In sexually reproducing organisms maintenance of germ stem cell immortality is fundamental for transmitting genetic material to future generations. While previous research has mainly considered intrinsic regulatory mechanisms in the germline, our recent study has found a direct contribution of somatic cells in preserving germline immortality via the somatically expressed endoribonuclease ENDU‐2 in Caenorhabditis elegans. We have identified ENDU‐2 as a secreted protein that can be taken up by the germline. Here, we discuss how ENDU‐2 might uncouple its RNA‐binding and (...) RNA‐cleavage activities to control gene expression via either an endoribonuclease dependent or an independent way. We also speculate on a possible functional conservation of its mammalian homologs in mediating cell‐cell communication as well as its potential significance in understanding human pathogenesis such as cancer development. (shrink)

Objective: To systematically analyze the effectiveness of technology-based interventions for reducing loneliness in older adults.Methods: We searched relevant electronic databases from inception to April 2021, which included Cochrane Library, PubMed, Web of Science, SpringerLink, EMBASE, CNKI, and Wanfang. The following criteria were used: study design—randomized controlled trial designs, people—older adults, intervention—technology-based interventions in which a core component involved the use of technology to reduce loneliness in older adults; and outcome—reduction of loneliness level in terms of rating scale scores. Two reviewers (...) independently identified eligible studies, extracted data, and assessed the risk of bias in the included studies. A third reviewer resolved any conflicts. The Cochrane Collaboration's bias assessment tool was used to evaluate the risk of bias for the included studies, and Review Manager 5.4 software was used for the meta-analysis. A random effects model was adopted to measure estimates of loneliness reduction, and standard mean differences with a 95% confidence interval were calculated for each intervention-control contrast, and the I2 statistic was applied to examine heterogeneity.Results: A total of 391 participants from six RCTs were included in the review. Of these, three studies were rated as low-quality, and the remaining three were rated as moderate-quality studies. The meta-analysis showed that the evidence regarding the effects on loneliness of technology-based interventions compared with control groups was uncertain, and suggested that technology-based interventions resulted in little to no difference in loneliness reduction compared to control groups. Two types of technology-based interventions were identified: smartphone-based video calls and computer-based training with Internet usage. The subgroup analysis found low-quality evidence to support the effectiveness of both intervention types.Conclusions: We found no current evidence to support that technology-based interventions were effective compared to different control conditions in reducing loneliness in older adults. This suggests that more research is needed to investigate the effects of technology-based interventions on loneliness in older adults. (shrink)

本书以宽广的哲学视野,分析了法治与德治及其相互关系的历史演变,指出了两者之间存在着“合—分—合”的历史运动,社会主义社会中法治与德治之间是一个不可分割的“法治—人—德治”双向动互动关系链条,坚持“以人 为本”进行法治与德治建设是构建社会主义和谐社会的必然选择。.

Previous studies have reported that general or photo-specific social media use was associated with women’s body dissatisfaction and body image disturbance. The current study replicated and expanded upon these findings by identifying the positive association between social media influencer viewing and intentions to change appearance. This study surveyed a sample of 7,015 adult female TikTok users in China regarding their social media influencer viewing frequency, self-objectification, social comparison tendencies when watching short videos, intentions to change appearance, and demographics. The results (...) showed that female TikTok users’ self-objectification mediated the association between their influencer viewing frequency and their intentions to change appearance. Furthermore, social comparison tendencies moderated the association between influencer viewing and intentions to change appearance in that the proposed association was stronger for female TikTok users who had lower social comparison tendencies when watching short videos, compared to female TikTok users who had higher social comparison tendencies. The counter-intuitive finding on social comparison tendencies indicated that women who have higher social comparison tendencies may be more aware of the negative influences and adjust their expectations. The observed association between social media influencer viewing and intentions to change appearance was statistically significant but trivial in terms of effect size. Although the result could warn policymakers and practitioners to design media and health literacy campaigns to cultivate body positivity, caution should be exercised when evaluating the practical implications. (shrink)

This study examined factors including health-related anxiety, preexisting misinformation beliefs, and repeated exposure contributing to individuals’ acceptance of health misinformation. Through a large-scale online survey, this study found that health-related anxiety was positively associated with health misinformation acceptance. Preexisting misinformation beliefs, as well as repeated exposure to health misinformation, were both positively associated with health misinformation acceptance. The results also showed that demographic variables were significantly associated with health misinformation acceptance. In general, females accepted more health misinformation compared to males. (...) Participants’ age was negatively associated with health misinformation acceptance. Participants’ education level and income were both negatively associated with their acceptance of health misinformation. (shrink)

Food safety and food quality are two closely related aspects of the food management system. The difference between the two is that one keeps consumers safe while the other keeps consumers satisfied. This study examined the differences in how consumers value food safety and food quality with a focus on the influence of loss aversion on one’s psychological level and of income effect on one’s socio-demographic level. Our findings indicate that loss aversion and income effect significantly influence the way consumers (...) value food safety vs. quality labels when considering potential health risks and food price. High risk-averse and low-income consumers with strong loss aversion and a weak income effect show a higher demand for food safety labels as a way to ensure easy access to safety indications. Low risk-averse and high-income consumers with weak loss aversion and a strong income effect show a higher demand for food quality labels because they hope to gain more health benefits from high-quality food at good prices. This study provides insights that will assist public authorities and food industry in balancing food safety control and food quality improvement in order to meet the heterogeneous market demand changing alongside the transition of China’s food consumption and production. (shrink)

This study empirically examines whether firms’ environmental capital expenditures impact institutional investors’ investment decisions in the Chinese market. We particularly examine the impact of ownership type on the relationship of environmental capital expenditures and the behavior of different types of institutional investors by classifying institutional investors into two categories, short-term and long-term investors. In addition, this study further investigates whether environmental capital expenditures related to ownership type increase firm value. We find that long-term institutional investors tend to invest in state-owned (...) firms making environmental capital expenditures. Results also indicate that, with governmental backing and encouragement, the market value of SOEs making more environmental capital expenditures is likely to increase. However, no similar results are found for non-SOEs. (shrink)

Job satisfaction, resilience, and teacher well-being, as the three major psychological variables emotioncy- based education, have received special attention among English as a foreign language researchers. To pursue the line of this inquiry, this particular study aimed to investigate the relationship between Chinese EFL teachers’ job satisfaction, resilience, and their well-being. To conduct the study, 343 Chinese EFL teachers with different academic qualifications, various academic degrees, and different majors voluntarily participated in this study. The results of the study showed that (...) job satisfaction and resilience could jointly predict 56.4 of the variance in psychological well-being. Both variables were the significant predictors of well-being, while job satisfaction was a better predictor, uniquely explaining 29.6 of well-being’s variance. Based on the findings, some pedagogical implication for administrators, educational institutions, and EFL teachers were discussed in the article. (shrink)

Recent studies have revealed an astonishing diversity of sex chromosomes in many vertebrate lineages, prompting questions about the mechanisms of sex chromosome turnover. While there is considerable population genetic theory about the evolutionary forces promoting sex chromosome replacement, this theory has not yet been integrated with our understanding of the molecular and developmental genetics of sex determination. Here, we review recent data to examine four questions about how the structure of gene networks influences the evolution of sex determination. We argue (...) that patterns of epistasis, arising from the structure of genetic networks, may play an important role in regulating the rates and patterns of sex chromosome replacement. (shrink)

The article explores a gradual refinement of the notion of reflection in Husserlian phenomenology. In his early period, Husserl takes phenomenological reflection to attain adequate evidence, since its object is self-given in an absolute and complete manner. However, this conception of reflection does not remain unchanged. Husserl later realizes that immanent perception or phenomenological reflection also involves a certain horizonality and naivety that has to do with its temporal nature and must be queried in a further critical, apodictic reflection. Focusing (...) more on the notion of apodicticity than adequacy, Husserl subsequently ascribes a new methodological role to reflection: instead of a mere epistemic warrant that guarantees for us the ultimate truth of our experiential life once and for all, phenomenological reflection ensures the strictness of phenomenology insofar as it entails an ethical-existential dimension as the norm of a life-form where the subject pursues full self-understanding and self-justification. (shrink)

Prior research suggests that ownership structure is associated to corporate social responsibility (CSR) in developed countries. This article examines whether and how ownership structure affects CSR in emerging markets using Chinese firms' social responsibility ranking. Our empirical evidences show that for non-state-owned firms, corporate ownership dispersion is positively associated to CSR. However, for state-owned firms, whose controlling shareholder is the state, this relation is reversed. We attribute the reversed relationship to political interferences and further test this hypothesis by demonstrating that (...) regional economic development is negatively related to CSR for state-owned firms due to decreased political interference in more developed areas. This study is the first to directly examine the relationship between the dispersion of corporate ownership and CSR in emerging markets, and our results depict that it is important to consider ownership type in assessing CSR in emerging market where state ownership is still prevalent such as China. The results also reveal that firm size, profitability, employee power, leverage, and growth opportunity affect CSR in China. (shrink)

To realize the coordinated and sustainable development of hydropower projects and regional society, comprehensively evaluating hydropower projects’ influence is critical. Usually, hydropower project development has an impact on environmental geology and social and regional cultural development. Based on comprehensive consideration of complicated geological conditions, fragile ecological environment, resettlement of reservoir area, and other factors of future hydropower development in each country, we have constructed a comprehensive evaluation index system of hydropower projects, including 4 first-level indicators of social economy, environment, safety, (...) and fairness, which contain 26 second-level indicators. To solve the problem that existing models cannot evaluate dynamic nonlinear optimization, a projection pursuit model is constructed by using rough set reduction theory to simplify the index. Then, an accelerated genetic algorithm based on real number coding is used to solve the model and empirical study is carried out with the Y hydropower station as a sample. The evaluation results show that the evaluation index system and assessment model constructed in our paper effectively reduce the subjectivity of index weight. Applying our model to the social impact assessment of related international hydropower projects can not only comprehensively analyze the social impact of hydropower projects but also identify important social influencing factors and effectively analyze the social impact level of each dimension. Furthermore, SIA assessment can be conducive to project decision-making, avoiding social risks and social stability. (shrink)

Work procrastination is a retreat behavior associated with negative cognitive experience and it results in great losses to individual as well as organizational development. Understanding the antecedents of employees’ work procrastination behavior contributes to lower frequency of its occurrence. This research builds a dual-moderated mediation model from the perspective of cognitive appraisal theory and explored work procrastination behavior of employees subjected to abusive supervision. With 378 valid returned questionnaires, data collected from 32 companies in Beijing, Shanghai, Tianjin, and Chongqing supports (...) our hypotheses. This result has enriched the understanding of work procrastination behavior and provided practical implications to avoide its negative effects. (shrink)

This study aims to optimize the enterprise criminal law-based copyright protection. This exploration discusses the role of the entrepreneurial spirit in criminal law-based copyright protection. To study the relationship between ES and criminal law-based copyright protection, the concepts of ES, criminal law-based copyright protection, and enterprise innovation are given. Next, by collecting literature, hypotheses are put forward. They include the relationship between ES and enterprise innovation, ES and the criminal law-based copyright protection, and the intermediary role of ES in the (...) criminal law-based copyright protection and economic growth. Then, relevant models are established. Finally, the hypotheses are tested through experiments and empirical analysis, and the model is regressed to test the experimental data’s robustness and the scale’s reliability and validity. The empirical analysis shows that: the significance of ES under the 1% index is greater than 0. It indicates that the higher the managers’ ES is, the greater the enterprise innovation is. The significance of criminal law-based copyright protection on ES under the 1% index is greater than 0 and the regression coefficient is 0.59. This shows that criminal law-based copyright protection has a significant positive impact on ES. Under the l% index, the significance of ES on economic growth is greater than 0 and the regression coefficient is 0.63. It shows that ES mediates the relationship between criminal law-based copyright protection and economic growth. Therefore, strengthening criminal law-based copyright protection improves the ES and leads to faster enterprise and regional economic development. Therefore, the state should pay attention to criminal law-based copyright protection to encourage innovation to promote enterprise development. This exploration studies the relationship among ES, economic growth, enterprise innovation, and criminal law-based copyright protection. The finding provides a theoretical reference for criminal law-based copyright protection. (shrink)

The evolution of a variety of important chromophore‐dependent biological processes, including microbial light sensing and mammalian color vision, relies on protein modifications that alter the spectral characteristics of a bound chromophore. Three different color opsins share the same chromophore, but have three distinct absorptions that together cover the entire visible spectrum, giving rise to trichromatic vision. The influence of opsins on the absorbance of the chromophore has been studied through methods such as model compounds, opsin mutagenesis, and computational modeling. The (...) recent development of rhodopsin mimic that uses small soluble proteins to recapitulate the binding and wavelength tuning of the native opsins provides a new platform for studying protein‐regulated spectral tuning. The ability to achieve far‐red shifted absorption in the rhodopsin mimic system was attributed to a combination of the lack of a counteranion proximal to the iminium, and a uniformly neutral electrostatic environment surrounding the chromophore. (shrink)

Between the sense of self and the reality of self Content Type Journal Article Category Book Review Pages 113-118 DOI 10.1007/s11097-011-9234-y Authors Wenjing Cai, Center for Subjectivity Research, University of Copenhagen, Njalsgade 140-142, 5th floor, 2300 Copenhagen, Denmark Journal Phenomenology and the Cognitive Sciences Online ISSN 1572-8676 Print ISSN 1568-7759 Journal Volume Volume 11 Journal Issue Volume 11, Number 1.

Corruption has been a major obstacle to economic growth around the world. In this paper, we examine how firms interact with corrupt government officials either to minimize the impact of corruption on their operations or to maximize their benefit of paying a bribe. Our estimates show that firms know exactly what they need and use their limited resources to bribe only relevant government authorities. In other words, firms are rational bribers who know exactly what they need and optimize their bribes (...) to fulfill that need. This type of intentional bribery could be reduced by enhanced institutional environments and improved openness of the economy. (shrink)

ABSTRACTThe guiding question of this comparative study is the relation between transcendental theory and common-sense realism: how to understand their compatibility, but also possible tensions between the two. This question concerns, in a broader sense, the relation between philosophy and natural life, or more precisely, what philosophy possibly can and cannot do for natural life. In the following discussion, I first introduce the idealism-realism controversy in Husserl’s transcendental phenomenology. I then move on to McDowell’s theory and look into a significant (...) convergence between the two philosophies, namely, their insistence on the “unboundedness” of subjectivity, and I clarify how this shared viewpoint makes their proposals compatible with common-sense realism. In a third section, I elaborate the relation between a transcendental and a natural stance by turning to Husserl’s method of phenomenological reduction. In the end, by attending to the anti-naturalism of Husserl and McDowell, I wish to shed s... (shrink)

The present article aims to illuminate a notion of finite freedom in both Heidegger and Levinas. Levinas criticizes the Heideggerian ontology for holding an egoistic, unconstrained notion of freedom. The article first responds to such a criticism by showing that the Heideggerian notion of freedom as self-binding involves normativity. It then argues that both Heidegger and Levinas propose a notion of finite freedom as the unity of autonomy and heteronomy. Finally, the article also sheds light on what different approaches to (...) the source of normativity separate the two philosophers’ understandings of freedom. (shrink)

ABSTRACTThis paper examines critically the notion of reflection as self-objectification and points out its insufficiency in accounting for the pathological phenomenon of hyperreflexivity. It proposes an understanding of reflection as situated and motivated from within a world and having a normative aspect that concerns the very life of the reflecting person. On this account, the paper argues, on the one hand, that both phenomenological reflection and hyperreflexivity can be viewed as forms of reflection characterized by loss of the world. On (...) the other hand, by construing the phenomenological loss as imaginative vis-à-vis the real loss of hyperreflexivity, the paper emphasizes a difference between the two domains. (shrink)

Résumé Cet article est centré sur une récente initiative de jeunes chinoises occupant ostensiblement à Canton – la capitale du sud – les toilettes publiques réservées aux hommes : cette manifestation visait, parmi d’autres, à lutter contre les discriminations faites aux femmes, nécessitant des toilettes plus nombreuses pour éviter les longues queues qui ne manquent de se former régulièrement dans les rues. Replacée dans le contexte d’un Etat-parti autoritaire prompt à la répression, cette initiative est ici décortiquée pour en comprendre (...) la genèse tant au niveau des individus que du collectif féminin qui l’a fait vivre. (shrink)

本书用史论结合的方法,从中西方的古代直到近代道德观念和道德学说的发展历史中,揭示了伦理道德学说的发展规律。.

本书评介了普列汉诺夫及其美学思想,尤其是从艺术的起源、艺术与社会心理等方面讨论了普列汉诺夫的观点,提出许多新的见解。.

本书系统考察了认识论产生及其理论发展,特别是对主体和客体、认识工具和认识方法、经验认识和理论认识、精确思维和模糊思维价值、真理等问题,以及认识发展的一般规律,在理论上作出了一新的概括。.

It could be said that chinese aesthetics merges together three cornerstones of the western tradition. It might be intended as the study of beauty in the Platonic sense, because of the vaste debate on the topic rooted back in chinese’s ancient times; it could match the sense of aesthetics as intended by Baumgarten, because of the long tradition of chinese perceptual studies, and it may also be compared to the Hegelian philosophy of art, given the abundance of chinese artistic manufacts (...) and theories. Chinese aesthetics is distinctive and very different from the western one. While the latter tries to grasp the inner beauty of things by breaking them and accounts for beauty as an object, chinese aesthetics considers beauty as a subject, rather aiming at feeling the beauty of things for what they are. Compared to the occidental tradition, which is rooted in sensation but deviates from sensation to pursue a rational goal, chinese aesthetics originates from the sensation and adheres to it all the time. Therefore, the chinese stance makes for a unique and genuine approach to the discipline. (shrink)

Assuming the existence of a measurable cardinal, we define a hierarchy of Ramsey cardinals and a hierarchy of normal filters. We study some combinatorial properties of this hierarchy. We show that this hierarchy is absolute with respect to the Dodd-Jensen core model, extending a result of Mitchell which says that being Ramsey is absolute with respect to the core model.