BackgroundCurrent preimplantation genetic testing (PGT) technologies enable embryo genotyping across the whole genome. This has led to the development of polygenic risk scoring of human embryos (PGT-P). Recent implementation of PGT-P, including screening for intelligence, has been extensively covered by media reports, raising major controversy. Considering the increasing demand for assisted reproduction, we evaluated how information about PGT-P is communicated in press media and explored the diversity of ethical themes present in the public debate.MethodsLexisNexis Academic database and Google News were (...) searched to identify articles about polygenic embryo screening. This led to 535 news articles. 59 original articles met the inclusion criteria. Inductive content analysis was used to analyse these articles.Results8.8% of articles gave embryo polygenic scoring a positive portrayal, while 36.8% expressed a negative attitude. 54.4% were neutral, mostly highlighting limited practical value of the technology in in vitro fertilization settings. We identified five main ethical themes that are also present in academic literature and the broader debate on reproductive technologies: a slippery slope towards designer babies, well-being of the child and parents, impact on society, deliberate choice and societal readiness.ConclusionsImplementation of embryo polygenic profiling engenders a need for specific recommendations. Current media analysis discloses important ethical themes to consider when creating future guidelines for PGT-P. (shrink)

In Western countries a considerable number of older people move to a residential home when their health declines. Institutionalization often results in increased dependence, inactivity and loss of identity or self-worth (dignity). This raises the moral question as to how older, institutionalized people can remain autonomous as far as continuing to live in line with their own values is concerned. Following Walker's meta-ethical framework on the assignment of responsibilities, we suggest that instead of directing all older people towards more autonomy (...) in terms of independence, professional caregivers should listen to the life narrative of older people and attempt to find out how their personal identity, relations and values in life can be continued in the new setting. If mutual normative expectations between caregivers and older people are not carefully negotiated, it creates tension. This tension is illustrated by the narrative of Mr Powell, a retired successful public servant now living in a residential home. The narrative describes his current life, his need for help, his independent frame of mind, and his encounters with institutional and professional policies. Mr Powell sees himself as a man who has always cared for himself and others, and who still feels that he has to fulfil certain duties in life. Mr Powell's story shows that he is not always understood well by caregivers who respond from a one-sided view of autonomy as independence. This leads to misunderstanding and an underestimation of his need to be noticed and involved in the residential community. (shrink)

Trust has been identified as an indicator within Social Quality theory. As an important component of social quality, trust has become increasingly important in modern society because literature suggests that trust in a number of democratic countries is declining. Modern technologies and specialties are often beyond the understanding of lay individuals and thus, the need for trusting relations between lay individuals and organizations/individuals has grown. The purpose of the study was to examine the extent to which Australians (dis)trust individuals and (...) organizations/institutions. A national postal survey was conducted with 1,044 respondents recruited using the electronic white pages directory. Findings from multivariate analyses suggest that income, age, sex, and health status are associated with trust in groups of individuals and trust in organizations/institutions. The findings highlight populations where trust needs to be (re)built. Future government policy and practice should utilize these findings as a means of facilitating social quality. (shrink)

Background Thirst and dry mouth are common symptoms in terminally ill patients. In their day-to-day practice, palliative care physicians regularly encounter ethical dilemmas, especially regarding artificial hydration. Few studies have focused on thirst and the ethical dilemmas palliative care physicians encounter in relation to this, leading to a knowledge gap in this area. Aim The aim of this study was to explore palliative care physicians’ experiences of ethical challenges in relation to thirst in terminally ill patients. Methods A qualitative interview (...) study with an inductive approach was conducted. Sixteen physicians working in four different specialised palliative care units and one geriatric care unit in different hospitals in Sweden were interviewed. The interviews were transcribed verbatim and analysed with a reflexive thematic analysis. Results When presented with an ethical challenge relating to thirst, physicians attempted to balance benefits and harms while emphasizing respect for the patient’s autonomy. The ethical challenges in this study were: Starting, continuing or discontinuing drips; lack of evidence and traditions create doubt; and lack of interest and time may result in patient suffering. Conclusions All physicians in this study reported that “Starting, continuing or discontinuing drips” was the main ethical challenge they encountered, where some were so accustomed to the decision that they had a standard answer ready to offer patients and families. Physicians reported that drips were a symbol of thirst quenching, life and survival but were not necessary in end-of-life care. Others questioned the traditions regarding thirst and emphasised drips in particular. (shrink)

Background Ethical principles behind prioritization in healthcare are continuously relevant. However, applying ethical principles during times of increased need, such as during the COVID-19 pandemic, is challenging. Also, little is known about nursing home nurses’ prioritizations in their work to achieve well-being and health for nursing home residents. Aim The aim of this study was to explore nursing home nurses’ priority-setting for older nursing home residents in Sweden during the COVID-19 pandemic. Research design, participants, and research context We conducted a (...) qualitative interview study. Data were collected through in-depth interviews (retrospective self-reports) between February and May 2021 with 21 nursing home nurses. To help respondents to recall their memories, we used the critical incident technique (CIT). We analyzed data within the theoretical framework and the methodological orientation of content analysis. Ethical considerations Written and verbal consent was obtained before the interviews, and information was given to participants informing them that participation was entirely voluntary. The Swedish Ethical Review Agency gave an advisory opinion stating that there were no ethical objections to the research project (Dnr. 2020-05649). Findings We identified an overarching theme—nursing home nurses struggling on multiple fronts, “just do it”—and seven categories: striving for survival and caring about a dignified death; responding sensitively to relatives’ expectations; ranking the urgency of needed care; responding to input from different actors; combating the spread of infection in unconventional ways; taking the lead and doing what is required; and following the ideals of person-centered nursing. Conclusions Nurses’ priority-setting for older nursing homes residents during the COVID-19 pandemic meant strain and struggle. In some cases, nurses had taken responsibility for priorities falling outside their statutory powers. Different demands and interests affected nurses’ priorities. Nursing home nurses need organizational and managerial support to prioritize. (shrink)

The topic of this thesis is how we should treat tiny probabilities of vast value. This thesis consists of six independent papers. Chapter 1 discusses the idea that utilities are bounded. It shows that bounded decision theories prescribe prospects that are better for no one and worse for some if combined with an additive axiology. Chapter 2, in turn, points out that standard axiomatizations of Expected Utility Theory violate dominance in cases that involve possible states of zero probability. Chapters (...) 3–6 discuss the idea that we should ignore tiny probabilities in practical decision-making. Chapter 3 argues that discounting small probabilities solves the ‘Intrapersonal Addition Paradox’ and thus helps avoid the Repugnant Conclusion. Chapter 4 explores what the most plausible version of this view might look like and what problems the different versions have. Chapter 5 focuses on one type of problem, namely, money pumps. The Independence Money Pump, in particular, presents a difficult challenge for those who wish to discount small probabilities. Finally, Chapter 6 discusses the implications of discounting small probabilities for the value of the far future. (shrink)

Why are we here? What is the meaning of life? How can we feel happy and free? The answers to these and other life questions are gathered in Tiny Buddha, Simple Wisdom for Life's Hard Questions. Tiny Buddha began as a quote-a-day Twitter account, @tinybuddha, in 2008. Lori Deschene's daily wisdom posts about mindfulness, non-attachment, and happiness became so popular that she now has more than 200,000 twitter followers who share quotes and stories about inspiration in their daily (...) lives.Deschene asked her Twitter followers to contribute their thoughts and perspectives on the difficult questions that influence how we live our everyday lives: thoughts about the meaning of life, pain, happiness, fate, and more.Tiny Buddha, Simple Wisdom for Life's Hard Questions is a combination of the amazing responses that she received along with her own insightful essays, and insights from wise teachers around the world and throughout time. Deschene explores how these issues have played out in her own life and offers action-oriented suggestions to help people empower themselves, even in a world with so much uncertainty. The result is a guide that helps readers discover the endless possibilities for a life lived mindfully in the present, and connected to others. (shrink)

We begin by showing that every theory of the value of uncertain prospects must have one of three unpalatable properties. _Reckless_ theories recommend giving up a sure thing, no matter how good, for an arbitrarily tiny chance of enormous gain; _timid_ theories permit passing up an arbitrarily large potential gain to prevent a tiny increase in risk; _non-transitive_ theories deny the principle that, if A is better than B and B is better than C, then A must be (...) better than C. Having set up this trilemma, we study its horns. Non-transitivity has been much discussed; we focus on drawing out the costs and benefits of recklessness and timidity when it comes to axiology, decision theory, and normative uncertainty. (shrink)

Would a tiny contribution such as the addition of one drop of water to the canteen of a thirsty person relieve her suffering? According to Barnett’s 2017 paper ‘No free lunch’, the answer is ‘yes’: even tiny contributions can make a morally relevant difference. To defend this answer, Barnett raises an objection against the rival view that tiny contributions never make any difference. I argue that we should reject both Barnett’s and the rival view. I propose an (...) alternative account that reflects the vagueness at play in the outcome of tiny contributions and entails that, in a range of cases, it is indeterminate whether these contributions make any difference. (shrink)

This paper explores the way in which Agamben takes part in the dialogue on “impolitical communities” that was inaugurated by J. L. Nancy and was soon followed by authors like M. Blanchot, J. Derrida and R. Esposito, among others. Although Agamben’s ontological exploration of ‘whatever being,’ followed later by the political idea of form-of-life, are still very close particularly to Nancy’s work, the article will show in which ways Agamben’s view of a political coming community explores different paths and moves (...) in unusual registers, that help to understand in new ways the kind of inoperativeness involved in a contemporary rethinking of community. The notion of experience of thought as potentiality and its relationship to that “tiny displacement” of the world which Agamben seems to connect with his idea of a coming community will play a central role in the analysis. (shrink)

Traditionally, theorists suggested that imaginative resistance is limited to morally repugnant claims. More recently, theorists have argued that the phenomenon of imaginative resistance is wider in scope, extending to descriptive claims. On both sides, though, theorists have focused on cases where imaginative resistance goes right, tracking something that is wrong with the story—that it is morally repugnant, or conceptually contradictory. I use a rarely cited discussion from Kant to argue that imaginative resistance can also occur when something goes wrong with (...) the reader—namely, when a reader imports their own biases into the story, and resists a descriptive claim as a result. In identifying this new class of claims that can meet imaginative resistance, Kant presses the question: when should we cultivate imaginative resistance and when should we fight it? (shrink)

We explore the existence and the size of infinite models of categorical theories having cardinality less than the size of the associated Tarski-Lindenbaum algebra. Restricting to totally transcendental, categorical theories we show that “Every tiny model is countable” is independent of ZFC. IfT is trivial there is at most one tiny model, which must be the algebraic closure of the empty set. We give a new proof that there are no tiny models ifT is not totally transcendental (...) and is non-trivial. (shrink)

In a discussion of Parfit's Drops of Water case, Zach Barnett has recently proposed a novel argument against “No Small Improvement”; that is, the claim that a single drop of water cannot affect the magnitude of a thirsty person's suffering. We first show that Barnett's argument can be significantly strengthened, and also that the fundamental idea behind it yields a straightforward argument for the transitivity of equal suffering. We then suggest that defenders of No Small Improvement could reject a Pareto (...) principle that is presupposed in Barnett's argument and our developments of it. However, this does not save No Small Improvement, since there is a convincing argument against this claim that does not presuppose the Pareto principle. (shrink)

This paper explores the way in which Agamben takes part in the dialogue on “impolitical communities” that was inaugurated by J. L. Nancy and was soon followed by authors like M. Blanchot, J. Derrida and R. Esposito, among others. Although Agamben’s ontological exploration of ‘whatever being,’ followed later by the political idea of form-of-life, are still very close particularly to Nancy’s work, the article will show in which ways Agamben’s view of a political coming community explores different paths and moves (...) in unusual registers, that help to understand in new ways the kind of inoperativeness involved in a contemporary rethinking of community. The notion of experience of thought as potentiality and its relationship to that “tiny displacement” of the world which Agamben seems to connect with his idea of a coming community will play a central role in the analysis. (shrink)

Summoning insights from dzimbahwe cultures of knowing—specifically indigenous ways of seeing, thinking, knowing, and doing as archived in local languages—this essay will first argue that the word “insect” did not exist among the author’s ancestors before the colonial moment and is too light and narrow to account for their sciences and what they did with and through them. Second, it proposes indigenous concepts that more adequately capture meanings of and human actions toward flying, crawling, burrowing, and swimming tiny animals, (...) possible through lived experience. Third, the author goes into and speaks through the language of his ancestors about their little animals without bones. He devotes the entire essay to just one type of boneless little animal—chifemanemusana (the one that breathes with its back)—drawing on both his ancestors’ and his own experiences with several zvifemanemusana (plural). (shrink)

We propose certain clases that seem unable to form a completed totality though they are very small, finite, in fact. We suggest that the existence of such clases lends support to an interpretation of the existence of proper clases in terms of availability, not size.

The World of a Tiny Insect: A Memoir of the Taiping Rebellion and Its Aftermath. By Zhang Daye, translated by XiaofeI Tian. Seattle: University of Washington Press, 2013. Pp. viii + 200. $75 ; $30.

Scientific realism is fundamentally a view about unobservable things, events, processes, and so on, but things can be unobservable either because they are tiny or because they are past. The familiar abductive arguments for scientific realism lend more justification to scientific realism about the tiny than to realism about the past. This paper examines both the “basic” abductive arguments for realism advanced by philosophers such as Ian Hacking and Michael Devitt, as well as Richard Boyd’s version of the (...) inference to the best explanation of the success of science, and shows that these arguments provide less support to historical than to experimental realism. This is because unobservably tiny things can function both as unifiers of the phenomena and as tools for the production of new phenomena, whereas things in the past can only serve as unifiers of the phenomena. The upshot is that realists must not suppose that by presenting arguments for experimental realism they have thereby defended realism in general.Author Keywords: Author Keywords: Realism; Abduction; Historical science; Hacking; Devitt; Boyd. (shrink)

Contrary to popular belief, population-wide preventive measures are rarely cost-reducing. Yet they can still be cost-effective, and indeed more cost-effective than treatment. This is often true of preventive measures that work by slightly reducing the already low risks of death faced by many people. This raises a difficult moral question: when we must choose between life-saving treatment, on the one hand, and preventive measures that avert even more deaths, on the other, is the case for prevention weakened when it works (...) by reducing many healthy people’s already low risks by a further tiny amount? I argue the answer is no. (shrink)

The essays in this Focus section expand the notion of writing insect histories of science by attending to matters of space and scale, ecological relationships, and institutional silences. They magnify diverse understandings about how the worlds of insects are noticed and understood by humans, what has historically counted as “insect,” and who narrates histories (of science). In doing so, the collection offers methodological suggestions for studying tiny animals in history that broaden the scope of often overlapping material, cultural, linguistic, (...) political, ethical, economic, and biological domains. It is precisely this magnified attention that foregrounds the domains’ interdependence and is necessary to make sense of additional bearers or forms of agency. (shrink)

Throughout the paper, I intersperse intimate movement episodes where I respond through my body and personal self to Naess. In grounding his own ecosophy, Naess makes his stand on a very certain place high up in the mountains called “Tvergastein.” His ecosophy T springs directly from his personalhome. Engaging with his texts I find I am not merely immersed in the usual way into a symbolic realm of ideas detached from my body, but have the odd feeling that I must (...) tilt my head to one side and slightly back so I can listen from where he speaks up there on that mountain. Thinking on an incline like this, I become aware that I am listening from down here. But from where down here? From where do I respond? Where is my home? Reading Naess in his place compels me to place my own response more particularly, more intimately. (shrink)

There is a well-known moral quandary concerning how to account for the rightness or wrongness of acts that clearly contribute to some morally significant outcome – but which each seem too small, individually, to make any meaningful difference. One consequentialist-friendly response to this problem is to deny that there could ever be a case of this type. This paper pursues this general strategy, but in an unusual way. Existing arguments for the consequentialist-friendly position are sorites-style arguments. Such arguments imagine varying (...) a subject’s predicament bit by bit until it is clear that a relevant difference has been achieved. The arguments offered in this paper are structurally different, and do not rely on any sorites series. For this reason, they are not vulnerable to objections that have been leveled against the sorites-style arguments. (shrink)

Dooley provides background information for each of the interviews, along with a thorough index.

Ethylene (C2H4) is a gaseous plant hormone produced by higher and lower (green) plants and, when grown on appropriate substrates, also by fungi, yeasts and bacteria. Ethylene is involved in many developmental processes in plants and is biologically active in trace amounts (10 – 100 nl/I of air) that may be present in the outside air due to industrial air pollution(1). Fruit ripening and flower senescence especially, in a variety of commercially important crops, are dramatically stimulated by ethylene. Following characterization (...) of the genes coding for the key enzymes in ethylene biosynthesis, i.e. ACC synthase and ACC oxidase, it has become clear that their expression is regulated in a complex manner involving developmental, hormonal and tissue‐specific factors. This was recently very elegantly demonstrated for the expression of ACC oxidase genes in developing petunia flowers by Tang et al.(2). The spatial and temporal expression patterns, especially in the reproductive organs, suggest a hitherto unknown role for ethylene in reproductive processes such as the self‐incompatible response and the secretion of cellular exudate by the stigma and nectary. (shrink)

A short article on philosophy in Malta, its tradition and practice.

This article discusses the transformation of a tiny three-dimensional artwork created in the metaverse that takes its inspiration from Jorge Luis Borges’s story of ‘the Aleph’ – a tale that revolves around a minute artefact that is ‘one of the points in space that contains all other points’. The visualization of a concept as complex as ‘the Aleph’ led the author of the project through a process that started from Cartesian precepts, from where it transformed itself into an investigation (...) of ‘code’ as a basal, life-giving presence that is abstract, enigmatic and hermetic in its essence. This correlation between ‘code’ and the magical nature of ‘the Aleph’ has led to further considerations regarding the significance of such a marvellous object within virtual worlds. Accordingly, this text will conclude with the description of an intriguing, novel usage for ‘the Aleph’ that materializes as a time machine for virtual-world avatars. (shrink)

No cure yet exists for devastating Alzheimer's disease (AD), despite many years and humongous efforts to find efficacious pharmacological treatments. So far, neither designing drugs to disaggregate amyloid plaques nor tackling solely inflammation turned out to be decisive. Mesenchymal stem cells (MSCs) and, in particular, extracellular vesicles (EVs) originating from them could be proposed as an alternative, strategic approach to attack the pathology. Indeed, MSC‐EVs—owing to their ability to deliver lipids/proteins/enzymes/microRNAs endowed with anti‐inflammatory, amyloid‐β degrading, and neurotrophic activities—may be exploited (...) as therapeutic tools to restore synaptic function, prevent neuronal death, and slow down memory impairment in AD. Herein the results presented in the most recently published studies on this topic are critically evaluated, providing a strong rationale for possible employment of MSC‐EVs in AD. (shrink)

A study of the reception of Aristotle's Prior Analytics in the first half of the twelfth century. It is shown that Peter Abaelard was perhaps acquainted with as much as the first seven chapters of Book I of the Prior Analytics but with no more. The appearance at the beginning of the twelfth century of a short list of dialectical loci which has puzzled earlier commentators is explained by noting that this list formalises the classification of extensional relations between general (...) terms and that this classification had already be put forward by Boethius in his de Syllogismo Categorico and Introductio ad Syllogismos Categoricas . It is pointed out the kind of text referred to as an ` Introductio ' at the beginning of the twelfth-century follows very closely the structure of Boethius own Introductio and adds to it material drawn from his accounts of loci and the conditional propositions. It is argued that the reception of the Prior Analytics has to be understood against the background of this well developed tradition of treating together syllogisms, loci , and conditional propostions. Referring to a challenge to the formal validity of Darapti in the Ars Meliduna the paper concludes by illustrating that the theory of the syllogism presented in Prior Analytics was still controversial in the middle of the twelfth-century. (shrink)