The US FDA currently encourages the addition of vitamin D to milk and cereals, with the aim of reducing rickets in children and osteoporosis in adults. However, vitamin D not only regulates the expression of genes associated with calcium homeostasis, but also genes associated with cancers, autoimmune disease, and infection. It does this by controlling the activation of the vitamin D receptor (VDR), a type 1 nuclear receptor and DNA transcription factor. Molecular biology is rapidly coming to an understanding of (...) the multiplicity of roles played by the VDR, but clinical medicine is having difficulty keeping up with the pace of change. For example, the FDA recently proposed a rule change that will encourage high levels of vitamin D to be added to even more foods, so that the manufacturers can claim those foods “reduce the risk of osteoporosis”. The FDA docket does not review one single paper detailing the transcriptional activity of vitamin D, even though, on average, one new paper a day is being published on that topic. Nor do they review whether widespread supplementation with vitamin D, an immunomodulatory secosteroid, might predispose the population to immune dysfunction. This BioEssay explores how lifelong supplementation of the food chain with vitamin D might well be contributing to the current epidemics of obesity and chronic disease. BioEssays 30:173–182, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

We show that a semiclassical theory which takes account of vacuum fluctuations of the electromagnetic field is capable of giving a fully local realist description of the coincidence data from atomic-cascade experiments. Such a theory explains, in a unified manner, why there is a natural upper limit on detector efficiency, and also why, for certain values of the “hidden” variables, there is enhancement of the detection efficiency.

Each Local Research Ethics Committee (LREC) is expected to produce an annual report for its establishing authority. Reports from 145 LRECs were examined with regard to (a) whether the committees were working within the terms of the most recent guidelines from the Department of Health and (b) observations on the role of LRECs with particular reference to accountability. Most LRECs had produced a report, although their length varied greatly. Most reports showed how seriously the committee took its task. Most committees (...) met many of the guidelines; for example, almost all had two or more lay-members. The guideline most frequently not met was that committees should have no more than 12 members. Many committees review very large numbers of projects (maximum 351). Approximately two-thirds provide details in the annual report of individual project titles, their author and the committee decision; all reports should contain this information. Although it may in fact happen more generally, only 23 per cent of the reports referred to any form of monitoring of the eventual outcome of the research. A significant issue to arise from the reports is the extent to which the framework for the operation of LRECs has been confused by the development of the purchaser-provider split. The paper concludes with suggestions for remedying the situation. (shrink)

Using the Q representation, we study the disagreement between quantum optical formalism and local realism and we show that the phenomenon of enhancement, first revealed by the local realist analysis, could receive a simple explanation if we use this particular version of the quantum formalism. Nevertheless, some fundamental difficulties remain.

We show that the divergence between the predictions of quantum optics and the local realist theory known as stochastic optics, for the extended type of photon-coincidence experiment described recently by de Caro, is of the same order of magnitude as for Aspect-type experiments. This means that, in such new experiments, as in those so far performed, counting statistics will have to be greatly improved before a discrimination between the two theories becomes possible.We also show that the outstanding difference between the (...) two theories is that, while stochastic optics uses a genuine, that is, positive, detection probability, the corresponding quantum formalism leads to a pseudoprobability. Nevertheless, there is a striking parallel, in that both theories recognize the phenomenon known as enhancement, and both describe it as having its origin in a mixing of the signal field with the zero-point field by a polarizing device. (shrink)

It is shown that the Kapitza-Dirac effect with atoms, which has been considered to be evidence for their wavelike character, can be interpreted as a scattering of pointlike objects by the periodic laser field.

It is argued that the way towards understanding the experiments with visible light which purport to exhibit nonlocality lies in a return to the wave theory of light. A connection is also indicated between the present-day photon description and the pre-wave-theory corpuscular description, and hence we see that, essentially, the problem of nonlocality in physics was solved nearly two centuries ago by Young and Fresnel.

Representing the themes guiding the past forty years’ work of one of the foremost theologians and philosophers of the twentieth century, these extraordinary volumes, in twenty-nine, twenty-four, and twenty-six chapters respectively, trace the tensions or problems emerging from the origins of what defines the West: the questions posed by Jerusalem and Athens and the relations of each; the place of Rome or Christianity in that equation, as well as the theological-political problem deriving therefrom; and the principles of republican government. Until (...) now, Ernest Fortin’s pathfinding work on these questions has been scattered either in articles appearing in diverse compendia or academic journals, or else in two books published in France and difficult to obtain, on the fifth-century debate between the neoplatonic philosophers and the Church Fathers and on the political teaching behind Dante’s Divine Comedy. (shrink)

Quantum optics does not give a local explanation of the coincidence counts in spatially separated photodetectors. This is the case for a wide variety of phenomena, including the anticorrelated counting rates in the two channels of a beam splitter, the coincident counting rates of the two “photons” in an atomic cascade, and the “antibunching” observed in resonance fluorescence.We propose a local realist theory that explains all of these data in a consistent manner. The theory uses a completely classical description of (...) the electromagnetic field, but with boundary conditions of the far field that are equivalent to assuming a real fluctuating, zero-point field. It is related to stochastic electrodynamics similarly to the way classical optics is related to classical electromagnetic theory.The quantitative aspects of the theory are developed sufficiently to show that there is agreement with all experiments performed till now. (shrink)

The range of this volume, and thus the task especially of its editor, is enormous: to confront the question of teleology from Plato through Aristotle, Maimonides, Aquinas’s commentaries on the Physics, Copernicus, Machiavelli, Bacon, Galileo, Descartes, Spinoza, and Newton, to Kant, Hegel, and then to Einstein, and to recent theories of anthropic-principle cosmology or else versions of the many-worlds cosmology of chance and necessity, and then to Niels Bohr and quantum mechanics, and finally to the problem of current molecular-biological theories (...) of evolution. (shrink)

An attempt to understand a problem fundamental to Plato's thought, and in a way which avoids the pitfalls of modern opinion, the author's expressed intention is to understand Plato as he understood himself. Though not indicated by the table of contents, her expository procedure is to present a sequential interpretation of the dialogues in relation to one another. As a result, the book does not relate in any systematic detail what might be the similarities and differences within the family of (...) Platonic terms related to desire; horme, himeros, boulesthai, eros, epithymia, thymos, and philia. The author's procedure might be readily understandable insofar as the dialogue form requires contextual interpretation. But it is puzzling insofar as her reflections on the hermeneutic problem posed by the dialogue are limited to a brief footnote remark : "Ce n'est pas seulement en vertu de son génie littéraire que la forme s'est imposée à l'oeuvre, au sens de l'oeuvre; sans le recours au moindre artifice, les Dlalogues sont une éducation en train de se faire.". (shrink)