intuition and figure. Geometric intuition is the recognition of certain properties or relations in a geometric configuration not through deduction and is held to be parallel to, if not dependent on, the empirical observation of a physical figure. Method 12 provides a curious case where an intuitive fact is not only unrepresented, but even hindered by the diagrams, and the proof assumes that the reader has come to realise that fact, which is most easily achieved when the diagrams are ignored. (shrink)

Architecture culture is the synthesis of material possession and spiritual wealth, created by human society history development and reflects historic continuity and nationality character. This paper has a comprehensive comparison analysis on distinctions of originality, architecture characteristic, developing logic, art forms, and intention between China and Western Countries exhibited on architectural culture, including three parts: ancient period, current period, and future development. Through comparison studies, it presents a comprehensive cognition on different cultural backgrounds and unique exhibition forms for different architectural (...) styles on China and Western Countries; have a deeper understanding on architectural culture communion in two different civilization zones; and find a future developing way with ethical features and spirit for Chinese and Western architecture. (shrink)

ObjectiveThe purpose of this study was to investigate the relationship between work passion and work engagement among university music teachers in flow experience and teaching well-being.MethodsThree hundred forty-three university music teachers were tested by using the Flow State Scale, Teacher Well-Being Scale, Work Passion Scale, and Work Engagement Scale.ResultsUniversity music teachers’ flow experience can predict teaching well-being. University music teachers’ flow experience has an indirect impact on teaching well-being through work passion, and university music teachers’ flow experience has an indirect (...) impact on teaching well-being through work engagement. In addition, work passion and work engagement play a chain-mediating role between university music teachers’ flow experience and teaching well-being.ConclusionWork passion and work engagement play a sequential mediating role between university music teachers’ flow experience and teaching well-being. (shrink)

Many studies have linked idealized body image on social media to negative psychological well-being among young females. However, social media influencers’ imagery has not attracted much research attention in either the Western or the Asian context. This study aimed to experimentally investigate the impact of high versus low popular social media influencer images on young Chinese females’ body satisfaction and mood. The participants were 420 female RED users who were randomly assigned to three groups: the influencer-high group ; the influencer-low (...) group ; or a control set of nature images. The results revealed that the groups exposed to influencer imagery had lower body satisfaction and more negative mood than the control group. Notably, this comparison showed no significant difference between the low-influencer and high-influencer groups in body satisfaction and mood. Additionally, this effect was moderated by individuals’ self-discrepancy between personal ideals and their own bodies. That is, exposure to idealized body images does not always produce harmful effects. For those with lower self-discrepancy, idealized body posts somewhat positively affected their body satisfaction. The current research contributes to the media effect literature by providing critical new insights into the study of body image in the context of China. (shrink)

In the context of English as a Foreign Language, burnout study dominantly revolves around teachers but learners’ academic burnout is largely underexplored. Academic burnout is a concerning issue worldwide that is particularly predicted by academic motivation. However, we know little about the association between motivation and burnout among EFL learners and whether maladaptive emotion regulation strategies could moderate their association. To fill this research gap, we recruited 841 EFL undergraduates from two universities in China. Descriptive analysis showed that participants reported (...) high levels of language learning burnout. Correlational and bootstrapped moderation analysis found that motivation and maladaptive ERS were significantly correlated with burnout in opposite directions and the correlation between motivation and burnout was significantly influenced by students’ use of two maladaptive ERS. The more frequently students chose to avoid and vent unpleasant feelings, the protective role of motivation on burnout was weaker. The implications of these findings are discussed. (shrink)

As the answer to sustainability concerns, green economic growth has gradually attracted considerable attention. Notably, the optimization of the institutional environment contributes to green economic growth from the perspective of new institutional economics. However, few studies have systematically explained the connection between the institutional environment and green growth. In this study, the institutional environment was divided into three dimensions: governmental, legal, and cultural subenvironments. We adopted econometric models with the effect of every dimension on green growth and empirically analyzed with (...) the generalized method of moments, based on Chinese provincial panel data from the years 2000–2016. The results indicated that there was an inverted U-shaped relationship between China’s institutional environment and its green growth. That is, the institutional environment can initially promote China’s green growth but, if it is not changed, will eventually inhibit it. In addition, the analysis on the three dimensions of the institutional environment highlighted that the role of the cultural subenvironment in green growth is greater than those of the governmental and legal subenvironments. (shrink)

The COVID-19 pandemic has had a profound psychological and behavioral impact on people around the world. Consumer purchase behaviors have thus changed greatly, and consumer services companies need to adjust their business models to adapt to this change. From the perspective of consumer psychology, this paper explores the impact of consumer purchase behavior changes over the course of the pandemic on the business model design of consumer services companies using a representative survey of 1,742 individuals. Our results show that changes (...) in consumer purchase behavior have a significant impact on the design of consumer services firms’ business models. Specifically, changes in consumers’ purchase object, motive, and timeframe are more likely to spark a novelty-centered business model design, whereas changes in purchase method tend to inspire an efficiency-centered one. Our findings provide a theoretical reference for consumer services companies in designing business models when faced with unexpected crises. (shrink)

This chapter contains section titled: Literary Revolution and its Meaning The Naturalistic Conception of the Universe and the Experimentalist Method History of Chinese Philosophy and Systematizing the National Heritage Political Philosophy and Liberalism Hu Shi as an Enlightenment Philosopher.

I first present a brief interpretation of Sosa’s virtue epistemology by showing how it is arguably better than Goldman’s process reliabilism, why Sosa distinguishes between animal knowledge and reflective knowledge, and how Sosa’s recent account of knowing full well can deal with pragmatic encroachment. Then, I raise two worries about Sosa’s account: (a) Sosa’s claim that one might have animal knowledge without knowing reflectively or knowing full well implies that one’s true belief might manifest both competence and luck, which seems (...) to pose a challenge to Sosa’s solution to the Gettier problem; (b) intellectual virtue or competence does not seem to be a necessary condition for knowledge: there are cases where one knows without possessing the relevant intellectual virtue or competence. Finally, I suggest a responsibilist account of knowledge and show how it can not only handle the cases that pose a problem for Sosa’s account but also explain our intuitions about different grades of knowledge. (shrink)

On December 3 last year, Comrade Zhao Fusan of the Research Institute of Religion of the Chinese Academy of Social Sciences wrote a letter to Comrade Hu Qiaomu outlining his personal reflections on the Party Center's Document 19 [1982].

Science, the proud son of the era and the crystallization of man's wisdom, is inlaid in the crown of our times like a lustrous and brilliant pearl. Social science discloses to mankind the general law governing the development of society and leads it in marching forward to the higher stages of social system - socialist society and communist society. Natural science creates for mankind tremendous productive forces like miracles, enabling the human race to live a life in fairyland. Who is (...) there who does not praise the power of science and refuses to admit that science is the great force pushing history forward? Who is there that dares openly to set up forbidden zones in science, thus serving as an executioner to strangle science? In our times, people who dare openly to do this, perhaps, are increasingly few. However, this does not mean that science can completely extricate itself from disaster. Science has to pay dearly for every step of exploration and has to undergo a stern struggle for it. Science is an undertaking that is most creative and filled with the spirit of innovation. It openly declares that it will wage an irreconcilable struggle against all the old stuff which is reactionary, dark, ignorant and superstitious. Because of this, it is bound to suffer bans and buffets from the reactionary forces. Science has no forbidden zone! This is a call of reason; but there are forbidden zones in science, and that is what we see in the picture of history and reality. What are the forbidden zones? And how should we destroy the forbidden zones and set science free? For many years Lin Biao and the "gang of four" brought terrible disasters to science. In consequence, the aforementioned question is sharply raised before us, requiring us to deal with it strictly and try to resolve it correctly. (shrink)

The debate over the existence of a “public sphere” in China’s Late Qing/Early Republican era began nearly three decades ago, but it has yet to generate a special socio-cultural review on the “Confucian social imaginary” of the Chinese people. The article builds on existing “economic-political approach” and “idea-communication approach” to argue decisive factors hindering the development of a Habermasian “public sphere.” These includes (1) people’s traditional-collectivist lifestyle, (2) lack of understanding of “universal equality,” (3) conservative self-positioning during social transition, (4) (...) regionalist attitude toward outsiders, (5) lack of access to Enlightenment ideas, (6) disregard for parliamentary systems, and (7) ignorance of the rule of law. (shrink)

Machine learning algorithms bring out an under-appreciated puzzle of discrimination, namely figuring out when a decision made on the basis of a factor correlated with race is a decision made on the basis of race. I argue that prevailing approaches, which are based on identifying and then distinguishing among causal effects of race, in their metaphysical timidity, fail to get off the ground. I suggest, instead, that adopting a constructivist theory of race answers this puzzle in a principled manner. On (...) what I call a “thick constructivist” account of race, to be raced is to be socially positioned in the way indicated by a certain set of statistical regularities on the basis of particular phenotypical traits. A thick constructivist sees that acting on the basis of correlations that constitute race qua social position just is acting on the basis of race, because races just are social positions that subject their member individuals to a particular matrix of social relations that define the raced position. This conclusion has considerable ramifications for our understanding of discrimination, algorithms and beyond. (shrink)

The theory of embodied semantics holds that verbal metaphors are strongly grounded in sensorimotor experience. Many studies have proven that besides sensorimotor simulation, the comprehension of verbal metaphors also requires semantic abstraction. But the interaction between simulation and abstraction, as well as the time course of metaphorical meaning integration, is not well understood. In the present study, we aimed to investigate whether embodiment or abstraction, or both, is employed in the processing of Chinese verbal metaphor. Participants were asked to read (...) subject-verb metaphorical, verb-object metaphorical, literal-concrete and literal-abstract sentences, and the target words were measured at the verb and the object of each sentence. The results revealed that a similar N400 effect was elicited by the target verbs in the verb-object metaphorical and the literal-concrete sentences, and a similar P600/LPC effect was induced by the target verbs in the subject-verb metaphorical and the literal-abstract sentences, reflecting that the verb-object metaphors trigger a simulation process, while the subject-verb metaphors trigger an abstraction process in the verb processing stage. Moreover, the subject-verb metaphors elicited a stronger P600/LPC effect by the target verbs than the verb-object metaphors, but there was no difference of the P600/LPC caused by the target objects between the two kinds of metaphors, revealing that the metaphorical meaning of a subject-verb metaphor is integrated in the verb processing stage, while that of a verb-object metaphor is reanalyzed in the object processing stage. These results suggest that a verbal metaphor is processed both by simulation and abstraction, and the metaphorical meaning is integrated immediately with the unfolding of the sentence meaning. The position where the semantic conflict lies in a sentence modulates the time course of metaphor sentence comprehension. (shrink)

Objective: To investigate the correlation between preoperative response to the L-dopa challenge test and efficacy of deep brain stimulation (DBS) on motor function in Parkinson’s disease (PD).Methods: We retrospectively reviewed the data of 38 patients with idiopathic PD who underwent DBS surgery with a median follow-up duration of 7 months. Twenty underwent bilateral globus pallidus interna (GPi) DBS, and 18 underwent bilateral subthalamic nucleus (STN) DBS. The Movement Disorder Society Unified Parkinson Disease Rating Scale-Motor Part (MDS UPDRS-III) was assessed before (...) surgery and at the last follow-up in different medication and stimulation conditions, respectively.Results: Pearson’s correlation analysis revealed a positive correlation between preoperative L-dopa challenge responsiveness and GPi-DBS responsiveness on the total score (R2 = 0.283, p = 0.016) but not on the non-tremor total score (R2 = 0.158, p = 0.083) of MDS UPDRS-III. Such correlation remained significant (R2′ = 0.332, p = 0.010) after controlling for age at the time of surgery as confounding factor by partial correlation analysis. The preoperative L-dopa challenge responsiveness was significantly correlated with the tremor-controlling outcome of GPi-DBS (R2 = 0.390, p = 0.003). In contrast, we found a positive correlation between preoperative L-dopa challenge responsiveness and STN-DBS responsiveness on the non-tremor total score (R2 = 0.290, p = 0.021), but not on the total score (R2 = 0.130, p = 0.141) of MDS UPDRS-III. The partial correlation analysis further demonstrated that the predictive value of preoperative L-dopa challenge responsiveness on the non-tremor motor outcome of STN-DBS was eliminated (R2′ = 0.120, p = 0.174) after controlling for age at the time of surgery as confounding factor.Interpretation: The short-term predictive value of preoperative response to the L-dopa challenge test for the motor outcome of GPi-DBS in PD was systematically described. Our findings suggest: (1) a solid therapeutic effect of GPi-DBS in treating L-dopa-responsive tremors; (2) a negative effect of age at the time of surgery on motor outcomes of STN-DBS, (3) a possible preference of STN- to GPi-DBS in L-dopa-resistant tremor control, and (4) a possible preference of GPi- to STN-DBS in elderly PD patients who have a satisfactory dopamine response. (shrink)

En este mundo no existen dos culturas iguales, la traducción es una actividad de comunicación intercultural. En la década de los noventa, Suan Bussnett propuso “la gira de la cultura”, y enfatizó que la traducción no se debe aislar de la cultura. Como un importante elemento cultural 妾 (Qiè) es llevada a la novela en Sueño en el Pabellón Rojo. Desde la perspectiva de “traducción cultural”, se pone enfoque en cómo se puede traducir el significado y también transmitir las informaciones (...) culturales de 妾 (Qiè)). (shrink)