En la atención médica y en la investigación en salud resulta indispensable favorecer la toma de decisiones de los pacientes y/o participantes bajo el principio de autonomía. En particular, esta capacidad, consignada en la Convención de los Derechos de las Personas con Discapacidad, se concreta mediante la detección de necesidades de asistencia, ajustes y apoyos que dan paso a una plena y efectiva capacidad de ejercicio. Las reflexiones bioéticas hechas desde la perspectiva principialista, personalista y de los Derechos Humanos ofrecen (...) elementos para potenciar la autonomía de las personas con discapacidad, promoviendo la figura de asistencia personal y enfatizando el interés superior, la gradualidad y la revisión judicial permanente como principios de figuras sustitutivas. (shrink)

Among the hundreds of sites that housed survivors of Nazi persecution who came to Sweden in the spring and summer of 1945, one of the largest was at the small village of Öreryd. Between June 1945 and September 1946, around a thousand Jewish and non-Jewish Polish survivors came to this site, where they were expected to stay only until they were well enough to return to their home countries or migrate elsewhere. This article contributes to filling a gap in refugee (...) history in Sweden, dealing with how survivors experienced Swedish refugee camps and shaped the refugee camp environment on their own terms. Thinking with Peter Gatrell’s framework of ‘refugeedom’, a wide range of sources have been examined for insight into how Polish survivors in the Öreryd refugee camp navigated the precarity and uncertainty of their existence as survivors and refugees in Sweden and endeavoured to shape their immediate and future lives. (shrink)

The topology of DNA duplexes changes during replication and also after deproteinization in vitro. Here we describe these changes and then discuss for the first time how the distribution of superhelical stress affects the DNA topology of replication intermediates, taking into account the progression of replication forks. The high processivity of Topo IV to relax the left‐handed (+) supercoiling that transiently accumulates ahead of the forks is not essential, since DNA gyrase and swiveling of the forks cooperate with Topo IV (...) to accomplish this task in vivo. We conclude that despite Topo IV has a lower processivity to unlink the right‐handed (+) crossings of pre‐catenanes and fully replicated catenanes, this is indeed its main role in vivo. This would explain why in the absence of Topo IV replication goes‐on, but fully replicated sister duplexes remain heavily catenated. (shrink)