First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

The emergence of the genetic counseling profession has allowed laypeople to understand and benefit from biological advances, and to make critical decisions about their application. The discipline of genetic counseling has been criticized from its very beginning, in particular because of its early association with the eugenics movement. This paper presents a critical and reflective overview of how genetic counseling is implicitly embedded in the history of eugenics but also counteracts past eugenic practices and ideas. After World War II, attempts (...) were made to distance genetic counseling from eugenics. The first definition of genetic counseling did not position this field as a medical encounter but "as a kind of genetic social work aimed primarily to provide people with an understanding of their family's genetics problems." This approach was a reaction to the genetic and social evolutionary ideas that informed eugenic theories during the first half of the 20th century. Professionals engaged in genetic counseling during the 1940s and1950s rejected eugenic practices, but there was still support for eugenics’ goals of improving heredity and eliminating disease. From the 1960s, genetic counseling underwent professionalization alongside feminization and a definition of core values. Among these values were nondirectiveness counseling and the autonomy of the counselee. The dark shadow of Nazi ideology and other eugenic practices, attempts to employ the historical responsibility of geneticists, and the dynamic medical, social, political, and educational changes of the 1960s and 1970s helped to frame approaches and delineate the goals and limits of the new profession of “genetic counseling.”. (shrink)

Since the onset of the SARS-CoV-2 pandemic, an array of off-label interventions has been used to treat patients, either provided as compassionate care or tested in clinical trials. There is a challenge in determining the justification for conducting randomised controlled trials over providing compassionate use in an emergency setting. A rapid and more accurate evaluation tool is needed to assess the effect of these treatments. Given the similarity to the Ebola Virus Disease (EVD) pandemic in Africa in 2014, we suggest (...) using a tool designed by the WHO committee in the aftermath of the EVD pandemic: Monitored Emergency Use of Unregistered and Investigational Interventions (MEURI). Considering the uncertainty around SARS-CoV-2, we propose using an improved MEURI including the Plan–Do–Study–Act tool. This combined tool may facilitate dynamic monitoring, analysing, re-evaluating and re-authorising emergency use of unproven treatments and repeat it in cycles. It will enable adjustment and application of outcomes to clinical practice according to changing circumstances and increase the production of valuable data to promote the best standard of care and high-quality research—even during a pandemic. (shrink)

Both young children and agrammatic aphasic speakers have difficulty interpreting pronouns, but not reflexive elements. This phenomenon is known as the delay of Principle B effect in language acquisition. The interpretation of pronouns is non-adult-like for children and disturbed in agrammatic aphasia, yet there is evidence that interpretation of pronouns is not always problematic for these populations and that it seems to be governed by linguistic principles. This chapter examines the linguistic principles underlying the interpretation of pronouns and reflexives among (...) children and agrammatic aphasic speakers whose native languages were Dutch, Spanish, and Italian by focusing on two types of sentences: simple transitive sentences and Exceptional Case Marking constructions. It first looks at earlier research on language acquisition and agrammatism before discussing two important linguistic theories, Government and Binding Theory and Reflexivity and Primitives of Binding. (shrink)

An uneasy alliance.--The impact of technology.--Facts and reason in a nuclear age.--Through the crystal ball.--Priorities and secrecy in science.--Liberty in the age of science.--The social function of science.