Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, (...) and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment. PTEN is a guardian of the genome. However, the role of PTEN in guarding the genome has not been revealed until recently. PTEN controls multiple fundamental processes of genomic transmission. By physically interacting with key molecules in DNA replication, DNA repair/decatenation, and chromosome segregation during the cell cycle, PTEN maintains genomicintegrity and fitness. (shrink)

The twenty-first century is arguably the century of computing. In such a world saturated by computing, Computational Thinking is now recognized as a foundational competency for being an informed citizen and being successful in STEM work. Nevertheless, how to effectively import different types of teaching methods in university courses is subjected to further evaluation. Currently, the arguments in favor of tangible robots including high interaction, great practicality, and specific operation results make themselves to be often used as a teaching medium (...) and tool for teaching activities between teachers and students. Hence, in addition to cultivating students with computational thinking ability, this paper discussed how to integrate tangible robots into project-based learning courses of thinking skills training to improve the learning performance of the computational thinking ability. This study conducted in one semester on the 105 students from three classes. Experimental results show that the project-based learning method integrated with the teaching material of robotic visual programs approach had significantly better effectiveness in improving students' learning achievements than the traditional teaching method integrated with paper practice teaching materials approach. Analysis of the questionnaire results showed that the proposed learning approach did not increase the students' cognitive burden. In sum, the proposed approach helps students' learning achievement and cognitive load. (shrink)

Ben shu nei rong bao kuo: ren lei wei he ru ci duo shi; dong fang gu dian de Afanda Wutuobang; sheng ren jiu jing wei shui xiao lao; zhi li de xian du yu xu wei you guo lun; deng gao si wang, man mu zhu ji hai shi man mu la ji; nan yi yong yu yan wen zi biao da yu chuan shou de da dao deng.

民国大先生金岳霖的一生,注定了是一段传奇.因为他的名士风,因为他的痴情.本书叙述金岳霖在成长,情趣,交友等方面的经历,说出身,说成长,说游艺,说治学,谈爱好,忆故交,展现他真实的人生——学术成就卓然的 哲学大师,天真烂漫如孩童,洒脱飘逸如名士.对爱简单而执着,一生痴情于才女林徽因,动人而神圣,一辈子"逐林而居",终身未娶.是真名士,自风流.

本书分为“生于天命，成在自身”、“去除优越感，一切从头再来”、“独立思考，独善其身”、“悠然处世，平和做人”等十章。.

Ben shu cong da liang xi fang zhe xue de chuan bo fen fan xian xiang zhong xun chu ma ke si zhu yi zhe xue zai zhong guo cheng wei li shi fa zhan zhi bi ran, qi ta zhe xue si xiang dou zai zhong guo chuan bo guo, zhi you ma ke si zhu yi cai you wu bi qiang da de sheng ming li.

v. 1. Sheng ji tu -- v. 2. Mengzi sheng ji tu.

本书围绕《论语》一书,梁漱溟从自己的理解出发,把儒家思想解释为十三个方面:乐、讷言敏行、看自己、看当下、反宗教、不迁怒不贰过、天命等。同时,还结合中国现时的思想及西方思想,谈了新时期对儒家思想的再审视 、再理解。.

孟學與荀學作為兩種儒家心理的原型，而儒學又作為中國思想場域的大傳統，是以可說思想史脈絡中的孟荀論辯與交鋒，即為建構中國思想場域中人格特質的關鍵來源。亦即思想史上尊孟抑荀的現象，事實上便是孟學意識型態所 形塑之性善心理結構對於性惡陰影的潛抑現象。那是在孟學「四端」理論下所形塑儒家存有具有一不可見卻如四體般存在的「良知器官」之集體驅力。亦即在中國思想場域中的存有只能是「道德人」，而不存在西方基督宗教場域 中「生物人」脈絡下的自我認同與表述。而這樣的孟學心理結構已然成為具有集體性的無意識，驅動著存有的思維與行動，是以產生性善的權威、成聖的焦慮、他律的創傷與政治的昇華等現象。本書將通過孟荀而思，藉由荀學視 域涉入孟學意識型態形塑下之儒家心理結構，去反思、批判與重建存有的心理結構，進而作為思索當代華人乃至東亞儒學場域之人格特質的來源與基礎。.

內容介紹 荀子性惡論是有意與性善論針鋒相對，企圖在批判中回歸孔門正道的論述。但學者多以孔孟一體的思維批判荀學之歧出，儒學史上「作為他者的孟子」往往被忽略。本書即企圖回到孟子尚未成聖成經的脈絡去思考荀孟關係，探問 為何荀子必要攻訐性善而主張性惡？關鍵在於荀子不滿孟子以「道德人」作為存有原初狀態的指涉，將儒學的社會性倫理轉向了超越性道德；是以企圖回歸存有原初的「經濟人」面向。性惡論的誕生，可以說是作為「經濟人」的 存有對「道德人」之反擊；必須理解到：「性惡論」不僅是人性的表述，而是一種認知自我與世界的態度。其中涵攝了「經濟人」的本體、修養、政治、經濟與社會等面向之完整儒學系統。一旦否認「性惡論」的意義，早期儒學 的根基將全然崩解並遭受曲解——忽視了「孔荀」一系在儒學史脈絡中的重要性意義。.

Legal Judgment Prediction (LJP) is an essential component of legal assistant systems, which aims to automatically predict judgment results from a given criminal fact description. As a vital subtask of LJP, researchers have paid little attention to the numerical LJP, i.e., the prediction of imprisonment and penalty. Existing methods ignore numerical information in the criminal facts, making their performances far from satisfactory. For instance, the amount of theft varies, as do the prison terms and penalties. The major challenge is how (...) the model can obtain the ability of numerical comparison and magnitude perception, e.g., 400 < 500 < 800, 500 is closer to 400 than to 800. To this end, we propose a judicial knowledge-enhanced magnitude-aware reasoning architecture, called NumLJP, for the numerical LJP task. Specifically, we first implement a contrastive learning-based judicial knowledge selector to distinguish confusing criminal cases efficiently. Unlike previous approaches that employ the law article as external knowledge, judicial knowledge is a quantitative guideline in real scenarios. It contains many numerals (called anchors) that can construct a reference frame. Then we design a masked numeral prediction task to help the model remember these anchors to acquire legal numerical commonsense from the selected judicial knowledge. We construct a scale-based numerical graph using the anchors and numerals in facts to perform magnitude-aware numerical reasoning. Finally, the representations of fact description, judicial knowledge, and numerals are fused to make decisions. We conduct extensive experiments on three real-world datasets and select several competitive baselines. The results demonstrate that the macro-F1 of NumLJP improves by at least 9.53% and 11.57% on the prediction of penalty and imprisonment, respectively. (shrink)

In this research we apply the Theory of Planned Behavior (TPB) to study decisions related to information privacy protection. A TPB-based model was proposed to investigate whether organization-based self-esteem and perceived deindividuation can be employed to measure the strength of the perceived behavioral control construct. In addition, we examined if the addition of a causal path linking subjective norms to attitudes and another causal path linking organization-based self-esteem to subjective norms enhanced our research model's predicting power. Our study shows that (...) information systems (IS) professionals' intentions to protect personal information privacy are influenced by their attitudes, subjective norms, perceived deindividuation, and organization-based self-esteem. It further shows that attitudes are influenced by subjective norms, which, in turn, are influenced by organization-based self-esteem. (shrink)

This essay considers the way Georges Bataille associates sovereignty with ecstasy through his peculiar emotive reactions to the photographic images of lingchi execution. Aside from the traditional views relating to political authority, I show how Bataille holds an idiosyncratic notion of sovereignty that is firmly connected with ecstasy, which is disclosed and best exemplified in his fascination with the lingchi photos with intolerable imagery of torture and cruelty. I argue that the reasons for Bataille to seek ecstatic experience is to (...) overcome banality and servility derived from the instrumentalization of our culture, so as to allow sovereignty to come into being. Although cruelty is a persistent theme in Bataille’s writings, I point out that what makes the lingchi photos pivotal for him is that it is the mirror of somatic disintegration, extreme physical violence and cruelty that corresponds to the rupture of psychological integrity as the state of ecstatic loss of self in a metaphysical sense, reflecting thus the non-boundary of uncontained sovereign individual. Furthermore, in the experience of ecstatic self-loss, an empathic identity is built up between Bataille and the victim of the lingchi execution, which not only allows the conception of ecstatic sovereignty to be endowed with ethical implication but also makes it an alternative approach to the issue of intercultural communication. (shrink)

In the real-world complex product design process, task allocating is an ongoing reactive process where the presence of unexpected design change is usually inevitable. Therefore, reallocating is necessary to respond to design change positively as a procedure to repair the affected task plan. General reallocating literature addressed the reallocating versions with fixed executing time. In this paper, a multi-objective reallocation model is developed with a feasible assumption that the task executing time is controllable. To illustrate this idea, a compressing executing (...) time strategy is proposed in CPD process, where the executing time can be controlled with a non-linear compression cost. When design change occurs during the executing, task-resource reallocating is required to absorb the interference effects. Reallocating implies an increase in design cost and system instability; the proposed method CETS can address this issue effectively. CETS considers three objectives: completing time, stability, and change-adaptation cost. An adaptive multi-objective hybrid genetic algorithm and tabu search is developed to solve this mathematical method. The computational results of specific simulation examples verify the superiority. It shows that CETS is sensitive to design change, and the proposed algorithm AMOGATS can be effective to achieve the allocating by coordinating the objective consistency. (shrink)