Mitochondrial function and biogenesis depend on the transport of a large variety of proteins, ions, and metabolites across the two surrounding membranes. While several specific transporters are present in the inner membrane, transport processes across the outer membrane are less understood. Recent studies reveal that the number of outer membrane channels and their transport mechanisms are more diverse than originally thought. Four protein‐conducting channels promote transport of distinct sets of precursor proteins across and into the outer membrane. The voltage‐dependent anion (...) channel (VDAC) forms the major channel for small hydrophilic molecules. In addition, three channels with yet unknown substrate specificity exist in the outer membrane. In this review, we outline the emerging functional diversity, selectivity, and regulation of mitochondrial outer membrane channels. The presence of several channel‐forming proteins challenges the traditional view that the outer membrane forms an unspecific size‐exclusion filter for the flux of small hydrophilic molecules. (shrink)

In the 20th century, genetic explanatory approaches became dominant in both developmental and evolutionary biological research. By contrast, physical approaches, which appeal to properties such as mechanical forces, were largely relegated to the margins, despite important advances in modeling. Recently, there have been renewed attempts to find balanced viewpoints that integrate both biological physics and molecular genetics into explanations of developmental and evolutionary phenomena. Here we introduce the 2017 SICB symposium “Physical and Genetic Mechanisms for Evolutionary Novelty” that was dedicated (...) to exploring empirical cases where both biological physics and developmental genetic considerations are crucial. To further contextualize these case studies, we offer two theoretical frameworks for integrating genetic and physical explanations: combining complementary perspectives and comprehensive unification. We conclude by arguing that intentional reflection on conceptual questions about investigation, explanation, and integration is critical to achieving significant empirical and theoretical advances in our understanding of how novel forms originate across the tree of life. (shrink)

Several proof-theoretic notions of validity have been proposed in the literature, for which completeness of intuitionistic logic has been conjectured. We define validity for intuitionistic propositional logic in a way which is common to many of these notions, emphasizing that an appropriate notion of validity must be closed under substitution. In this definition we consider atomic systems whose rules are not only production rules, but may include rules that allow one to discharge assumptions. Our central result shows that Harrop’s rule (...) is valid under substitution, which refutes the completeness conjecture for intuitionistic logic. (shrink)

Firm innovation creates an informational asymmetry between the firm and outside stakeholders. Since CSR activities have been shown to reduce asymmetries and risk we surmise that firms use discretionary CSR activities to reduce the asymmetries from innovation. We study an innovation intense industry and find results that support the hypothesis that firms use CSR to signal long term viability of innovative activities.

This research tests a model of employee helping behavior (a component of Organizational Citizenship Behavior, OCB) that involves a direct path (Intrinsic Motives → Helping Behavior, the Good Samaritan Effect) and an indirect path (the Love of Money → Extrinsic Motives → Helping Behavior). Results for the full sample supported the Good Samaritan Effect. Further, the love of money was positively related to extrinsic motives that were negatively related with helping behavior. We tested the model across four cultures (the USA., (...) Taiwan, Poland, and Egypt). The Good Samaritan Effect was significant for all four countries. For the indirect path, the first part was significant for all countries, except Egypt, whereas the second part was significant for Poland only. For Poland, the indirect path was significant and positive. The love of money may cause one to help in one culture (Poland) but not to help in others. Results were discussed in the light of ethical decision making. (shrink)

The inversion principle for logical rules expresses a relationship between introduction and elimination rules for logical constants. Hallnäs & Schroeder-Heister proposed the principle of definitional reflection, which embodies basic ideas of inversion in the more general context of clausal definitions. For the context of admissibility statements, this has been further elaborated by Schroeder-Heister . Using the framework of definitional reflection and its admissibility interpretation, we show that, in the sequent calculus of minimal propositional logic, the left introduction rules are admissible (...) when the right introduction rules are taken as the definitions of the logical constants and vice versa. This generalizes the well-known relationship between introduction and elimination rules in natural deduction to the framework of the sequent calculus. (shrink)

Why are negative emotions so central in art reception far beyond tragedy? Revisiting classical aesthetics in the light of recent psychological research, we present a novel model to explain this much discussed (apparent) paradox. We argue that negative emotions are an important resource for the arts in general, rather than a special license for exceptional art forms only. The underlying rationale is that negative emotions have been shown to be particularly powerful in securing attention, intense emotional involvement, and high memorability, (...) and hence is precisely what artworks strive for. Two groups of processing mechanisms are identified that conjointly adopt the particular powers of negative emotions for art's purposes. The first group consists of psychological distancing mechanisms that are activated along with the cognitive schemata of art, representation, and fiction. These schemata imply personal safety and control over continuing or discontinuing exposure to artworks, thereby preventing negative emotions from becoming outright incompatible with expectations of enjoyment. This distancing sets the stage for a second group of processing components that allow art recipients to positively embrace the experiencing of negative emotions, thereby rendering art reception more intense, more interesting, more emotionally moving, more profound, and occasionally even more beautiful. These components include compositional interplays of positiveandnegative emotions, the effects of aesthetic virtues of using the media of (re)presentation (musical sound, words/language, color, shapes) on emotion perception, and meaning-making efforts. Moreover, our Distancing-Embracing model proposes that concomitant mixed emotions often help integrate negative emotions into altogether pleasurable trajectories. (shrink)

Philosophical arguments often assume that the folk tends towards moral objectivism. Although recent psychological studies have indicated that lay persons’ attitudes to morality are best characterized in terms of non-objectivism-leaning pluralism, it has been maintained that the folk may be committed to moral objectivism _implicitly_. Since the studies conducted so far almost exclusively assessed subjects’ metaethical attitudes via explicit cognitions, the strength of this rebuttal remains unclear. The current study attempts to test the folk’s implicit metaethical commitments. We present results (...) of a newly developed Implicit Association Test (IAT) for metaethical attitudes which indicate that the folk generally tend towards moral non-objectivism on the implicit level as well. We discuss implications of this finding for the philosophical debate. (shrink)

In this article we present a new experimental paradigm: comparative visual search. Each half of a display contains simple geometrical objects of three different colors and forms. The two display halves are identical except for one object mismatched in either color or form. The subject's task is to find this mismatch. We illustrate the potential of this paradigm for investigating the underlying complex processes of perception and cognition by means of an eye‐tracking study. Three possible search strategies are outlined, discussed, (...) and reexamined on the basis of experimental results. Each strategy is characterized by the way it partitions the field of objects into “chunks.” These strategies are: (i) Stimulus‐wise scanning with minimization of total scan path length (a “traveling salesman” strategy), (ii) scanning of the objects in fixed‐size areas (a “searchlight” strategy), and (iii) scanning of object sets based on variably sized clusters defined by object density and heterogeneity (a “clustering” strategy). To elucidate the processes underlying comparative visual search, we introduce besides object density a new entropy‐based measure for object heterogeneity. The effects of local density and entropy on several basic and derived eye‐movement variables clearly rule out the traveling salesman strategy, but are most compatible with the clustering strategy. (shrink)

On analyse l’interprétation BHK de constantes logiques sur la base d’une prise en compte systématique de Prawitz, résultant en une reformulation de l’interprétation BHK dans laquelle l’assertabilité de propositions atomiques est déterminée par des systèmes de Post. On démontre que l’interprétation BHK reformulée rend davantage de propositions assertables que la logique propositionnelle intuitionniste rend prouvable. La loi de Mints est examinée en tant qu’exemple d’une telle proposition. La logique propositionnelle intuitionniste devrait par conséquent être considérée comme étant incomplète. Nous concluons (...) par une discussion sur l’adéquation de l’interprétation BHK de l’implication. (shrink)

Cigarette smoking and other addictive behaviors are among the main preventable risk factors for several severe and potentially fatal diseases. It has been argued that addictive behavior is controlled by an automatic-implicit cognitive system and by a reflective-explicit cognitive system, that operate in parallel to jointly drive human behavior. The present study addresses the formation of implicit attitudes towards smoking in both smokers and non-smokers, using a Go/NoGo association task, and behavioral and electroencephalographic measures. The GNAT assesses, via quantifying participants’ (...) reaction times, the strength of association between a target category and either pole of an evaluative dimension. EEG analysis is performed to determine the temporal course of the event-related potential components underlying Go/NoGo decisions and implicit attitude formation. Both smokers and non-smokers showed prolonged reaction times to smoking-related pictures when the pictures were coupled with positive evaluative words. This indicates negative implicit attitudes towards smoking in both groups alike at the time point of the behavioral response. However, only the non-smokers, not the smokers, were found to show a delay of the N200 component in the incongruent condition. This is interpreted as reflecting ambivalent or even positive implicit attitudes towards smoking in the smoker group at the time point of the N200. Our study thus provides evidence for the hypothesis that implicit attitudes are subject to changes within several hundred milliseconds after stimulus presentation, and can be altered in the course of their formation. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

Aristotelian commenters have long noted an apparent contradiction between what Aristotle says in Posterior Analytics I.2 and Physics I.1 about how we obtain first principles of a science. At Posterior 71b35–72a6, Aristotle states that what is most universal (καθόλου) is better-known by nature and initially less-known to us, while the particular (καθ’ ἕκαστον) is initially better-known to us, but less-known by nature. At Physics 184a21-30, however, Aristotle states that we move from what is better-known to us, which is universal (καθόλου), (...) to what is better-known absolutely, which is particular (καθ’ ἕκαστον). This paper turns to two of Aristotle’s most notable medieval commentators—Albertus Magnus and Thomas Aquinas—to resolve this apparent contradiction. The key to Thomas and Albert’s solutions, we will argue, is a twofold distinction between a sense-perceptive and scientific universal, and the particulars as sensed individuals and as differentiating attributes. Our Synthetic treatment of these distinctions contributes to the ongoing scholarly effort to understand the Stagyrite’s complex theory of knowledge. (shrink)

In his groundbreaking Grundlagen, Frege (1884) pointed out that number words like ‘four’ occur in ordinary language in two quite different ways and that this gives rise to a philosophical puzzle. On the one hand ‘four’ occurs as an adjective, which is to say that it occurs grammatically in sentences in a position that is commonly occupied by adjectives. Frege’s example was (1) Jupiter has four moons, where the occurrence of ‘four’ seems to be just like that of ‘green’ in (...) (2) Jupiter has green moons. On the other hand, ‘four’ occurs as a singular term, which is to say that it occurs in a position that is commonly occupied by paradigmatic cases of singular terms, like proper names: (3) The number of moons of Jupiter is four. Here ‘four’ seems to be just like ‘Wagner’ in (4) The composer of Tannhäuser is Wagner, and both of these statements seem to be identity statements, ones with which we claim that what two singular terms stand for is identical. But that number words can occur both as singular terms and as adjectives is puzzling. Usually adjectives cannot occur in a position occupied by a singular term, and the other way round, without resulting in ungrammaticality and nonsense. To give just one example, it would be ungrammatical to replace ‘four’ with ‘the number of moons of Jupiter’ in (1): (5) *Jupiter has the number of moons of Jupiter moons. This ungrammaticality results even though ‘four’ and ‘the number of moons of Jupiter’ are both apparently singular terms standing for the same object in (3). So, how can it be that number words can occur both as singular terms and as adjectives, while other adjectives cannot occur as singular terms, and other singular terms cannot occur as adjectives? (shrink)

Johann Jakob Wagner (1775-1841), disciple de Schelling et important acteur de la Naturphilosophie allemande, publie en 1803 un ouvrage intitulé Von der Natur der Dinge où il lance le projet d’une réforme de la mathématique visant à l’intégrer à la philosophie. Il provoque ainsi un débat animé dans lequel divers acteurs, scientifiques et philosophes, vont exprimer leur point de vue sur la relation entre les deux disciplines. Nous nous intéresserons en particulier à la réponse de Johann Schön (1771-1839), un (...) mathématicien qui publie l’année suivante un livre aujourd’hui oublié dans lequel il rejette vigoureusement le projet de Wagner. L’analyse de ce débat aide, dans le contexte des réformes universitaires du début du xixe, à comprendre l’histoire de l’émergence en Allemagne d’une discipline mathématique autonome, ainsi que l’apparition de nouvelles problématiques autour de l’axiomatisation et de la systématique. (shrink)

As frequently pointed out in this discussion, one of the most characteristic features of Mayr's approach to the history of biology stems from the fact that he is dealing to a considerable degree with his own professional history. Furthermore, his main criterion for the selection of historical episodes is their relevance for modern biological theory. As W. F. Bynum and others have noted, the general impression of his reviewers is that “one of the towering figures of evolutionary biology has now (...) written a towering history of his discipline.”138 Bynum is here referring to The Growth of Biological Thought, but this observation holds equally true for Mayr's other historical writings: One must surely read this book [One Long Argument] not only for its content in itself, but for what it tells of its author. And certainly as one does so, one comes away full-handed. Many, if not all, of the disputes and controversies that have driven Mayr through his long intellectual life reappear, stated as forcefully and elegantly as ever.139Up to this point, most reviewers agree; the bone of contention is, rather, how to evaluate Mayr's historical work, considering this observation. The two related characteristics of his work-I will call them subjectivity and presentism-stand in opposition to a widespread approach in the history of science exemplified by Kuhn's suggestion that “insofar as possible..., the historian should set aside the science that he knows. His science should be learned from the textbooks and journals of the period he studies.”140 There are, however, historians who consider the close connection between Mayr and the subject matter of his historical studies to be an advantage.141On the other hand, it is assumed that the connection between past and present must result in a distortion of the historical truth and lead to a historiographical fallacy, commonly referred to as “Whig history”. Herbert Butterfield, who in 1931 gave the term its now generally accepted meaning, believed that “real historical understanding is not achieved by the subordination of the past to the present, but rather by our making the past our present and attempting to see life with the eyes of another century than our own”142. Unfortunately, Butterfield's definition of what he considers Whig history remains somewhat vague, and modern authors have emphasized what they consider most important. Butterfield's “subordination of the past to the present” is referred to in respect to the selection of subjects (there are more biographies of Charles Darwin than of, let's say, Louis Agassiz),143 to the evaluation of historical authors,144 or, more generally, to all kinds of histories “with one eye, so to speak, upon the present.”145 The underlying tendency of Whig historians is to produce a “historical account told from the viewpoint of those in power,”146 leading to a “glorification of the present.”147 It is obvious that Mayr's strongly presentist approach to the history of biology can be called Whiggish, if we apply the criteria of “selection” or “reference.” However, it might be worth mentioning that the program of writing a strictly historicist account of the history of science is challenged by various authors.148 For Mayr, it is not only legitimate but necessary to compare the present situation with the past. “Whiggish” is only the evaluation of an author in terms of our time.149I cannot discuss the Whit/anti-Whig controversy in any detail here, apart from saying that Mayr has defended himself rather extensively against the charges of being Whiggish.150 Nevertheless, it may be useful to touch on some of the criticisms that are predominant in reviews of his writings. First, we encounter the notion that historians can write a true and convincing historical account only if they have no personal interest or interpretation of their own; Mayr, on the other hand, because he “has such strong interpretations of his own, ... cannot possibly convince everyone that he is right about everything.”151 It makes one wonder, what historian has ever been able to convince everyone that he or she is right about everything? But apart from this peculiar idea, it unquestionably poses certain dangers if the subject matter of historical scrutiny and the author are identical. At the same time, this identity brings certain advantages with it, especially firsthand experiences of the period in discussion. Whether these personal memories ultimately result in a distorted picture of the past has to be decided in every particular instance. The notion that a scientific study can be conducted by a completely detached observer from a neutral standpoint has been shown to be impossible in physics, and it is also an illusion in historiography. The question is not whether, but which kind of interest are the underlying motivation for a historian. At this point, Mayr is ahead of his critics when he suggests that our understanding of the past always has a subjective component: The main reason, however, why histories are in constant need of revision is that at any given time they merely reflect the present state of understanding; they depend on how the author interpreted the current zeitgeist of biology and on his own conceptual framework and background. Thus, by necessity the writing of history is subjective and ephemeral.152Second, the temporal proximity between the event and the historical analysis makes difficulties inevitable and will finally result in certain false assessments. But this applies to all historians when they discuss recent problems, regardless of whether they are personally involved or not: As long as the battle between Darwinism and Lamarckism was raging, it was quite impossible to undertake an unbiased evaluation of Lamarck. ...[The] definite refutation of Lamarck's theory of evolutionary causation clears the air. We can now study him without bias and emotion and give him the attention that this major figure in the history of biology clearly deserves.153Third, Mayr is primarily interested in biological problems and not, for instance, historiographical, sociological, or psychological questions. Several authors have remarked that since the beginning of the professionalization of the history of science in the 1960s, a rift between two groups has developed, resulting from the heterogeneous professional backgrounds and interests of the people involved: the authors who were originally biologists and became interested in the history of their discipline only later on, and the authors who were trained as historians.154 Whereas the first group, the “biologists,” tend to be laymen in history proper, the “historians” are in most cases laymen in biology. Different professional backgrounds obviously shape the historical perspective in both groups, but neither approach is necessarily superior. The great number of important books in the history of biology written by “biologist” documents how valuable this point of view can be. On the other hand, it cannot be denied that the writings of biologists in the history of science tend to have a strong “internalist” tendency and often neglect the professional, cultural, and political context of science. Mayr's approach is that of a “biologist”; it is “internalist,” and typical for scientists who turn to the history of their discipline.I want to conclude my analysis with a quotation from a review by Douglas J. Futuyma, which gives a perceptive glimpse of Mayr's personality and style: One cannot help standing in awe of the germanic capacity for vast, allembracing synthesis: consider the lifelong devotion of Goethe to Faust, or Wagner's integration of the arts into a Gesamtkunstwerk in which all of human history and experience is wrought into epic myth. It is perhaps in this tradition that Ernst Mayr's The Growth of Biological Thought stands: a history of all of biology, a Ring des Nibelungen complete with leitmotivs such as the failures of reductionism, the struggle of biology for independence from physics, and the liberation of population thinking from the bounds of essentialism.155 Within this style of thinking Mayr has “to offer...nothing less than a vision of biology that places neodarwinian evolutionary theory firmly at the centre.”156 There may be other visions of biology, but few of them have as indefatigable and able representatives as Darwinism has in Ernst Mayr. (shrink)

Psychiatry as a discipline oscillates between the language of emotions and that of biology; ranging from the immersion into the subjective experience of another person to the objective approach of biomedical science. The tension between these different approaches may seem irreconcilable and confusing to some. This was not the case for Karl Jaspers who pioneered a systematic reflection on the concepts underlying psychiatric theory and practice. In this essay, we engage with Jaspers' thinking and create a dialogue with contemporary psychiatric (...) research and philosophy of mind. Jaspers' conception of erklären and verstehen and his position on research in the neuroscience of mental disorders is brought together with the thought of Thomas Nagel and John Searle. We argue for the compatibility of Jaspers' ideas with Nagel's and Searle's views on the mind/body problem. Furthermore, we look at current trends in biological research in psychiatry through the lens of Jaspers' General Psychopathology, from there we derive suggestions and insights for psychiatric theory and practice. (shrink)

The comparison of Thomas Aquinas’ Summa Theologiae with the architecture of a cathedral is not new. We find it in 1850 in Karl Werner’s System der christlichen Ethik (1850, 47), and in 1860 the German architect Gottfried Semper writes in the preface to his two-volume manual Style in the Technical and Tectonic Arts: art... appears isolated and relegated to a field especially marked out for it. The opposite was true in antiquity, where philosophy held sway over this field as (...) well. Philosophy was seen as an artist herself and a guide to the other arts. But in growing old, she turned to analysis and devised dead categories instead of living analogies. In just the same way, Gothic architecture was the.. (shrink)

While the words “utopia” and “anticipation” frequently appear together in discussions of the concepts of utopia and dystopia, little attention to the relationship of Anticipation Studies to utopian studies exists. Moreover, the relevance of literature and the arts to Anticipation Studies seems almost invisible. This essay focuses on the structuring of the original utopian narrative, Sir Thomas More’s Utopia, in order to understand how this seminal text conceptualizes utopia’s relation to past, present, and future. This analysis focuses on the (...) complex framing devices characteristic of utopian narrative, as well as its open-endedness. The embedding of narratives sets up the dynamic movement between past, present, and future – the various forms of temporality – that allows us to clarify the nature of utopian anticipation.Throughout the chapter, I attempt to connect utopian textual and conceptual theory to specific concepts in the emerging field of Anticipation Studies, with which Utopian Studies, a long-established interdisciplinary field, have not yet engaged. Of particular interest is the notion, promoted by Miguel Abensour, that utopia is always a disruption and thus not an anticipation in any “natural” or logical sense: “what matters is the orientation toward what is different, the wish for the advent of a radical alterity here and now” : 407, 2008). From this premise, we can reintroduce a neglected literary term from science fiction theorist, Darko Suvin: the novum. The eruption of a future from a point of radical alterity – an ontological accident – opens up radical implication for the nature of utopian anticipation and futurity.Finally the essay suggests that Robert Poli’s and Robert Rosen’s description of an anticipatory system as comprising “the predictive model of itself” within the genre’s formal characteristics is in fact present in the structure of the utopian narratives: that is, that the persistence of utopia – as a literary genre and as a political concept – inheres in the narratological structuring of the possibility of another story and another listener. Utopian narrative thus ultimately anticipates not only temporal relationality, but an ethical relation between the outside narrator, the utopian traveler/narrator, and the reader. It anticipates another story. (shrink)

The object of my dissertation is to demonstrate that the conceptual thrust of Nietzsche's philosophical activity is a sustained endeavor to negate the Socratic basis of Western ontology through the re-implementation of the Aeschylean tragic paideia. Nietzsche's most consequential objection against Socrates is the latter's neutralizing of Hellenic mythos with the "cold edge" of reason and the "naive optimism" of science. Accordingly, we may most properly understand Nietzsche's effort as a movement against aesthetic Socratism, since it is with its "supreme (...) law," "To be beautiful everything must be intelligible," that Socrates--from behind his "Euripidean mask"--quelled the Dionysian spirit in Attic aesthetics, ipso fact put into operation an impulse-taming didacticism, and thus made ready the social climate for the institutionalization of the Judeo-Christian moral system. ;Nor, as I urge, is this a mere intellectual position, a philosophical exercise for Nietzsche. Just as the Platonic Socrates saw the need for a new moral and aesthetic direction, so does Nietzsche regard the culturo-political reformulation of Western society as a practical goal. Two interrelated themes of his appear to speak in favor of this observation: his regard of the composer Richard Wagner as the new Aeschylus who would reanimate the Dionysian spirit within German culture, and his persistent call for the somato-intellectual overcoming of humankind as we know it. That is, Wagner's musical dramas would at once transform Western/Socratic aesthetics and prepare the socio-cultural mentality for the rise and establishment of the Ubermensch as a new and profoundly "superior" "species" of human beings. That the younger Nietzsche did indeed regard Wagner as useful toward the achievement of such an artistic and cultural inversion may be noticed from the fact that he terminated their friendship virtually immediately after the composer signalled that he was turning to a more traditional and acceptable subject--Christianity. ;Despite this loss, Nietzsche ineluctably presses on his vision of the future "masters" of the earth. Indeed, in The Will to Power he implicitly offers at least two dissimilar "blueprints" whereby that goal could be realized. Only one of these plans of action, however, could ultimately prove useful in the establishment of the Ubermensch, while the other could at best permit only isolated communities of Ubermenschen to exist for a relatively short time, before succumbing to the rabble's socio-cultural levelling tendency. Only after the rabble's lifestyle would have become intolerable even to themselves, such that they would collectively rise up to transcend their mass-identity in all its manifestations, could the emergence and future of the Ubermensch as a phenomenal being be assured. (shrink)

Paradoxes of Freedom is a study of the philosophical and historical concept of liberty. Centring his argument upon the Romantic exaltation of freedom, Thomas McFarland identifies freedom as one of the three chief transcendences, along with love and religion, by which humanity orientates itself. McFarland indicates, by an examination ranging from Shakespeare and Luther to the writings of Nietzsche and Wagner, both the reasons for the supreme valuation of freedom and the nature of the hindrances, in theory and (...) fact, that enmesh the actual realization of freedom. (shrink)

The object of this paper is to study the analogy, drawn both positively and negatively, between mathematics and fiction. The analogy is more subtle and interesting than fictionalism, which was discussed in part I. Because analogy is not common coin among philosophers, this particular analogy has been discussed or mentioned for the most part just in terms of specific similarities that writers have noticed and thought worth mentioning without much attention's being paid to the larger picture. I intend with this (...) analogy (looking at others' comparisons) to shed a little light on what is going on in mathematics, how one can understand it a bit other than experientially. This intention is philosophical and the way that I am attempting to accomplish it is also philosophical. I shall conclude my attempt to explain how it is possible and even natural for mathematics and fiction to have the analogy they have, taking it for granted, as argued in part I, that they are not to be identified. To this end I shall discuss philosophers' comparisons, mainly those of Hodes, Resnik, Tharp, and Wagner, who are the writers that seem to me to have written most thoughtfully and sufficiently extensively about fiction in making the comparison and of Körner, whose comparison is different. Whether either of these comparisons or the more general analogy is of permanent philosophical interest will have to be decided by philosophers now that they have had a fuller examination. I shall mention some other writers' reference to fiction, but not all; indeed, I am sure that I have not even found all the comparisons that there are. (shrink)

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction (...) error computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)