New imaging methodologies in quantitative fluorescence microscopy, such as Förster resonance energy transfer (FRET), have been developed in the last few years and are beginning to be extensively applied to biological problems. FRET is employed for the detection and quantification of protein interactions, and of biochemical activities. Herein, we review the different methods to measure FRET in microscopy, and more importantly, their strengths and weaknesses. In our opinion, fluorescence lifetime imaging microscopy (FLIM) is advantageous for detecting inter‐molecular interactions quantitatively, the (...) intensity ratio approach representing a valid and straightforward option for detecting intra‐molecular FRET. Promising approaches in single molecule techniques and data analysis for quantitative and fast spatio‐temporal protein‐protein interaction studies open new avenues for FRET in biological research. (shrink)

This article develops a hermeneutic study of Heidegger’s text The Word of Nietzsche: “God is Dead”. We attempt to read Heidegger’s remarks in the context of the “period of transition” that, according to Nietzsche, is occurring in the history of western thought and culture. This essay unfolds in the following manner: beginning with Heidegger’s contention that Nietzsche’s philosophy is the “fulfilment” of Platonism, we go over the problem of nihilism in relation to the metaphysics of the will to power, which (...) for Heidegger requires revising Cartesian subjectivity in search of a new ontology. Heidegger’s critique of modernity encompasses a narrative that goes from “Plato” to “Nietzsche”, leading to a reconsideration of the notions of art and truth. Finally, we attempt to interpret the meaning of the “madman’s lament” voicing the passing of God. (shrink)

For some time now we have noticed an increasing scepticism regarding the effectiveness of democracy, and its ability to represent citizens through elections. Elections are the central mechanism of political decision taking. However, there is a clear tendency to exploit electo­ rial processes by populist politicians. The ancient ideal of paideia was to educate citizens by following a civic program. Its aim was to enable the citizen to exercise the civil rights and duties. Since the 1970s, however, we had observed (...) two contrasting tendencies: a growth of individualization, and a ecrease of the level of civic education. In the 1990s populist politi­ cal parties entered the political scene of European democracies, some of which have man­ aged to establish a mob rule or ochlocracy (ὀχλοκρατία). Since then, ochlocratic parties have systematically intended to win the votes of politically less educated citizens by offering them a simplified political discourse. In fact, these parties have managed to neutralize the two­party system in many European countries. Thus they managed to block majority­based governments, forcing parties to form coalitions with ideologically opposing smaller parties. This has created a situation in which the “punishment vote” becomes the mean to gain the votes of undecided people who may be characterized as rebels without political culture. (shrink)

La psiquiatría nace con el siglo XIX, la fenomenología con el XX. Desde el advenimiento de la segunda ha querido la primera ver en ella una vía para la superación del positivismo que la atenazaba desde su mismo origen. Uno de sus intentos más logrados fue el del psiquiatra Ludwig Binswanger a lo largo de los años veinte del pasado siglo. Recorrió en ese tiempo las Investigaciones lógicas de Husserl y ensayó su acercamiento a la psicología estructural. Proponemos que una (...) deficiente lectura de las posibilidades de la fenomenología ―comprensible en su prematuridad, desgraciada en su ímpetu anti-(neo)kantiano― impidió que reconociera su horizonte trascendental y así pudiera entrever caminos de acceso al mundo, a la persona y a su concreto sufrimiento. Para concluir presentamos el intento que supone el proyecto La mirada filosófica como mirada médica por recuperar aquella problematicidad y ahondar en una aproximación respetuosa al padecer, tal como aparece, sin violentarlo por el concepto. (shrink)

Research suggests that the ability to understand one’s own and others’ minds, or mentalizing, is a key factor for mental health. Most studies have focused the attention on the association between global measures of mentalizing and specific disorders. In contrast, very few studies have analyzed the association between specific mentalizing polarities and global measures of mental health. This study aimed to evaluate whether self and other polarities of mentalizing are associated with a multidimensional notion of mental health, which considers symptoms, (...) functioning, and well-being. Additionally, the level or depth of mentalizing within each polarity was also analyzed. A sample of 214 adolescents was evaluated on measures of self- and other- mentalizing, multi-informed measures of psychopathology and functioning based on Achenbach’s system, and measures of psychological well-being. Results revealed no association between mentalizing polarities and higher-order symptom factors. Self-mentalizing was associated with self-esteem and motivation to life goals, and other-mentalizing was associated to general, social and role functioning. This association between aspects of self-other mentalizing and self-other function has important implications for treatment and prevention. Deeper mentalizing within each polarity revealed stronger associations with functioning and well-being. Because mentalizing polarities are associated with functioning and well-being but not with symptoms, a new hypothesis is developed: mentalizing does not contribute to resiliency by preventing symptoms, but by helping to deal with them, thus improving functioning and well-being independently of psychopathology. These findings support that promoting mentalizing across development may improve mental health, even in non-clinical population. (shrink)

This paper explores the most relevant proposals involving the notion of Open-Mindedness present in contemporary philosophy. After a short historical introduction, which allows us to establish some of the basic components of the notion of Open-mindedness, the paper presents the current theoretical context of the discussion: virtue epistemology. Two types of theories of Open-Mindedness are distinguished and reasons are given for focusing on one of them, whose three most relevant cases in the current literature are critically presented. The article discusses (...) the most significant challenges that theories of Open-Mindedness must face and draws some conclusions mainly regarding the interrelationships between epistemic virtues and the notion of wisdom. The article concludes with two points regarding the relationship between Open-Mindedness and education, which are analyzed in the light of the previous discussion: the first concerns the possibility of teaching to be open-minded and the second concerns the compatibility of Open-Mindedness with education. | Keywords: open-mindedness, virtue epistemology, epistemic virtues, intellectual humility, wisdom, education. (shrink)

Lloyd (2011) presents highly suggestive results regarding the specificity of the link between particular brain areas and cognitive tasks. Some of his evidence is derived from the analysis of data from the BrainMap database (available: www.brainmap.org), which has become a fundamental resource for the conduct of functional neuroimaging meta-analysis. In the present note, some observations regarding the possibilities and pitfalls of meta-analysis of functional neuroimaging data are given as a complement to Lloyd's excellent exposition of the topic. Additionally, some comments (...) are made on the particular meta-analytic results presented by Lloyd.Functional neuroimaging studies usually present their findings in the form .. (shrink)

While a growing number of works have been published about the use of mixed methods research in nursing, scarce attention has been devoted to the issue of the quality of mixed methods within the discipline. The quality appraisal of mixed methods research poses two problems to nursing science: first, current quality criteria are not nursing‐specific and consequently, they might not facilitate the application of mixed methods research findings into nursing practice. Second, criteria were theoretically derived and as such, they might (...) not faithfully account for the decisions that nurse researchers take when appraising mixed methods research studies. This qualitative, within‐case study explored the views of nurse researchers about mixed methods research in general and, more specifically, the question of quality in mixed methods research. An international sample of 13 nurse researchers was interviewed via Skype and phone. Thematic analysis revealed that the participants favored universal, cross‐disciplinary quality criteria, and not criteria specific to the nursing discipline, and a consensual and standardized approach to appraising the quality of mixed methods research. Recommendations are put forward to strengthen the quality appraisal of mixed methods research studies by nurse researchers, as well as future works on this topic within nursing science. (shrink)

Graham Priest has influentially claimed that the Sorites paradox is an Inclosure paradox, concluding that his favored dialetheic solution to the Inclosure paradoxes should be extended to the Sorites paradox. We argue that, given Priest’s dialetheic solution to the Sorites paradox, the argument purporting to show that that paradox is an Inclosure is unsound, and discuss some issues surrounding this fact.

For centuries, the Sorites Paradox has spurred philosophers to think and argue about the problem of vagueness. This volume offers a guide to the paradox which is both an accessible survey and an exposition of the state of the art, with a chapter-by-chapter presentation of all of the main solutions to the paradox and of all its main areas of influence. Each chapter offers a gentle introduction to its topic, gradually building up to a final discussion of some open problems. (...) Students will find a comprehensive guide to the fundamentals of the paradox, together with lucid explanations of the challenges it continues to raise. Researchers will find exciting new ideas and debates on the paradox. (shrink)

Asking “What is time?” can be both a simple and a profound question. In this article we intend to introduce the reader to the philosophy of time. To do so, we will deal with McTaggart's paradox. By explaining it and introducing the basic concepts to understand it, we will be able to get an idea of what this branch of philosophy is all about. The main intention of this article is not to explain anything new but to clarify the background (...) of a debate by explaining its roots. By taking a deep dive into the concept of time, we will see that it is not a simple concept at all. In any subsequent possible definition with regards to concepts such time for education or time for ethics, a logical clarification of what time is important and will color all further predication of the concept of time. Considering the impact of digital transformation in our lives in general, and in education in particular, a philosophy of time brings major elements such as paradoxes, which are not of practical character but important for the semantic of the words, such as “duration”, “temporal position” of events, etc. (shrink)

Este artículo presenta una reflexión sobre aquellas mujeres que siendomadres “optaron” por vincularse a las Autodefensas Unidas de Colombia, convirtiéndose la gran mayoría en “obreras de la guerra” para cumplir la función materna de no dejar morir a sus hijos. Son madres combatientesque fueron a la guerra para luchar por sus hijos/as, sacrificando su vida por ese otro que una vez hizo parte de ella. Intento demostrar que dichas madres combatientes, no transgreden las normas de la maternidad hegemónica. Transgreden sí, (...) la visión estereotipada de género, según la cual se considera a la mujer esencialmente “pacífica”. Pero no son efectivamente transgresoras de los ideales asociados a la maternidad vista fundamentalmente como esencia, como un hecho biológico e individual. Finalmente se hace una apuesta por repensar la(s) maternidad(es) en una sociedad en (pos) conflicto como la colombiana. (shrink)

In the last few decades, increasing attention has been given to gender issues in urban design. However, research on the urban environment continues to show large gender inequalities, which are especially evident when studying the use and enjoyment of the public space. This study aims to identify predominant patterns of use in public places and to explore the possible existence of traditional gender roles in the urban space. The study uses, three public spaces in the city of Barcelona as a (...) case study, an innovative combination of systematic observation techniques and network analysis procedures. Variables collected by EXOdES, a dedicated software analysis tool for systematic observation, are represented as nodes of a network system and analyzed using network analysis tools. Findings confirmed that, in spite of the progressive consolidation of feminist urbanism, uses in the public realm resulting from traditional gender roles remained explicitly recognizable. Whereas women’s occupation of space was related to playground and resting areas, generally involving care activities concerned with children or elderly people, men were primarily located in resting and sports areas, practicing sports, or participating in leisure activities. These patterns of use were more prone to emerge when users were part of a group than when they were alone. From a gender perspective, a contribution of the study is that it informed about main aspects of the analyzed public spaces reconfirming the existence of traditional roles in society, and the significance of exploring the public space as a key scenario where social features are explicitly exposed. From a methodological perspective, the processing of observational data with network analysis tools proved to be relevant and suitable for dealing with the intricacies of urban place analysis. Compared to more classical approaches and systems, these techniques allowed to identify and interpret complex systems composed of many variables and relationships in a relatively straightforward manner, which turns it into a useful aid for urban designers and architects. (shrink)

Interest in ethical aspects associated to product acquisition and consumption is a growing trend among consumers. In this context, the concept of “product with ethical attributes” has arisen to refer to products with explicit social and environmental characteristics. However, one of the factors that most hinders the purchasing of these products is certainly price. Given the difficulty of reducing price, the question that arises is the extent to which other product attributes can attenuate the negative impact of price on perceived (...) value. We assume that the special benefits associated to this type of products are, at a different level, attenuators of the relationship between price and perceived value. Focusing on Fair Trade organic coffee, hypotheses are tested regarding survey data from 407 customers. They were interviewed in an actual purchasing scenario. The models are tested using conventional Structural Equation Models and the Latent Moderated Structural Equation method. The results obtained shed some light on a highly generalised belief that the marketing of these products can only be improved by reducing their price. However, although a price reduction could be desirable, albeit complicated in this product category, its effects could be reduced by acting on other variables such as the ethical aspects, quality and healthiness of this product category. (shrink)

One of the main problems that Paul Horwich’s Minimalist theory of truth must face is the generalization problem, which shows that Minimalism is too weak to have the fundamental explanatory role Horwich claims it has. In this paper, I defend Horwich’s response to the generalization problem from an objection raised by Bradley Armour-Garb. I also argue that, given my response to Armour-Garb, Horwich’s proposal to cope with the generalization problem can be simplified. -/- L’un des principaux problèmes auxquels la théorie (...) minimaliste de la vérité de Paul Horwich doit faire face est le problème de la généralisation. Horwich soutient que le minimalisme a un rôle explicatif fondamental, mais le problème de la généralisation montre que cette théorie est trop faible pour tenir ce rôle. Dans cet article, je défends la réponse d’Horwich au problème de la généralisation à partir d’une objection soulevée par Bradley Armour-Garb. Je prétends également que ma réponse à Armour-Grab nous permet de formuler d’une manière plus simple la réponse d’Horwich au problème de la généralisation. (shrink)

In this paper I introduce Horwich’s deflationary theory of truth, called ‘Minimalism’, and I present his proposal of how to cope with the Liar Paradox. The proposal proceeds by restricting the T-schema and, as a consequence of that, it needs a constructive specification of which instances of the T-schema are to be excluded from Minimalism. Horwich has presented, in an informal way, one construction that specifies the Minimalist theory. The main aim of the paper is to present and scrutinize some (...) formal versions of Horwich’s construction. (shrink)

This paper argues that the traditional characterization of the notion of paradox — an apparently valid argument with apparently true premises and an apparently false conclusion — is too narrow; there are paradoxes that do not satisfy it. After discussing, and discarding, some alternatives, an outline of a new characterization of the notion of paradox is presented. A paradox is found to be an apparently valid argument such that, apparently, it does not present the kind of commitment to the conclusion (...) that should be implied by an acceptance of the truth of the premises and the validity of the argument. (shrink)

El siguiente artículo trata de investigar los diferentes tipos de narrativas visuales derivadas de las distorsiones de la posverdad como son la manipulación, la viralidad y el cuerpo humano considerado como documento. Para finalizar hablaremos de un tipo de ilustraciones que fomentan la construcción del pensamiento escéptico. Previamente contextualizaremos la situación actual donde tienen lugar el fenómeno de la posverdad y cómo procede ideológicamente de la forma de pensamiento posmoderno donde se exalta el lado irracional y la intuición.

In this paper, we analyze the relationship between the logic of gift and team performance. We explore this connection empirically, using a detailed data set from the National Basketball Association. In particular, we use the NBA Cares Community Assist Award as a way to measure gift-giving to the community. We explore the response of an entire team after one if its members has been recognized for his gift-giving behavior. Using two winners, we show that after a player has received the (...) award there is an increase in the number of assists given by each member of the team, and that there is also an increase in the number of wins. Therefore, our results show that the team’s performance would improve after a player has been recognized because of his gift-giving attitude. This finding to management implies that managers’ incentivization of a sharing and giving philosophy would not only improve their relationship bond but it would also help them increase their performance. (shrink)

This edited collection presents the state of the art in research related to lexical combinations and their restrictions in Spanish from a variety of theoretical approaches, ranging from Explanatory Combinatorial Lexicology to Distributed Morphology and Generative Lexicon Theory. Section 1 offers a presentation of the main theoretical and descriptive approaches to collocation. Section 2 explores collocation from the point of view of its lexicographical representation, while Section 3 offers a pedagogical perspective. Section 4 surveys current research on collocation in Catalan, (...) Galician and Basque. Collocations and other lexical combinations in Spanish will be of interest to students of Hispanic linguistics. ". (shrink)

El presente artículo aborda de manera breve la obra Pasado Negro de Rubem Fonseca, escritor y guionista del cine brasileño; partiendo del análisis semiótico y lingüístico de su obra, sin dejar de lado el matiz que ofrece en la narrativa clásica del siglo XX.

La escritura académica es esencial en la formación universitaria, pero también representa un desafío, ya que los niveles de escritura no siempre son óptimos. Esta investigación describe las percepciones de los estudiantes sobre la escritura académica. Se empleó un enfoque descriptivo no experimental de tipo transversal, aplicando el Cuestionario de Percepción sobre Alfabetización Académica a 295 estudiantes en tres programas universitarios: Educación, Literatura y Lingüística, y Psicología. Los resultados reflejan una apreciación positiva de su competencia comunicativa, considerando que los conocimientos (...) adquiridos han mejorado su proceso de escritura y la identificación de diversos géneros. Al mismo tiempo, reconocen la necesidad de profundizar en las estrategias de escritura. (shrink)

Fichte, Johann G. Lecciones de filosofía aplicada: Doctrina del EstadoSalamanca: Ediciones Sígueme, 288 p.ISBN 978-84-301-1962-2.