SUR2, similar to SUR1, is a regulatory subunit of the ATP‐sensitive potassium channel (KATP), which plays a key role in numerous important physiological processes and is implicated in various diseases. Recent structural studies have revealed that, like SUR1, SUR2 can undergo ligand‐dependent dynamic conformational changes, transitioning between an inhibitory inward‐facing conformation and an activating occluded conformation. In addition, SUR2 possesses a unique inhibitory Regulatory helix (R helix) that is absent in SUR1. The binding of the activating Mg‐ADP to NBD2 of (...) SUR2 competes with the inhibitory Mg‐ATP, thereby promoting the release of the R helix and initiating the activation process. Moreover, the signal generated by Mg‐ADP binding to NBD2 might be directly transmitted to the TMD of SUR2, prior to NBD dimerization. Furthermore, the C‐terminal 42 residues (C42) of SUR2 might allosterically regulate the kinetics of Mg‐nucleotide binding on NBD2. These distinctive properties render SUR2 intricate sensors for intracellular Mg‐nucleotides. (shrink)

Tianyi Zhang offers in this study an innovative philosophical reconstruction of Shihāb al-Dīn al-Suhrawardī's (d. 1191) Illuminationism. Commonly portrayed as either a theosophist or an Avicennian in disguise, Suhrawardīappears here as an original and hardheaded philosopher who adopts mysticism only as a tool of philosophical inquiry. Zhang makes use of Plato's cave allegory to explain Suhrawardī's Illuminationist project. Focusing on three areas-the theory of presential knowledge, the ontological discussion of mental considerations, and Light Metaphysics-Zhang convincingly reveals the Nominalist and (...) Existential nature of Illuminationism, and thereby proposes a new way of understanding how Suhrawardī's central philosophical ideas cohere. (shrink)

Amid great uncertainty along with the possibility of huge returns, venture investment decisions are both technical and artistic. Past studies have paid much attention to the influences of objective factors on venture investment. However, subjective factors have been relatively ignored. As a salient psychological mechanism, temporal focus is of great importance for venture capitalists when making their investment decisions. This study performed content analysis to investigate how temporal focus at the organizational level affects investment decisions of venture capital firms. The (...) results revealed that VCs with higher level of long-term orientation prefer to invest in less popular industries and ventures in the expansion period. Meanwhile, they are less likely to invest in very new start-ups. Moreover, long-term oriented VCs tend to re-invest in start-ups in their portfolios instead of just shooting once on numerous single start-ups. However, the author did not find any support on preferences of VCs for ventures with high level of human capital. (shrink)

Research investigating the underlying mechanisms and boundary conditions under which leader humility influences employee voice remains underdeveloped. Drawing from approach–inhibition theory of power and leader humility literature, we developed a moderated-mediation model in which personal sense of power (i.e., employees’ ability to influence other individuals such as their leader) was theorized as a unique mechanism underlining why employees feel motivated to speak up under the supervision of humble leaders. Additionally, the cultural value of power distance was proposed to be a (...) relevant boundary condition to influence such relationship. We tested the model using time-lagged supervisor–subordinate matched data. Results of mixed models analyses provided support for our hypotheses confirming that employees’ personal sense of power mediates the relationship between leader humility and employee voice, and such relationship was found to be stronger when employees’ power distance was lower rather than higher. (shrink)

When we say “I know why he was late”, we know not only the fact that he was late, but also an explanation of this fact. We propose a logical framework of “knowing why” inspired by the existing formal studies on why-questions, scientific explanation, and justification logic. We introduce the Kyi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{\mathcal {K}}{}\textit{y}}_i$$\end{document} operator into the language of epistemic logic to express “agent i knows why φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} (...) \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document}” and propose a Kripke-style semantics of such expressions in terms of knowing an explanation of φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document}. We obtain two sound and complete axiomatizations w.r.t. two different model classes depending on different assumptions about introspection. Finally we connect our logic with justification logic technically by providing an alternative semantics and an in-depth comparison on various design choices. (shrink)

It is well-documented that emotional stimuli impact both the cognitive and motor aspects of “goal-directed” behavior. However, how emotional distractors impact motor performance remains unclear. This study aimed to characterize how movement quality was impacted during emotional distractors. We used a modified oddball paradigm and documented the performance of pure movement. Participants were designated to draw a triangle or a polygon, while an emotional stimulus was presented. Speed was assessed using reaction time and movement time. The quality and precision of (...) movement were assessed by calculating the accuracy and root-mean-square error. Compared to drawings of triangles, polygons had higher accuracy under negative stimuli, but lower RMSE under positive stimuli. The results indicate that distracting emotional stimuli impact different aspects of movement quality, with movement complexity influencing accuracy under negative distractors and precision under positive distractors. This study provides further evidence that movement precision is an important feature of emotional embodiment that should be incorporated in future studies. (shrink)

Medical students lack opportunities to have authentic conversations with patients with cancer in busy hospitals. An improved understanding of what such communication might look like may provide a framework for end-of-life curricula. The authors performed thematic analysis using written correspondence between patient and student participants in the University of California, San Francisco’s Firefly Program whose letters discussed death or dying. Four themes emerged: (1) turmoil, (2) grief, (3) making peace, and (4) past, present, and future. Medical students expressed a fifth (...) theme: unmet student expectations. The study provides educators with a unique perspective to help inform curriculum development and patient care. (shrink)

Driven by the theory of sustainable development, Chinese firms have gradually realized the importance of ESG disclosure. Executives play a core role in ESG decision-making, but whether and how top management team (TMT) faultlines affect ESG disclosure has yet to be systematically discussed. Based on the attention-based view and faultline theory, we select 6456 observations of 910 Chinese A-share listed firms from 2012 to 2021 as the research object to empirically test the above critical practical issues that have not been (...) fully answered. We find that TMT information-based faultlines improve firms' ESG disclosure, but TMT social category faultlines reduce firms' ESG disclosure. In addition, the internal mechanism test showed that the TMT's future-oriented attention plays a mediating role in the above relationship. Finally, we also find that institutional shareholding enhances the positive impact of the TMT's future-oriented attention on ESG disclosure. This study enriches the literature on TMT faultlines and ESG disclosure, demonstrating that the composition of the TMT and its attention allocation are important factors for promoting firms' ESG disclosure. The conclusions of this study can help firms strengthen their ESG disclosure by building efficient TMTs and provide important implications for firms to better fulfill their ESG responsibilities. (shrink)

The study aims to help primary and secondary school students develop a good habit of physical exercise by exploring the current situation of physical exercise of primary and secondary school students and analyzing the factors affecting their physical exercise. Then, intervention strategies are figured out for different groups of students and help them develop a good habit of physical exercise. From the perspective of educational psychology and parents’ entrepreneurship education, the research on the physical exercise of primary and secondary school (...) students is conducted by a questionnaire survey, mathematical statistics and literature review. A total of 280 students from five schools in Tianjin are selected as the research subjects, and the current situation of students’ physical exercise in these five schools is investigated. The results show that 40.5% of boys and 39.4% of girls can take physical exercise more than three times a week; 48.9% of the students do physical exercise for more than 30 mins each time; the students who usually take regular exercise at school account for 82.1%. The physical exercise that students always do is running, badminton and table tennis, which rank the top three among the sports they do. The students usually play basketball, volleyball, and football, and they rarely do the sports like swimming, Wushu, and aerobics. This result is closely related to the characteristics and places of primary and middle school students. The survey shows that the physical exercise awareness of most primary and secondary school students is correct; most students can participate in physical exercise, but few students can do it regularly; parents’ support, parents’ habits of doing exercise, and family’s spending on physical exercise have a significant impact on developing students’ habits of doing physical exercise. Based on the above, it is concluded that the primary and secondary stage is very important for students. Physical education teachers should follow the principle of teaching different students with different methods, enrich teaching materials, and improve teaching quality. The study provides a reference for the reform of PE to guide primary and middle school students to participate in sports activities, improving students’ physical quality. (shrink)

This study examined the relationship between maternal sense of parenting efficacy and parental stress in children with autism and the moderating effect of family interaction. A total of 263 mothers of children with autism were investigated with the Parenting Ability Scale, Family Interaction Scale, and Parental Stress Scale. The results showed that maternal sense of parenting efficacy significantly predicted parental stress in children with autism; and family interaction significantly moderated the relationship between maternal sense of parenting efficacy and parental stress (...) in children with autism, that is, when family interaction was lower than −1.54 standard deviation, the sense of parenting efficacy did not significantly predict parental stress. When family interaction was higher than −1.54 SD, parenting efficacy had a significant negative predictive effect on parenting stress. (shrink)

In "Comparative Literature, Variation Theory, and a New Construction of World Literature" Wang Chao discusses Shunqing Cao's "variation theory" as a framework in the discipline of comparative literature and its applicability for a new construction of world literature. Wang argues that Goethe's concept of world literature can be expanded and developed for a new construction of the idea of world literature. Wang's principal argument is that comparative literature in today's heterogeneity and cross-cultural variabilities can be revived with the notions (...) of variation and its connecting aspect of world literature. Both variation theory and perspectives of the concept of "new world literature" are based in recent insights in comparative literature, on variations of literary exchange, on interpretation in cross-civilization literary circulation, translation, and production. Wang proposes that these views broaden and adjust the boundary of comparability, thus injecting much-needed vitality into comparative literature and world literature research. (shrink)

Business Ethics: A European Review, Volume 30, Issue 2, Page 231-243, April 2021.

Business Ethics: A European Review, Volume 30, Issue 2, Page 231-243, April 2021.

The choice of coping style of recruits under psychological stress in the process of military task execution has been an important topic in the promotion of military operations and cohesion of military forces. Taking a positive coping style under psychological stress can help recruits overcome the negative effects of stress and improve military morale and group combat effectiveness. Although soldiers' psychological stress in the process of military mission execution having an impact on coping style has been studied by a large (...) body of literature, very little literature has focused on the mechanism of self-efficacy and social support between recruits' psychological stress and coping style from the person-environment fit perspective. Therefore, this study was conducted to analyze the impact of recruits' psychological stress on coping style through a chain mediation model and to discuss the role of self-efficacy and social support in this relationship. Two waves of survey data were utilized to test the research hypotheses on a sample of 1028 Chinese recruits performing military tasks. The results indicated that recruits' psychological stress negatively impacted positive coping styles and positively correlated with negative ones. In addition, self-efficacy and social support mediated the relationship between psychological stress and positive coping style, and self-efficacy mediated the relationship between psychological stress and negative coping style. More importantly, self-efficacy and social support play the chain mediating effect between psychological stress and positive coping style. (shrink)

In ancient Chinese thoughts, de is a comparatively complicated idea. Most of the researchers translated it directly into "virtue", but this translation is not accurate for our understanding of the idea of "de" in pre-Qin times. Generally speaking, in Pre-Qin times, the idea of"de" underwent three developmental periods. The first is the de of Heaven, the de of ancestors; the second the de of system; and the third the de of spirit and moral conducts. In a long period of history, (...) the idea of "de" never cast off the influence of tian Dao (the way of Heaven). It was in Western Zhou Dynasty that the idea of "de" shook off the dense fog of the mandate of Heaven. However, it was the thinkers in Spring and Autumn Period and Warring States who made contributions to bring it deep into people's mind. The ancient Chinese thoughts were mainly concerned with people's recognition and development of their own abilities, with people's seeking harmony and balance between human-beings and nature, and with people's seeking harmonious and balanced human relations. The development of the idea of "de" played a very important role in this context. (shrink)

Considering the highly complex structure of quantum chaos and the nonstationary characteristics of speech signals, this paper proposes a quantum chaotic encryption and quantum particle swarm extraction method based on an underdetermined model. The proposed method first uses quantum chaos to encrypt the speech signal and then uses the local mean decomposition method to construct a virtual receiving array and convert the underdetermined model to a positive definite model. Finally, the signal is extracted using the Levi flight strategy based on (...) kurtosis and the quantum particle swarm optimization optimized by the greedy algorithm. The bit error rate and similarity coefficient of the voice signal are extracted by testing the source voice signal SA1, SA2, and SI943 under different SNR, and the similarity coefficient, uncertainty, and disorder of the observed signal and the source voice signal SA1, SA2, and SI943 verify the effectiveness of the proposed speech signal extraction method and the security of quantum chaos used in speech signal encryption. (shrink)

In coal mining industry, the running state of mine ventilators plays an extremely significant role for the safe and reliable operation of various industrial productions. To guarantee the better reliability, safety, and economy of mine ventilators, in view of early detection and effective fault diagnosis of mechanical faults which could prevent unscheduled downtime and minimize maintenance fees, it is imperative to construct some viable mathematical models for mine ventilator fault diagnosis. In this article, we plan to establish a data-based mine (...) ventilator fault diagnosis method to handle situations where engineers are absent or they are incapable of coming to a conclusion from multisource data. In the process of building the mine ventilator fault diagnosis model, considering that probabilistic rough sets could reduce the errors triggered by incompleteness, inconsistency, and inaccuracy without needing any additional assumptions and Pythagorean fuzzy multigranulation rough sets over the two universes’ model could effectively handle data representation, fusion, and analysis issues, we generalize the existing PF MGRSs over the two universes’ model to the PRS setting, as well as to further establish a novel model named Pythagorean fuzzy multigranulation probabilistic rough sets over two universes. In the granular computing paradigm, three types of PF MG-PRSs over two universes based on the risk attitude of engineers are proposed at first. Afterwards, several basic propositions of the newly proposed model are explored. Moreover, a PF multigranulation probabilistic model for mine ventilator fault diagnosis based on PF MG-PRSs over two universes is investigated. At last, a real-world case study of dealing with a mine ventilator fault diagnosis problem is given to illustrate the practicality of the presented model, and a validity test, a sensitivity analysis, and a comparison analysis are further explored to demonstrate the effectiveness of the presented model. (shrink)

How to make sense of Kant's theory of radical evil is a controversial problem, for the solution of which three approaches have been attempted: (1) the anthropological, (2) the transcendental, and (3) the quasi‐transcendental. This article aims at developing a new quasi‐transcendental approach to radical evil, and its main innovation consists in reinterpreting the propensity to evil as a potential for moral evil, whose nuanced modality (i.e., potentiality) lies between full actuality and logical (empty) possibility. This evil potential inherent to (...) our species' nature can be actualized by individual Willkür in one's evil Gesinnung. Thanks to this reinterpretation, not only the compatibility of radical evil with individual freedom will be convincingly demonstrated, because the potential for evil only strongly pushes rather than necessitating individuals to do evil, but also Kant's bold statement “the human being is by nature evil” becomes easily confirmable, because even a single individual's illegal action provides sufficient empirical evidence to a regressive argument for the transcendental precondition for evil in his species' nature. (shrink)

We examined how the cultural dimension of universalism–particularism influences managers’ attitudes toward relational favoritism. Paradoxically, we found in a survey study that Brazilian and Chinese managers perceived more negative consequences of relational favoritism than did American managers—even though the Brazilians and the Chinese perceived stronger particularistic cultural norms in their countries than Americans did in the United States. We attribute this pattern of results to “cultural reflexivity”—the ability of people from transforming economies to be culturally self-critical during a period of (...) dramatic societal change. This pattern of results also emerged in a scenario study in which we asked these same Brazilian, Chinese, and American participants to assess managerial succession decisions made by a General Manager. We varied the scenarios so that the promoted manager was either a colleague with no pre-existing relation with the GM or a colleague who was a relative, a close friend, from the same town, or from the same school. Consistent with the results of the survey study, we found that perceived cultural norms of particularism were negatively related to perceptions of fairness. In other words, Brazilians and Chinese, even while living in more particularistic cultures, were more harsh in judging relational favoritism. We conclude with a discussion on the implications of these paradoxical relationships. (shrink)

With the development of learning abroad, deep learning is used in research fields. On the basis of deep learning, this article studies physical education. First, this article analyzes and explains the related concepts and current situation of physical education, and explains the measurement and definition of the mental health. Then, the function analysis algorithm of deep learning is explained and analyzed, in which the algorithm of the convolution neural network of deep learning is mainly described. Finally, through experimental analysis, it (...) shows that the research performance of deep learning in the physical education on college students’ mental health is relatively high. At the same time, through investigation and analysis, it is proposed that physical education in deep learning can improve mental health and social adaptability relatively high. And the content of physical education should focus on increasing physical psychological education and physical practice education, which can improve college students’ mental health and social adaptability compared with other teaching contents. Therefore, when introducing deep learning, universities should strengthen the physical education of college students. (shrink)

In order to usurp the Party, seize power and restore capitalism, the Wang-Chang-Chiang-Yao anti-Party clique has turned out counterrevolutionary opinions in the ideological realm. They have tried in every way to distort and revise history and have fabricated the "struggle between the Confucianists and the Legalists" in history. They have confounded different social contradictions and have replaced the class struggle with the "struggle between the Confucianists and the Legalists" and the antagonism within the landlord class with the "line struggle." To (...) them, Legalists were always "progressive" and "innovative" while Confucianists always "represented the forces of restoration." They have tried their best to glorify emperors, kings, generals and ministers in history, to praise Legalists as "saviors," to cover up the Legalists' nature as an exploiting class, to call for metaphysics and the idealist viewpoint of history, and to turn out revisionist fallacies. Because important changes took place in the Confucian and Legalist schools during the periods of the Western and Eastern Han dynasties, the "Gang of Four" and the writers in its service have showed a great interest in histories of the dynasties and have published a series of articles on the so-called "struggle between the Confucianists and the Legalists." In the current struggle against the "Gang of Four," it is of great practical significance to review the changes in the Confucian and Legalist schools and their roles and class nature during the Han dynasties, to criticize and expose the criminal clique's counterrevolutionary political intrigues and plots, and to clarify the historical facts confused by the "Gang of Four.". (shrink)

We explored whether children could apply linguistic strategies for lying, i.e., manipulating linguistic content of speech to mislead others. We announced a knowledge-test entailing prizes in the classrooms of a primary school and a middle school. Altogether 79 Chinese children (6-18 years) voluntarily participated in the test: listening to a series of animal sounds before guessing the names of the animals. Meanwhile, behind the participants, a video was playing images that ostensibly corresponded to the sounds being played. In fact, this (...) was not necessarily the case, i.e., some items cannot be solved because the sounds played are not from any animal but machine-synthesized. Participants were instructed not to look back at the video. However, 51 children peeked at the video for the unsolvable items, although the peeking behavior decreased with age. Moreover, when explaining how they correctly guessed the unsolvable items, children as young as six years old were able to apply a linguistic strategy (i.e., "capability attribution") for lying. Besides "capability attribution", Children also applied "fortune attribution" and "topic shift" for lying. Finally, "fortune attribution" and "topic shift" increased with age. Therefore, educators need to be aware that children are able to apply verbal strategies for lying that could involve truthful statements (i.e., "topic shift") or statements that are difficult to be proved as untruthful (i.e., "fortune attribution"). (shrink)