The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines fo.

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines for local populations. However, the absence of appropriate structures for ethical review represents a barrier for certain countries. Currently there is very little information available on existing structures dedicated to ethics in western and central Africa. This article briefly describes historical milestones in the development of networks dedicated to capacity building in ethical review in these regions and outlines the major conclusions of two (...) workshops on this issue, which were held in September and October 2002 in Libreville, Gabon, and Paris, France. The workshops were the culmination of collaboration between the African Malaria Network Trust (AMANET) and the Pan African Bioethics Initiative (PABIN). They produced an update on ethics organizations with regard to mission, function, activities, members, and contact people, in eight countries within the regions discussed. As a result of the commitment of mandated delegates, a further prominent outcome followed these workshops: the creation of national structures, where none existed before, dedicated to the ethical review of clinical trials. (shrink)

Background: The high disease burden of Africa, the emergence of new diseases and efforts to address the 10/90 gap have led to an unprecedented increase in health research activities in Africa. Consequently, there is an increase in the volume and complexity of protocols that ethics review committees in Africa have to review. Methods: With a grant from the Bill and Melinda Gates Foundation, the African Malaria Network Trust (AMANET) undertook a survey of 31 ethics review committees (ERCs) across sub-Saharan Africa (...) as an initial step to a comprehensive capacity-strengthening programme. The number of members per committee ranged from 3 to 21, with an average of 11. Members of 10 institutional committees were all from the institution where the committees were based, raising prima facie questions as to whether independence and objectivity could be guaranteed in the review work of such committees. Results: The majority of the committees (92%) cited scientific design of clinical trials as the area needing the most attention in terms of training, followed by determination of risks and benefits and monitoring of research. The survey showed that 38% of the ERC members did not receive any form of training. In the light of the increasing complexity and numbers of health research studies being conducted in Africa, this deficit requires immediate attention. Outcome: The survey identified areas of weakness in the operations of ERCs in Africa. Consequently, AMANET is addressing the identified needs and weaknesses through a 4-year capacity-building project. (shrink)

This study examines the characteristics of request sequences in Chinese public service calls. The data analysis indicates that a prominent characteristic of Chinese public service calls is the frequent appearance of insert expansions and non-minimal post-expansions, with the latter occurring after both preferred response and dispreferred response. This is closely related to participants’ institutional identities and epistemic asymmetry; operators handling such service calls should pay due attention to this asymmetry to ensure mutual understanding in conversation.

A deterrence theory of punishment holds that the institution of criminal punishment is morally justified because it serves to deter crime. Because the fear of external sanction is an important incentive in crime deterrence, the deterrence theory is often associated with the idea of severe, disproportionate punishment. An objection to this theory holds that hope of escape renders even the severest punishment inapt and irrelevant. -/- This article revisits the concept of deterrence and defend a more plausible deterrence theory of (...) punishment—the wide-scope deterrence theory. The wide-scope theory holds that we must make the best use of all the deterrence tools available, including both external and internal sanctions. Drawing on insights from the early Confucian tradition, the article develops a deep deterrence theory, which holds that the most important deterrence tool involves internal, not external, sanction. It describes how internal sanctions deter potential offenses and why relevant policies need not conflict with liberalism’s respect for neutrality. (shrink)

A needs assessment survey of ethics review committees (ERCs) across Africa was conducted in order to establish their major needs and areas of weaknesses in terms of ethical review capacity. The response rate was 84% (31 of 37 targeted committees), and committees surveyed were located in 18 African countries. The majority of the responding committees (61%) have been in existence between 5 and 10 years; approximately 74% of the respondents were institutional committees, with the remainder being either national (6/31) or (...) regional (2/31). In terms of the ethical review process, nine of the 31 committees that responded did not have standard operating procedures (SOPs), and seven of the 22 that did have SOPs had never revised them after their initial development (an average period of three years). Of the 31 committees, 10 operated without any ethical guidelines. Many of the committees (13/30) met once per month, and the number of proposals reviewed annually varied, ranging from five to over 100. All respondents relied on paper-based data management and archiving systems. Overall, the survey identified the major constraints on ERCs as lack of office equipment, outdated or lack of SOPs, lack of electronic data management systems, inadequate resources, lack of or insufficient expertise on the committees, and poor recognition of the importance of the role of the committees. Consequently, the authors are addressing the identified needs and weaknesses through the Bill and Melinda Gates Foundation-funded capacity building project. The impact of the intervention project will be assessed during and at the end of the four-year longitudinal project. (shrink)

People are typically poor at telling apart truthful and deceptive statements. Based on the Unconscious Thought Theory, it has been suggested that poor lie detection arises from the intrinsic limitations of conscious thinking and can be improved by facilitating the contribution of unconscious thought. In support of this hypothesis, Reinhard, Greifeneder, and Scharmach (2013) observed improved lie detection among participants engaging in unconscious thought. The present study aimed to replicate this unconscious thought advantage using a similar experimental procedure but with (...) an important improvement in a key control condition. Specifically, participants judged the truthfulness of 8 video recordings in three thinking modes: immediately after watching them or after a period of unconscious or conscious deliberation. Results from two experiments (combined N = 226) failed to reveal a significant difference in lie detection accuracy between the thinking modes, even after efforts were made to facilitate the occurrence of an unconscious thought advantage in Experiment 2. The results imply that the unconscious thought advantage in deception detection is not a robust phenomenon. (shrink)

本书深入细致地介绍了刑法总论的基本理论问题,特别是犯罪构成和刑事责任问题。每个专题在系统介绍中外学者的观点之后,都提出了自己的观点。.

Short-term motor practice leads to plasticity in the primary motor cortex. The purpose of this study is to investigate the factors that determine the increase in corticospinal tract excitability after motor practice, with special focus on two factors; “the level of muscle activity” and “the presence/absence of a goal of keeping the activity level constant.” Fifteen healthy subjects performed four types of rapid thumb adduction in separate sessions. In the “comfortable task” and “forceful task”, the subjects adducted their thumb using (...) comfortable and strong forces. In the “comfortable with a goal task” and “forceful with a goal task”, subjects controlled the muscle activity at the same level as in the C and F, respectively, by adjusting the peak electromyographic amplitude within the target ranges. Paired associative stimulation, which combines peripheral nerve stimulation and transcranial magnetic stimulation, with an inter-stimulus interval of 25 ms was also done. Before and after the motor tasks and PAS25, TMS was applied to the M1. None of the four tasks showed any temporary changes in behavior, meaning no learning occurred. Motor-evoked potential amplitude increased only after the FG and it exhibited a positive correlation with the MEP increase after PAS25, suggesting that FG and PAS25 share at least similar plasticity mechanisms in the M1. Resting motor threshold decreased only after FG, suggesting that FG would also be associated with the membrane depolarization of M1 neurons. These results suggest task-dependent plasticity from the synergistic effect of forceful muscle activity and of setting a goal of keeping the activity level constant. (shrink)

Chinese Philosophy provides a clear, accessible conception of the Chinese philosophical sensibility and its evolution throughout history.

As disenchantment began to be recognized as a recurring, never-ending process in recent scholarship, “When Jupiter Meets Saturn” argues that Aby Warburg and Karl Sudhoff’s debate on Reformation astrological medicine provided a new theory of the emergence of modern science and rationality. Drawing on their encounter and divergence in interwar Germany, especially their curatorial collaboration for the 1911 Internationale Hygiene-Ausstellung, the article shows that Warburg and Sudhoff generated completely opposite historical evaluations of astrological medicine using the very same materials. Approaching (...) history as healers, they developed different ways of seeing from medical epistemologies and brought out entangled temporalities from images. (shrink)

While ancient civilizations worshipped strong, active emotions, modern societies have favored more peaceful attitudes, especially within the democratic process. We have largely forgotten the struggle to make use of _thymos_, the part of the soul that, following Plato, contains spirit, pride, and indignation. Rather, Christianity and psychoanalysis have promoted mutual understanding to overcome conflict. Through unique examples, Peter Sloterdijk, the preeminent posthumanist, argues exactly the opposite, showing how the history of Western civilization can be read as a suppression and return (...) of rage. By way of reinterpreting the _Iliad_, Alexandre Dumas's _Count of Monte Cristo_, and recent Islamic political riots in Paris, Sloterdijk proves the fallacy that rage is an emotion capable of control. Global terrorism and economic frustrations have rendered strong emotions visibly resurgent, and the consequences of violent outbursts will determine international relations for decades to come. To better respond to rage and its complexity, Sloterdijk daringly breaks with entrenched dogma and contructs a new theory for confronting conflict. His approach acknowledges and respects the proper place of rage and channels it into productive political struggle. (shrink)

Journal Name: Semiotica - Journal of the International Association for Semiotic Studies / Revue de l'Association Internationale de Sémiotique Volume: 2013 Issue: 196 Pages: 443-455.

Hsün Tzu was an eminent Legalist. The book Hsün Tzu fully reflects his Legalist thought. In the decisive period of great social change at the end of the Warring States period he stood in the front ranks of the age and created a great deal of public opinion in favor of the replacement of the slave system by the feudal system; he "disclosed the past, set forth the present, dispersed disorder, and propagated reason as easily as turning over his hand" (...) , creating a thick foundation of theory for the Legalist line and manifesting the vital and vigorous fighting spirit of the newly rising landlord class. (shrink)

Publication date: 30 November 2016 Source: Author: Wen Lee Ng, Manimangai Mani, Wan Roselezam Wan Yahya While the growing body of research on Tan Twan Eng’s The Gift of Rain focuses on the protagonist, Philip Hutton’s traumatic condition, his Chinese identity, and his ambiguous identity, this study devotes particular attention to the complexity of interactions between various cultures practised by Philip. This study aims to address this gap by applying the concept of transculturalism to analyse the processes of acquiring a (...) foreign culture and incorporating the foreign culture into traditional cultures experienced by Philip. In other words, this study employs the concept of transculturalism to examine multicultural depictions in the novel. Scholars, such as Khan, Tiwari, Sheoran and Tan C. S. who have examined multicultural depictions in various literary texts, have found that multicultural circumstances cause certain ethnic groups to lose their cultures and identities. Hence, the multicultural circumstances depicted are perceived as negative phenomena. However, this study has found that by examining the interactions between various cultures, rather than focusing on the end products such as portrayals of hybridity, the positive sides of multicultural depictions could be revealed. The transculturation process experienced by Philip shows that the new cultural practices he has created are made up of both his traditional cultures and the foreign culture he has acquired. This means that Philip does not totally lose his traditional cultures and identities. Therefore, this study concludes that multicultural depictions in The Gift of Rain could be read positively, provided that the interactions between various cultures, which resulted in the incorporation of a foreign culture into traditional cultures, are examined. (shrink)

Diese Arbeit wirft neues Licht auf das Verhältnis zwischen dem späten Husserl und dem frühen Heidegger. Der Schwerpunkt liegt in den Rückbezügen auf die epistemische Position Husserls, die den Vergleich vorbereiten. Der Autor liefert vor allem in der Analyse des Evidenzproblems besondere Ansatzpunkte für weitere Untersuchungen. Grundlegend ist die Unterscheidung zwischen der auf das Ur-Ich bezogenen epistemischen Genesis und der auf das Vor-Ich bezogenen ontologischen Genesis, denen entsprechend zwei gegensätzliche Verhältnisse zwischen dem Zweitbewußtsein und dem kinästhetischen Bewußtsein entstehen. Konsequent gelangt (...) die Arbeit zum Resultat: Das Vor-Ich kann sich in der epistemischen Position Husserls zum Ur-Ich, aber in der ontologischen Position Heideggers zum Dasein entwickeln. (shrink)

There is a perennial and universal concern about the "self." The question of "who I am" is a necessary step on the path of self-awakening. The Ancient Greek aphorism "know thyself" was inscribed in the forecourt of the Temple of Apollo at Delphi and has been widely praised. Within the philosophical scope of the "self," the problem of personal persistence or personal identity has attracted a great deal of attention and has been discussed extensively in the Western philosophical tradition. The (...) problem is as follows: how can we ensure that those "I"s that exist at different times, play different roles, present different appearances, and have different thoughts are the same person? For example, I am a scholar; I am a... (shrink)

This article analyzes the source of Confucian universal morality and human dignity from the perspective of the classic saying, ?what follows the dao is good, and what dao forms is nature? (jishan chengxing) found in the Great Commentaries of the Book of Changes. From a Classical Confucian perspective, human nature is generated by the natural dao of tian, so human dignity and morality also emerge from the natural dao of tian. This article discusses the relationship between the Confucian dao of (...) tian and the moral notion of human rights which ensues from the historical tradition of Chinese exegesis on this subject. Specifically, the authors reconstruct a naturalist version of Confucian morality which inherently motivates the beneficial outcomes generally associated with the modern Western conception of human rights. The authors argue that such a framework, which would draw upon Confucian ?natural goodness within human nature? differs significantly from the more commonly accepted Mencian version of human morality dependent upon the premise that ?human nature is good?. This intra-mural differentiation within Chinese philosophy can be helpful in structuring dialogue with various Western theories of human rights. (shrink)

The five papers translated here were first presented at a conference titled Metaphysics and Epistemology in Chinese Philosophy: A Systematic and Comparative Approach, which met on July 10-11, 2010, under the co-sponsorship of the School of Philosophy and the International Center for Chinese and Comparative Philosophy, both at the Renmin University of China, and the Association of Chinese Philosophers in America. The selected papers represent three main approaches to Chinese metaphysics: a traditional textual approach ; an approach drawing on both (...) Western and Eastern philosophy ; and a Western-style analytic approach. (shrink)

该书考察了传统理性主义的理性观从发端、变异到确立、扩展的历史演变,从中对理性与其相关的范畴进行了辨析;分析了由传统理性主义到非理性主义及反理性主义的转向等内容。.

本书以欧洲的社会政治、经济历史为背景,以技术史为基础,以欧洲哲学史的历史脉络为主线,研究从古希腊到19世纪中叶哲学的技术思想,揭示出技术哲学由萌芽到产生的历史过程。.

The phenomenon of recognition is a point of contention in the debate between the orthodox Hindus and Buddhists on whether the self exists. The Hindus, including Naiyāyikas and Mīmāṃsakas, argue that recognition evidences the existence of the self, while Buddhist philosopher Śāntarakṣita maintains that there is no self and recognition should be explained in another way. This article examined two disputes, focusing on the two subsidiary aspects of a recognition: memory and self-recognition. For Hindus, it is the existence of the (...) self that makes memory and self-recognition possible. For Buddhists, it is due to the phenomena of memories and self-recognitions that people postulate the existence of the self. I argue that Buddhist explanation of memory is more acceptable, while their debates on self-recognition should be considered as a tie. (shrink)

ObjectivesWuhan is the city where coronavirus disease was first reported and developed into a pandemic. However, the impact of the prolonged COVID-19 pandemic on medical staff burnout remains limited. We aimed to identify the prevalence and major determinants of burnout among medical staff 1 year after the beginning of the COVID-19 pandemic in Wuhan, China.Materials and MethodsA total of 1,602 medical staff from three hospitals in Wuhan, China, were included from November 1–28, 2021. Chi-square tests were conducted to compare the (...) prevalence of burnout across groups based on sociodemographic and professional characteristics. A multivariate analysis was performed using a forward stepwise logistic regression model.ResultsApproximately 37.39% of the medical staff experienced burnout 1 year after COVID-19 pandemic. Emotional exhaustion was the most common symptom of burnout, with 1,422 participants reporting a severe EE. Burnout was associated with insufficient social support and “neutral” or “dissatisfied” patient-physician relationships. Respondents who participated in the care of COVID-19 patients had a higher risk of burnout symptoms than those who did not participate. In particular, mental resilience was negatively associated with burnout among the medical staff.ConclusionNearly two-fifths of the participants had symptoms of burnout, with reduced personal accomplishment being the predominant symptom 1 year after COVID-19. Healthcare organizations should regularly measure and monitor burnout among the medical staff. In addition, creating positive work environments and improving the mental resilience of medical staff may be effective ways to reduce burnout. (shrink)

Research on couples’ earnings arrangements has focused on men’s and women’s conformance to the male-breadwinner/female-homemaker model. By doing so, research has ignored the following: Breadwinning can be a source of stress for men; the male-breadwinner/female-homemaker model does not apply to all racial groups; and the proportion of women in an occupation may moderate the stress process associated with divergent earnings arrangements. To address factors overlooked, I applied mixed-effects models to the 1999–2017 Panel Study of Income Dynamics data to examine the (...) internalizing and externalizing responses to stress among married, non-Hispanic white and Black men and women. Greater relative earnings reduce Black women’s psychological distress and heavy drinking, but increase Black men’s heavy drinking. Among white men, greater relative earnings reduce psychological distress and demonstrate a curvilinear relationship with heavy drinking, whereas no significant pattern emerges for white women. Occupational sex composition moderates these relationships. Among Black women, greater relative earnings lower psychological distress the most for those in women-concentrated occupations, and moving from economic dependency to equal breadwinning decreases heavy drinking the most for white men in men-concentrated occupations. Findings showcase the value of an intersectional approach to capture the diverse meanings associated with earnings arrangements. (shrink)

The term nirvyāpāra, which literally means “non-activity”, can be a key point in understanding Śāntarakṣita’s causal theory. It is a necessary step in his argument for the doctrine of Dependent Origination. This paper presents the views of the orthodox Indian schools that endorses the existence of causal activity and examines how Śāntarakṣita establishes the idea of non-activity mainly by discussing his objection to causal activity. In addition, the paper also briefly investigate the history of the concept of “non-activity” in Buddhist (...) philosophy, trying to show that Śāntarakṣita contributes to this view by explicitly spelling it out and providing a detailed argument for it. (shrink)

Metrics and their weaker forms are used to measure the difference between two data. There are many metrics that are available but not desired by a practitioner. This paper recommends in a plausible reasoning manner an easy-to-understand method to construct desired distance-like measures: to fuse easy-to-obtain pseudo-semi-metrics, pseudo-metrics, or metrics by making full use of well-known t-norms, t-conorms, aggregation operators, and similar operators. The simple reason to do this is that data for a real world problem are sometimes from multiagents. (...) A distance-like notion, called weak interval-valued pseudo-metrics, is defined by using known notions of pseudo-semi-metrics, pseudo-metrics, and metrics; this notion is topologically good and shows precision, flexibility, and compatibility than single pseudo-semi-metrics, pseudo-metrics, or metrics. Propositions and detailed examples are given to illustrate how to fabricate an expected or demanded WIVP-metric in practical problems, and WIVP-metric and its special cases are characterized by using axioms. Moreover, some WIVP-metrics pertinent to quantitative logic theory or interval-valued fuzzy graphs are constructed, and fixed point theorems and common fixed point theorems in weak interval-valued metric spaces are also presented. Topics and strategies for further study are also put forward concretely and clearly. (shrink)