When not acting in ways that are recognised as physical self-defence, women are often – in psychology and in other dominant discourses – generalised as inherently passive during subjection to sexualised coercion (rape and attempted rape). Likewise, in the aftermaths, their (in)actions are frequently pathologised as ‘maladaptive coping strategies’. We present theoretically and empirically based arguments for an agency-oriented approach to women’s perspectives on sexualised coercion. Agency is understood as intentional, situated and strategic. Sexualised coercion is not generalised as a (...) single “traumatic” event, but conceptualised as life events. Meanings of coercion are embedded in social activities connected to discourses on ‘rape’ and ‘trauma’. Thus personal meanings of subjection are understood as developed in and through participation in trajectories across diverse contexts. Adopted in our study, this approach points to the great diversity of personal meanings of sexualised coercion. Moreover, it reveals intimate connections between situated, personal and dominant discursive meanings of coercion, and women’s strategies of (in)actions during and in the aftermaths of the events. Our analysis of participants’ perspectives also indicates an imperative need for reinterpreting concepts such as ‘victim’ and ‘passivity’. In a reinterpretation women, although subjected to sexualised coercion, emerge as subjects both during subjection and in the aftermaths. Furthermore their seemingly pathological behaviour may be re-conceptualised as person ally sense-making strategies of action in reflected attempts at (re)formulating and (re)organising their life strategies. (shrink)

Discussions about the nature of the emotions in Hellenistic philosophy have aroused intense scholarly interest over the last few years. The topics covered by the essays in this volume range from the classical background of Hellenistic theories, through debates on emotion in the major Hellenistic schools, to discussions in later antiquity. Special emphasis is placed on the development of the Stoic views on the nature and value of the emotions. The essays are written with a high level of philosophical and (...) classical scholarship, but contain no exclusive technicalities. Audience: This first comprehensive treatment of the emotions in Hellenistic philosophy can be read with pleasure and profit not only by professionals in ancient philosophy but also all those who are interested in the philosophy of mind and its history. (shrink)

Drawing on both anthropology and philosophy, this paper argues that the profiled form of the human hand is a universally recognizable image; one whose significance transcends temporally and geographically defined cultural divisions, and represents the earliest known artistic symbol of the human form. The unique co-occurrence of five properties in the image of the human hand and the way it is recognized support this argument, including that it is: (1) unmistakably a hand, (2) unmistakably human, (3) a universal point of (...) interface, (4) a universal referent of scale, and (5) an easy way of making a complex shape. This underappreciated aspect of hand art makes these images among the most important forms of early artistic expression encountered in the prehistoric record. (shrink)

-/- Continuous first-order logic has found interest among model theorists who wish to extend the classical analysis of “algebraic” structures (such as fields, group, and graphs) to various natural classes of complete metric structures (such as probability algebras, Hilbert spaces, and Banach spaces). With research in continuous first-order logic preoccupied with studying the model theory of this framework, we find a natural question calls for attention. Is there an interesting set of axioms yielding a completeness result? -/- The primary purpose (...) of this article is to show that a certain, interesting set of axioms does indeed yield a completeness result for continuous first-order logic. In particular, we show that in continuous first-order logic a set of formulae is (completely) satisfiable if (and only if) it is consistent. From this result it follows that continuous first-order logic also satisfies an approximated form of strong completeness, whereby Σ⊧φ (if and) only if Σ⊢φ ∸2−n for all n < ω. This approximated form of strong completeness asserts that if Σ⊧φ, then proofs from Σ, being finite, can provide arbitrarily better approximations of the truth of φ. -/- Additionally, we consider a different kind of question traditionally arising in model theory—that of decidability. When is the set of all consequences of a theory (in a countable, recursive language) recursive? Say that a complete theory T is decidable if for every sentence φ, the value φ T is a recursive real, and moreover, uniformly computable from φ. If T is incomplete, we say it is decidable if for every sentence φ the real number φ T o is uniformly recursive from φ, where φ T o is the maximal value of φ consistent with T. As in classical first-order logic, it follows from the completeness theorem of continuous first-order logic that if a complete theory admits a recursive (or even recursively enumerable) axiomatization then it is decidable. (shrink)

This is the first edited collection entirely dedicated to non-evidentialist epistemology or non-evidentialism—the controversial view that evidence is not required in order for doxastic attitudes to enjoy a positive epistemic status. Belief or acceptance can be epistemically justified, warranted, or rational without evidence. The volume is divided into three section: the first focuses on hinge epistemology, the second offers a critical reflection about evidentialist and non-evidentialist epistemologies, and the third explores extensions of non-evidentialism to the fields of social psychology, psychiatry, (...) and mathematics. Contributors: N. Ashton, A. Coliva, J. Kim, K. McCain, A. Meylan, L. Moretti, S. Moruzzi, J. Ohlorst, N. Pedersen, T. Piazza, L. Zanetti. (shrink)

This is the introduction to Moretti, Luca and Nikolaj Pedersen (eds), Non-Evidentialist Epistemology. Brill. Contributors: N. Ashton, A. Coliva, J. Kim, K. McCain, A. Meylan, L. Moretti, S. Moruzzi, J. Ohlorst, N. Pedersen, T. Piazza, L. Zanetti.

Alethic pluralism is the view that the nature of truth is not uniform across domains. There are several ways of bang true $(T_1 ...\,T_n )$ A simple argument, the 'instability challenge', purports to show that this view is inherently unstable. One can simply say that something is uniformly true if and only if it is T₁ or ... or $\,T_n $ . Being uniformly true is a single truth property that applies across the board, and so the nature of truth (...) is uniform across domains, contra pluralism. I defend pluralism against the instability challenge. I show that the challenge bifurcates: one Challenge is formulated in terms of predicates, and the other is formulated in terms of properties. Vie pluralist has the resources to defuse both of these. The sparse/abundant property distinction and considerations of explanatory asymmetry play a crucial role in my argument. (shrink)

hiS volume in the Synthese Library Series is the result of a conference T held at the University of Roskilde, Denmark, October 31st-November 1st, 1997. The aim was to provide a forum within which philosophers, math ematicians, logicians and historians of mathematics could exchange ideas pertaining to the historical and philosophical development of proof theory. Hence the conference was called Proof Theory: History and Philosophical Significance. To quote from the conference abstract: Proof theory was developed as part of Hilberts Programme. (...) According to Hilberts Programme one could provide mathematics with a firm and se cure foundation by formalizing all of mathematics and subsequently prove consistency of these formal systems by finitistic means. Hence proof theory was developed as a formal tool through which this goal should be fulfilled. It is well known that Hilbert's Programme in its original form was unfeasible mainly due to Gtldel's incompleteness theorems. Additionally it proved impossible to formalize all of mathematics and impossible to even prove the consistency of relatively simple formalized fragments of mathematics by finitistic methods. In spite of these problems, Gentzen showed that by extending Hilbert's proof theory it would be possible to prove the consistency of interesting formal systems, perhaps not by finitis tic methods but still by methods of minimal strength. This generalization of Hilbert's original programme has fueled modern proof theory which is a rich part of mathematical logic with many significant implications for the philosophy of mathematics. (shrink)

It is undeniable that computer technology has had a major impact on how we engage enquiry. We use computer devices to store information that helps us in our daily lives—just think of the contacts on your phone and whatever calendar app you might use to keep track of your schedule. Furthermore, people enjoy easy and quick access to a wide range of reliable online resources such as Nature, Reuters, and Encyclopedia Britannica through their laptops or smartphones. Powerful search engines such (...) as Google open up the door to swaths of information, enabling people easily to acquire a wide range of true beliefs through reliable means about all kinds of subject matters. However, what is the status of such true beliefs? In particular, once beliefs cease to be occurrent, do we still have non-occurrent beliefs, and, if true and reliably sustained, do they still qualify as knowledge? If they do, we would have cases of extended belief and knowledge, as these computer devices go beyond onboard capacities such as perception and memory. However, unlike our beliefs and desires, many information-storing apps and resources do not have the capacity automatically to “update” their information in light of new information. Moreover, wouldn’t extended belief and knowledge lead to massive cognitive bloat—an unpalatable explosion of belief and knowledge completely detached from an ability naturally to recall the relevant information? It would seem so given the wide variety of storage repositories and devices at one’s fingertips. Doesn’t cognitive bloat threaten to undermine the notion of expertise? Is it really possible to become an expert on a given topic by simply and easily looking up information via one’s smartphone and saving it? And where, now, would we place cognitive effort—steps taken by individuals to commit details to memory, to apply knowledge, to deliberate, and to assess and reflect? In “Extended Knowledge Overextended?”, Nikolaj Jang Lee Linding Pedersen and Jens Christian Bjerring offer a comprehensive discussion of extended belief and knowledge. They criticize two recent attempts to mitigate concerns about cognitive bloat by arguing that their effectiveness is contingent on the current state of technology—in particular, the fact that computer devices are currently external to us. However, if computer devices seamlessly integrated with our own onboard capacities—the so-called neuromedia—become reality, it may be much more difficult to resist extended belief and knowledge and, with them, massive cognitive bloat. (shrink)

Crispin Wright has recently introduced a non-evidential notion of warrant – entitlement of cognitive project – as a promising response to certain sceptical arguments, which have been subject to extensive discussion within mainstream epistemology. The central idea is that, for a given class of cognitive projects, there are certain basic propositions – entitlements – which one is warranted in trusting provided there is no sufficient reason to think them false. (See Wrigh [2].) The aim of this paper is to provide (...) an account of the notion of entitlement of cognitive project and briefly discuss the question whether there is any work for the notion of entitlement to do within the philosophy of mathematics. Bearing in mind its applications in mainstream epistemology, it will be suggested that the notion can be used to formulate a response to certain kinds of scepticism which call into question the warrantability of (acceptances of) propositions that appear integral to mathematical theorizing in a given mathematical theory T – in particular, that T is consistent and that T ’s background logic is sound. (shrink)

Continuous first-order logic has found interest among model theorists who wish to extend the classical analysis of “algebraic” structures to various natural classes of complete metric structures. With research in continuous first-order logic preoccupied with studying the model theory of this framework, we find a natural question calls for attention. Is there an interesting set of axioms yielding a completeness result?The primary purpose of this article is to show that a certain, interesting set of axioms does indeed yield a completeness (...) result for continuous first-order logic. In particular, we show that in continuous first-order logic a set of formulae is satisfiable if it is consistent. From this result it follows that continuous first-order logic also satisfies an approximated form of strong completeness, whereby Σ⊨φ only if Σ⊢φ∸ 2-n for all n < ω. This approximated form of strong completeness asserts that if Σ⊨φ, then proofs from Σ, being finite, can provide arbitrarily better approximations of the truth of φ.Additionally, we consider a different kind of question traditionally arising in model theory—that of decidability. When is the set of all consequences of a theory recursive? Say that a complete theory T is decidable if for every sentence φ, the value φT is a recursive real, and moreover, uniformly computable from φ. If T is incomplete, we say it is decidable if for every sentence φ the real number φT∘ is uniformly recursive from φ, where φT∘is the maximal value of φ consistent with T. As in classical first-order logic, it follows from the completeness theorem of continuous first-order logic that if a complete theory admits a recursive axiomatization then it is decidable. (shrink)

I joined Trevelyan College (Trevs), Durham University in 2011 as a mature student under former professor and principle of the college Martyn Evans. It was to be the beginning of a transformative journey culminating in my doctoral thesis: Balanced Wonder: A Philosophical Inquiry into the Role of Wonder in Human Flourishing. -/- In 2020 Trevs kindly asked me to contribute to the Alumni Magazine Hippocampus and in particular to the ‘Where Are They Now’ section. -/- “You Haven’t Done Anything” is (...) my contribution and it highlights in a humorous fashion some of the things I have achieved since I left Trevs. -/- Sections: -/- Standing still is rarely a good strategy in life -/- If One Lives Wisely Sometimes Less is More and Infinately More Valuable. (shrink)

Animals are at work everywhere in education, yet existing nowhere: Education doesn’t know them beyond their instrumental use value; as animals-for-us (Pedersen, 2019a, p. 7; Wallin, 2014, p. 149; c...

A mathematical theory T is categorical if, and only if, any two models of T are isomorphic. If T is categorical, it can be shown to be semantically complete: for every sentence ϕ in the language of T, either ϕ follows semantically from T or ¬ϕ does. For this reason some authors maintain that categoricity theorems are philosophically significant: they support the realist thesis that mathematical statements have determinate truth-values. Second-order arithmetic (PA2) is a case in hand: it can be (...) shown to be categorical and semantically complete. The status of second-order logic is a controversial issue, however. Worries about the purported set-theoretic nature and ontological commitments of second-order logic have been influential in the debate. (shrink)

Dette kapitel fokuserer på ’etik og patientinddragelse’, men søger med afsæt i devisen ‘sapere aude’ også at skabe interesse for filosofi og etik blandt sygeplejestuderende. Kapitlet er en opfordring til sygeplejestuderende om at betjene sig af egen forstand og finde mod til at filosofere over problematikker i forbindelse med patientinddragelse frem for at falde tilbage i umyndighedens bekvemmelighed og vente på at andre træder til. Kapitlet starter med at se nærmere på, hvordan patientinddragelse italesættes i vor tid efterfulgt af en (...) kort eksposition af to af oplysningstidens vigtigste libera- le filosoffer, herunder pligtetikeren Immanuel Kant og nytteetikeren John Stuart Mill, hvis syn på henholdsvis autonomi og frihed influerer debatten om patientinddragelse. Efterfølgende præsenteres og diskuteres to eksempler, hvor patientinddragelse og etik er i rampelyset. Mere specifikt rettes fokus på 1) etik, patientinddragelse og den psykiatriske patient og 2) etik, patientinddragelse og unge mennesker. Eksemplerne er udvalgte med henblik på at belyse, hvad der kan komme på spil i sundhedsfaglige situationer udspændt mellem individuel frihed, herunder også ideen om autonomi; sygehusvæsenet, inklusive personale, som autoritær vi- dens-institution/aktør og det etiske, herunder ideen om ’det gode’ eller efterstræbelsesværdige. Afslutningsvis argumenteres der for, at sundhedsarbejdere med blik for etik og patientinddragelse kan udgøre en positiv kraft for den inddragede patient, men at det kræver, at denne vover at være vis. Afsnit: Resume Patientinddragelse i vor tid Autonomi, frihed og patientinddragelse Etik, patientinddragelse og den psykiatriske patient Etik, patientinddragelse og den unge Afslutning . (shrink)

Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

We provide counterexamples to some purported characterizations of dilation due to Pedersen and Wheeler :1305–1342, 2014, ISIPTA ’15: Proceedings of the 9th international symposium on imprecise probability: theories and applications, 2015).

The book is an introductory exposition of the development of the physical and astronomical notions of the universe. It covers the period from Greek antiquity to the Copernican revolution and the Renaissance, half of the text being devoted to medieval science within both the Aristotelian and the Archimedean traditions. The book is intended for a general audience interested in intellectual and scientific developments, but should also be useful as a guide to further studies. Thus it has an extensive bibliography classifying (...) much of the secondary literature on the subject, and also a sixty page 'dictionary' of all the scientists and philosophers mentioned in the text. This contains references to printed editions of the sources and to a selection of books and periodicals. (shrink)

Sustainability challenges typically occur across sectoral boundaries, calling the state, market, and civil society to action. Although consensus exists on the merits of cross-sector collaboration, our understanding of whether and how it can create value for various, collaborating stakeholders is still limited. This special issue focuses on how new combined knowledge on cross-sector collaboration and business models for sustainability can inform the academic and practitioner debates about sustainability challenges and solutions. We discuss how cross-sector collaboration can play an important role (...) for the transition to new and potentially sustainability-driven business models given that value creation, delivery, and capture of organizations are intimately related to the collaborative ties with their stakeholders. Sustainable alternatives to conventional business models tend to adopt a more holistic perspective of business by broadening the spectrum of solutions and stakeholders and, when aligned with cross-sector collaboration, can contribute new ways of addressing the wicked sustainability problems humanity faces. (shrink)

Background: A fair distribution of healthcare services for older patients is an important challenge, but qualitative research exploring clinicians’ consideration in daily clinical prioritisation in healthcare services for the aged is scarce.Objectives: To explore what kind of criteria, values, and other relevant considerations are important in clinical prioritisations in healthcare services for older patients.Design: A semi-structured interview-guide was used to interview 45 clinicians working with older patients. The interviews were analysed qualitatively using hermeneutical content analysis and template organising style.Participants: 20 (...) physicians and 25 nurses working in public hospitals and nursing homes in different parts of Norway.Results and interpretations: Important dilemmas relate to under-provision of community care and comprehensive approaches, and over-utilisation of certain specialised services. Overt ageism is generally not reported, but the healthcare services for the aged seem to be inadequate due to more subtle processes, for example, dominating considerations and ideals and operating conditions that do not pay sufficient attention to older patients’ needs and considerations of justice. Clinical prioritisations are described as being dominated by adapting traditional biomedical approaches to the operating conditions. Many of the clinicians indicate that there is a potential for improving end of life decisions and for reducing exaggerated use of life-prolonging treatment and hospitalisations.Conclusion: The interviews in this study indicate that considerations of justice and patients’ perspectives should be given more attention to strike a balance between specialised medical approaches and more general and comprehensive approaches in healthcare services for older patients. (shrink)

The relative merits and demerits of historically prominent views such as the correspondence theory, coherentism, pragmatism, verificationism, and instrumentalism have been subject to much attention in the truth literature and have fueled the long-lived debate over which of these views is the most plausible one. While diverging in their specific philosophical commitments, adherents of these historically prominent views agree in at least one fundamental respect. They are all alethic monists. They all endorse the thesis that there is only one property (...) in virtue of which propositions can be true, and so, in this sense, take truth to be one. The truth pluralist, on the other hand, rejects this idea. There are several properties in virtue of which propositions can be true. The literature on truth pluralism has been growing steadily for the past twenty years. This volume, however, is the first of its kind—the first collection of papers focused specifically on pluralism about truth. Part I is dedicated to the development, investigation, and critical discussion of different forms of pluralism. An additional reason to look at truth pluralism with interest is the significant connections it bears to other debates in the truth literature—the debates concerning traditional theories of truth and the deflationism/inflationism divide being cases in hand. Parts II and III of the volume connect truth pluralism to these two debates. (shrink)

Here is a well-known thought about truth: Truth consists in correspondence with reality. A sentence is true just in case what it says corresponds with how the world is. Theories of truth that incorporate this thought are naturally regarded as robust or “heavyweight”. Truth is to be understood in a realist fashion. The world decides what is true and what is not. A recent incarnation of the correspondence view is found in truth-maker theories, whose adherents maintain that truths are true (...) in virtue of there being something – a truth-maker – in the world that makes them so.2. (shrink)

In this critical comment, we argue that nondemocratic, but decent regimes fail to constitute legitimate governance under Applbaum’s free group agency account. To make this case, we first introduce the three principles of liberty, equality and agency that Applbaum takes to flow directly from his free agency conception of legitimacy. Against this backdrop, we discuss Applbaum’s claim that a nondemocratic regime along the lines of a Rawlsian decent consultation hierarchy could meet the threshold of legitimacy. Contrary to this suggestion, we (...) argue that nondemocratic, but decent regimes cannot claim legitimacy under Applbaum’s account because they are constitutively inegalitarian, thus failing to adequately grant citizens the equal normative power without which legitimacy is unattainable under the free group agency account. (shrink)

In this article, I critically assess Hélène Landemore's new model of Open Democracy, asking whether it requires of citizens to blindly defer to the decisions of the mini-public. To address this question, I, first, discuss three institutional mechanisms in Open Democracy, all of which can be read to grant citizens democratic control. I argue that neither the capacity to authorize the selection mechanism (random sortition), nor the lottocratic conception of political equality, nor the self-selection mechanisms of Landemore's model deliver the (...) form of control that would insulate Open Democracy from the charge of blind deference. I then discuss the direct democracy mechanisms that Landemore incorporates into her model. Although these devices grant citizens control and, by extension, offer the resources for repudiating the charge of blind deference, they also, I argue, subvert the logic of Landemore's lottocratic model, rendering Open Democracy predictably unstable. Given the deliberative asymmetries between the mini-public and the citizenry, a high frequency of bottom-up challenges is to be expected that would throw the whole system into jeopardy. Thus, the challenge for lottocrats is to show how democratic control can be achieved in a lottocratic system without undermining the benefits of the legislature by lot. (shrink)

Vann McGee claims that open-ended schemas are more innocuous than ordinary second-order quantification, particularly in terms of ontological commitment. We argue that this is not the case.

This second volume in the series "Studies in Hellenistic Civilization", published for the Danish Research Council for the Humanities, offers a comprehensive analysis of the Stoic theory of Oikeiosis.

Including empirical examples and theoretical clarifications on many of the analytical issues raised in his recently published Down to Earth, this conversation with Bruno Latour and his collaborator, Danish sociologist Nikolaj Schultz, offers key insights into Latour’s recent and ongoing work. Revolving around questions on political ecology and social theory in our ‘New Climatic Regime’, Latour argues that in order to have politics you need a land and you need a people. This interview present reflections on such politics, such land (...) and such people, and it ends with a call for a sociology that takes up the task of connecting the three by investigating what he and Schultz call ‘geo-social classes’. The interview was conducted by Jakob Stein in Paris in November 2018. (shrink)

From Stoicism to Platonism describes the change in philosophy from around 100 BCE, when monistic Stoicism was the strongest dogmatic school in philosophy, to around 100 CE, when dualistic Platonism began to gain the upper hand - with huge consequences for all later Western philosophy and for Christianity. It is distinguished by querying traditional categories like 'eclecticism' and 'harmonization' as means of describing the period. Instead, it highlights different strategies of 'appropriation' of one school's doctrines by philosophers from the other (...) school, with all philosophers being highly conscious of their own identity. The book also sets out to break down the traditional boundaries between, on the one hand, the study of Greco-Roman philosophy in the period and, on the other hand, that of contemporary Hellenistic Jewish and early Christian writings with a philosophical profile. In these ways, the book opens up an immensely fruitful period in the history of philosophy. (shrink)

At the top of his ethical system Aristotle placed, as the supreme value, eudai- monia (happiness). But what does this really mean? ...

It is well-known that a sense of belonging is crucial in relation to gaining and maintaining sound mental health. Work is also known to be an essential aspect of recovery from mental health problems. However, there is scant knowledge of what a sense of belonging in the workplace represents. This study explores the nature and meaning of a sense of belonging in the workplace as experienced by persons struggling with mental health issues.Using a descriptive phenomenological methodology, sixteen descriptions of the (...) lived experience of belonging in the workplace were analyzed. The analysis reveals that the experience of belonging in the workplace is restricted and fragile until the moment one becomes accepted, but grows stronger and more resilient as one chooses how one wants to participate. Nonetheless, the sense of belonging is haunted by mixed emotions and ambivalence between the wish to be taken care of and the longing for professional appreciation. (shrink)

This article examines Swedish, Danish and Norwegian governments’ participation in the European Return Platform for Unaccompanied Minors project and its failed attempts to deport unaccompanied minors to Afghanistan. It argues that ERPUM is an interesting and urgent case of a “deportation corridor”, and suggests that this framework can benefit from analysis through normative and applied ethics and in particular discussions of feasibility constraints. It therefore identifies and critically assesses two nationalistic arguments for deportation common in Nordic politics, based on appeals (...) credibility and humanitarianism. Considering the growth of nationalistic immigration policies in Nordic states, the article turns the usual discussions of feasibility on its head by showing that not only cosmopolitan, but also nationalistic ethics must face up to charges of lacking realism. More specifically, it argues that the case of ERPUM illustrates how nationalistic deportation ethics can rely on inconsistent normative and erroneous empirical assumptions, which can be criticized for their arbitrariness, ideological grounding and lacking feasibility. (shrink)

Secretion is a fundamental cellular process involving the regulated release of intracellular products from cells. Physiological functions such as neurotransmission, or the release of hormones and digestive enzymes, are all governed by cell secretion. Anomalies in the processes involved in secretion contribute to the development and progression of diseases such as diabetes and other hormonal disorders. To unravel the mechanisms that govern such diseases, it is essential to understand how hormones, growth factors and neurotransmitters are synthesized and processed, and how (...) their signals are recognized, amplified and transmitted by intracellular signaling pathways in the target cells. Here, we discuss diverse aspects of the detailed mechanisms involved in secretion based on mathematical models. The models range from stochastic ones describing the trafficking of secretory vesicles to deterministic ones investigating the regulation of cellular processes that underlie hormonal secretion. In all cases, the models are closely related to experimental results and suggest theoretical predictions for the secretion mechanisms. (shrink)