Mechanical pain sensing, adipogenesis, and STING‐dependent innate immunity seem three distinct biological processes without substantial relationships. Intriguingly, TMEM120A, a transmembrane protein, has been shown to detect mechanical pain stimuli as a mechanosensitive channel, contribute to adipocyte differentiation/function by regulating genome organization and promote STING trafficking to active cellular innate immune response. However, the role of TMEM120A as a mechanosensitive channel was challenged by recent studies which cannot reproduce data supporting its role in mechanosensing. Furthermore, the molecular mechanism by which TMEM120A (...) contributes to adipocyte differentiation/function and promotes STING trafficking remains elusive. In this review, we discuss these multiple proposed functions of TMEM120A and hypothesize the molecular mechanism underlying TMEM120A's role in fatty acid metabolism and STING signaling. (shrink)

At present, urban traffic congestion is a common problem of urban development in China. Therefore, China’s government issued the policy of opening the gated communities in 2016, hoping to alleviate traffic pressure to some extent. But, at present, the quantitative empirical research on the effect of the policy implementation is less and more idealistic. In order to complete the leap from research on local isolated traffic capacity of static gated communities to research on global coupling traffic capacity of dynamic multilayer (...) network and, to a certain extent, reflect the innovation of the research model and method, we make a quantitative analysis of the effect of the policy more consistent with the actual situation, which provides a quantitative management basis for the implementation of the policy. Based on literature review, this paper carried out two stages of research. Stage one consists of constructing traffic capacity assessment model—Road Capacity Assessment model based on BPR impedance function from a simple local static perspective. Considering the factors such as delay of signalized intersection and travel time, through modeling analysis and empirical test, it is found that about 12% of local traffic capacity can be improved after open community. Stage two consists of constructing a global capacity model based on multilayer complex network coupling from the perspective of complex global dynamics. Considering the various network nodes of pedestrians, nonmotor vehicles, and other factors, we construct a multilayer complex network and dynamic superposition coupling. The empirical data show that the overall traffic capacity of the open community is improved by at least 11.3%. Finally, it can be concluded that a significant increase in the global traffic capacity of complex urban road networks means that the losses caused by traffic congestion will be reduced. In some first-tier cities, the direct monthly income of the open-gated community is as high as 230 million yuan, not to mention its overall economic, social, and environmental benefits. (shrink)

In this paper, we propose a method to design the pseudorandom number generator using three kinds of four-wing memristive hyperchaotic systems with different dimensions as multientropy sources. The principle of this method is to obtain pseudorandom numbers with good randomness by coupling XOR operation on the three kinds of FWMHSs with different dimensions. In order to prove its potential application in secure communication, the security of PRNG based on this scheme is analyzed from the perspective of cryptography. In addition, PRNG (...) has passed the NIST 800.22 and ENT test, which shows that PRNG has good statistical characteristics. Finally, an image encryption algorithm based on PRNG is adopted. In the encryption algorithm, the optimized Arnold matrix scrambling method and the diffusion processing based on XOR are used to obtain the final encrypted image. Through the evaluation of encryption performance, it is concluded that there is no direct relationship between the pristine image and encrypted image. The results show that the proposed image encryption scheme has good statistical output characteristics and security performance in line with cryptography. (shrink)

In recent years, the research of chaos theory has developed from simple cognition and analysis to practical engineering application. In particular, hyperchaotic systems with more complex and changeable chaotic characteristics are more sensitive and unpredictable, so they are widely used in more fields. In this paper, two important engineering applications based on hyperchaos pseudorandom number generator and image encryption are studied. Firstly, the coupling 6D memristive hyperchaotic system and a 2D SF-SIMM discrete hyperchaotic mapping are used as the double entropy (...) source structure. The double entropy source structure can realize a new PRNG that meets the security requirements, which can pass the NIST statistical test when the XOR postprocessing method is used. Secondly, based on the double entropy source structure, a new image encryption algorithm is proposed. The algorithm uses the diffusion-scrambling-diffusion encryption scheme to realize the conversion from the original plaintext image to the ciphertext image. Finally, we analyze the security of the proposed PRNG and image encryption mechanism, respectively. The results show that the proposed PRNG has good statistical output characteristics and the proposed image encryption scheme has high security, so they can be effectively applied in the field of information security and encryption system. (shrink)

本书对于一分为三的现实与历史、形式与内容、继承与创新等的关系,进行了论述。全书分为四部分,分别是天地之道——一分为三、人间之道——一分为三、一分为三与辩证法、一分为二之粗疏等。.

Ben shu tong guo dui yu Li Zhuowu he Yangming xue de chan shi, dui yu Zhongguo qian jin dai bu tong yu xi fang de lu xiang jin xing le bian xi, ren wei"zai Zhongguo si xiang zhong cun zai zhe bu tong yu Ouzhou si xiang shi de zhan kai de Zhongguo du zi de si xiang shi de zhan kai", fan dui yi ban chang jian de, yi Ouzhou de li shi zhan kai he jia zhi (...) guan wei ji zhun de xi fang zhong xin lun li shi guan, cong er zai Zhongguo nei zai de si xiang li lu zhong xun zhao Zhongguo de"jin dai"ji qi"qu she yu fa zhan"; ta hai da po le zai Riben tong xing de dui yu Li Zhuowu tong xin shuo shi ge ren zhu yi biao xian de fu qian shuo fa, ba Li Zhuowu wan qi de fu za si xiang, te bie shi fo jiao si xiang zai ta shen shang de du te ti xian tui xiang dui yu ming dai si xiang ben shen de jie shi. (shrink)

This article suggests that reading Zhou Dunyi’s 周敦頤 Explanation to the Diagram of Supreme Polarity synchronously instead of diachronically yields a new understanding on the relatedness between infinitude and finitude, or on the One and many. Zhou’s attitude is introduced as a living riddle, in which “Non-Polar and Supreme Polarity” is understood as a new conceptual construct, and one which is issued as a call for action at the end of the text: it is a call to investigate the beginnings (...) and endings of one’s life. In this way, the text demonstrates how a person embodies the cosmological as riddle. The article follows both the diagram and text. It first refers to the riddle, then moves on to its embodiment in the ongoing processes of living as yin-yang 陰陽, the five phases, qian 乾 and kun 坤, and the myriad things, including human beings. According to the approach presented here, it is the sage who is the human embodiment of “Non-Polar and Supreme Polarity.”. (shrink)

Ben shu tong guo li shi shang de yi ge ge xiao gu shi lai shuo li,Rang du zhe kan dao le yi ge zhong min ai min,Shou min ai dai de yan zi,Yi ge qin zheng lian jie,Chi shen li jie de yan zi,Yi ge chong shang jie jian,Fan dui she hua de yan zi.

本书系统、扼要地介绍与评述了维也纳学派的理论原则和思想方法,还阐发了该学派对传统形而上学问题的基本观点。.

Based on work-family border theory and work-home resource theory, this paper examines the impact of border keeper’s support on work-family enrichment and whether or how work-family boundary flexibility mediates the relationship between border keeper’s support and work-family enrichment. A sample of 504 preschool teachers in Guangdong province, China completed questionnaires. The research results show a two-way process of work-family enrichment for preschool teachers in China. Organizational support was directly and significantly correlated with work-to-family enrichment, and family support was significantly and (...) directly correlated with family-to-work enrichment. Organizational support had no significant positive predictive effect on work boundary flexibility which has a significant positive predictive effect on WFE. Family support had a significant positive predictive effect on family boundary flexibility which had a significant positive predictive effect on the FWE. In addition, the study found that family boundary flexibility mediates the relationships between family support and FWE whereas work boundary flexibility did not mediate the relationships between organizational support and WFE. The above research results are partly consistent with the existing research, and partly inconsistent, which is related to the profound influence of traditional culture in Chinese society and the current situation of preschool teachers in China. Such findings have important implications for improving the work-family enrichment of preschool teachers. (shrink)

The evaluation of tourism competitiveness is an important tool for analyzing the potential of tourism in a specific context. Enshi Autonomous Prefecture in China is selected as a case through which to explore the potential of mountain tourism and its competitiveness in the tourism industry. This study develops EAP’s mountain tourism competitiveness model focusing on three criteria: core competitiveness of mountain tourism, the economic environment’s competitiveness, and infrastructure competitiveness. Context-specific customized evaluation index has been applied to data collected from EAP (...) Statistical Yearbook for 2005–2014. The study reveals that the value of EAP’s mountain tourism core competitiveness, economic and environmental competitiveness, and infrastructure competitiveness are 84.292, 13.4, and 2.308%, respectively. When tourism core competitiveness is increased by one unit, EAP’s mountain tourism competitiveness will increase by 0.84292 units. Similarly, when economic environment competitiveness is increased by one unit, EAP’s mountain tourism competitiveness will increase by 0.134 units. EAP’s mountain tourism competitiveness increases by 0.02308 units when infrastructure competitiveness increases by one unit. The major reasons for low levels of competitiveness were lack of awareness of the county authority, a low level of cooperation, and weak infrastructure. The recommendations from the study’s findings are as follows. Firstly, the county authority should appropriately improve the relationship between competition and cooperation, maintaining cooperation in competition, and competition in cooperation. Secondly, the county authority should strengthen communication by establishing an effective coordinated mechanism. Thirdly, the county authority should improve the sense of cooperation and jointly develop the mountain tourism market. Fourthly, the county authority should improve the construction of tourism infrastructure and break down the barriers to tourism cooperation. The study’s findings help develop a “win-win” cooperation mechanism within the competition and support the sustainable development of the mountain tourism industry while reducing poverty and promoting the revitalization of the mountains of China. (shrink)

ObjectiveThis systematic review aims to analyze existing literature of the effects of transcranial direct current stimulation (tDCS) on motor skills learning of healthy adults and discuss the underlying neurophysiological mechanism that influences motor skills learning.MethodsThis systematic review has followed the recommendations of the Preferred Reporting Items for Systematic reviews and Meta-Analyses. The PubMed, EBSCO, and Web of Science databases were systematically searched for relevant studies that were published from database inception to May 2022. Studies were included based on the Participants, (...) Intervention, Comparison, Outcomes, and Setting inclusion strategy. The risk of bias was evaluated by using the Review manager 5.4 tool. The quality of each study was assessed with the Physiotherapy Evidence Database (PEDro) scale.ResultsThe electronic search produced 142 studies. Only 11 studies were included after filtering. These studies performed well in terms of distribution, blinding availability and selective reporting. They reported that tDCS significantly improved motor skills learning. The main outcomes measure were the improvement of the motor sequence tasks and specific motor skills. Nine studies showed that tDCS interventions reduced reaction time to complete motor sequence tasks in healthy adults and two studies showed that tDCS interventions improved golf putting task performance.ConclusionThe included studies showed that tDCS can help healthy adults to improve the motor skills learning by activating different brain regions, such as the primary motor cortex, left dorsolateral prefrontal cortex and right cerebellum. However, the number of included studies was limited, and the sample sizes were small. Therefore, more studies are urgently needed to validate the results of current studies and further explore the underlying neurophysiological mechanisms of tDCS in the future. (shrink)

Through an analysis of the work of the Yi poets, Aku Wuwu, Jidi Majia, and Jimu Langge, this paper discusses the significance of Yi literature in translation, circulation, and production, with an additional focus on the development of minority literature in the context of world literature. A variety of factors enable the translation of ethnic minority literature, including the content and characteristics of the literature itself, the cultural ideologies and literary values of societies, and the personal motivations of authors and (...) translators. In turn, the translation and distribution process introduce the unique experiences of the minority subject into the realm of world literature. Presenting ethnic minority literature in various forms, including recitation performance and multimedia, these Yi poets enhance the range of sensory experiences for readers while drawing attention to poetic traditions and enriching the ways in which world literature circulates. Moreover, the travels of ethnic minority writers introduce new cross-cultural writing and advances world literature’s ideals of prosperity, equality, and freedom. In sum, Yi literature represents a global development of ethnic minority literature as “anthropological literature” that enriches the content of world literature. (shrink)

This policy-capturing study, conducted in China, investigated the cognitive basis of managerial decisions to make a corporate charitable donation, a global issue in the context of corporate social responsibility research and practice. Participants responded to a series of scenarios manipulating pressure from the five stakeholders most commonly addressed by CSR research. The independent variables examined included organizational factors and the participants’ personal values. Results indicate a large positive effect of shareholder and governmental pressure on the decision with lesser positive effects (...) from customers and competitors. Surprisingly, employee pressure had a negative effect on the decision to make a charitable donation. Further, personal values and perceived CEO attitudes toward charity were significantly related to the decisions participants made. In line with our theorizing, the findings indicate that a combination of personal, organizational, and institutional factors was salient in the minds of decision makers. (shrink)

Supporting families of people with developmental disabilities from culturally diverse backgrounds is receiving increased attention in the era of globalisation. However, there is little information about how disability policy and cultural values work together to support families. This article examined how disability policy and Chinese cultural values influence family care of children and young people with developmental disabilities. By comparing qualitative interview data from Chinese families in Taipei (15) and Sydney (10), we analysed how their expression of cultural values in (...) family care differs by policy context, relative to ethics of care claims for recognition, rights and redistribution. We found that positive expressions of Chinese culture in family care fade if policies do not complement them. Policies can alleviate potential tension with cultural values in three ways: reinforcing family capacity to care; ensuring the rights of both family caregivers and people with disabilities; and extending care choices for families. These approaches resonate with ethics of care principles. We argue that culturally responsive disability policy for families means working with cultural values to achieve ethics of care. This implies that incorporating principles of ethics of care could inform cultural responsiveness in disability policy development. (shrink)