In the automatic detection of epileptic seizures, the monitoring of critically ill patients with time varying EEG signals is an essential procedure in intensive care units. There is an increasing interest in using EEG analysis to detect seizure, and in this study we aim to get a better understanding of how to visualize the information in the EEG time-frequency feature, and design and train a novel random forest algorithm for EEG decoding, especially for multiple-levels of illness. Here, we propose an (...) automatic detection framework for epileptic seizure based on multiple time-frequency analysis approaches; it involves a novel random forest model combined with grid search optimization. The short-time Fourier transformation visualizes seizure features after normalization. The dimensionality of features is reduced through principal component analysis before feeding them into the classification model. The training parameters are optimized using grid search optimization to improve detection performance and diagnostic accuracy by in the recognition of three different levels epileptic of conditions (healthy subjects, seizure-free intervals, seizure activity). Our proposed model was used to classify 500 samples of raw EEG data, and multiple cross-validations were adopted to boost the modeling accuracy. Experimental results were evaluated by an accuracy, a confusion matrix, a receiver operating characteristic curve and an area under the curve. The evaluations indicated that our model achieved the more effective classification than some previous typical methods. Such a scheme for computer-assisted clinical diagnosis of seizures has a potential guiding significance, which not only relieves the suffering of patient with epilepsy to improve quality of life, but also helps neurologists reduce their workload. (shrink)

PurposeTo investigate spontaneous brain activity in patients with dry eye and healthy control using the fractional amplitude of low frequency fluctuation technique with the aim of elucidating the relationship between the clinical symptoms of DE and changes in brain function.Material and MethodsA total of 28 patients with DE and 28 matched healthy volunteers were enrolled. Resting-state functional magnetic resonance imaging scans were performed in both groups. Then all subjects were required to complete a comprehensive Hospital Anxiety and Depression Scale. Receiver (...) operating characteristic curve analysis was used to evaluate the differences in fALFF values between the two groups and their diagnostic value. Linear correlations between HADS and fALFF values in different brain regions of DE patients were analyzed using the Pearson correlation coefficient.ResultsPatients with DE had significantly higher fALFF values in the left calcarine sulcus than the HC group, while fALFF values in the bilateral middle frontal gyrus and right MFG/right inferior frontal gyrus were significantly lower in DE patients than in HC group. fALFF values had a high diagnostic value for differentiating patients with DE from the HC group. Right MFG and right MFG/IFG were significantly correlated with HADS values.ConclusionOur study found that DE mainly involved functional disorders in the brain areas of the left CS, bilateral MFG and right MFG/right IFG, which helped us to find possible clinical features of DE disease and reflected the potential pathological mechanism of DE. (shrink)

在发展的时代主旋律里，中国奏响了科学发展的最强音。这是当今中国发展的“好声音”：是建设“美丽中国”的呐喊，是实现“中国梦”的呼唤；它蕴含着一个民族的期望，聚焦着整个世界的目光。但正在实现伟大振兴的中华 民族，要想驾驭科学发展的时代大船，长风破浪，高帆远航，还必须接受灯塔般的科学发展观的指引。因此，我们有必要从科学发展观谈起。.

孙子一书,即孙子兵法,该书以其睿智而富有思辨性,反映了春秋末期,战国初年社会变革的历史,总结了一套科学,实用的系统军事理论.

本书分“德治论坛”、“全球化与伦理问题论坛”、“青少年道德教育论坛”三部分,收录了“儒家伦理与道德义务的权利性条件”、“生命伦理学的前沿问题”、“荀子的生态伦理思想”、“科技时代性伦理问题的向度”等文 章。.

国家社会科学基金规划项目,中共广东省委宣传部重大委托项目,中山岩石学马克思主义哲学与中国现代化研究所主持研究。.

以严复的中西文化观为核心,将中国与西欧这两大思想文化体系,在历史的纵向发展与时代的横向座标这一大背景下,作宏观与微观的对比分析。.

本书是作者关于马克思主义哲学和可持续发展方面的研究成果,全书共收录了五篇文章,从不同方面论述了马克思主义的科学性,核心观点认为马克思主义哲学是当今全球化时代社会可持续发展的理论依据。.

本書旨在探討董仲舒如何藉由《春秋》詮釋，進而建構其獨特之春秋學體系。內容含攝董仲舒春秋學所賴以形成之傳承統緒、理論基礎、詮釋方法，以及董仲舒解會《春秋》所得之「義法」、「歷史」、「災異」、「經權」等相 關理論。【秀威資訊科技股份有限公司製作】.

本书涵盖了国家教委《法理学教学指导纲要》规定的知识要点,同时增加了近年我国法理学研究的新成果以及西方法理学中的经典课题。.

西元前256年，周赧王被秦昭襄王所征服。由此，戰國時代最後階段的華夏世界進入三十五年的「後周魯時代」。 本書提出：在此時期周天子不在的政治權威空白時期，實為《荀子》和《呂氏春秋》兩書之出現的主要契機。以這樣歷史背景為主要契機誕生的兩書，其政治哲學的目標便應該在於構想能治理全天下人民之國家的建立──《荀子 》探求未來以禮義治理天下的君王；《呂氏春秋》則向已成為「de facto天子」的秦王，為提升至名正言順的天子，提供政策綱要和實踐細則。 作者根據較為嚴謹的「觀念史／概念史」分析，闡述《荀》、《呂》兩書在思維上、概念上、論述內容上等多層次的思想特質及其歷史角色。期盼本書在戰國秦漢時代的歷史和思想相關議題之探討能夠提供較新的切入點，並擴大 研究視野。.