BackgroundCentral to ethically justified clinical trial design is the need for an informed consent process responsive to how potential subjects actually comprehend study participation, especially study goals, risks, and potential benefits. This will be particularly challenging when studying deep brain stimulation and whether it impedes symptom progression in Parkinson’s disease, since potential subjects will be Parkinson’s patients for whom deep brain stimulation will likely have therapeutic value in the future as their disease progresses.MethodAs part of an expanded informed consent process (...) for a pilot Phase I study of deep brain stimulation in early stage Parkinson’s disease, an ethics questionnaire composed of 13 open-ended questions was distributed to potential subjects. The questionnaire was designed to guide potential subjects in thinking about their potential participation.ResultsWhile the purpose of the study (safety and tolerability) was extensively presented during the informed consent process, in returned responses 70 percent focused on effectiveness and 91 percent included personal benefit as potential benefit from enrolling. However, 91 percent also indicated helping other Parkinson’s patients as motivation when considering whether or not to enroll.ConclusionsThis combination of responses highlights two issues to which investigators need to pay close attention in future trial designs: (1) how, and in what ways, informed consent processes reinforce potential subjects’ preconceived understandings of benefit, and (2) that potential subjects see themselves as part of a community of Parkinson’s sufferers with responsibilities extending beyond self-interest. More importantly, it invites speculation that a different paradigm for informed consent may be needed. (shrink)

_Contemporary Moral and Social Issues_ is a uniquely entertaining introduction that brings ethical thought to life. It makes innovative use of engaging, topically oriented original short fiction, together with classic and influential readings and editorial discussion as a means of helping students think philosophically about ethical theory and practical ethical problems. Introduces students to ethical theory and a range of practical moral issues through a combination of key primary texts, clear editorial commentary, and engaging, original fiction Includes discussion of topics (...) such as world poverty, abortion, animals, the environment, and genetic engineering, containing “Facts and Factual Issues” for each topic to give students an up-to-date understanding of related factual issues. Uses immersive, original short works of fiction as a means to engage students to think philosophically about serious ethical issues. (shrink)

Then is the moral that we all require forgiveness and that forgiveness is always a miracle, taking time but beyond time? This can be said, but how can we establish or deliver the weight or gravity of any such answer? Consider the lament with which Elisabeth Young-Bruehl opens her recent Why Arendt Matters: “What do people make of it when, every time some especially appalling, hard-to-fathom mass crime takes place, ‘the banality of evil’ turns up in their morning newspapers or (...) jumps out of the mouths of TV pundits?”2 Well, do people make anything of it at all? Does reading or hearing “the banality of evil” prompt us to stop and think? Or does its “newspeak” use inoculate against that very possibility?. (shrink)

Researches over many years have examined whether levonorgestrel emergency contraception has a postfertilization effect. In a recent article in the Catholic Health Association’s journal Health Progress, Sandra Reznik, MD, asserts that “levonorgestrel acts to prevent pregnancy before, and only before, fertilization occurs.” A companion article by Ron Hamel, PhD, argues for the moral certainty that Plan B is not an abortifacient. Reznik fails to address the principal model supporting a potential postfertil­ization mechanism of action, specifically, that preovulatory administration of levonorgestrel (...) disrupts the delicate ratio of estrogen and progesterone essential to healthy endometrial development and induces the equivalent of luteal phase insufficiency, thereby jeopardizing implantation. Hamel’s argument for moral certitude is similarly inadequate. This article critically reviews both articles and the sources on which they rely. National Catholic Bioethics Quarterly 10.4 : 741–772. (shrink)

Stories of Philosophy is an introduction to philosophy textbook that combines both fiction and philosophical discussion. It combines compelling stories devoted to particular philosophical problems followed by clear and detailed guided discussions of the topics and ideas explored within the fictional stories. The text includes chapters on Logic, Appearance and Reality, The Nature of Mind, Freedom and Responsibility, The Existence of God, and Morality. Each chapter has several highly praised pedagogical features, including chapter-opening learning objectives, boldfaced key terms, questions for (...) discussion, definitions of terms, and suggested further readings. It will be accompanied by online support material for the instructor and the student. (shrink)